Hpse (heparanase) - Rat Genome Database

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Gene: Hpse (heparanase) Rattus norvegicus
Analyze
Symbol: Hpse
Name: heparanase
RGD ID: 61969
Description: Enables heparanase activity. Predicted to be involved in several processes, including positive regulation of osteoblast proliferation; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and proteoglycan metabolic process. Predicted to be located in lysosome; membrane raft; and nucleus. Predicted to be part of heparanase complex. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human HPSE (heparanase); PARTICIPATES IN syndecan signaling pathway; glycosaminoglycan degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endo-glucoronidase; Hep; heparanase-like; Hpa; LOC100362546
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,200,971 - 9,241,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,188,275 - 9,241,754 (+)EnsemblGRCr8
mRatBN7.2148,896,593 - 8,937,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,896,593 - 8,937,010 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,870,273 - 8,910,720 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,170,116 - 10,210,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,866,737 - 8,907,192 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01410,534,358 - 10,576,686 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1410,534,423 - 10,575,224 (+)Ensemblrn6Rnor6.0
Rnor_5.01410,483,116 - 10,523,890 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41410,144,322 - 10,185,115 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera149,005,457 - 9,045,081 (+)NCBICelera
RGSC_v3.11410,144,321 - 10,185,115NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-amygdalin  (ISO)
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitriptyline  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (EXP)
heparan sulfate  (EXP,ISO)
heparin  (ISO)
hydralazine  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
lipopolysaccharide  (ISO)
lisinopril dihydrate  (EXP)
methamphetamine  (ISO)
methotrexate  (ISO)
NAD zwitterion  (EXP)
NAD(+)  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
propofol  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
spironolactone  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of a novel intracellular heparanase that has a FERM domain. Bame KJ, etal., Biochem J 2002 May 15;364(Pt 1):265-74.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6. Characterization of heparanase from a rat parathyroid cell line. Podyma-Inoue KA, etal., J Biol Chem 2002 Sep 6;277(36):32459-65.
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10395326   PMID:12213822   PMID:12773484   PMID:12927802   PMID:14522979   PMID:15044433   PMID:15126626   PMID:15292202   PMID:15728796   PMID:15793281   PMID:15877677   PMID:16320243  
PMID:16452201   PMID:16899518   PMID:17051139   PMID:17368723   PMID:17689495   PMID:18095597   PMID:18222122   PMID:18278514   PMID:18557927   PMID:18589009   PMID:19096032   PMID:19218500  
PMID:20130710   PMID:20309870   PMID:20634491   PMID:21424539   PMID:22339633   PMID:23063054   PMID:23471235   PMID:24115032   PMID:24608441   PMID:26638897   PMID:27979811   PMID:28720149  
PMID:29581478  


Genomics

Comparative Map Data
Hpse
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,200,971 - 9,241,377 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl149,188,275 - 9,241,754 (+)EnsemblGRCr8
mRatBN7.2148,896,593 - 8,937,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,896,593 - 8,937,010 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx148,870,273 - 8,910,720 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,170,116 - 10,210,568 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,866,737 - 8,907,192 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01410,534,358 - 10,576,686 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1410,534,423 - 10,575,224 (+)Ensemblrn6Rnor6.0
Rnor_5.01410,483,116 - 10,523,890 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41410,144,322 - 10,185,115 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera149,005,457 - 9,045,081 (+)NCBICelera
RGSC_v3.11410,144,321 - 10,185,115NCBI
Cytogenetic Map14p22NCBI
HPSE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38483,292,461 - 83,335,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl483,292,461 - 83,335,153 (-)Ensemblhg38GRCh38
GRCh37484,213,614 - 84,256,306 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36484,435,492 - 84,475,330 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34484,570,793 - 84,613,484NCBI
Celera481,506,894 - 81,546,444 (-)NCBICelera
Cytogenetic Map4q21.23NCBI
HuRef479,956,669 - 79,999,104 (-)NCBIHuRef
CHM1_1484,190,339 - 84,232,732 (-)NCBICHM1_1
T2T-CHM13v2.0486,622,557 - 86,665,251 (-)NCBIT2T-CHM13v2.0
Hpse
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395100,827,350 - 100,867,582 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5100,827,350 - 100,867,582 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm385100,679,484 - 100,719,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5100,679,484 - 100,719,716 (-)Ensemblmm10GRCm38
MGSCv375101,108,505 - 101,148,702 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365100,920,698 - 100,959,985 (-)NCBIMGSCv36mm8
Celera598,006,862 - 98,047,031 (-)NCBICelera
Cytogenetic Map5E4NCBI
cM Map548.51NCBI
Hpse
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554746,367,467 - 6,394,395 (+)Ensembl
ChiLan1.0NW_0049554746,367,467 - 6,394,395 (+)NCBIChiLan1.0ChiLan1.0
HPSE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2346,730,513 - 46,772,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1446,919,902 - 46,962,373 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0440,863,491 - 40,905,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1446,709,621 - 46,755,157 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl446,709,621 - 46,755,157 (+)EnsemblpanPan2panpan1.1
HPSE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,166,437 - 7,199,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,167,856 - 7,199,665 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3234,685,950 - 34,719,173 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0327,187,761 - 7,220,727 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,187,761 - 7,220,717 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,257,986 - 7,290,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,127,254 - 7,160,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03232,801,148 - 32,834,425 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hpse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052855,146,217 - 5,181,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367381,308,345 - 1,343,145 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367381,308,350 - 1,341,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPSE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8135,097,725 - 135,120,887 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18135,082,199 - 135,120,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28144,378,429 - 144,417,256 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPSE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1731,689,449 - 31,730,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl731,686,304 - 31,730,043 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603710,285,023 - 10,325,651 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hpse
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624900296,676 - 335,570 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624900296,626 - 335,624 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hpse
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11110,905,095 - 10,945,127 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hpse
296 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:124
Interacting mature miRNAs:152
Transcripts:ENSRNOT00000002983
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
AA690179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,935,448 - 8,935,572 (+)MAPPERmRatBN7.2
Rnor_6.01410,575,124 - 10,575,247NCBIRnor6.0
Rnor_5.01410,522,328 - 10,522,451UniSTSRnor5.0
RGSC_v3.41410,183,553 - 10,183,676UniSTSRGSC3.4
Celera149,043,519 - 9,043,642UniSTS
Cytogenetic Map14p22UniSTS
RH141764  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,935,636 - 8,935,856 (+)MAPPERmRatBN7.2
Rnor_6.01410,575,312 - 10,575,531NCBIRnor6.0
Rnor_5.01410,522,516 - 10,522,735UniSTSRnor5.0
RGSC_v3.41410,183,741 - 10,183,960UniSTSRGSC3.4
Celera149,043,707 - 9,043,926UniSTS
RH 3.4 Map14152.28UniSTS
Cytogenetic Map14p22UniSTS
RH141824  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8149,233,900 - 9,234,081 (+)Marker Load Pipeline
mRatBN7.2148,929,533 - 8,929,714 (+)MAPPERmRatBN7.2
Rnor_6.01410,569,210 - 10,569,390NCBIRnor6.0
Rnor_5.01410,516,414 - 10,516,594UniSTSRnor5.0
RGSC_v3.41410,177,639 - 10,177,819UniSTSRGSC3.4
Celera149,037,605 - 9,037,785UniSTS
RH 3.4 Map14130.19UniSTS
Cytogenetic Map14p22UniSTS
RH128886  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,936,736 - 8,936,926 (+)MAPPERmRatBN7.2
Rnor_6.01410,576,412 - 10,576,601NCBIRnor6.0
Rnor_5.01410,523,616 - 10,523,805UniSTSRnor5.0
RGSC_v3.41410,184,841 - 10,185,030UniSTSRGSC3.4
Celera149,044,807 - 9,044,996UniSTS
RH 3.4 Map11174.7UniSTS
Cytogenetic Map14p22UniSTS
BE115323  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,925,000 - 8,925,150 (+)MAPPERmRatBN7.2
Rnor_6.01410,563,209 - 10,563,358NCBIRnor6.0
Rnor_5.01410,511,684 - 10,511,833UniSTSRnor5.0
Celera149,033,270 - 9,033,419UniSTS
RH 3.4 Map14152.88UniSTS
Cytogenetic Map14p22UniSTS
D21S1270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,911,269 - 8,912,431 (+)MAPPERmRatBN7.2
Rnor_6.01410,549,451 - 10,550,610NCBIRnor6.0
Rnor_5.01410,498,209 - 10,499,368UniSTSRnor5.0
Celera149,019,591 - 9,020,750UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 137 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002983   ⟹   ENSRNOP00000002983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,200,917 - 9,241,754 (+)Ensembl
mRatBN7.2 Ensembl148,896,593 - 8,937,010 (+)Ensembl
Rnor_6.0 Ensembl1410,534,423 - 10,575,224 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000145472   ⟹   ENSRNOP00000105739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl149,188,275 - 9,241,754 (+)Ensembl
RefSeq Acc Id: NM_022605   ⟹   NP_072127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8149,200,971 - 9,241,377 (+)NCBI
mRatBN7.2148,896,593 - 8,937,011 (+)NCBI
Rnor_6.01410,534,358 - 10,576,686 (+)NCBI
Rnor_5.01410,483,116 - 10,523,890 (+)NCBI
RGSC_v3.41410,144,322 - 10,185,115 (+)RGD
Celera149,005,457 - 9,045,081 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_072127 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF04563 (Get FASTA)   NCBI Sequence Viewer  
  AAQ15189 (Get FASTA)   NCBI Sequence Viewer  
  EDL99556 (Get FASTA)   NCBI Sequence Viewer  
  EDL99557 (Get FASTA)   NCBI Sequence Viewer  
  EDL99558 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002983
GenBank Protein Q71RP1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_072127   ⟸   NM_022605
- Peptide Label: precursor
- UniProtKB: F1M581 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002983   ⟸   ENSRNOT00000002983
Ensembl Acc Id: ENSRNOP00000105739   ⟸   ENSRNOT00000145472

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q71RP1-F1-model_v2 AlphaFold Q71RP1 1-536 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699192
Promoter ID:EPDNEW_R9716
Type:initiation region
Name:Hpse_1
Description:heparanase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01410,534,328 - 10,534,388EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61969 AgrOrtholog
BioCyc Gene G2FUF-16414 BioCyc
Ensembl Genes ENSRNOG00000002188 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002983 ENTREZGENE
Gene3D-CATH Glycosidases UniProtKB/Swiss-Prot
InterPro Glyco_hydro_79 UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
KEGG Report rno:64537 UniProtKB/Swiss-Prot
NCBI Gene Hpse ENTREZGENE
PANTHER HEPARANASE UniProtKB/Swiss-Prot
  HEPARANASE UniProtKB/Swiss-Prot
Pfam Glyco_hydro_79n UniProtKB/Swiss-Prot
PhenoGen Hpse PhenoGen
RatGTEx ENSRNOG00000002188 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
TIGR TC230485
UniProt A0ABK0LU77_RAT UniProtKB/TrEMBL
  A6K5Y6_RAT UniProtKB/TrEMBL
  A6K5Y7_RAT UniProtKB/TrEMBL
  A6K5Y8_RAT UniProtKB/TrEMBL
  F1M581 ENTREZGENE, UniProtKB/TrEMBL
  HPSE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9QZF8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Hpse  heparanase  LOC100362546  heparanase-like  Data merged from RGD:2324508 737654 PROVISIONAL
2010-05-06 LOC100362546  heparanase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Hpse  heparanase      Name updated 70584 APPROVED
2001-12-06 Hpse  heparanase      Symbol updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization activity suggests function in extralysosomal compartments 632901