Hpse (heparanase) - Rat Genome Database

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Pathways
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Gene: Hpse (heparanase) Heterocephalus glaber
Analyze
Symbol: Hpse
Name: heparanase
RGD ID: 18910359
Description: ENCODES a protein that exhibits heparanase activity (ortholog); syndecan binding (ortholog); INVOLVED IN establishment of endothelial barrier (ortholog); heparan sulfate proteoglycan catabolic process (ortholog); heparin metabolic process (ortholog); PARTICIPATES IN syndecan signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); chromosome 4q21 deletion syndrome (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN extracellular space (ortholog); heparanase complex (ortholog); intracellular membrane-bounded organelle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624900296,676 - 335,570 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624900296,626 - 335,624 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Hpse
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624900296,676 - 335,570 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624900296,626 - 335,624 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
HPSE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38483,292,461 - 83,335,153 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl483,292,461 - 83,335,153 (-)EnsemblGRCh38hg38GRCh38
GRCh37484,213,614 - 84,256,306 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36484,435,492 - 84,475,330 (-)NCBINCBI36Build 36hg18NCBI36
Build 34484,570,793 - 84,613,484NCBI
Celera481,506,894 - 81,546,444 (-)NCBICelera
Cytogenetic Map4q21.23NCBI
HuRef479,956,669 - 79,999,104 (-)NCBIHuRef
CHM1_1484,190,339 - 84,232,732 (-)NCBICHM1_1
T2T-CHM13v2.0486,622,557 - 86,665,251 (-)NCBIT2T-CHM13v2.0
Hpse
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395100,827,350 - 100,867,582 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5100,827,350 - 100,867,582 (-)EnsemblGRCm39 Ensembl
GRCm385100,679,484 - 100,719,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5100,679,484 - 100,719,716 (-)EnsemblGRCm38mm10GRCm38
MGSCv375101,108,505 - 101,148,702 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365100,920,698 - 100,959,985 (-)NCBIMGSCv36mm8
Celera598,006,862 - 98,047,031 (-)NCBICelera
Cytogenetic Map5E4NCBI
cM Map548.51NCBI
Hpse
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8149,200,971 - 9,241,377 (+)NCBIGRCr8
mRatBN7.2148,896,593 - 8,937,011 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,896,593 - 8,937,010 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,870,273 - 8,910,720 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01410,170,116 - 10,210,568 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,866,737 - 8,907,192 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01410,534,358 - 10,576,686 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1410,534,423 - 10,575,224 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01410,483,116 - 10,523,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41410,144,322 - 10,185,115 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11410,144,321 - 10,185,115NCBI
Celera149,005,457 - 9,045,081 (+)NCBICelera
Cytogenetic Map14p22NCBI
Hpse
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554746,367,467 - 6,394,395 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554746,367,467 - 6,394,395 (+)NCBIChiLan1.0ChiLan1.0
HPSE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2346,730,513 - 46,772,977 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1446,919,902 - 46,962,373 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0440,863,491 - 40,905,693 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1446,709,621 - 46,755,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl446,709,621 - 46,755,157 (+)Ensemblpanpan1.1panPan2
HPSE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,166,437 - 7,199,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,167,856 - 7,199,665 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3234,685,950 - 34,719,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,187,761 - 7,220,727 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,187,761 - 7,220,717 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,257,986 - 7,290,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,127,254 - 7,160,461 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03232,801,148 - 32,834,425 (+)NCBIUU_Cfam_GSD_1.0
Hpse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052855,146,217 - 5,181,190 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367381,308,345 - 1,343,145 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367381,308,350 - 1,341,421 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPSE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8135,097,725 - 135,120,887 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18135,082,199 - 135,120,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28144,378,429 - 144,417,256 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HPSE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1731,689,449 - 31,730,176 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl731,686,304 - 31,730,043 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603710,285,023 - 10,325,651 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000026850   ⟹   ENSHGLP00000026613
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624900296,676 - 335,570 (-)Ensembl
RefSeq Acc Id: XM_004872330   ⟹   XP_004872387
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624900296,629 - 335,624 (-)NCBI
RefSeq Acc Id: XM_021250311   ⟹   XP_021105970
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624900296,626 - 335,624 (-)NCBI
RefSeq Acc Id: XM_021250312   ⟹   XP_021105971
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624900296,626 - 335,624 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004872387 (Get FASTA)   NCBI Sequence Viewer  
  XP_021105970 (Get FASTA)   NCBI Sequence Viewer  
  XP_021105971 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00176 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026613
  ENSHGLP00100023080
Reference Protein Sequences
RefSeq Acc Id: XP_021105970   ⟸   XM_021250311
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021105971   ⟸   XM_021250312
- Peptide Label: isoform X3
RefSeq Acc Id: XP_004872387   ⟸   XM_004872330
- Peptide Label: isoform X1
- UniProtKB: G5AT15 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000026613   ⟸   ENSHGLT00000026850


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018930 Ensembl, ENTREZGENE
  ENSHGLG00100016963 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000026850 ENTREZGENE
  ENSHGLT00100023320 UniProtKB/TrEMBL
Gene3D-CATH Glycosidases UniProtKB/TrEMBL
InterPro Glyco_hydro_79 UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
KEGG Report hgl:101721140 UniProtKB/TrEMBL
NCBI Gene Hpse ENTREZGENE
PANTHER HEPARANASE UniProtKB/TrEMBL
  HEPARANASE UniProtKB/TrEMBL
Pfam Glyco_hydro_79n UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt G5AT15 ENTREZGENE, UniProtKB/TrEMBL