Vegfc (vascular endothelial growth factor C) - Rat Genome Database

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Gene: Vegfc (vascular endothelial growth factor C) Rattus norvegicus
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Symbol: Vegfc
Name: vascular endothelial growth factor C
RGD ID: 619800
Description: Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein autophosphorylation; and regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ceramide signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: flt4 ligand; flt4-L; vascular endothelial growth factor-related protein; VEGF-C; VRP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81644,445,293 - 44,560,887 (-)NCBIGRCr8
mRatBN7.21637,712,251 - 37,827,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1643,068,855 - 43,184,449 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01646,429,675 - 46,545,267 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01641,783,170 - 41,898,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01640,440,371 - 40,555,178 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01640,216,307 - 40,331,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41640,624,435 - 40,739,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11640,624,509 - 40,739,767 (-)NCBI
Celera1635,834,400 - 35,949,683 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
VegfcRatatherosclerosis  ISOVegfc (Mus musculus)7483588associated with hypercholesterolemia and protein:increased expression:serum:RGD 
VegfcRatbreast carcinoma  ISOVEGFC (Homo sapiens)2315477 RGD 
VegfcRatcolon adenocarcinoma  IEP 2315488mRNA:increased expression:colonRGD 
VegfcRathepatocellular carcinoma  ISOVEGFC (Homo sapiens)15003200associated with liver cirrhosis and protein:increased expression:liver:RGD 
VegfcRatinvasive ductal carcinoma disease_progressionISOVEGFC (Homo sapiens)2315471 RGD 
VegfcRatliver cirrhosis  ISOVEGFC (Homo sapiens)15003200protein:increased expression:liver:RGD 
VegfcRatLymphatic Metastasis disease_progressionISOVEGFC (Homo sapiens)7483611associated with thyroid diseases and mRNA:increased expression:thyroid gland:RGD 
VegfcRatLymphatic Metastasis exacerbatesISOVEGFC (Homo sapiens)155630642associated with pancreatic adenocarcinoma and protein:increased expression:pancreas (human)RGD 
VegfcRatLymphatic Metastasis  ISOVEGFC (Homo sapiens)2315484associated with Carcinoma more ...RGD 
VegfcRatLymphatic Metastasis  ISOVEGFC (Homo sapiens)2315469associated with Breast NeoplasmsRGD 
VegfcRatLymphatic Metastasis  ISOVEGFC (Homo sapiens)2315474associated with Prostatic NeoplasmsRGD 
VegfcRatLymphatic Metastasis  ISOVEGFC (Homo sapiens)2315475associated with Cervix NeoplasmsRGD 
VegfcRatLymphatic Metastasis  ISOVEGFC (Homo sapiens)7488946associated with Lymphatic MetastasisRGD 
VegfcRatnephroblastoma disease_progressionISOVEGFC (Homo sapiens)2315481 RGD 
VegfcRatovarian cancer disease_progressionISOVEGFC (Homo sapiens)2315470 RGD 
VegfcRatpancreatic adenocarcinoma exacerbatesISOVEGFC (Homo sapiens)155630643protein:increased expression:pancreas (human)RGD 
VegfcRatpapillary carcinoma disease_progressionISOVEGFC (Homo sapiens)7483611associated with thyroid diseases and mRNA:increased expression:thyroid gland:RGD 
VegfcRatpterygium  ISOVEGFC (Homo sapiens)8548457mRNA:increased expression:bulbar conjunctiva:RGD 
VegfcRatrenal cell carcinoma  ISOVEGFC (Homo sapiens)2315476 RGD 
VegfcRatReperfusion Injury  IEP 2315487 RGD 
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Original Reference(s)
VegfcRatgenetic disease  ISOVEGFC (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868
VegfcRathereditary lymphedema ID  ISOVEGFC (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphedema more ...ClinVarPMID:23410910 more ...
VegfcRatNeurodevelopmental Disorders  ISOVEGFC (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Original Reference(s)
VegfcRatangiosarcoma  ISOVEGFC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17569031
VegfcRatBreast Neoplasms  ISOVEGFC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18509974 and PMID:26124351
VegfcRatmelanoma  ISOVEGFC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17562445
VegfcRatRecurrence  ISOVEGFC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26124351
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Original Reference(s)
VegfcRathereditary lymphedema  ISSVegfc (Mus musculus)13592920OMIM:153100 more ...MouseDO 
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VegfcRathereditary lymphedema ID  ISOVEGFC (Homo sapiens)7240710 OMIM 

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Original Reference(s)
VegfcRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of VEGFC mRNA]CTDPMID:31150632
VegfcRat1,2-dichloroethane decreases expressionISOVegfc (Mus musculus)6480464ethylene dichloride results in decreased expression of VEGFC mRNACTDPMID:28960355
VegfcRat1,2-dimethylhydrazine multiple interactionsISOVegfc (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of VEGFC mRNACTDPMID:22206623
VegfcRat1-chloro-2,4-dinitrobenzene increases expressionISOVEGFC (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of VEGFC mRNACTDPMID:25617811
VegfcRat1-octadec-9-enoylglycero-3-phosphate increases expressionISOVEGFC (Homo sapiens)6480464lysophosphatidic acid results in increased expression of VEGFC mRNACTDPMID:18642114
VegfcRat1-octadec-9-enoylglycero-3-phosphate increases secretionISOVEGFC (Homo sapiens)6480464lysophosphatidic acid results in increased secretion of VEGFC proteinCTDPMID:18642114
VegfcRat17beta-estradiol multiple interactionsISOVEGFC (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of VEGFC mRNACTDPMID:30165855
VegfcRat17beta-estradiol decreases expressionISOVEGFC (Homo sapiens)6480464Estradiol results in decreased expression of VEGFC mRNACTDPMID:31614463
VegfcRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOVegfc (Mus musculus)6480464AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFC mRNA]CTDPMID:16214954
VegfcRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOVegfc (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of VEGFC mRNACTDPMID:21570461
VegfcRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of VEGFC mRNACTDPMID:20558275 and PMID:33387578
VegfcRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOVegfc (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of VEGFC mRNACTDPMID:12167310 more ...
VegfcRat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionISOVEGFC (Homo sapiens)64804642 more ...CTDPMID:26705709
VegfcRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOVegfc (Mus musculus)64804642 more ...CTDPMID:38648751
VegfcRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of VEGFC mRNACTDPMID:21346803
VegfcRat2-palmitoylglycerol increases expressionISOVEGFC (Homo sapiens)64804642-palmitoylglycerol results in increased expression of VEGFC mRNACTDPMID:37199045
VegfcRat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
VegfcRat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOVEGFC (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VEGFC mRNACTDPMID:28628672
VegfcRat4'-epidoxorubicin multiple interactionsISOVEGFC (Homo sapiens)6480464VEGFC mRNA results in increased susceptibility to [Paclitaxel co-treated with Epirubicin co-treated with CMF regimen]CTDPMID:23146280
VegfcRat4,4'-sulfonyldiphenol affects expressionISOVegfc (Mus musculus)6480464bisphenol S affects the expression of VEGFC mRNACTDPMID:30951980

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Biological Process
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Original Reference(s)
VegfcRatangiogenesis  IMP 1580593 RGD 
VegfcRatangiogenesis involved_inIEAUniProtKB-KW:KW-00371600115GO_REF:0000043UniProtGO_REF:0000043
VegfcRatanimal organ morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatanimal organ morphogenesis acts_upstream_of_or_withinISOVegfc (Mus musculus)1624291MGI:3026650 PMID:14634646RGDPMID:14634646
VegfcRatcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
VegfcRatcell population proliferation acts_upstream_ofISOVegfc (Mus musculus)1624291MGI:3026650 PMID:16462734RGDPMID:16462734
VegfcRatcell population proliferation acts_upstream_ofIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOVegfc (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
VegfcRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatglial cell proliferation acts_upstream_ofISOVegfc (Mus musculus)1624291MGI:3026650 PMID:16462734RGDPMID:16462734
VegfcRatglial cell proliferation acts_upstream_ofIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatinduction of positive chemotaxis involved_inISOVEGFC (Homo sapiens)1624291 PMID:19275959RGDPMID:19275959
VegfcRatinduction of positive chemotaxis involved_inIBAPANTHER:PTN000246442 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VegfcRatinduction of positive chemotaxis involved_inIEAUniProtKB:P49767 and ensembl:ENSP000004800431600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatmorphogenesis of embryonic epithelium acts_upstream_of_or_withinISOVegfc (Mus musculus)1624291MGI:3026650 PMID:14634646RGDPMID:14634646
VegfcRatmorphogenesis of embryonic epithelium acts_upstream_of_or_withinIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatnegative regulation of blood pressure  IMP 2315485 RGD 
VegfcRatnegative regulation of osteoblast differentiation involved_inISOVegfc (Mus musculus)1624291 PMID:26934950RGDPMID:26934950
VegfcRatnegative regulation of osteoblast differentiation involved_inIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatpositive chemotaxis involved_inIEAGO:00420561600115GO_REF:0000108GOCGO_REF:0000108
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Cellular Component

  
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Original Reference(s)
VegfcRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
VegfcRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
VegfcRatextracellular space is_active_inIBAMGI:103178 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VegfcRatextracellular space located_inISOVegfc (Mus musculus)1624291 PMID:24552833 and PMID:9247316RGDPMID:24552833 and PMID:9247316
VegfcRatextracellular space located_inIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatmembrane located_inIEAInterPro:IPR0000721600115GO_REF:0000002InterProGO_REF:0000002

Molecular Function
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VegfcRatchemoattractant activity enablesISOVEGFC (Homo sapiens)1624291 PMID:19275959RGDPMID:19275959
VegfcRatchemoattractant activity enablesIEAUniProtKB:P49767 and ensembl:ENSP000004800431600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatchemoattractant activity enablesIBAMGI:103178 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VegfcRatgrowth factor activity enablesIEAUniProtKB-KW:KW-03391600115GO_REF:0000043UniProtGO_REF:0000043
VegfcRatgrowth factor activity  TAS 727326 RGD 
VegfcRatgrowth factor activity enablesIBAMGI:108037 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VegfcRatgrowth factor activity enablesIEAInterPro:IPR0000721600115GO_REF:0000002InterProGO_REF:0000002
VegfcRatprotein binding enablesISOVEGFC (Homo sapiens)1624291UniProtKB:P35916 more ...RGDPMID:20145116 more ...
VegfcRatprotein binding enablesISOVegfc (Mus musculus) and PR:P97953-11624291UniProtKB:O60462 and PMID:25752543RGDPMID:25752543
VegfcRatvascular endothelial growth factor receptor 3 binding enablesISOVEGFC (Homo sapiens)1624291UniProtKB:P35916 and PMID:23878260RGDPMID:23878260
VegfcRatvascular endothelial growth factor receptor 3 binding  IMP 727326 RGD 
VegfcRatvascular endothelial growth factor receptor 3 binding enablesISOVegfc (Mus musculus)1624291PR:P35917 more ...RGDPMID:9012504 and PMID:9247316
VegfcRatvascular endothelial growth factor receptor 3 binding enablesIBAMGI:109124 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
VegfcRatvascular endothelial growth factor receptor 3 binding enablesIEAUniProtKB:P49767 and ensembl:ENSP000004800431600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatvascular endothelial growth factor receptor 3 binding enablesIEAUniProtKB:P97953 and ensembl:ENSMUSP000000339191600115GO_REF:0000107EnsemblGO_REF:0000107
VegfcRatvascular endothelial growth factor receptor binding enablesIEAARBA:ARBA000273331600115GO_REF:0000117UniProtGO_REF:0000117
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RGD Manual Annotations


  
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Original Reference(s)
VegfcRatvascular endothelial growth factor signaling pathway   IMP 727326 RGD 
VegfcRatvascular endothelial growth factor signaling pathway   ISOVEGFC (Homo sapiens)2298727 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
VegfcRatceramide signaling pathway  IEA 6907045 KEGGrno:05212
VegfcRatcytokine mediated signaling pathway  IEA 6907045 KEGGrno:04060
VegfcRatmTOR signaling pathway   IEA 6907045 KEGGrno:04150
VegfcRatpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
VegfcRatrenal cell carcinoma pathway   IEA 6907045 KEGGrno:05211
VegfcRaturinary bladder cancer pathway  IEA 6907045 KEGGrno:05219

Imported Annotations - PID (archival)

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Original Reference(s)
VegfcRatvascular endothelial growth factor signaling pathway   ISOVEGFC (Homo sapiens)6484113 PIDPID:200109

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#
Reference Title
Reference Citation
1. Differential vascular endothelial growth factor A protein expression between small hepatocellular carcinoma and cirrhosis correlates with serum vascular endothelial growth factor A and alpha-fetoprotein. Corradini SG, etal., Liver Int. 2009 Jan;29(1):103-12. doi: 10.1111/j.1478-3231.2008.01781.x. Epub 2008 Jun 9.
2. Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. Di JM, etal., Arch Med Res. 2009 May;40(4):268-75. Epub 2009 Jun 4.
3. Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model. Doi K, etal., Oncology. 2007;73(3-4):252-60. Epub 2008 Apr 17.
4. [Correlation analysis of vascular endothelial growth factor-C expression and clinicopathology in breast cancer.] Fu JM, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov;29(11):2266-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gaudio E, etal., Gastroenterology. 2006 Apr;130(4):1270-82.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma. Guo B, etal., Anat Rec (Hoboken). 2009 May;292(5):633-9.
9. The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Huang C, etal., Neoplasma. 2012;59(1):52-61. doi: 10.4149/neo_2012_007.
10. Interpretation of Pin-1 and VEGF-C expression in breast infiltrating duct carcinoma. Kim BC, etal., Oncol Rep. 2009 Dec;22(6):1381-90.
11. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin V, etal., Eur J Biochem 2001 Nov;268(21):5530-40.
12. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Le Bras B, etal., Nat Neurosci. 2006 Mar;9(3):340-8. Epub 2006 Feb 5.
13. Increasing lymphatic microvessel density in primary pterygia. Ling S, etal., Arch Ophthalmol. 2012 Jun;130(6):735-42. doi: 10.1001/archophthalmol.2012.293.
14. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Machnik A, etal., Nat Med. 2009 May;15(5):545-52. Epub 2009 May 3.
15. Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis. McColl BK, etal., APMIS 2004 Jul-Aug;112(7-8):463-80.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Evaluation of the vascular endothelial growth factor (VEGF)-C role in urothelial carcinomas of the bladder. Mylona E, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3567-71.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. The significance of VEGF-C/VEGFR-2 interaction in the neovascularization and prognosis of nephroblastoma (Wilms' tumour). Nowicki M, etal., Histopathology. 2007 Feb;50(3):358-64.
20. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
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PMID:9012504   PMID:9247316   PMID:10878616   PMID:14634646   PMID:17400713   PMID:18571474   PMID:19275959   PMID:20133819   PMID:20142563   PMID:20415667   PMID:20439489   PMID:22258325  
PMID:22818386   PMID:22959907   PMID:23565129   PMID:23878260   PMID:23990681   PMID:24006456   PMID:24379135   PMID:24464750   PMID:24552833   PMID:24559584   PMID:24654984   PMID:25124602  
PMID:25943477   PMID:26934950   PMID:30771456   PMID:31211440   PMID:31757960   PMID:32170506   PMID:34291766   PMID:35259773   PMID:35817403   PMID:38728943  



Vegfc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81644,445,293 - 44,560,887 (-)NCBIGRCr8
mRatBN7.21637,712,251 - 37,827,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1643,068,855 - 43,184,449 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01646,429,675 - 46,545,267 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01641,783,170 - 41,898,773 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01640,440,371 - 40,555,178 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01640,216,307 - 40,331,753 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41640,624,435 - 40,739,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11640,624,509 - 40,739,767 (-)NCBI
Celera1635,834,400 - 35,949,683 (-)NCBICelera
Cytogenetic Map16p11NCBI
VEGFC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384176,683,538 - 176,792,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4176,683,538 - 176,792,922 (-)EnsemblGRCh38hg38GRCh38
GRCh374177,604,689 - 177,714,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364177,841,685 - 177,950,889 (-)NCBINCBI36Build 36hg18NCBI36
Build 344177,979,839 - 178,089,044NCBI
Celera4174,932,577 - 175,041,751 (-)NCBICelera
Cytogenetic Map4q34.3NCBI
HuRef4173,355,495 - 173,464,332 (-)NCBIHuRef
CHM1_14177,581,139 - 177,690,417 (-)NCBICHM1_1
T2T-CHM13v2.04180,022,579 - 180,131,932 (-)NCBIT2T-CHM13v2.0
Vegfc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39854,530,567 - 54,639,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl854,530,641 - 54,640,131 (+)EnsemblGRCm39 Ensembl
GRCm38854,077,532 - 54,186,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,077,606 - 54,187,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv37855,162,886 - 55,271,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36855,576,324 - 55,685,149 (+)NCBIMGSCv36mm8
Celera856,790,779 - 56,893,425 (+)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.2NCBI
Vegfc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540331,016,423 - 31,130,892 (+)NCBIChiLan1.0ChiLan1.0
VEGFC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23174,404,689 - 174,551,470 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14174,784,868 - 174,914,832 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04168,870,941 - 168,999,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14181,104,737 - 181,236,024 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4181,104,737 - 181,236,030 (-)Ensemblpanpan1.1panPan2
VEGFC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11652,883,242 - 52,987,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1652,883,139 - 52,987,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1648,384,891 - 48,489,160 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01655,195,930 - 55,300,949 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1655,195,409 - 55,300,821 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11653,090,819 - 53,195,148 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01653,687,065 - 53,791,871 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01653,925,224 - 54,029,839 (+)NCBIUU_Cfam_GSD_1.0
Vegfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494326,803,257 - 26,918,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365167,217,543 - 7,332,559 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365167,217,543 - 7,332,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VEGFC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1539,039,311 - 39,132,936 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11539,037,764 - 39,136,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21544,742,834 - 44,773,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VEGFC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17122,772,539 - 122,893,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7122,772,182 - 122,893,512 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037102,869,061 - 102,989,877 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vegfc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247697,689,407 - 7,817,450 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247697,689,812 - 7,817,366 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Vegfc
333 total Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
16 40631739 40631740 T G snv FHH/EurMcwi (MCW), SR/JrHsd (MCW) View more Information
16 40666126 40666127 C G snv SR/JrHsd (MCW) View more Information


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
16 40223865 40223866 T G snv FHH/EurMcwi (MCW), SR/JrHsd (MCW) View more Information
16 40256726 40256727 C G snv SR/JrHsd (MCW), FHH/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:142
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000015529
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 27 rows
D16Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81644,498,650 - 44,498,873 (+)Marker Load Pipeline
mRatBN7.21637,765,608 - 37,765,831 (+)MAPPERmRatBN7.2
Rnor_6.01640,492,300 - 40,492,522NCBIRnor6.0
Rnor_5.01640,268,236 - 40,268,458UniSTSRnor5.0
RGSC_v3.41640,677,635 - 40,677,858RGDRGSC3.4
RGSC_v3.41640,677,636 - 40,677,858UniSTSRGSC3.4
RGSC_v3.11640,677,710 - 40,677,933RGD
Celera1635,887,600 - 35,887,830UniSTS
SHRSP x BN Map1612.43UniSTS
SHRSP x BN Map1612.43RGD
Cytogenetic Map16p11UniSTS
AW228853  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21637,712,422 - 37,712,518 (+)MAPPERmRatBN7.2
Rnor_6.01640,440,386 - 40,440,481NCBIRnor6.0
Rnor_5.01640,216,322 - 40,216,417UniSTSRnor5.0
RGSC_v3.41640,624,450 - 40,624,545UniSTSRGSC3.4
Celera1635,834,415 - 35,834,510UniSTS
Cytogenetic Map16p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000015529   ⟹   ENSRNOP00000015529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)Ensembl
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119624   ⟹   ENSRNOP00000091258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1637,720,140 - 37,827,848 (-)Ensembl
RefSeq Acc Id: NM_053653   ⟹   NP_446105
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81644,445,293 - 44,560,887 (-)NCBI
mRatBN7.21637,712,251 - 37,827,845 (-)NCBI
Rnor_6.01640,440,371 - 40,555,178 (-)NCBI
Rnor_5.01640,216,307 - 40,331,753 (-)NCBI
RGSC_v3.41640,624,435 - 40,739,692 (-)RGD
Celera1635,834,400 - 35,949,683 (-)RGD
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_446105 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63248 (Get FASTA)   NCBI Sequence Viewer  
  AAK96009 (Get FASTA)   NCBI Sequence Viewer  
  EDL78943 (Get FASTA)   NCBI Sequence Viewer  
  EDL78944 (Get FASTA)   NCBI Sequence Viewer  
  EDL78945 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015529
  ENSRNOP00000015529.2
GenBank Protein O35757 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_446105   ⟸   NM_053653
- Peptide Label: precursor
- UniProtKB: Q91ZE3 (UniProtKB/Swiss-Prot),   O35757 (UniProtKB/Swiss-Prot),   A6JPH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015529   ⟸   ENSRNOT00000015529
Ensembl Acc Id: ENSRNOP00000091258   ⟸   ENSRNOT00000119624
Name Modeler Protein Id AA Range Protein Structure
AF-O35757-F1-model_v2 AlphaFold O35757 1-415 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11465 BioCyc
Ensembl Genes ENSRNOG00000011416 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015529 ENTREZGENE
  ENSRNOT00000015529.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro CXCXC_repeat UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PD_growth_factor_CS UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  PDGF/VEGF_growth_factor UniProtKB/Swiss-Prot
KEGG Report rno:114111 UniProtKB/Swiss-Prot
NCBI Gene 114111 ENTREZGENE
PANTHER VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR C UniProtKB/Swiss-Prot
Pfam CXCXC UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
PhenoGen Vegfc PhenoGen
PROSITE PDGF_1 UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011416 RatGTEx
SMART PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A8I6AEW4_RAT UniProtKB/TrEMBL
  A6JPH7_RAT UniProtKB/TrEMBL
  A6JPH8 ENTREZGENE, UniProtKB/TrEMBL
  A6JPH9_RAT UniProtKB/TrEMBL
  O35757 ENTREZGENE
  Q91ZE3 ENTREZGENE
  VEGFC_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q91ZE3 UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Vegfc  vascular endothelial growth factor C      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vegfc  vascular endothelial growth factor C      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_physical_interaction can bind and activate VEGFR-3 receptors 727326
gene_product member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family 727326