Gene:	Vav1 ( Rattus norvegicus ) vav 1 guanine nucleotide exchange factor
Description:	guanine nucleotide exchange factor (GEF) from the Rho family of GTP binding proteins; plays a role in T-cell and B-cell development; can activate the c-Jun N-terminal kinase-1 (JNK1) pathway
Synonyms:	Vav; Vav 1 oncogene;  (details...)
ArrayIDs:	1369387_at; U39476_at;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Ciaa3 - CIA Autoantibody QTL 3
Homologs
Homo sapiens: VAV1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Vav1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Vav1 Rat Celera Assembly 9 6313197 - 6360059     Cytogenetic 9 q11-q12 Mus musculus Vav1 Mouse genome assembly build 36.1 17 57418538 - 57467376     Cytogenetic 17 17 D Homo sapiens VAV1 human genome assembly 19 6723721 - 6808371     Human genome assembly build 36.2 19 6723722 - 6808371     Cytogenetic 19 p13.2   View comparative maps:
Genome
View:
Annotation
Molecular Function	Gene Ontology Rac guanyl-nucleotide exchange factor activity,  protein binding,  Rho guanyl-nucleotide exchange factor activity ...  (details...)
Biological Process	Gene Ontology immune response-regulating cell surface receptor signaling pathway,  integrin-mediated signaling pathway,  immune response ...  (details...)
Cellular Component	Gene Ontology intracellular,  plasma membrane,  cytosol (details...)
Disease	Ontology Carcinoma, Hepatocellular,  Lymphopenia,  Diabetes Mellitus, Insulin-Dependent ...  (details...)
Pathway	Note Reference can activate the c-Jun N-terminal kinase-1 (JNK1) pathway 727273
Product	Note Reference member of the Db1 subfamily of the Rho family of GTP binding proteins 727273
External Links
Databases	DATABASE ID SOURCE SMART: PH IPI SMART: CH IPI SMART: C1 IPI SMART: RhoGEF IPI SMART: SH2 IPI SMART: SH3 IPI PROSITE: ZF_DAG_PE_1 IPI PROSITE: ZF_DAG_PE_2 IPI PROSITE: SH3 IPI PROSITE: CH IPI PROSITE: DH_1 IPI PROSITE: DH_2 IPI PROSITE: PH_DOMAIN IPI PROSITE: SH2 IPI UNIPARC: UPI00004E5BD1 IPI UNIPARC: UPI0000138214 IPI KEGG Report: rno:25156 ENTREZGENE Germonline: 3951 Pfam: SH3_1 IPI Pfam: SH3_2 IPI Pfam: C1_1 IPI Pfam: CH IPI Pfam: PH IPI Pfam: RhoGEF IPI Pfam: SH2 IPI KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE InterPro: SM22_calponin. IPI InterPro: SH3_region. IPI InterPro: SH3_domain. IPI InterPro: SH3_2. IPI InterPro: SH2. IPI InterPro: Prot_Kinase_C-like_PE/DAG_bd. IPI InterPro: Pleckstrin_homology. IPI InterPro: GDS_CDC24_CS. IPI InterPro: DH-domain. IPI InterPro: Calponin_act_bd. IPI InterPro: Calponin-homology. IPI IPI: IPI00210878 IPI IPI: IPI00882506 IPI Gene3D-CATH: Calponin-homology IPI Gene3D-CATH: SH2 IPI Gene3D-CATH: RhoGEF IPI Entrez Gene: Vav1 ENTREZGENE IMAGE_CLONE: IMAGE:7373783 IMAGE-MGC_LOAD MGC_CLONE: MGC:108735 IMAGE-MGC_LOAD UniProt: Q5BK91_RAT IPI UniProt: VAV_RAT IPI RatMap: 39709 ENTREZGENE Superfamily-SCOP: DH-domain IPI Superfamily-SCOP: SH3 IPI Superfamily-SCOP: Calponin-homology IPI PRINTS: SH2DOMAIN. IPI PRINTS: SM22CALPONIN. IPI PRINTS: SH3DOMAIN. IPI
Sequences	Nucleotide: CH474092 Get FASTA Search GEO Profiles Nucleotide: U39476 Get FASTA Search GEO Profiles Nucleotide: NM_012759 Get FASTA Search GEO Profiles Nucleotide: BC091160 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: AAH91160 Get FASTA Protein: NP_036891 Get FASTA Protein: AAA98606 Get FASTA Protein: EDL83565 Get FASTA Protein: Q5BK91 Get FASTA Protein: P54100 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 48861
References
Curated References	11 references in RGD related to Vav1
Other References	7 other references at PubMed related to Vav1
Database Information
RGD ID	3951
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 15-DEC-08: Vav1 vav 1 guanine nucleotide exchange factor Vav1 vav 1 oncogene APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 09-APR-03: Vav1 vav 1 oncogene Vav 1 oncogene APPROVED Name updated 629478 10-JUN-02: Vav1 Vav 1 oncogene APPROVED Symbol and Name status set to approved 70586