Gene: Vav1 (vav 1 oncogene)
Mus musculus |
| Symbol: |
Vav1
|
| Name: |
vav 1 oncogene
|
| Description: |
ENCODES a protein that exhibits Rac guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN immune response; integrin-mediated signaling pathway; intracellular signal transduction; PARTICIPATES IN interleukin-6 signaling pathway; B cell receptor signaling pathway; T cell receptor signaling pathway; ASSOCIATED WITH abnormal B cell activation; abnormal B cell differentiation; abnormal B cell number; ASSOCIATED WITH Carcinoma, Hepatocellular (ortholog); Diabetes Mellitus, Type 1 (ortholog); Endometriosis (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene |
| Type: |
protein-coding
|
| RefSeq Status: |
VALIDATED
|
| Also known as: |
OTTMUSP00000053044; OTTMUSP00000053045; p95vav; proto-oncogene vav; Vav; vav oncogene; vav-T
|
| Orthologs: |
Homo sapiens : VAV1
(vav 1 guanine nucleotide exchange factor)
HGNC
Rattus norvegicus : Vav1
(vav 1 guanine nucleotide exchange factor)
|
| Latest Assembly: |
Mouse Genome Assembly Build 37
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Mouse Genome Assembly GRCm38 | 17 | 57,279,100 - 57,329,236 | + | NCBI | Mouse cM Map | 17 | 29.76 | | NCBI | Mouse Celera Assembly | 17 | 61,628,185 - 61,678,969 | + | NCBI | Mouse Genome Assembly Build 37 | 17 | 57,418,523 - 57,468,659 | + | NCBI | Mouse Genome Assembly Build 36.1 | 17 | 57,418,538 - 57,467,376 | + | NCBI | Mouse Cytogenetic Map | 17 | D | | NCBI |
|
| Model |
|
|
 Gene-Chemical Interaction Annotations
| 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of VAV1 mRNA | CTD | PMID:17942748 | | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VAV1 mRNA | CTD | PMID:17942748 | | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of VAV1 mRNA | CTD | PMID:17942748 | | 2,3,7,8-tetrachlorodibenzodioxine | increases phosphorylation | ISO | RGD:737234 | 6480464 | Tetrachlorodibenzodioxin results in increased phosphorylation of VAV1 protein | CTD | PMID:20561557 | | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:737234 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of VAV1 protein | CTD | PMID:20561557 | | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:737234 | 6480464 | Genistein inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of VAV1 protein]; more ... | CTD | PMID:20561557 | | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of VAV1 mRNA | CTD | PMID:15328365 | | acetylsalicylic acid | decreases expression | ISO | RGD:737234 | 6480464 | Aspirin results in decreased expression of VAV1 mRNA | CTD | PMID:15928584 | | all-trans-retinoic acid | increases expression | ISO | RGD:737234 | 6480464 | Tretinoin results in increased expression of VAV1 mRNA | CTD | PMID:15894607 | | all-trans-retinoic acid | multiple interactions | ISO | RGD:737234 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in increased expression of VAV1 mRNA | CTD | PMID:15894607 | | ammonium chloride | affects expression | ISO | RGD:3951 | 6480464 | Ammonium Chloride affects the expression of VAV1 mRNA | CTD | PMID:16483693 | | azathioprine | increases expression | ISO | RGD:737234 | 6480464 | Azathioprine results in increased expression of VAV1 protein | CTD | PMID:12697733 | | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of VAV1 mRNA | CTD | PMID:21569818 | | chloroprene | decreases expression | EXP | | 6480464 | Chloroprene results in decreased expression of VAV1 mRNA | CTD | PMID:23125180 | | diarsenic trioxide | multiple interactions | ISO | RGD:737234 | 6480464 | [Tretinoin co-treated with arsenic trioxide] results in increased expression of VAV1 mRNA | CTD | PMID:15894607 | | genistein | multiple interactions | ISO | RGD:737234 | 6480464 | Genistein inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of VAV1 protein] | CTD | PMID:20561557 | | mercaptopurine | increases expression | ISO | RGD:737234 | 6480464 | 6-Mercaptopurine results in increased expression of VAV1 protein | CTD | PMID:12697733 | | N-nitrosodiethylamine | decreases expression | ISO | RGD:3951 | 6480464 | Diethylnitrosamine results in decreased expression of VAV1 mRNA | CTD | PMID:20360939 | | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of VAV1 mRNA | CTD | PMID:17562736 | | pirinixic acid | decreases expression | ISO | RGD:3951 | 6480464 | pirinixic acid results in decreased expression of VAV1 mRNA | CTD | PMID:19162173 | | purine-6-thiol | increases expression | ISO | RGD:737234 | 6480464 | 6-Mercaptopurine results in increased expression of VAV1 protein | CTD | PMID:12697733 | | tamibarotene | increases expression | ISO | RGD:737234 | 6480464 | Am 80 results in increased expression of VAV1 mRNA; more ... | CTD | PMID:17229644 | | trichloroethene | multiple interactions | EXP | | 6480464 | PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of VAV1 mRNA] | CTD | PMID:15363585 | |
Biological Process
| immune response | | IMP | MGI:MGI:2387838 | 2290270 | MGI:MGI:2388463|PMID:11070165 | MGI | MGI:MGI:2388463 PMID:11070165 |
| integrin-mediated signaling pathway | | IGI | MGI:MGI:1888518 | 2290270 | MGI:MGI:3050945|PMID:15249579 | MGI | MGI:MGI:3050945 PMID:15249579 |
| intracellular signal transduction | | IMP | MGI:MGI:2387838 | 2290270 | MGI:MGI:2388463|PMID:11070165 | MGI | MGI:MGI:2388463 PMID:11070165 |
| phagocytosis | | IGI | MGI:MGI:1888518 | 2290270 | MGI:MGI:3050945|PMID:15249579 | MGI | MGI:MGI:3050945 PMID:15249579 |
| positive regulation of cell adhesion | | IGI | MGI:MGI:1888518 | 2290270 | MGI:MGI:3050945|PMID:15249579 | MGI | MGI:MGI:3050945 PMID:15249579 |
| regulation of catalytic activity | | IEA | UniProtKB-KW:KW-0344 | 2290270 | MGI:MGI:1354194 | GOC | MGI:MGI:1354194 |
| regulation of catalytic activity | | IEA | InterPro:IPR001331 | 2290270 | MGI:MGI:2152098 | GOC | MGI:MGI:2152098 |
| regulation of GTPase activity | | IGI | MGI:MGI:1888518 | 2290270 | MGI:MGI:3050945|PMID:15249579 | MGI | MGI:MGI:3050945 PMID:15249579 |
| regulation of Rho protein signal transduction | | IEA | InterPro:IPR000219 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| T cell activation | | IMP | MGI:MGI:2387838 | 2290270 | MGI:MGI:2388463|PMID:11070165 | MGI | MGI:MGI:2388463 PMID:11070165 |
| T cell differentiation | | TAS | | 2290270 | MGI:MGI:2388463|PMID:11070165 | MGI | MGI:MGI:2388463 PMID:11070165 |
Molecular Function
| guanyl-nucleotide exchange factor activity | | ISO | UniProtKB:P15498 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| metal ion binding | | IEA | UniProtKB-KW:KW-0479 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| phospholipid binding | | IEA | InterPro:IPR001849 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| protein binding | | IPI | UniProtKB:P29351 | 2290270 | MGI:MGI:78931|PMID:8632004 | MGI | MGI:MGI:78931 PMID:8632004 |
| protein binding | | IPI | UniProtKB:Q8BGW0|UniProtKB:Q91YX0 | 2290270 | MGI:MGI:5446993|PMID:22732588 | MGI | MGI:MGI:5446993 PMID:22732588 |
| protein binding | | IPI | UniProtKB:Q91WK7 | 2290270 | MGI:MGI:3844204|PMID:19064729 | MGI | MGI:MGI:3844204 PMID:19064729 |
| Rac guanyl-nucleotide exchange factor activity | | IGI | MGI:MGI:1888518 | 2290270 | MGI:MGI:3050945|PMID:15249579 | MGI | MGI:MGI:3050945 PMID:15249579 |
| Rho guanyl-nucleotide exchange factor activity | | IGI | MGI:MGI:1888518 | 2290270 | MGI:MGI:3050945|PMID:15249579 | MGI | MGI:MGI:3050945 PMID:15249579 |
| 1301454 | Eae5_m | susceptibility to experimental allergic encephalomyelitis 5 (mouse) | | | Not determined | | 17 | 24438808 | 58438922 | Mouse |
| 1558916 | Egq5_m | early growth QTL 5 (mouse) | | | Not determined | | 17 | 24935172 | 58935320 | Mouse |
| 1558908 | W10q12_m | weight 10 weeks QTL 12 (mouse) | | | Not determined | | 17 | 24935172 | 58935320 | Mouse |
| 1558830 | Egaq2_m | early growth adjusted QTL 2 (mouse) | | | Not determined | | 17 | 24935172 | 58935320 | Mouse |
| 1558969 | W6q11_m | weight 6 weeks QTL 11 (mouse) | | | Not determined | | 17 | 24935172 | 58935320 | Mouse |
| 4142150 | Stheal11_m | soft tissue heal 11 (mouse) | | | Not determined | | 17 | 26641790 | 60641943 | Mouse |
| 1558878 | Tria3_m | T-cell receptor induced activation 3 (mouse) | | | Not determined | | 17 | 26641790 | 60641943 | Mouse |
| 1302005 | Loco2_m | locomotor activity 2 (mouse) | | | Not determined | | 17 | 26711030 | 60711172 | Mouse |
| 1301338 | Lmr1_m | leishmaniasis resistance 1 (mouse) | | | Not determined | | 17 | 27392666 | 61392810 | Mouse |
| 1301538 | Trbv4c1_m | T cell receptor beta variable 4 (mouse) | | | Not determined | | 17 | 27392666 | 61392810 | Mouse |
| 1302008 | Gasa4_m | gastritis type A susceptibility locus 4 (mouse) | | | Not determined | | 17 | 27392666 | 61392810 | Mouse |
| 1300703 | Uvbi2_m | UVB induced immunosuppression 2 (mouse) | | | Not determined | | 17 | 28448429 | 62448677 | Mouse |
| 1300652 | Vmbic9_m | ventral midbrain iron content 9 (mouse) | | | Not determined | | 17 | 28448429 | 62448677 | Mouse |
| 1300589 | Myaa2_m | modifier of Yaa 2 (mouse) | | | Not determined | | 17 | 29958578 | 63958689 | Mouse |
| 1301234 | Hscfr_m | hematopoietic stem cell frequency regulator (mouse) | | | Not determined | | 17 | 30690141 | 64690271 | Mouse |
| 4140974 | Advh2_m | adenovirus induced hyperthyroidism 2 (mouse) | | | Not determined | | 17 | 30859524 | 64859654 | Mouse |
| 1301495 | Cocia13_m | cocaine induced activation 13 (mouse) | | | Not determined | | 17 | 30859524 | 64859654 | Mouse |
| 4141504 | Bodwt2_m | body weight 2 (mouse) | | | Not determined | | 17 | 34571276 | 68571419 | Mouse |
| 1302012 | Char7_m | P. chabaudi malaria resistance QTL 7 (mouse) | | | Not determined | | 17 | 38545184 | 72545267 | Mouse |
| 1300592 | Pcyts5_m | plasmacytoma susceptibility 5 (mouse) | | | Not determined | | 17 | 38545184 | 72545267 | Mouse |
| 1301600 | Hdlq29_m | HDL QTL 29 (mouse) | | | Not determined | | 17 | 40366870 | 74367046 | Mouse |
| 1558750 | Cxam_m | CD86 expression in activated macrophages (mouse) | | | Not determined | | 17 | 40366870 | 74367046 | Mouse |
| 4142263 | Obwq4_m | obesity and body weight QTL 4 (mouse) | | | Not determined | | 17 | 40366870 | 74367046 | Mouse |
| 1357754 | Ahl3_m | age related hearing loss 3 (mouse) | | | Not determined | | 17 | 50246302 | 84246448 | Mouse |
| 1357532 | Bmch7_m | bone mechanical trait 7 (mouse) | | | Not determined | | 17 | 51800770 | 85800957 | Mouse |
| 4141879 | Chlq9_m | circulating hormone level QTL 9 (mouse) | | | Not determined | | 17 | 51800770 | 85800957 | Mouse |
| 4141011 | Bmd26_m | bone mineral density 26 (mouse) | | | Not determined | | 17 | 57149996 | 91150148 | Mouse |
| 4141589 | Brml6_m | bone response to mechanical loading 6 (mouse) | | | Not determined | | 17 | 57149996 | 91150148 | Mouse |
| 4141758 | Pstc5_m | periosteal circumference 5 (mouse) | | | Not determined | | 17 | 57149996 | 91150148 | Mouse |
| 4142414 | Pregq4_m | pregnancy QTL 4 (mouse) | | | Not determined | | 17 | 57366870 | 93599091 | Mouse |