GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2j4 | decreases expression | ISO | CYP2J2 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of CYP2J2 mRNA | PMID:29803840 | Cyp2j4 | decreases expression | ISO | Cyp2j9 (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased expression of CYP2J2 protein | PMID:19429816 | Cyp2j4 | multiple interactions | ISO | Cyp2j9 (Mus musculus) | 6480464 | CTD | CYP2J2 protein affects the reaction [Doxorubicin results in increased activity of CASP3 protein]; CYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of ANKRD1 protein]; CYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of CAT protein]; CYP2J2 protein inhibits the reaction [Doxorubicin results in increased activity of MYH7 protein]; CYP2J2 protein results in increased metabolism of and results in decreased susceptibility to Doxorubicin | PMID:19429816 | |
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