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Gene: Rraga (Ras-related GTP binding A) Rattus norvegicus

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Symbol:

Rraga

Name:

Ras-related GTP binding A

RGD ID:

619804

Description:

Enables GTP binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within several processes, including TORC1 signaling; cellular response to methionine; and regulation of translational initiation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP; GATOR1 complex; and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGA (Ras related GTP binding A); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3H-1,2-dithiole-3-thione.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

rag A; Raga; ras-related GTP-binding protein A; Ras-related GTP-binding protein ragA

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RRAGA (Ras related GTP binding A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Rraga (Ras-related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rraga (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RRAGA (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RRAGA (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rraga (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RRAGA (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RRAGA (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rraga (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rraga (Ras related GTP binding A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RRAGB (Ras related GTP binding B)	HGNC	OrthoDB
Homo sapiens (human):	CD33 (CD33 molecule)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RRAGA (Ras related GTP binding A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rraga (Ras-related GTP binding A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rraga (Ras-related GTP binding A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rraga (Ras-related GTP binding A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rraga (Ras-related GTP binding A)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GTR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GTR1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RagA-B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	raga-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rraga	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rraga	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	106,159,335 - 106,160,930 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	106,158,853 - 106,160,504 (+)	Ensembl				GRCr8
mRatBN7.2	5	101,113,341 - 101,114,936 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	101,112,859 - 101,114,510 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	103,494,750 - 103,496,346 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	105,285,292 - 105,286,888 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	105,318,424 - 105,320,020 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	104,941,067 - 104,942,662 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	104,941,066 - 104,942,662 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	108,928,874 - 108,930,469 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	105,659,659 - 105,661,254 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	99,598,082 - 99,599,677 (+)	NCBI		Celera
RGSC_v3.1	5	105,664,899 - 105,666,476 (+)	NCBI
Cytogenetic Map	5	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cadmium atom (ISO)

calcium atom (EXP)

calcium(0) (EXP)

captan (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

copper(II) sulfate (ISO)

cyclophosphamide (ISO)

Dibutyl phosphate (ISO)

dimethyl sulfoxide (ISO)

disodium selenite (ISO)

doxorubicin (ISO)

flutamide (EXP)

folic acid (ISO)

folpet (ISO)

methapyrilene (EXP)

methimazole (EXP)

ozone (ISO)

paracetamol (EXP)

phenobarbital (ISO)

phenol (ISO)

picoxystrobin (ISO)

resorcinol (ISO)

resveratrol (ISO)

rotenone (ISO)

scopolamine (EXP)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (EXP)

sulfadimethoxine (EXP)

temozolomide (ISO)

tetrachloromethane (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

triticonazole (EXP)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

biological_process (ND)

cellular response to amino acid starvation (IEA,ISO,ISS)

cellular response to amino acid stimulus (IEA,ISO,ISS)

cellular response to nutrient levels (IEA,ISO)

cellular response to starvation (IBA,IEA,ISO)

glucose homeostasis (IEA,ISO)

intracellular protein localization (IEA,ISO,ISS)

intracellular signal transduction (IEA,ISO)

negative regulation of autophagy (IBA,IEA,ISO,ISS)

positive regulation of TOR signaling (IEA,ISO)

positive regulation of TORC1 signaling (IBA,IEA,ISO,ISS)

protein localization to lysosome (IEA,ISO)

protein localization to membrane (IEA,ISO,ISS)

regulation of TORC1 signaling (ISS)

response to amino acid (ISS)

tumor necrosis factor-mediated signaling pathway (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO,ISS)

FNIP-folliculin RagC/D GAP (IEA,ISO)

GATOR1 complex (IEA,ISO,ISS)

Gtr1-Gtr2 GTPase complex (IBA,IEA,ISO)

lysosomal membrane (IEA,ISO,ISS)

lysosome (IBA,IEA,ISO,ISS)

nucleoplasm (IEA,ISO)

nucleus (IBA,IEA,ISO,ISS)

Molecular Function

GTP binding (IBA,IDA,IEA,ISO,ISS)

GTPase activity (IBA,IEA,ISO,ISS)

hydrolase activity (IEA)

nucleotide binding (IEA)

phosphoprotein binding (IEA,ISO,ISS)

protein binding (ISO)

protein heterodimerization activity (IEA,ISO,ISS)

protein homodimerization activity (IEA,ISO,ISS)

protein-membrane adaptor activity (IEA,ISO,ISS)

ubiquitin protein ligase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Regulation of mTORC1 by amino acids.	Bar-Peled L and Sabatini DM, Trends Cell Biol. 2014 Jul;24(7):400-6. doi: 10.1016/j.tcb.2014.03.003. Epub 2014 Mar 31.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Molecular mechanisms of mTOR-mediated translational control.	Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
4.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation
9.	Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.	Schurmann A, etal., J Biol Chem 1995 Dec 1;270(48):28982-8.
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:8995684	PMID:9394008	PMID:11073942	PMID:14660641	PMID:15489334	PMID:17897319	PMID:20381137	PMID:22424946	PMID:23723238	PMID:25936802	PMID:31505169

Genomics

Comparative Map Data

Rraga
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	106,159,335 - 106,160,930 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	5	106,158,853 - 106,160,504 (+)	Ensembl				GRCr8
mRatBN7.2	5	101,113,341 - 101,114,936 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	101,112,859 - 101,114,510 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	5	103,494,750 - 103,496,346 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	105,285,292 - 105,286,888 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	105,318,424 - 105,320,020 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	104,941,067 - 104,942,662 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	104,941,066 - 104,942,662 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	5	108,928,874 - 108,930,469 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	5	105,659,659 - 105,661,254 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	5	99,598,082 - 99,599,677 (+)	NCBI		Celera
RGSC_v3.1	5	105,664,899 - 105,666,476 (+)	NCBI
Cytogenetic Map	5	q31	NCBI

RRAGA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	19,049,427 - 19,051,025 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	19,049,427 - 19,051,025 (+)	Ensembl			hg38	GRCh38
GRCh37	9	19,049,425 - 19,051,023 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	19,039,372 - 19,041,023 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	19,039,371 - 19,041,019	NCBI
Celera	9	18,975,567 - 18,977,218 (+)	NCBI		Celera
Cytogenetic Map	9	p22.1	NCBI
HuRef	9	19,010,976 - 19,012,627 (+)	NCBI		HuRef
CHM1_1	9	19,049,357 - 19,051,008 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	19,062,292 - 19,063,890 (+)	NCBI		T2T-CHM13v2.0

Rraga
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	86,493,910 - 86,495,522 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	86,493,905 - 86,495,522 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	4	86,575,673 - 86,577,285 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	86,575,668 - 86,577,285 (+)	Ensembl			mm10	GRCm38
MGSCv37	4	86,221,577 - 86,223,189 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	4	86,046,917 - 86,048,516 (+)	NCBI		MGSCv36	mm8
Celera	4	85,090,453 - 85,092,065 (+)	NCBI		Celera
Cytogenetic Map	4	C4	NCBI
cM Map	4	40.69	NCBI

Rraga
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955434	21,509,529 - 21,510,470 (+)	Ensembl
ChiLan1.0	NW_004955434	21,509,528 - 21,510,885 (+)	NCBI	ChiLan1.0	ChiLan1.0

RRAGA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	105,486,096 - 105,488,277 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	105,492,082 - 105,495,742 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	18,868,781 - 18,870,356 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	19,362,181 - 19,363,964 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	19,362,599 - 19,363,540 (+)	Ensembl			panPan2	panpan1.1

RRAGA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	38,886,990 - 38,888,634 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	38,886,397 - 38,888,184 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	37,545,897 - 37,547,387 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	39,820,183 - 39,821,680 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	39,820,017 - 39,821,680 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	38,513,447 - 38,514,944 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	38,308,366 - 38,309,857 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	38,945,442 - 38,946,939 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rraga
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	153,322,322 - 153,323,975 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936652	991,832 - 993,439 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RRAGA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	203,772,759 - 203,774,577 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	203,772,063 - 203,774,580 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	227,419,614 - 227,421,440 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RRAGA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	60,669,841 - 60,671,482 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	48,795,138 - 48,796,787 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rraga
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624736	23,035,836 - 23,049,574 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rraga
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	67,412,997 - 67,414,612 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rraga
10 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	38
Interacting mature miRNAs:	38
Transcripts:	ENSRNOT00000009225
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357396	Bw44	Body weight QTL 44	4.19		body mass (VT:0001259)	body weight (CMO:0000012)	5	73779642	118779642	Rat
1331796	Thshl2	Thyroid stimulating hormone level QTL 2	2.3		blood thyroid-stimulating hormone amount (VT:0005119)	serum thyroid stimulating hormone level (CMO:0001248)	5	102105698	152749382	Rat
2303586	Gluco52	Glucose level QTL 52	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	100826632	145826632	Rat
1549845	Scl44	Serum cholesterol level QTL 44	6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	44924861	153890773	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	38207390	136631402	Rat
1298070	Scl18	Serum cholesterol level QTL 18	3.7		blood LDL cholesterol amount (VT:0000181)	calculated plasma low density lipoprotein cholesterol level (CMO:0001245)	5	84630798	129630798	Rat
61452	Ciaa5	CIA Autoantibody QTL 5	3.5		blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	5	99905133	172190305	Rat
1331801	Rf33	Renal function QTL 33	4.149		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	5	48523123	134369373	Rat
2302381	Bw84	Body weight QTL 84	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
1357402	Bw46	Body weight QTL 46	4.47		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	5	73779642	118779642	Rat
7411582	Foco3	Food consumption QTL 3	7.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
61393	Bp7	Blood pressure QTL 7	4.5	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	65089051	166764498	Rat
1598859	Cm66	Cardiac mass QTL 66	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	5	84630798	129630798	Rat
1578766	Tcas11	Tongue tumor susceptibility QTL 11	4.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	5	51657967	166600247	Rat
1582212	Livw2	Liver weight QTL 2	3.5	0.0004	liver mass (VT:0003402)	liver weight to body weight ratio (CMO:0000633)	5	104018576	124314782	Rat
7411564	Bw135	Body weight QTL 135		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	92583776	137583776	Rat
8657050	Bw146	Body weight QTL 146	19.84	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	5	98972960	143972960	Rat
1576312	Emca8	Estrogen-induced mammary cancer QTL 8	4.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	55124766	172190305	Rat
7411601	Foco12	Food consumption QTL 12	19.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	5	92583776	137583776	Rat
2303618	Vencon1	Ventilatory control QTL 1	3.8		respiration trait (VT:0001943)	oxygen consumption (CMO:0002169)	5	100826632	145826632	Rat
7394708	Emca11	Estrogen-induced mammary cancer QTL 11			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	73176602	118176602	Rat
1598846	Bp293	Blood pressure QTL 293	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	84630798	129630798	Rat
7394710	Emca12	Estrogen-induced mammary cancer QTL 12			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	94034903	139034903	Rat
1578673	Bmd13	Bone mineral density QTL 13	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	5	69474415	114474415	Rat
1358909	Kidm25	Kidney mass QTL 25	1.87		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	5	95062526	133270832	Rat
70189	Mcs5	Mammary carcinoma susceptibility QTL 5	10.51		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	60601597	137492949	Rat
2290448	Scl54	Serum cholesterol level QTL 54	2.93		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	5	36460764	136631402	Rat
61426	Scl2	Serum cholesterol level QTL 2	7.3	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	64589016	109589016	Rat
1354598	Srn6	Serum renin concentration QTL 6	3.8		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	5	74335621	156302135	Rat
1600362	Mcs19	Mammary carcinoma susceptibility QTL 19	2.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	82032155	127032155	Rat
1298086	Bp156	Blood pressure QTL 156			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	5	89369373	134369373	Rat
2290005	Mcs24	Mammary carcinoma susceptibility QTL 24			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	69835120	114835120	Rat
2306971	Anxrr21	Anxiety related response QTL 21	9.47		fear/anxiety-related behavior trait (VT:1000241)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	5	70969494	136328156	Rat
1358895	Bp254	Blood pressure QTL 254	3.6	0.0003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	97492524	133270832	Rat
2312671	Scl64	Serum cholesterol level QTL 64		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	5	73779642	118779642	Rat
6903316	Bw113	Body weight QTL 113	2	0.0103	body mass (VT:0001259)	body weight (CMO:0000012)	5	92881678	137881678	Rat
1358889	Bp261	Blood pressure QTL 261	2.86		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	5	95062526	133270832	Rat
1358187	Emca1	Estrogen-induced mammary cancer QTL 1	4.4		mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	5	104262817	153890625	Rat

Markers in Region

D5Got131

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	101,112,265 - 101,112,414 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	104,939,992 - 104,940,140	NCBI	Rnor6.0
Rnor_5.0	5	108,927,799 - 108,927,947	UniSTS	Rnor5.0
RGSC_v3.4	5	105,658,583 - 105,658,732	RGD	RGSC3.4
RGSC_v3.4	5	105,658,584 - 105,658,732	UniSTS	RGSC3.4
Celera	5	99,597,007 - 99,597,155	UniSTS
RGSC_v3.1	5	105,663,810 - 105,663,958	RGD
RH 3.4 Map	5	741.8	UniSTS
RH 3.4 Map	5	741.8	RGD
RH 2.0 Map	5	660.2	RGD
Cytogenetic Map	5	q32	UniSTS

RH140944

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	101,114,607 - 101,114,788 (+)	MAPPER	mRatBN7.2
Rnor_6.0	5	104,942,334 - 104,942,514	NCBI	Rnor6.0
Rnor_5.0	5	108,930,141 - 108,930,321	UniSTS	Rnor5.0
RGSC_v3.4	5	105,660,926 - 105,661,106	UniSTS	RGSC3.4
Celera	5	99,599,349 - 99,599,529	UniSTS
RH 3.4 Map	5	735.3	UniSTS
Cytogenetic Map	5	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC108974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK599679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X85183	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009225 ⟹ ENSRNOP00000009225

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	5	106,158,853 - 106,160,504 (+)	Ensembl
mRatBN7.2 Ensembl	5	101,112,859 - 101,114,510 (+)	Ensembl
Rnor_6.0 Ensembl	5	104,941,066 - 104,942,662 (+)	Ensembl

RefSeq Acc Id:

NM_053973 ⟹ NP_446425

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	106,159,335 - 106,160,930 (+)	NCBI
mRatBN7.2	5	101,113,341 - 101,114,936 (+)	NCBI
Rnor_6.0	5	104,941,067 - 104,942,662 (+)	NCBI
Rnor_5.0	5	108,928,874 - 108,930,469 (+)	NCBI
RGSC_v3.4	5	105,659,659 - 105,661,254 (+)	RGD
Celera	5	99,598,082 - 99,599,677 (+)	RGD

Sequence:

show sequence

TAGGCTGGAGCTGATCGCATCACTAGTTTGGTCTCCCTAGCTCCGAGCTGCTGTGGCCATTGCC
TCCAGCGCTGTTTTCTGAGGCCTCGCCTCCGCCGTCTTTCCTGCCCGAGCTCCGGTGCAAGGCC
TCCGCTGCCAGACGGTGCCTGGTGTCCCGCCGTTCCCATCCTCGGTTGGTCCGCCGTTAGGCCG
TGCCTCAGGCCCAATCCGCGGCGACGCCGGCAGGTGATGCCAAATACAGCCATGAAGAAAAAGG
TGCTGTTGATGGGAAAGAGCGGGTCGGGGAAGACCAGCATGAGGTCGATCATCTTTGCAAATTA
TATTGCGCGCGACACCAGGCGCCTGGGTGCCACCATCGACGTGGAGCACTCCCACGTCCGATTC
TTGGGGAACCTGGTGCTGAACCTGTGGGACTGTGGCGGCCAGGACACCTTTATGGAAAATTACT
TCACCAGCCAGCGGGACAACATCTTCCGTAATGTGGAGGTTCTGATCTACGTGTTTGACGTAGA
GAGCCGCGAACTGGAAAAAGATATGCATTATTATCAGTCGTGTCTGGAAGCCATCCTCCAGAAT
TCACCTGATGCCAAAATCTTCTGCCTGGTGCACAAAATGGATCTGGTTCAGGAAGATCAACGTG
ACCTGATTTTTAAAGAGCGAGAAGAAGACCTGAGGCGTTTGTCTCGCCCGCTGGAGTGCGCTTG
TTTTCGAACGTCCATCTGGGATGAGACGCTCTACAAAGCCTGGTCCAGCATCGTCTATCAGCTG
ATCCCCAACGTTCAGCAGCTGGAGATGAACCTAAGGAATTTTGCCCAGATTATTGAGGCTGATG
AAGTTCTGCTGTTCGAGAGAGCTACGTTCTTGGTGATTTCCCACTACCAGTGCAAAGAGCAGCG
AGATGTACACCGCTTTGAGAAGATCAGCAACATCATCAAGCAGTTTAAGCTAAGCTGTAGTAAA
TTGGCCGCTTCTTTCCAGAGCATGGAAGTGAGGAATTCTAACTTCGCTGCCTTCATCGACATCT
TTACATCAAACACGTATGTGATGGTGGTCATGTCAGATCCATCCATCCCTTCTGCAGCTACTCT
GATCAACATTCGTAATGCCAGGAAACACTTTGAGAAGCTAGAGAGAGTAGATGGCCCCAAGCAC
AGCCTCCTCATGCGCTGACATAATGCCAAATGCTCTTTAGTAAATGCTGAATTATGGTGGGTTT
TTTTTTTTGCATCATTTGTTTTTAATATTCATAATGTCATGTGCTTAAAAGTGGGCTTTGAAAC
GTGTGCTTACTATCTCATCTCTTCCCTAGTCTTAGTATTGGACGCTATTTACTCAGCTATCCAG
TAGAGATCCTCAAGACGGCCTTTATGAAAAGTTAGTGTGGTGTTAACACTAAAGTAGGTGGTGT
GTATGGGTGTGTGTGTGTGTGGGTGTGTTATGGTTACCTGGTTATAATAGAGTATTAAAGCAGT
TATCTTCTGTATTATCAGATCACAAAGGTGGAATGTTACTATTTTATCAGCAAGATATTAAAAT
GTATTTCTAAATCCTCCTTGGTTTCAATCATGAATAAACATTTATTATTAGCAATTTAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_446425	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH61850	(Get FASTA)	NCBI Sequence Viewer
	CAA59466	(Get FASTA)	NCBI Sequence Viewer
	EDM10442	(Get FASTA)	NCBI Sequence Viewer
	Q63486	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446425 ⟸ NM_053973

- UniProtKB:

Q63486 (UniProtKB/Swiss-Prot), A6J865 (UniProtKB/TrEMBL), A0A8L2Q4X0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCG
GQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHK
MDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLR
NFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRN
SNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR

hide sequence

Ensembl Acc Id:

ENSRNOP00000009225 ⟸ ENSRNOT00000009225

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q63486-F1-model_v2	AlphaFold	Q63486	1-313	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693824

Promoter ID:

EPDNEW_R4349

Type:

initiation region

Name:

Rraga_1

Description:

Ras-related GTP binding A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	5	104,941,088 - 104,941,148	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619804	AgrOrtholog
BioCyc Gene	G2FUF-40850	BioCyc
Ensembl Genes	ENSRNOG00000007051	Ensembl
Gene3D-CATH	3.30.450.190	UniProtKB/Swiss-Prot
	3.40.50.300	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:5621998	IMAGE-MGC_LOAD
InterPro	Gtr1_RagA	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
	RagA/B	UniProtKB/Swiss-Prot
KEGG Report	rno:117044	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72342	IMAGE-MGC_LOAD
NCBI Gene	117044	ENTREZGENE
PANTHER	PTHR11259	UniProtKB/Swiss-Prot
	RAS-RELATED GTP-BINDING PROTEIN A	UniProtKB/Swiss-Prot
Pfam	Gtr1_RagA	UniProtKB/Swiss-Prot
PhenoGen	Rraga	PhenoGen
RatGTEx	ENSRNOG00000007051	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
UniProt	A0A8L2Q4X0	ENTREZGENE, UniProtKB/TrEMBL
	A6J865	ENTREZGENE, UniProtKB/TrEMBL
	Q63486	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Rraga	Ras-related GTP binding A		Ras-related GTP-binding protein ragA	Name updated	1299863	APPROVED
2004-09-10	Rraga	Ras-related GTP-binding protein ragA	Raga		Symbol and Name updated	1299863	APPROVED
2002-08-07	Raga	Ras-related GTP-binding protein ragA			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_homology	along with Ragb, may be mammalian homologs of the yeast protein Gtr1	633888

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

RGD Manual Annotations

Imported Annotations - PID (archival)

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RGD Manual Annotations

Imported Annotations - PID (archival)