Rala (RAS like proto-oncogene A) - Rat Genome Database

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Gene: Rala (RAS like proto-oncogene A) Rattus norvegicus
Analyze
Symbol: Rala
Name: RAS like proto-oncogene A
RGD ID: 619851
Description: Predicted to enable several functions, including Edg-2 lysophosphatidic acid receptor binding activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human RALA (RAS like proto-oncogene A); PARTICIPATES IN ceramide signaling pathway; pancreatic cancer pathway; INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: -ral simian leukemia viral oncogene homolog A (ras related); RALA Ras like proto-oncogene A; ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81751,787,682 - 51,840,738 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1751,787,699 - 51,840,733 (+)EnsemblGRCr8
mRatBN7.21747,092,163 - 47,145,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1747,092,207 - 47,144,063 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1750,320,930 - 50,334,044 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01754,323,855 - 54,336,969 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01748,425,724 - 48,438,842 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01749,676,073 - 49,729,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1749,714,294 - 49,727,664 (+)Ensemblrn6Rnor6.0
Rnor_5.01747,733,086 - 47,785,809 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41755,017,444 - 55,030,555 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1743,214,914 - 43,228,029 (+)NCBICelera
RGSC_v3.11755,020,284 - 55,033,396 (+)NCBI
Cytogenetic Map17q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
citalopram  (EXP)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dichlorine  (EXP)
doxorubicin  (ISO)
escitalopram  (EXP)
ethyl methanesulfonate  (ISO)
eugenol  (EXP)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
ozone  (EXP)
pentachlorophenol  (ISO)
phenol red  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP)
pyrimidifen  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cleavage furrow  (IEA,ISO,ISS)
cytosol  (TAS)
endocytic vesicle  (IEA,ISO)
Flemming body  (IEA)
membrane  (IEA)
midbody  (IEA)
mitochondrion  (IEA,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS)
Schaffer collateral - CA1 synapse  (EXP,IDA,IMP)
synaptic membrane  (IDA,IEP)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Cantor SB, etal., Mol Cell Biol 1995 Aug;15(8):4578-84.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. Han K, etal., PLoS Biol. 2009 Sep;7(9):e1000187. Epub 2009 Sep 8.
4. Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome. Lemstrova R, etal., Oncol Lett. 2017 Nov;14(5):5980-5988. doi: 10.3892/ol.2017.6946. Epub 2017 Sep 14.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins. Wildey GM, etal., Biochem Biophys Res Commun 1993 Jul 15;194(1):552-9.
Additional References at PubMed
PMID:10051605   PMID:15034142   PMID:15592429   PMID:15817490   PMID:15920473   PMID:15980073   PMID:16330713   PMID:17202486   PMID:17634366   PMID:17765682   PMID:17875936   PMID:18426794  
PMID:18697830   PMID:18756269   PMID:19056867   PMID:19199708   PMID:19306925   PMID:19383721   PMID:19890390   PMID:20005108   PMID:20025911   PMID:20458337   PMID:21148297   PMID:21423176  
PMID:22820503   PMID:22871113   PMID:23063435   PMID:23346930   PMID:23533145   PMID:24056301   PMID:24165023   PMID:25931508  


Genomics

Comparative Map Data
Rala
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81751,787,682 - 51,840,738 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1751,787,699 - 51,840,733 (+)EnsemblGRCr8
mRatBN7.21747,092,163 - 47,145,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1747,092,207 - 47,144,063 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1750,320,930 - 50,334,044 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01754,323,855 - 54,336,969 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01748,425,724 - 48,438,842 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01749,676,073 - 49,729,133 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1749,714,294 - 49,727,664 (+)Ensemblrn6Rnor6.0
Rnor_5.01747,733,086 - 47,785,809 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41755,017,444 - 55,030,555 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1743,214,914 - 43,228,029 (+)NCBICelera
RGSC_v3.11755,020,284 - 55,033,396 (+)NCBI
Cytogenetic Map17q11NCBI
RALA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38739,623,572 - 39,708,120 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl739,623,445 - 39,708,124 (+)Ensemblhg38GRCh38
GRCh37739,663,171 - 39,747,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36739,629,687 - 39,714,244 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34739,436,401 - 39,520,955NCBI
Celera739,650,672 - 39,735,235 (+)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef739,547,203 - 39,631,708 (+)NCBIHuRef
CHM1_1739,665,812 - 39,750,388 (+)NCBICHM1_1
T2T-CHM13v2.0739,781,130 - 39,865,684 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2739,701,014 - 39,785,596 (+)NCBI
Rala
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391318,055,160 - 18,118,802 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1318,055,156 - 18,118,824 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381317,880,575 - 17,944,217 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1317,880,571 - 17,944,239 (-)Ensemblmm10GRCm38
MGSCv371317,972,409 - 18,036,051 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361317,665,717 - 17,729,359 (-)NCBIMGSCv36mm8
Celera1318,186,452 - 18,249,466 (-)NCBICelera
Cytogenetic Map13A2NCBI
cM Map136.05NCBI
Rala
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554603,789,136 - 3,808,676 (-)Ensembl
ChiLan1.0NW_0049554603,789,136 - 3,853,315 (-)NCBIChiLan1.0ChiLan1.0
RALA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2648,727,420 - 48,816,968 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1797,052,156 - 97,141,708 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0744,528,146 - 44,611,431 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1744,559,380 - 44,580,495 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl744,559,380 - 44,580,495 (-)EnsemblpanPan2panpan1.1
RALA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11810,022,490 - 10,047,583 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1810,024,311 - 10,039,183 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha189,870,700 - 9,943,845 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01810,071,028 - 10,144,177 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1810,071,028 - 10,144,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11810,047,951 - 10,121,169 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01810,023,815 - 10,096,978 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01810,132,824 - 10,205,970 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rala
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511895,943,354 - 95,974,863 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647815,167,751 - 15,186,633 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647815,167,651 - 15,186,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RALA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1854,550,238 - 54,588,980 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11854,548,523 - 54,630,746 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21859,906,510 - 59,921,749 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RALA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12118,826,569 - 18,911,379 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2118,826,582 - 18,911,357 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660623,483,982 - 3,570,415 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rala
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474021,281,602 - 21,346,928 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474021,281,678 - 21,347,109 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rala
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11436,445,579 - 36,458,818 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rala
354 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:14
Interacting mature miRNAs:14
Transcripts:ENSRNOT00000018190
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173219953455604694Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
Rasl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21747,133,327 - 47,133,456 (+)MAPPERmRatBN7.2
Rnor_6.01749,717,271 - 49,717,399NCBIRnor6.0
Rnor_5.01747,773,947 - 47,774,075UniSTSRnor5.0
RGSC_v3.41755,020,425 - 55,020,553UniSTSRGSC3.4
Celera1743,217,895 - 43,218,023UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018190   ⟹   ENSRNOP00000018190
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1751,787,699 - 51,840,733 (+)Ensembl
mRatBN7.2 Ensembl1747,092,207 - 47,144,063 (+)Ensembl
Rnor_6.0 Ensembl1749,714,294 - 49,727,664 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102020   ⟹   ENSRNOP00000090376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1751,787,809 - 51,840,733 (+)Ensembl
mRatBN7.2 Ensembl1747,092,253 - 47,143,462 (+)Ensembl
RefSeq Acc Id: NM_001414180   ⟹   NP_001401109
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81751,787,708 - 51,840,738 (+)NCBI
mRatBN7.21747,092,163 - 47,145,192 (+)NCBI
RefSeq Acc Id: NM_031093   ⟹   NP_112355
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81751,787,708 - 51,840,738 (+)NCBI
mRatBN7.21747,092,163 - 47,145,192 (+)NCBI
Rnor_6.01749,714,290 - 49,727,401 (+)NCBI
Rnor_5.01747,733,086 - 47,785,809 (+)NCBI
RGSC_v3.41755,017,444 - 55,030,555 (+)RGD
Celera1743,214,914 - 43,228,029 (+)RGD
Sequence:
RefSeq Acc Id: XM_039096110   ⟹   XP_038952038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81751,824,772 - 51,840,738 (+)NCBI
mRatBN7.21747,129,356 - 47,145,192 (+)NCBI
RefSeq Acc Id: XM_039096112   ⟹   XP_038952040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81751,787,942 - 51,840,738 (+)NCBI
mRatBN7.21747,092,604 - 47,145,192 (+)NCBI
RefSeq Acc Id: XM_063276773   ⟹   XP_063132843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81751,787,682 - 51,840,738 (+)NCBI
RefSeq Acc Id: NP_112355   ⟸   NM_031093
- UniProtKB: P63322 (UniProtKB/Swiss-Prot),   A6K9A2 (UniProtKB/TrEMBL),   A0A8L2Q942 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018190   ⟸   ENSRNOT00000018190
RefSeq Acc Id: XP_038952040   ⟸   XM_039096112
- Peptide Label: isoform X1
- UniProtKB: P63322 (UniProtKB/Swiss-Prot),   A6K9A2 (UniProtKB/TrEMBL),   A0A8L2Q942 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952038   ⟸   XM_039096110
- Peptide Label: isoform X1
- UniProtKB: P63322 (UniProtKB/Swiss-Prot),   A6K9A2 (UniProtKB/TrEMBL),   A0A8L2Q942 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090376   ⟸   ENSRNOT00000102020
RefSeq Acc Id: NP_001401109   ⟸   NM_001414180
- UniProtKB: P63322 (UniProtKB/Swiss-Prot),   A6K9A2 (UniProtKB/TrEMBL),   A0A8L2Q942 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132843   ⟸   XM_063276773
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63322-F1-model_v2 AlphaFold P63322 1-206 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619851 AgrOrtholog
BioCyc Gene G2FUF-9115 BioCyc
Ensembl Genes ENSRNOG00000013454 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018190 ENTREZGENE
  ENSRNOT00000102020 ENTREZGENE
  ENSRNOT00000102020.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot
KEGG Report rno:81757 UniProtKB/Swiss-Prot
NCBI Gene 81757 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rala PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013454 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2Q942 ENTREZGENE, UniProtKB/TrEMBL
  A6K9A1_RAT UniProtKB/TrEMBL
  A6K9A2 ENTREZGENE, UniProtKB/TrEMBL
  A6K9A3_RAT UniProtKB/TrEMBL
  P63322 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P05810 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 Rala  RAS like proto-oncogene A  Rala  RALA Ras like proto-oncogene A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-20 Rala  RALA Ras like proto-oncogene A  Rala  v-ral simian leukemia viral oncogene homolog A (ras related)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rala  v-ral simian leukemia viral oncogene homolog A (ras related)      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rala  #NAME?      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript has two transcripts approximately 1.1 kb in size and a 2.9 kb transcript 633818