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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61890
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k5decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of MAP2K5 mRNAPMID:25181051
Map2k5increases expressionEXP 6480464CTDbisphenol A results in increased expression of MAP2K5 mRNAPMID:30816183 PMID:32528016
Map2k5increases methylationEXP 6480464CTDbisphenol A results in increased methylation of MAP2K5 genePMID:28505145
Map2k5decreases expressionISOMAP2K5 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of MAP2K5 mRNAPMID:22576693
Map2k5decreases methylationISOMAP2K5 (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of MAP2K5 genePMID:31601247
Map2k5increases methylationISOMAP2K5 (Homo sapiens)6480464CTDbisphenol A results in increased methylation of MAP2K5 genePMID:22576693
Map2k5multiple interactionsISOMAP2K5 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of MAP2K5 mRNAPMID:28628672
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