Map2k5 (mitogen activated protein kinase kinase 5) - Rat Genome Database

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Gene: Map2k5 (mitogen activated protein kinase kinase 5) Rattus norvegicus
Analyze
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
RGD ID: 61890
Description: Enables ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of macromolecule metabolic process. Predicted to be located in spindle. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2,4-trimethylbenzene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; Mek5; mitogen-activated protein kinase kinase 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Map2k5Tn(sb-T2/Bart3)2.150Mcwi
Genetic Models: F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8872,520,616 - 72,748,395 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl872,520,617 - 72,747,373 (-)EnsemblGRCr8
mRatBN7.2863,625,220 - 63,852,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,625,221 - 63,851,983 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx869,140,369 - 69,367,101 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,412,831 - 67,639,556 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,282,951 - 65,509,687 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,055,972 - 68,282,590 (-)Ensemblrn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera863,038,974 - 63,262,592 (-)NCBICelera
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arecoline  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium acetate  (EXP,ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
haloperidol  (EXP)
hesperidin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
nitrates  (ISO)
oxaliplatin  (EXP)
oxytocin  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
potassium chromate  (ISO)
resveratrol  (ISO)
rutin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (EXP)
sulfates  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,TAS)
membrane  (IEA)
spindle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Isolation of MEK5 and differential expression of alternatively spliced forms. English JM, etal., J Biol Chem 1995 Dec 1;270(48):28897-902.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Mehta PB, etal., Oncogene. 2003 Mar 6;22(9):1381-9.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. Nicol RL, etal., EMBO J. 2001 Jun 1;20(11):2757-67.
8. Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4). Ohnesorge N, etal., J Biol Chem. 2010 Aug 20;285(34):26199-210. doi: 10.1074/jbc.M110.103127. Epub 2010 Jun 15.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease. Sato Y, etal., Am J Pathol. 2005 Jan;166(1):49-60.
14. Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes. Takahashi N, etal., J Mol Cell Cardiol. 2005 Jan;38(1):185-92. Epub 2004 Dec 10.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Thomas JA, etal., Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H597-606.
17. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
18. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. Woo CH, etal., FASEB J. 2010 Dec;24(12):4917-28. doi: 10.1096/fj.10-162636. Epub 2010 Aug 19.
Additional References at PubMed
PMID:11544482   PMID:12477932   PMID:15489334   PMID:15509711   PMID:15601854   PMID:16415348   PMID:17947239   PMID:19103177   PMID:19484198   PMID:20607863   PMID:25666619  


Genomics

Comparative Map Data
Map2k5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8872,520,616 - 72,748,395 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl872,520,617 - 72,747,373 (-)EnsemblGRCr8
mRatBN7.2863,625,220 - 63,852,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,625,221 - 63,851,983 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx869,140,369 - 69,367,101 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,412,831 - 67,639,556 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,282,951 - 65,509,687 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,055,972 - 68,282,590 (-)Ensemblrn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera863,038,974 - 63,262,592 (-)NCBICelera
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Cytogenetic Map8q24NCBI
MAP2K5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,542,703 - 67,807,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,542,611 - 67,807,123 (+)Ensemblhg38GRCh38
GRCh371567,835,041 - 68,099,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,622,075 - 65,886,506 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341565,719,944 - 65,886,505NCBI
Celera1544,722,555 - 44,987,508 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1544,669,592 - 44,933,408 (+)NCBIHuRef
CHM1_11567,952,970 - 68,217,538 (+)NCBICHM1_1
T2T-CHM13v2.01565,364,709 - 65,628,974 (+)NCBIT2T-CHM13v2.0
Map2k5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,071,050 - 63,288,964 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,071,050 - 63,285,184 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38963,163,768 - 63,381,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,163,768 - 63,377,902 (-)Ensemblmm10GRCm38
MGSCv37963,011,577 - 63,225,659 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36962,961,776 - 63,175,858 (-)NCBIMGSCv36mm8
Celera960,383,063 - 60,597,534 (-)NCBICelera
Cytogenetic Map9B- CNCBI
cM Map933.96NCBI
Map2k5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,203,569 - 8,458,258 (-)Ensembl
ChiLan1.0NW_0049554508,207,577 - 8,458,258 (-)NCBIChiLan1.0ChiLan1.0
MAP2K5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,797,445 - 57,064,491 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,970,950 - 61,238,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,493,139 - 46,760,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,761,465 - 65,029,655 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,761,394 - 65,029,655 (+)EnsemblpanPan2panpan1.1
MAP2K5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,665,032 - 31,920,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,664,564 - 31,920,751 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3031,599,952 - 31,856,489 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03031,860,861 - 32,117,463 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,861,062 - 32,117,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,790,015 - 32,045,842 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,850,721 - 32,107,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03032,096,413 - 32,353,048 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map2k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,643,236 - 109,880,510 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,491,342 - 27,728,607 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,491,255 - 27,728,572 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1165,458,258 - 165,740,297 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11165,458,263 - 165,733,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21183,148,368 - 183,197,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12615,694,760 - 15,956,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2615,693,811 - 15,956,918 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048125,513,002 - 125,773,972 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247815,224,724 - 5,489,488 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247815,224,722 - 5,489,517 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Map2k5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1857,453,510 - 57,674,322 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Map2k5
741 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:88
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000010991, ENSRNOT00000051558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat

Markers in Region
D8Got101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,634,971 - 63,635,232 (+)MAPPERmRatBN7.2
Rnor_6.0868,065,730 - 68,065,988NCBIRnor6.0
Rnor_5.0867,794,622 - 67,794,880UniSTSRnor5.0
RGSC_v3.4867,323,225 - 67,323,484RGDRGSC3.4
RGSC_v3.4867,323,226 - 67,323,484UniSTSRGSC3.4
Celera863,048,725 - 63,048,983UniSTS
RGSC_v3.1867,342,280 - 67,342,538RGD
RH 3.4 Map8799.2UniSTS
RH 3.4 Map8799.2RGD
RH 2.0 Map8593.8RGD
Cytogenetic Map8q24UniSTS
D8Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,440,770 - 147,441,022 (+)MAPPERmRatBN7.2
mRatBN7.2863,713,366 - 63,714,054 (+)MAPPERmRatBN7.2
Rnor_6.0868,145,077 - 68,145,764NCBIRnor6.0
Rnor_6.05153,552,704 - 153,552,955NCBIRnor6.0
Rnor_5.0867,872,683 - 67,873,370UniSTSRnor5.0
Rnor_5.05157,322,066 - 157,322,317UniSTSRnor5.0
RGSC_v3.45153,989,202 - 153,989,453UniSTSRGSC3.4
RGSC_v3.4867,401,029 - 67,401,716UniSTSRGSC3.4
Celera863,126,644 - 63,127,331UniSTS
Celera5145,850,612 - 145,850,863UniSTS
Cytogenetic Map8q24UniSTS
BF394715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,660,375 - 63,660,475 (+)MAPPERmRatBN7.2
Rnor_6.0868,091,216 - 68,091,315NCBIRnor6.0
Rnor_5.0867,820,108 - 67,820,207UniSTSRnor5.0
RGSC_v3.4867,348,566 - 67,348,665UniSTSRGSC3.4
Celera863,074,061 - 63,074,160UniSTS
RH 3.4 Map8801.1UniSTS
Cytogenetic Map8q24UniSTS
RH138128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,667,592 - 63,667,801 (+)MAPPERmRatBN7.2
Rnor_6.0868,099,307 - 68,099,515NCBIRnor6.0
Rnor_5.0867,826,913 - 67,827,121UniSTSRnor5.0
RGSC_v3.4867,355,258 - 67,355,466UniSTSRGSC3.4
Celera863,080,873 - 63,081,081UniSTS
Cytogenetic Map8q24UniSTS
RH138410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,625,307 - 63,625,557 (+)MAPPERmRatBN7.2
Rnor_6.0868,056,064 - 68,056,313NCBIRnor6.0
Rnor_5.0867,784,956 - 67,785,205UniSTSRnor5.0
RGSC_v3.4867,313,560 - 67,313,809UniSTSRGSC3.4
Celera863,039,062 - 63,039,311UniSTS
RH 3.4 Map8802.9UniSTS
Cytogenetic Map8q24UniSTS
UniSTS:469815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,625,330 - 63,625,553 (+)MAPPERmRatBN7.2
Rnor_6.0868,056,087 - 68,056,309NCBIRnor6.0
Rnor_5.0867,784,979 - 67,785,201UniSTSRnor5.0
RGSC_v3.4867,313,583 - 67,313,805UniSTSRGSC3.4
Celera863,039,085 - 63,039,307UniSTS
Cytogenetic Map8q24UniSTS


Genetic Models
This gene Map2k5 is modified in the following models/strains:
F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063265018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010991   ⟹   ENSRNOP00000010991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl872,520,617 - 72,747,373 (-)Ensembl
mRatBN7.2 Ensembl863,625,221 - 63,851,983 (-)Ensembl
Rnor_6.0 Ensembl868,055,977 - 68,282,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051558   ⟹   ENSRNOP00000050528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl872,520,617 - 72,747,373 (-)Ensembl
mRatBN7.2 Ensembl863,625,221 - 63,851,983 (-)Ensembl
Rnor_6.0 Ensembl868,055,977 - 68,282,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079122   ⟹   ENSRNOP00000070803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl872,520,617 - 72,747,373 (-)Ensembl
mRatBN7.2 Ensembl863,625,221 - 63,851,983 (-)Ensembl
Rnor_6.0 Ensembl868,055,972 - 68,275,720 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114643   ⟹   ENSRNOP00000083354
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl872,520,617 - 72,747,373 (-)Ensembl
mRatBN7.2 Ensembl863,625,242 - 63,851,983 (-)Ensembl
RefSeq Acc Id: NM_001033987   ⟹   NP_001029159
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,520,616 - 72,747,373 (-)NCBI
mRatBN7.2863,625,220 - 63,851,983 (-)NCBI
Rnor_6.0868,055,976 - 68,282,590 (-)NCBI
Rnor_5.0867,784,868 - 68,010,809 (-)NCBI
RGSC_v3.4867,313,472 - 67,542,723 (-)RGD
Celera863,038,974 - 63,262,592 (-)RGD
Sequence:
RefSeq Acc Id: NM_017246   ⟹   NP_058942
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,520,616 - 72,747,373 (-)NCBI
mRatBN7.2863,625,220 - 63,851,983 (-)NCBI
Rnor_6.0868,055,976 - 68,282,590 (-)NCBI
Rnor_5.0867,784,868 - 68,010,809 (-)NCBI
RGSC_v3.4867,313,472 - 67,542,723 (-)RGD
Celera863,038,974 - 63,262,592 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243229   ⟹   XP_006243291
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,520,616 - 72,748,395 (-)NCBI
mRatBN7.2863,625,220 - 63,852,084 (-)NCBI
Rnor_6.0868,055,976 - 68,282,656 (-)NCBI
Rnor_5.0867,784,868 - 68,010,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595501   ⟹   XP_017450990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,520,616 - 72,748,395 (-)NCBI
mRatBN7.2863,625,220 - 63,852,085 (-)NCBI
Rnor_6.0868,055,976 - 68,282,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080953   ⟹   XP_038936881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,555,595 - 72,748,395 (-)NCBI
mRatBN7.2863,660,201 - 63,852,089 (-)NCBI
RefSeq Acc Id: XM_039080954   ⟹   XP_038936882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,555,595 - 72,748,395 (-)NCBI
mRatBN7.2863,660,201 - 63,852,090 (-)NCBI
RefSeq Acc Id: XM_039080955   ⟹   XP_038936883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,555,595 - 72,748,395 (-)NCBI
mRatBN7.2863,660,201 - 63,852,090 (-)NCBI
RefSeq Acc Id: XM_039080956   ⟹   XP_038936884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,555,595 - 72,748,395 (-)NCBI
mRatBN7.2863,660,201 - 63,852,090 (-)NCBI
RefSeq Acc Id: XM_039080960   ⟹   XP_038936888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,555,595 - 72,746,730 (-)NCBI
mRatBN7.2863,660,201 - 63,851,329 (-)NCBI
RefSeq Acc Id: XM_063265018   ⟹   XP_063121088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8872,555,595 - 72,700,832 (-)NCBI
RefSeq Acc Id: NP_001029159   ⟸   NM_001033987
- Peptide Label: isoform a
- UniProtKB: Q62863 (UniProtKB/Swiss-Prot),   Q62864 (UniProtKB/Swiss-Prot),   Q62862 (UniProtKB/Swiss-Prot),   A6J595 (UniProtKB/TrEMBL),   A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_058942   ⟸   NM_017246
- Peptide Label: isoform b
- UniProtKB: A6J594 (UniProtKB/TrEMBL),   A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243291   ⟸   XM_006243229
- Peptide Label: isoform X5
- UniProtKB: A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450990   ⟸   XM_017595501
- Peptide Label: isoform X6
- UniProtKB: A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070803   ⟸   ENSRNOT00000079122
Ensembl Acc Id: ENSRNOP00000050528   ⟸   ENSRNOT00000051558
Ensembl Acc Id: ENSRNOP00000010991   ⟸   ENSRNOT00000010991
RefSeq Acc Id: XP_038936883   ⟸   XM_039080955
- Peptide Label: isoform X3
- UniProtKB: A0A8L2R4U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936884   ⟸   XM_039080956
- Peptide Label: isoform X4
- UniProtKB: A0A8L2R4U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936882   ⟸   XM_039080954
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R4U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936881   ⟸   XM_039080953
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R4U8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936888   ⟸   XM_039080960
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000083354   ⟸   ENSRNOT00000114643
RefSeq Acc Id: XP_063121088   ⟸   XM_063265018
- Peptide Label: isoform X8
Protein Domains
PB1   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62862-F1-model_v2 AlphaFold Q62862 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696058
Promoter ID:EPDNEW_R6583
Type:initiation region
Name:Map2k5_1
Description:mitogen activated protein kinase kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0868,282,594 - 68,282,654EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61890 AgrOrtholog
BioCyc Gene G2FUF-30137 BioCyc
Ensembl Genes ENSRNOG00000007926 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010991 ENTREZGENE
  ENSRNOT00000010991.7 UniProtKB/Swiss-Prot
  ENSRNOT00000051558 ENTREZGENE
  ENSRNOT00000051558.5 UniProtKB/Swiss-Prot
  ENSRNOT00000114643 ENTREZGENE
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7122708 IMAGE-MGC_LOAD
InterPro Dual_spec_MAPK_kinase UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PB1-like UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PB1_MAP2K5 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:29568 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93521 IMAGE-MGC_LOAD
NCBI Gene 29568 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 UniProtKB/Swiss-Prot
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 UniProtKB/Swiss-Prot
Pfam PB1 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Map2k5 PhenoGen
PROSITE PB1 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007926 RatGTEx
SMART PB1 UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC216643
UniProt A0A8I5ZZ49_RAT UniProtKB/TrEMBL
  A0A8L2R4U8 ENTREZGENE, UniProtKB/TrEMBL
  A6J594 ENTREZGENE, UniProtKB/TrEMBL
  A6J595 ENTREZGENE, UniProtKB/TrEMBL
  A6J596_RAT UniProtKB/TrEMBL
  A6J597_RAT UniProtKB/TrEMBL
  A6J598_RAT UniProtKB/TrEMBL
  MP2K5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62863 ENTREZGENE
  Q62864 ENTREZGENE
UniProt Secondary Q62863 UniProtKB/Swiss-Prot
  Q62864 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Map2k5  mitogen activated protein kinase kinase 5       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function does not phosphorylate ERK1, ERK2, ERK3, JNK/SAPK, or p38/HOG1 61658