Cysltr1 (cysteinyl leukotriene receptor 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cysltr1 (cysteinyl leukotriene receptor 1) Rattus norvegicus
Analyze
Symbol: Cysltr1
Name: cysteinyl leukotriene receptor 1
RGD ID: 619796
Description: Enables leukotriene receptor activity. Involved in several processes, including cellular response to hypoxia; positive regulation of glial cell proliferation; and positive regulation of vasoconstriction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Used to study pulmonary hypertension. Biomarker of pulmonary fibrosis. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1); PARTICIPATES IN endothelin signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrolein; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyslt1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,734,281 - 75,762,873 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX75,734,270 - 75,763,050 (-)EnsemblGRCr8
mRatBN7.2X71,661,421 - 71,690,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,663,821 - 71,690,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX73,181,064 - 73,182,083 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,680,942 - 76,681,961 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X74,236,459 - 74,237,478 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,671,028 - 77,700,491 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,674,150 - 77,700,269 (-)Ensemblrn6Rnor6.0
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X94,802,078 - 94,803,097 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX72,975,213 - 72,976,232 (-)NCBICelera
RGSC_v3.1X94,875,510 - 94,876,530 (-)NCBI
Cytogenetic MapXq22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Analysis of 927T > C CYSLTR1 and -444A > C LTC4S polymorphisms in children with asthma. Arriba-Méndez S, etal., Allergol Immunopathol (Madr). 2008 Sep-Oct;36(5):259-63. doi: 10.1016/s0301-0546(08)75220-0.
2. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Beller TC, etal., Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3047-52. Epub 2004 Feb 17.
3. Leukotriene pathway polymorphisms are associated with altered cysteinyl leukotriene production in children with acute asthma. Bizzintino JA, etal., Prostaglandins Leukot Essent Fatty Acids. 2009 Jul;81(1):9-15. doi: 10.1016/j.plefa.2009.05.022. Epub 2009 Jun 12.
4. Ribavirin and cysteinyl leukotriene-1 receptor blockade as treatment for severe bronchiolitis. Bonville CA, etal., Antiviral Res. 2006 Feb;69(2):53-9. Epub 2005 Nov 28.
5. Cysteinyl leukotriene 1 receptor expression in nasal polyps. Chao SS, etal., Ann Otol Rhinol Laryngol. 2006 May;115(5):394-7.
6. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Chen X, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2003 Jul;34(3):555-8.
7. Leukotriene antagonism reduces the generation of endothelin-1 and interferon-gamma and inhibits eosinophilic airway inflammation. Finsnes F, etal., Respir Med 2002 Nov;96(11):901-6.
8. Role of cysteinyl leukotrienes in airway inflammation and responsiveness following RSV infection in BALB/c mice. Fullmer JJ, etal., Pediatr Allergy Immunol. 2005 Nov;16(7):593-601.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The cysteinyl-leukotriene type 1 receptor polymorphism 927T/C is associated with atopy severity but not with asthma. Hao L, etal., Clin Exp Allergy. 2006 Jun;36(6):735-41.
12. Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. Henderson WR Jr, etal., Am J Respir Crit Care Med. 2006 Apr 1;173(7):718-28. Epub 2005 Dec 30.
13. [Lung fibrosis induced by mechanical ventilation with different tidal volume in neonatal rats]. Huang JJ, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2010 Oct;12(10):799-803.
14. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. Huang XJ, etal., Glia. 2008 Jan 1;56(1):27-37.
15. Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Ichinose F, etal., Circ Res. 2001 Apr 27;88(8):832-8.
16. CYSLTR1 rs320995 (T927C) and GSDMB rs7216389 (G1199A) Gene Polymorphisms in Asthma and Allergic Rhinitis: A Proof-of-Concept Study. Jin Z, etal., J Asthma Allergy. 2022 Aug 20;15:1105-1113. doi: 10.2147/JAA.S371120. eCollection 2022.
17. Cysteinyl leukotriene receptors are expressed by tonsillar T cells of children with obstructive sleep apnea. Kaditis AG, etal., Chest. 2008 Aug;134(2):324-31. Epub 2008 May 19.
18. Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males. Kim SH, etal., Clin Exp Allergy. 2006 Apr;36(4):433-9.
19. Differential contribution of the CysLTR1 gene in patients with aspirin hypersensitivity. Kim SH, etal., J Clin Immunol. 2007 Nov;27(6):613-9. doi: 10.1007/s10875-007-9115-x. Epub 2007 Jul 20.
20. Effect of 5-lipoxygenase blockade on blood pressure and acetylcholine-evoked endothelium-dependent contraction in aorta from spontaneously hypertensive rats. Lefebvre B, etal., J Hypertens. 2006 Jan;24(1):85-93.
21. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. Maekawa A, etal., J Biol Chem 2002 Jun 7;277(23):20820-4. Epub 2002 Apr 3.
22. Study of cysteinyl leukotriene-1 receptor in rat renal ischemia-reperfusion injury. Matsuyama M, etal., Transplant Proc. 2008 Sep;40(7):2149-51.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. A double-blind non-inferiority clinical study of montelukast, a cysteinyl leukotriene receptor 1 antagonist, compared with pranlukast in patients with seasonal allergic rhinitis. Okubo K and Baba K, Allergol Int. 2008 Dec;57(4):383-90. Epub 2008 Nov 1.
26. Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer. Osman J, etal., Oncotarget. 2017 May 23;8(21):34773-34786. doi: 10.18632/oncotarget.16718.
27. Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis. Perez-Novo CA, etal., Respir Res. 2006 May 12;7:75.
28. Inhibition of allergen-induced bronchoconstriction in hyperreactive rats as a model for testing 5-lipoxygenase inhibitors and leukotriene D4 receptor antagonists. Piechuta H, etal., Agents Actions. 1987 Oct;22(1-2):69-74.
29. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
30. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
31. An open audit of montelukast, a leukotriene receptor antagonist, in nasal polyposis associated with asthma. Ragab S, etal., Clin Exp Allergy. 2001 Sep;31(9):1385-91.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiency. Roa J, etal., Immunology. 2007 Nov;122(3):438-44. Epub 2007 Jul 11.
37. Effects of a cysteinyl leukotriene receptor antagonist on eosinophil recruitment in experimental allergic rhinitis. Saito H, etal., Immunology. 2004 Oct;113(2):246-52.
38. Analysis of 927T> C CYSLTRI and -444A > C LTC4S polymorphisms in patients with asthma. Sanz C, etal., J Investig Allergol Clin Immunol. 2006;16(6):331-7.
39. Anti-inflammatory effects of montelukast in mild cystic fibrosis. Schmitt-Grohe S, etal., Ann Allergy Asthma Immunol. 2002 Dec;89(6):599-605.
40. Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast. Sener G, etal., Prostaglandins Other Lipid Mediat. 2007 Jun;83(4):257-67. Epub 2007 Jan 20.
41. Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury. Shigematsu M, etal., Sci Rep. 2016 Oct 5;6:34560. doi: 10.1038/srep34560.
42. Effects of 6 weeks of therapy with oral doses of ICI 204,219, a leukotriene D4 receptor antagonist, in subjects with bronchial asthma. ACCOLATE Asthma Trialists Group. Spector SL, etal., Am J Respir Crit Care Med. 1994 Sep;150(3):618-23.
43. Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery. Trandafir CC, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1027-33.
44. The long-term effect of Helicobacter pylori eradication on COX-1/2, 5-LOX and leukotriene receptors in patients with a risk gastritis phenotype--a link to gastric carcinogenesis. Venerito M, etal., Cancer Lett. 2008 Nov 8;270(2):218-28. doi: 10.1016/j.canlet.2008.05.015. Epub 2008 Jun 20.
45. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in a mouse asthma model. Wong WS, etal., Eur J Pharmacol. 2007 Dec 1;575(1-3):134-41. Epub 2007 Jul 24.
46. Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. Xu L, etal., Pharmazie. 2010 Oct;65(10):750-4.
47. Expression of cysteinyl leukotriene receptor in brain tissues of rats with Streptococcus pneumoniae meningitis. Yu S, etal., Int J Clin Exp Pathol. 2019 Dec 1;12(12):4242-4252. eCollection 2019.
48. Sceptridium ternatum extract exerts antiasthmatic effects by regulating Th1/Th2 balance and the expression levels of leukotriene receptors in a mouse asthma model. Yuan Y, etal., J Ethnopharmacol. 2013 Oct 7;149(3):701-6. doi: 10.1016/j.jep.2013.07.032. Epub 2013 Aug 9.
49. Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. Zhang J, etal., Pediatr Allergy Immunol. 2006 Jun;17(4):242-9.
50. Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa. Zhu J, etal., Am J Respir Cell Mol Biol. 2005 Dec;33(6):531-40. Epub 2005 Aug 25.
Additional References at PubMed
PMID:11226226   PMID:16002666   PMID:16650938   PMID:20574000   PMID:22230957   PMID:22499509   PMID:27909742  


Genomics

Comparative Map Data
Cysltr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X75,734,281 - 75,762,873 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX75,734,270 - 75,763,050 (-)EnsemblGRCr8
mRatBN7.2X71,661,421 - 71,690,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX71,663,821 - 71,690,121 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX73,181,064 - 73,182,083 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X76,680,942 - 76,681,961 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X74,236,459 - 74,237,478 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X77,671,028 - 77,700,491 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX77,674,150 - 77,700,269 (-)Ensemblrn6Rnor6.0
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X94,802,078 - 94,803,097 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX72,975,213 - 72,976,232 (-)NCBICelera
RGSC_v3.1X94,875,510 - 94,876,530 (-)NCBI
Cytogenetic MapXq22NCBI
CYSLTR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X78,271,468 - 78,327,611 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX78,271,468 - 78,327,691 (-)Ensemblhg38GRCh38
GRCh37X77,526,965 - 77,583,108 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X77,414,786 - 77,469,743 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X77,334,275 - 77,389,232NCBI
CeleraX77,768,935 - 77,823,895 (-)NCBICelera
Cytogenetic MapXq21.1NCBI
HuRefX71,107,425 - 71,162,464 (-)NCBIHuRef
CHM1_1X77,421,213 - 77,476,168 (-)NCBICHM1_1
T2T-CHM13v2.0X76,708,793 - 76,764,940 (-)NCBIT2T-CHM13v2.0
Cysltr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X105,617,952 - 105,647,329 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX105,617,952 - 105,647,285 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X106,576,509 - 106,603,679 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX106,574,346 - 106,603,679 (-)Ensemblmm10GRCm38
MGSCv37X103,771,856 - 103,798,801 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X102,779,236 - 102,806,181 (-)NCBIMGSCv36mm8
CeleraX93,425,096 - 93,451,782 (-)NCBICelera
Cytogenetic MapXDNCBI
cM MapX47.36NCBI
Cysltr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555571,667,518 - 1,702,272 (-)NCBIChiLan1.0ChiLan1.0
CYSLTR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X77,810,414 - 77,868,764 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X77,813,609 - 77,872,375 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X67,412,410 - 67,469,366 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X77,523,188 - 77,579,350 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX77,524,455 - 77,525,468 (-)EnsemblpanPan2panpan1.1
CYSLTR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X60,462,290 - 60,513,155 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX60,463,526 - 60,464,548 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX51,475,377 - 51,526,196 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X61,701,015 - 61,766,649 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX61,701,032 - 61,766,592 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X59,407,128 - 59,457,919 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X61,017,129 - 61,067,958 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X60,605,215 - 60,656,035 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cysltr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X54,157,074 - 54,184,386 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936547479,261 - 504,757 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYSLTR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX62,380,780 - 62,456,689 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X62,380,778 - 62,407,736 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X71,478,976 - 71,505,912 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYSLTR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X67,218,777 - 67,300,655 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX67,220,048 - 67,221,061 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 EnsemblX67,220,048 - 67,221,061 (-)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606714,187,837 - 14,265,684 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cysltr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248362,556,269 - 2,597,008 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cysltr1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X72,447,173 - 72,448,254 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cysltr1
41 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:74
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000042799
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
PMC30125P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X71,665,566 - 71,665,787 (+)MAPPERmRatBN7.2
Rnor_6.0X77,675,174 - 77,675,394NCBIRnor6.0
Rnor_5.0X77,870,164 - 77,870,384UniSTSRnor5.0
RGSC_v3.4X94,802,903 - 94,803,123UniSTSRGSC3.4
CeleraX72,976,038 - 72,976,258UniSTS
Cytogenetic MapXq31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 56 115 90 89 58 91 58 6 332 179 11 90 71 85 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000042799   ⟹   ENSRNOP00000040761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX71,663,821 - 71,689,269 (-)Ensembl
Rnor_6.0 EnsemblX77,674,150 - 77,675,487 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092418   ⟹   ENSRNOP00000075854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX75,734,270 - 75,763,050 (-)Ensembl
mRatBN7.2 EnsemblX71,663,821 - 71,690,121 (-)Ensembl
Rnor_6.0 EnsemblX77,674,272 - 77,700,269 (-)Ensembl
RefSeq Acc Id: NM_053641   ⟹   NP_446093
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X75,734,281 - 75,762,873 (-)NCBI
mRatBN7.2X71,661,421 - 71,690,012 (-)NCBI
Rnor_6.0X77,674,349 - 77,675,368 (-)NCBI
Rnor_5.0X77,868,476 - 77,895,363 (-)NCBI
RGSC_v3.4X94,802,078 - 94,803,097 (-)RGD
CeleraX72,975,213 - 72,976,232 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446093 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB60825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000040761.3
  ENSRNOP00000075854
  ENSRNOP00000075854.2
GenBank Protein Q924T8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446093   ⟸   NM_053641
- UniProtKB: Q924T8 (UniProtKB/Swiss-Prot),   A0A0U1RRX8 (UniProtKB/TrEMBL),   A6IV49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075854   ⟸   ENSRNOT00000092418
Ensembl Acc Id: ENSRNOP00000040761   ⟸   ENSRNOT00000042799
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924T8-F1-model_v2 AlphaFold Q924T8 1-339 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701911
Promoter ID:EPDNEW_R12428
Type:single initiation site
Name:Cysltr1_1
Description:cysteinyl leukotriene receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X77,700,297 - 77,700,357EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619796 AgrOrtholog
BioCyc Gene G2FUF-1909 BioCyc
Ensembl Genes ENSRNOG00000037845 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000042799.5 UniProtKB/Swiss-Prot
  ENSRNOT00000092418 ENTREZGENE
  ENSRNOT00000092418.2 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro CLT1_recept UniProtKB/Swiss-Prot
  Cyst_leuk_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:114099 UniProtKB/Swiss-Prot
NCBI Gene 114099 ENTREZGENE
PANTHER CYSTEINYL LEUKOTRIENE RECEPTOR 1 UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB CYSLTR1 RGD
PhenoGen Cysltr1 PhenoGen
PRINTS CYSLT1RECPTR UniProtKB/Swiss-Prot
  CYSLTRECPTR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000037845 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A0A0U1RRX8 ENTREZGENE, UniProtKB/TrEMBL
  A6IV49 ENTREZGENE, UniProtKB/TrEMBL
  CLTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Cysltr1  cysteinyl leukotriene receptor 1  Cyslt1    Symbol updated 625702 APPROVED
2002-08-07 Cyslt1  cysteinyl leukotriene receptor 1      Symbol and Name status set to provisional 70820 PROVISIONAL