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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620007
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2j4
Name: cytochrome P450, family 2, subfamily j, polypeptide 4
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2j4decreases expressionISOCYP2J2 (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of CYP2J2 mRNAPMID:29803840
Cyp2j4decreases expressionISOCyp2j9 (Mus musculus)6480464CTDDoxorubicin results in decreased expression of CYP2J2 proteinPMID:19429816
Cyp2j4multiple interactionsISOCyp2j9 (Mus musculus)6480464CTDCYP2J2 protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]; CYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of ANKRD1 protein]; CYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; CYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of MYH7 protein]; CYP2J2 protein results in increased metabolism of and results in decreased susceptibility to DoxorubicinPMID:19429816
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