Vav1 (vav guanine nucleotide exchange factor 1)

Gene: Vav1 (vav guanine nucleotide exchange factor 1) Rattus norvegicus

Analyze

Symbol:

Vav1

Name:

vav guanine nucleotide exchange factor 1

RGD ID:

3951

Description:

Predicted to enable guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1); PARTICIPATES IN interleukin-6 signaling pathway; B cell receptor signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

p95; proto-oncogene vav; Vav; vav 1 guanine nucleotide exchange factor; Vav 1 oncogene

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	VAV1 (vav guanine nucleotide exchange factor 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Vav1 (vav 1 oncogene)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Vav1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	VAV1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	VAV1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Vav1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	VAV1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	VAV1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Vav1 (vav guanine nucleotide exchange factor 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Vav1 (vav 1 oncogene)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	VAV1 (vav guanine nucleotide exchange factor 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Vav	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	vav-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	vav1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Candidate Gene For:

Ciaa3 Eae4

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	2,248,856 - 2,295,905 (+)	NCBI		GRCr8
mRatBN7.2	9	2,161,985 - 2,209,951 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	2,157,900 - 2,208,937 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	2,589,440 - 2,636,410 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,938,822 - 7,985,803 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,894,673 - 6,941,653 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,617,551 - 9,675,167 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,617,786 - 9,675,110 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,626,445 - 8,655,152 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	9	8,682,235 - 8,682,495 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,313,197 - 6,360,060 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult T-cell leukemia/lymphoma (ISO)

autistic disorder (ISO)

endometriosis (IEP)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hepatocellular carcinoma (IEP)

lung adenocarcinoma (ISO)

lymphopenia (IEP)

medulloblastoma (ISO)

mucolipidosis type IV (ISO)

type 1 diabetes mellitus (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,7-dihydropurine-6-thione (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acetylsalicylic acid (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (ISO)

buta-1,3-diene (ISO)

butanal (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

diuron (ISO)

ethanol (ISO)

fenvalerate (EXP)

genistein (ISO)

Licochalcone B (ISO)

lidocaine (EXP)

lipopolysaccharide (ISO)

mercaptopurine (ISO)

methoxychlor (EXP)

N-formyl-L-methionyl-L-leucyl-L-phenylalanine (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nickel atom (ISO)

paracetamol (ISO)

pentanal (ISO)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (EXP)

propanal (ISO)

protein kinase inhibitor (ISO)

purine-6-thiol (ISO)

pyrethrins (EXP)

resveratrol (ISO)

silicon dioxide (ISO)

tamibarotene (ISO)

testosterone (EXP)

thioacetamide (EXP)

tipifarnib (EXP)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

trichloroethene (EXP,ISO)

triptonide (ISO)

tungsten (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell development (TAS)

cell migration (IBA,IEA)

cell surface receptor signaling pathway (IEA)

G protein-coupled receptor signaling pathway (IEA,ISO)

immune response (IEA,ISO)

immune response-regulating cell surface receptor signaling pathway (IEP)

integrin-mediated signaling pathway (IEA,ISO)

intracellular signal transduction (IEA,ISO)

natural killer cell mediated cytotoxicity (ISO)

neutrophil chemotaxis (IEA,ISO)

phagocytosis (IEA,ISO)

positive regulation of cell adhesion (IEA,ISO)

positive regulation of natural killer cell mediated cytotoxicity (IEA,ISO)

reactive oxygen species metabolic process (IEA,ISO)

regulation of cell size (IEA,ISO)

T cell activation (ISO)

T cell differentiation (IEA,ISO)

Cellular Component

cell-cell junction (IEA,ISO)

cytoplasm (IBA,IEA,ISO)

Molecular Function

guanyl-nucleotide exchange factor activity (IBA,IEA,ISO,TAS)

metal ion binding (IEA)

phosphorylation-dependent protein binding (IEA,ISO)

phosphotyrosine residue binding (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

B cell receptor signaling pathway (IEA)

chemokine mediated signaling pathway (IEA)

Fc epsilon receptor mediated signaling pathway (IEA)

Fc gamma receptor mediated signaling pathway (IEA)

interleukin-6 signaling pathway (ISO)

T cell receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Differential expression of p95vav in primary lymphoid tissue of BB rats congenic for the lymphopenia gene.	Bieg S Autoimmunity. 1999;30(1):37-42.
2.	Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci	Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis.	Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
6.	DNA methylation and oncogene expression in methapyrilene-induced rat liver tumors and in treated hepatocytes in culture.	Hernandez L, etal., Mol Carcinog. 1991;4(3):203-9.
7.	Gene expression profiling of the rat endometriosis model.	Konno R, etal., Am J Reprod Immunol. 2007 Oct;58(4):330-43.
8.	Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs.	Margolis B, etal., Nature. 1992 Mar 5;356(6364):71-4.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
11.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
12.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Tyrosine phosphorylation of Vav stimulates IL-6 production in mast cells by a Rac/c-Jun N-terminal kinase-dependent pathway.	Song JS, etal., J Immunol 1999 Jul 15;163(2):802-10.

Additional References at PubMed

PMID:8990121	PMID:11070165	PMID:12477932	PMID:15249579	PMID:15618286	PMID:15644420	PMID:15696170	PMID:16203968	PMID:17721087	PMID:20624904	PMID:20962259	PMID:21178006
PMID:22467863	PMID:23793062	PMID:26163585	PMID:30361391	PMID:34147481

Genomics

Comparative Map Data

Vav1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	2,248,856 - 2,295,905 (+)	NCBI		GRCr8
mRatBN7.2	9	2,161,985 - 2,209,951 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	2,157,900 - 2,208,937 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	2,589,440 - 2,636,410 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,938,822 - 7,985,803 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,894,673 - 6,941,653 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,617,551 - 9,675,167 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,617,786 - 9,675,110 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,626,445 - 8,655,152 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	9	8,682,235 - 8,682,495 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,313,197 - 6,360,060 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

VAV1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	6,772,708 - 6,857,361 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	6,772,708 - 6,857,366 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	6,772,719 - 6,857,372 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	6,723,722 - 6,808,371 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	6,723,721 - 6,808,371	NCBI
Celera	19	6,714,968 - 6,799,596 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	6,535,153 - 6,619,808 (+)	NCBI		HuRef
CHM1_1	19	6,772,530 - 6,857,195 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	6,762,101 - 6,846,684 (+)	NCBI		T2T-CHM13v2.0

Vav1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	57,586,080 - 57,636,236 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	57,586,100 - 57,635,031 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	57,279,100 - 57,329,236 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	57,279,100 - 57,328,031 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	57,418,523 - 57,468,659 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	56,964,450 - 57,013,288 (+)	NCBI		MGSCv36	mm8
Celera	17	61,628,185 - 61,678,969 (+)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.76	NCBI

Vav1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	2,695,730 - 2,755,824 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	2,697,508 - 2,755,468 (-)	NCBI	ChiLan1.0	ChiLan1.0

VAV1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	11,185,888 - 11,272,029 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	10,411,972 - 10,494,172 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	5,805,121 - 5,888,203 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	6,726,578 - 6,832,795 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	6,726,578 - 6,806,112 (+)	Ensembl	panpan1.1		panPan2

VAV1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	53,482,239 - 53,532,399 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	53,482,498 - 53,531,296 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	53,231,024 - 53,280,874 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	54,137,307 - 54,187,259 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	54,137,311 - 54,193,863 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	53,204,407 - 53,254,232 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	53,652,377 - 53,702,224 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	53,881,726 - 53,931,647 (-)	NCBI		UU_Cfam_GSD_1.0

Vav1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	213,727,422 - 213,748,901 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	4,058,343 - 4,107,109 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	4,058,312 - 4,107,330 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VAV1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	72,326,716 - 72,391,648 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	72,327,433 - 72,391,649 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	72,827,628 - 72,890,504 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VAV1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	6,337,255 - 6,415,851 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	1,571,908 - 1,654,139 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vav1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	3,838,706 - 3,897,080 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	3,838,464 - 3,896,698 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Vav1
499 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	122
Count of miRNA genes:	99
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000073294
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10054141	Gmadr4	Adrenal mass QTL 4	2.45	0.0074	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	9	1	14209783	Rat
70226	Eae4	Experimental allergic encephalomyelitis QTL 4			nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	9	1	25661317	Rat
9589055	Scfw5	Subcutaneous fat weight QTL 5	5.55	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	9	1	37999212	Rat
7411592	Foco8	Food consumption QTL 8	7.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	9	1	37999212	Rat
9589158	Gluco65	Glucose level QTL 65	6.82	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	9	1	37999212	Rat
1300124	Cm4	Cardiac mass QTL 4	3.55		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	9	1	40594091	Rat
1298088	Edpm11	Estrogen-dependent pituitary mass QTL 11	2.5		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	9	1	43718459	Rat
1641911	Alcrsp13	Alcohol response QTL 13			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	9	1	43718459	Rat
10054125	Srcrt7	Stress Responsive Cort QTL 7	3.33	0.0011	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	9	1	87073594	Rat
1331757	Cdexp1	CD45RC expression in CD8 T cells QTL 1	4.3		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	9	1024537	67509080	Rat
1354650	Despr5	Despair related QTL 5	4.01	0.0017	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	9	1254084	46254084	Rat
2303559	Gluco54	Glucose level QTL 54	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	9	1254084	46254084	Rat

Markers in Region

RH94621

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	2,208,768 - 2,208,917 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	9,617,573 - 9,617,721	NCBI	Rnor6.0
Rnor_5.0	9	8,626,467 - 8,626,615	UniSTS	Rnor5.0
Celera	9	6,313,219 - 6,313,367	UniSTS
Cytogenetic Map	9	q11-q12	UniSTS

RH141231

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	9	2,209,187 - 2,209,406 (-)	MAPPER	mRatBN7.2
Rnor_6.0	9	9,617,084 - 9,617,302	NCBI	Rnor6.0
Rnor_5.0	9	8,625,978 - 8,626,196	UniSTS	Rnor5.0
Celera	9	6,312,730 - 6,312,948	UniSTS
Cytogenetic Map	9	q11-q12	UniSTS

MARC_12285-12286:1005663674:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Celera	9	6,331,629 - 6,332,509	UniSTS
Cytogenetic Map	9	q11-q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		22	14	19	14					1	7
Low	1	43	35	27		27	7	9	74	35	35	4	7
Below cutoff							1	2			5		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012759	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063266662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC091160	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219993	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U39476	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000073294 ⟹ ENSRNOP00000064264

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	2,161,985 - 2,208,937 (+)	Ensembl
Rnor_6.0 Ensembl	9	9,617,786 - 9,675,110 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094489 ⟹ ENSRNOP00000086561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	2,161,985 - 2,208,937 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096076 ⟹ ENSRNOP00000077767

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	2,161,985 - 2,208,937 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111335 ⟹ ENSRNOP00000081960

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	9	2,157,900 - 2,208,937 (+)	Ensembl

RefSeq Acc Id:

NM_012759 ⟹ NP_036891

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	2,248,955 - 2,295,905 (+)	NCBI
mRatBN7.2	9	2,161,985 - 2,208,939 (+)	NCBI
Rnor_6.0	9	9,617,551 - 9,675,167 (-)	NCBI
Rnor_5.0	9	8,626,445 - 8,655,152 (-)	NCBI
Rnor_5.0	9	8,682,235 - 8,682,495 (-)	NCBI
Celera	9	6,313,197 - 6,360,060 (-)	RGD

Sequence:

show sequence

AGGAACGAGGGTGCACGGGGCCTCCCCGAGGGGCCAAGGGAGAGGCAGGCAGCCACTATGGAGC
TCTGGCGACAGTGCACCCACTGGCTGATCCAGTGTCGGGTGCTGCCTCCCAGCCACCGTGTGAC
CTGGGAGGGGGCCCAGGTGTGTGAGCTGGCACAGGCACTGCGGGATGGTGTCCTCCTGTGTCAA
CTGCTTAACAACCTGCTCCCCCACGCCATCAATCTGCGGGAAGTTAACTTGTGGCCCCAGATGT
CCCAGTTCCTTTGTCTTAAGAACATCCGAACCTTCCTGTCTACTTGCTGTGAGAAATTCGGCCT
CAAGCGCAGCGAACTCTTTGAGGCTTTTGACCTCTTTGATGTGCAGGACTTTGGAAAGGTCATC
TACACCCTGTCTGCCCTGTCATGGACACCCATTGCCCAGAACAAAGGGATCATGCCCTTCCCAA
CAGAGGACAGCGCCCTGGGTGATGAAGATATTTACAGTGGCCTTTCAGACCAGATTGATGACAC
CGCAGAGGAAGATGAGGACCTTTATGACTGCGTGGAGAATGAGGAGGCAGAGGGGGACGAGATC
TACGAGGACCTAATGCGCTCGGAGTCGGTGCCCACACCTCCCAAGATGACAGAGTACGATAAGC
GCTGCTGCTGCCTGCGGGAGATCCAGCAGACTGAGGAGAAGTACACAGACACACTGGGCTCCAT
CCAGCAGCACTTCATGAAGCCCCTCCAGCGATTCCTCAAGCCTCAAGACATGGAGACCATCTTT
GTCAACATTGAGGAGCTGCTCTCTGTGCACACCCACTTCTTAAAGGAACTGAAGGATGCCCTGT
CTGGCCCGGGAGCAACGATGCTGTATCAGGTCTTCATCAAGTATAAGGAGAGGTTCCTTGTTTA
TGGCCGTTATTGCAGTCAGGTGGAGTCAGCCAGCAAGCACTTGGATCAAGTGGCCACAGCACGG
GAGGATGTGCAGATGAAGCTGGAGGAATGCTCTCAAAGAGCCAACAATGGCCGCTTCACCCTGC
GGGATCTGCTGATGGTGCCTATGCAGCGGGTGCTGAAGTATCACCTCCTCCTCCAGGAGCTAGT
GAAACACACACAGGATACTACAGAAAAGGAGAACCTGCGGTTGGCCCTGGACGCCATGAGGGAC
CTGGCGCAGTGTGTGAATGAGGTCAAGAGGGACAATGAAACCTTACGGCAGATCACAAACTTTC
AGCTGTCCATTGAGAACCTGGACCAGTCTCTGGCCAACTATGGCCGGCCTAAGATTGACGGTGA
GCTCAAGATTACCTCAGTGGAACGGCGCTCCAAGACAGACAGGTATGCCTTCCTGCTGGACAAA
GCACTGCTCATCTGTAAGCGCCGCGGGGACTCTTATGACCTCAAGGCCTCAGTGAACCTGCACA
GCTTCCAAGTTCGGGATGACTCTTCCGGGGAGCGGGACAACAAGAAGTGGAGCCACATGTTCCT
TCTGATTGAGGATCAAGGTGCCCAGGGGTATGAGCTGTTCTTCAAGACTCGGGAGCTAAAAAAG
AAGTGGATGGAACAGTTTGAAATGGCCATCTCCAACATCTACCCAGAAAATGCTACAGCCAATG
GACATGATTTTCAGATGTTCTCCTTTGAGGAGACCACTTCCTGCAAGGCCTGCCAGATGTTACT
CAGGGGCACATTCTACCAGGGATATCGCTGTTACAGGTGCCGTGCACCCGCACACAAGGAGTGT
CTGGGAAGGGTGCCTCCATGTGGCCGTCAAGATTTCTCAGGAACCATGAAGAAGGACAAGCTAC
ATCGAAGGGCCCAGGACAAGAAAAGGAATGAATTGGGCCTTCCTAAGATGGAGGTGTGTCAGGA
ATACTACGGGATCCCTCCTCCTCCCGGAGCCTTTGGGCCATTTCTGCGGCTCAACCCTGGGGAC
ATTGTGGAACTCACTAAGGCAGAGGCTGAACACAACTGGTGGGAGGGAAGAAATACAGCTACGA
ATGAAGTCGGCTGGTTTCCCTGTAACAGAGTTCGTCCCTACGTCCACGGCCCTCCCCAGGACCT
GTCTGTGCACCTCTGGTATGCGGGCCCCATGGAGCGAGCAGGCGCCGAGGGCATCCTCACCAAC
CGCTCTGATGGGACCTACCTGGTGCGGCAAAGGGTGAAAGATACAGCGGAATTCGCCATCAGCA
TTAAGTATAATGTGGAGGTCAAGCATATTAAAATCATGACGTCAGAGGGGTTGTACCGCATCAC
AGAGAAGAAGGCTTTCCGGGGCCTCCCGGAACTGGTAGAGTTTTATCAGCAGAATTCCCTAAAA
GATTGCTTCAAGTCGTTGGACACCACCTTGCAGTTTCCTTACAAGGAACCTGAGAGGAGAGCCA
TCAACAAGCCGCCGGTTGGAAGCACCAAGTATTTTGGCACTGCCAAAGCCCGCTACGACTTCTG
TGCCCGGGACCGATCGGAACTGTCCCTTAAGGAGGGTGACATCATCAAGATCCTCAACAAGAAG
GGACAGCAAGGCTGGTGGCGTGGGGAGATCTATGGCCGGATTGGCTGGTTTCCCTCTAACTATG
TGGAGGAAGACTATTCTGAATACTGCTGAGCCCGATGCCCTGCAGGACACAGAGAGAGGCAGAT
GATGGCTGAGCCCAGGATGCCAGCAGGGTTGAGGGGCTGTGAGCTGTTCTCATTGGCAGAGGAT
CTGGATGGAGCTCAGATGGCTAGTGGCCAGCTAGCAGGGTTCCCAGGATGAAGCCCAGAGATGG
TTAATTTATAGCACACTGATTTTTTCGAGTCCTCCAAGAAAGCTGATTCTAATAAAGTGAGGAC
AGCAGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063266662 ⟹ XP_063122732

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	9	2,248,856 - 2,278,923 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_036891	(Get FASTA)	NCBI Sequence Viewer
	XP_063122732	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA98606	(Get FASTA)	NCBI Sequence Viewer
	AAH91160	(Get FASTA)	NCBI Sequence Viewer
	EDL83565	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064264.3
	ENSRNOP00000077767
	ENSRNOP00000077767.1
	ENSRNOP00000081960.1
	ENSRNOP00000086561.1
GenBank Protein	P54100	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036891 ⟸ NM_012759

- UniProtKB:

P54100 (UniProtKB/Swiss-Prot), Q5BK91 (UniProtKB/TrEMBL), A0A8I5Y9Q8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWP
QMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQNKGIMP
FPTEDSALGDEDIYSGLSDQIDDTAEEDEDLYDCVENEEAEGDEIYEDLMRSESVPTPPKMTEY
DKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEELLSVHTHFLKELKD
ALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMKLEECSQRANNGRF
TLRDLLMVPMQRVLKYHLLLQELVKHTQDTTEKENLRLALDAMRDLAQCVNEVKRDNETLRQIT
NFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDKALLICKRRGDSYDLKASVN
LHSFQVRDDSSGERDNKKWSHMFLLIEDQGAQGYELFFKTRELKKKWMEQFEMAISNIYPENAT
ANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRAPAHKECLGRVPPCGRQDFSGTMKKD
KLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGPFLRLNPGDIVELTKAEAEHNWWEGRNT
ATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAGAEGILTNRSDGTYLVRQRVKDTAEFA
ISIKYNVEVKHIKIMTSEGLYRITEKKAFRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPER
RAINKPPVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRIGWFPS
NYVEEDYSEYC

hide sequence

RefSeq Acc Id:

ENSRNOP00000064264 ⟸ ENSRNOT00000073294

RefSeq Acc Id:

ENSRNOP00000086561 ⟸ ENSRNOT00000094489

RefSeq Acc Id:

ENSRNOP00000077767 ⟸ ENSRNOT00000096076

RefSeq Acc Id:

ENSRNOP00000081960 ⟸ ENSRNOT00000111335

RefSeq Acc Id:	XP_063122732 ⟸ XM_063266662
- Peptide Label:	isoform X1

Protein Domains

Calponin-homology (CH) DH PH Phorbol-ester/DAG-type SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P54100-F1-model_v2	AlphaFold	P54100	1-843	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696432

Promoter ID:

EPDNEW_R6956

Type:

multiple initiation site

Name:

Vav1_1

Description:

vav guanine nucleotide exchange factor 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	9	9,675,192 - 9,675,252	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3951	AgrOrtholog
BioCyc Gene	G2FUF-28479	BioCyc
Ensembl Genes	ENSRNOG00000050430	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000073294.3	UniProtKB/TrEMBL
	ENSRNOT00000094489.1	UniProtKB/TrEMBL
	ENSRNOT00000096076	ENTREZGENE
	ENSRNOT00000096076.1	UniProtKB/TrEMBL
	ENSRNOT00000111335.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.418.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	1.20.900.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.60.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7373783	IMAGE-MGC_LOAD
InterPro	CAMSAP_CH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CH-domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CH_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DBL_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DH-domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GDS_CDC24_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_Vav	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM22_calponin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAV1_SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAV1_SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	VAV1_SH3_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:25156	UniProtKB/TrEMBL
MGC_CLONE	MGC:108735	IMAGE-MGC_LOAD
NCBI Gene	25156	ENTREZGENE
PANTHER	PROTEIN VAV	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45818:SF2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CAMSAP_CH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00169	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PF00307	UniProtKB/TrEMBL
	RhoGEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Vav1	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM22CALPONIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	DH_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DH_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50021	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000050430	RatGTEx
SMART	RhoGEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00033	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00109	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00233	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF47576	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48065	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF50044	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF55550	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5Y9Q8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZTA6_RAT	UniProtKB/TrEMBL
	A0A8I6A1G3_RAT	UniProtKB/TrEMBL
	M0R4H8_RAT	UniProtKB/TrEMBL
	P54100	ENTREZGENE
	Q5BK91	ENTREZGENE, UniProtKB/TrEMBL
	VAV_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-02	Vav1	vav guanine nucleotide exchange factor 1	Vav1	vav 1 guanine nucleotide exchange factor	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-12-15	Vav1	vav 1 guanine nucleotide exchange factor	Vav1	vav 1 oncogene	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	Vav1	vav 1 oncogene		Vav 1 oncogene	Name updated	629478	APPROVED
2002-06-10	Vav1	Vav 1 oncogene			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_pathway	can activate the c-Jun N-terminal kinase-1 (JNK1) pathway	727273
gene_product	member of the Db1 subfamily of the Rho family of GTP binding proteins	727273

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)