Ucp1 (uncoupling protein 1) - Rat Genome Database

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Gene: Ucp1 (uncoupling protein 1) Rattus norvegicus
Analyze
Symbol: Ucp1
Name: uncoupling protein 1
RGD ID: 3931
Description: Enables GDP binding activity; GTP binding activity; and oxidative phosphorylation uncoupler activity. Involved in several processes, including cellular response to dehydroepiandrosterone; mitochondrial transmembrane transport; and proton transmembrane transport. Located in mitochondrion. Biomarker of prediabetes syndrome. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human UCP1 (uncoupling protein 1); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; Huntington's disease pathway; INTERACTS WITH (+)-taxifolin; (-)-epigallocatechin 3-gallate; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100909612; MGC108736; mitochondrial brown fat uncoupling protein 1; mitochondrial brown fat uncoupling protein 1-like; solute carrier family 25 member 7; thermogenin; Ucp; UCP 1; Ucpa; Uncoupling protein; uncoupling protein 1 (mitochondrial, proton carrier); uncoupling protein 1 mitochondrial; uncoupling protein 1, mitochondrial; Uncp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,713,350 - 41,721,421 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,713,351 - 41,721,420 (-)EnsemblGRCr8
mRatBN7.21924,808,782 - 24,816,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,808,783 - 24,816,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,627,843 - 31,635,958 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01932,282,249 - 32,290,366 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,500,303 - 34,508,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,456,976 - 24,464,808 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,434,980 - 35,442,812 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,527,548 - 26,535,621 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,348,444 - 24,356,517 (-)NCBICelera
RGSC_v3.11926,532,373 - 26,540,447 (-)NCBI
Cytogenetic Map19q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-noradrenaline  (EXP,ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP,ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,4-dinitrophenol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
9-cis-retinoic acid  (EXP,ISO)
abacavir  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (EXP)
Amibegron  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
ATP  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bucladesine  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
CL316243  (EXP,ISO)
clenbuterol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
cortisol  (ISO)
curcumin  (ISO)
Cyclopamine  (ISO)
cyclophosphamide  (ISO)
D-glucose  (EXP,ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
enniatin  (ISO)
ethylparaben  (ISO)
flavonoids  (EXP)
fonofos  (ISO)
fructose  (EXP)
Ganoderic acid A  (ISO)
Geniposide  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
harmine  (ISO)
hexadecanoic acid  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
indinavir  (ISO)
indometacin  (ISO)
Iopanoic acid  (EXP)
isoprenaline  (EXP)
kaempferol  (EXP)
Licarin A  (ISO)
Liensinine  (ISO)
LY294002  (EXP)
mangiferin  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
methoprene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
nevirapine  (ISO)
nickel sulfate  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
ochratoxin A  (ISO)
olanzapine  (EXP)
orlistat  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
Prenalterol  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
ruxolitinib  (ISO)
selumetinib  (ISO)
sodium arsenite  (ISO)
stavudine  (ISO)
superoxide  (EXP)
T-2 toxin  (EXP)
telmisartan  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
mitochondrial envelope  (IEA,ISO)
mitochondrial inner membrane  (IBA,IEA,ISO,ISS,TAS)
mitochondrion  (IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The gene for rat uncoupling protein: complete sequence, structure of primary transcript and evolutionary relationship between exons. Bouillaud F, etal., Biochem Biophys Res Commun 1988 Dec 15;157(2):783-92.
2. Complete cDNA-derived amino acid sequence of rat brown fat uncoupling protein. Bouillaud F, etal., J Biol Chem 1986 Feb 5;261(4):1487-90.
3. Central stimulatory effect of leptin on T3 production is mediated by brown adipose tissue type II deiodinase. Cettour-Rose P, etal., Am J Physiol Endocrinol Metab 2002 Nov;283(5):E980-7.
4. Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Clement K, etal., Int J Obes Relat Metab Disord. 1996 Dec;20(12):1062-6.
5. Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: role of vitagenes. Cornelius C, etal., Immun Ageing. 2013 Oct 17;10(1):41. doi: 10.1186/1742-4933-10-41.
6. High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. Couplan E, etal., J Biol Chem 2002 Nov 8;277(45):43079-88.
7. Fatty acids change the conformation of uncoupling protein 1 (UCP1). Divakaruni AS, etal., J Biol Chem. 2012 Oct 26;287(44):36845-53. doi: 10.1074/jbc.M112.381780. Epub 2012 Sep 5.
8. The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue. Dlaskova A, etal., Biochim Biophys Acta. 2010 Aug;1797(8):1470-6. doi: 10.1016/j.bbabio.2010.04.008. Epub 2010 Apr 21.
9. Superoxide activates mitochondrial uncoupling proteins. Echtay KS, etal., Nature 2002 Jan 3;415(6867):96-9.
10. Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Esteves TC, etal., Biochem J. 2006 May 1;395(3):619-28.
11. Nutritional and hormonal regulation of uncoupling protein gene expression in rat adipocytes. Fukuda H, etal., J Nutr Sci Vitaminol (Tokyo). 2007 Oct;53(5):426-31.
12. Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes. Fukuyama K, etal., Biochem Biophys Res Commun. 2006 Jan 27;339(4):1212-6. Epub 2005 Dec 5.
13. Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes. Garcia B and Obregon MJ, Am J Physiol Cell Physiol 2002 Jan;282(1):C105-12.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats. Gullicksen PS, etal., Physiol Behav 2002 Apr 1;75(4):473-82.
17. Resveratrol protects against peripheral deficits in a mouse model of Huntington's disease. Ho DJ, etal., Exp Neurol. 2010 Sep;225(1):74-84. doi: 10.1016/j.expneurol.2010.05.006. Epub 2010 Jun 1.
18. Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1. Jimenez-Jimenez J, etal., Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1292-6. Epub 2006 May 24.
19. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Kazak L, etal., Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19.
20. The uncoupling protein-1 gene -3826A/G polymorphism and hypertension in Japanese subjects. Kotani K, etal., Clin Chem Lab Med. 2007;45(9):1186-9.
21. Putative role of polymorphisms in UCP1-3 genes for diabetic nephropathy. Lindholm E, etal., J Diabetes Complications. 2004 Mar-Apr;18(2):103-7.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. A polymorphism in the 5' untranslated region and a Met229-->Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus. Mori H, etal., Diabetologia. 2001 Mar;44(3):373-6.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. GOA pipeline RGD automated data pipeline
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein of rat brown adipose tissue: lack of a mitochondrial targeting presequence. Ridley RG, etal., Nucleic Acids Res 1986 May 27;14(10):4025-35.
30. DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats. Ryu JW, etal., Biochem Biophys Res Commun. 2003 Apr 4;303(2):726-31.
31. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
32. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
33. Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. Teruel T, etal., J Biol Chem 2003 Jan 3;278(1):263-9.
34. Substitutional mutations in the uncoupling protein-specific sequences of mitochondrial uncoupling protein UCP1 lead to the reduction of fatty acid-induced H+ uniport. Urbankova E, etal., Int J Biochem Cell Biol. 2003 Feb;35(2):212-20.
35. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Weydt P, etal., Cell Metab. 2006 Nov;4(5):349-62. Epub 2006 Oct 19.
Additional References at PubMed
PMID:2421800   PMID:7691596   PMID:9054939   PMID:9139827   PMID:11748291   PMID:11940593   PMID:12127082   PMID:12477932   PMID:12603007   PMID:12678439   PMID:12706490   PMID:12734183  
PMID:12910269   PMID:12912909   PMID:12960080   PMID:14529581   PMID:14605003   PMID:14651853   PMID:14766012   PMID:15099666   PMID:15262832   PMID:15489334   PMID:15567149   PMID:15695816  
PMID:15720470   PMID:15727948   PMID:15887043   PMID:15891081   PMID:15896707   PMID:16291746   PMID:17592729   PMID:17670746   PMID:17686539   PMID:17878603   PMID:17923681   PMID:18239634  
PMID:18471433   PMID:18479902   PMID:18614015   PMID:18626658   PMID:19187776   PMID:19227473   PMID:19747168   PMID:20719854   PMID:20948513   PMID:22226924   PMID:22531154   PMID:23063128  
PMID:23084644   PMID:23169784   PMID:23404793   PMID:24196960   PMID:25132457   PMID:25858881   PMID:26129910   PMID:26767982   PMID:27027295   PMID:27438137   PMID:27560796   PMID:27686967  
PMID:27750036   PMID:27916641   PMID:28763438   PMID:30624981   PMID:33202085   PMID:33441773   PMID:33815288   PMID:36650072  


Genomics

Comparative Map Data
Ucp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,713,350 - 41,721,421 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1941,713,351 - 41,721,420 (-)EnsemblGRCr8
mRatBN7.21924,808,782 - 24,816,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,808,783 - 24,816,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1931,627,843 - 31,635,958 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01932,282,249 - 32,290,366 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,500,303 - 34,508,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,456,976 - 24,464,808 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)Ensemblrn6Rnor6.0
Rnor_5.01935,434,980 - 35,442,812 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41926,527,548 - 26,535,621 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1924,348,444 - 24,356,517 (-)NCBICelera
RGSC_v3.11926,532,373 - 26,540,447 (-)NCBI
Cytogenetic Map19q11NCBI
UCP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384140,559,431 - 140,568,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4140,559,431 - 140,569,001 (-)Ensemblhg38GRCh38
GRCh374141,480,585 - 141,490,115 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364141,700,500 - 141,709,457 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344141,838,654 - 141,847,612NCBI
Celera4138,811,044 - 138,819,947 (-)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4137,211,503 - 137,220,406 (-)NCBIHuRef
CHM1_14141,458,398 - 141,467,306 (-)NCBICHM1_1
T2T-CHM13v2.04143,879,138 - 143,888,662 (-)NCBIT2T-CHM13v2.0
Ucp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,016,977 - 84,025,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,016,981 - 84,025,081 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38883,290,348 - 83,298,456 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,290,352 - 83,298,452 (+)Ensemblmm10GRCm38
MGSCv37885,814,247 - 85,822,355 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36886,180,467 - 86,188,157 (+)NCBIMGSCv36mm8
Celera887,564,747 - 87,572,801 (+)NCBICelera
Cytogenetic Map8C2NCBI
cM Map839.65NCBI
Ucp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,274,810 - 3,283,237 (+)Ensembl
ChiLan1.0NW_0049554283,253,363 - 3,282,518 (+)NCBIChiLan1.0ChiLan1.0
UCP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23138,435,652 - 138,445,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14138,823,275 - 138,832,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04132,921,033 - 132,930,714 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14144,230,858 - 144,239,803 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4144,230,858 - 144,240,178 (-)EnsemblpanPan2panpan1.1
UCP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1192,254,881 - 2,289,902 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha192,528,227 - 2,536,537 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0192,346,071 - 2,354,913 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl192,344,973 - 2,354,916 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1192,283,269 - 2,291,546 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0192,644,470 - 2,652,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,000,436 - 3,008,747 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ucp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530149,820,808 - 49,828,140 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365357,258,343 - 7,265,398 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365357,258,146 - 7,265,475 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1886,522,028 - 86,526,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2891,981,524 - 91,985,738 (-)NCBISscrofa10.2Sscrofa10.2susScr3
UCP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1787,492,444 - 87,502,894 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl787,492,195 - 87,502,665 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603767,019,274 - 67,029,935 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ucp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004625006155,100 - 162,551 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004625006155,179 - 162,544 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ucp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11716,930,174 - 16,937,909 (-)NCBIRrattus_CSIRO_v1

Variants

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Variants in Ucp1
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000004900
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)194172060949971820Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
D19Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81941,720,609 - 41,720,770 (+)Marker Load Pipeline
mRatBN7.21924,816,041 - 24,816,202 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,627 - 24,457,787NCBIRnor6.0
Rnor_5.01935,435,631 - 35,435,791UniSTSRnor5.0
RGSC_v3.41926,534,809 - 26,534,971UniSTSRGSC3.4
RGSC_v3.41926,534,810 - 26,534,971RGDRGSC3.4
Celera1924,355,706 - 24,355,866UniSTS
RGSC_v3.11926,539,634 - 26,539,797RGD
Cytogenetic Map19p11-q11UniSTS
D19Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81941,722,546 - 41,722,671 (+)Marker Load Pipeline
mRatBN7.21924,817,978 - 24,818,103 (-)MAPPERmRatBN7.2
Rnor_6.01924,455,726 - 24,455,850NCBIRnor6.0
Rnor_5.01935,433,730 - 35,433,854UniSTSRnor5.0
RGSC_v3.41926,536,747 - 26,536,872RGDRGSC3.4
RGSC_v3.41926,536,748 - 26,536,872UniSTSRGSC3.4
Celera1924,357,643 - 24,357,761UniSTS
RGSC_v3.11926,541,573 - 26,541,698RGD
Cytogenetic Map19p11-q11UniSTS
D19Arb8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,813,116 - 24,813,393 (-)MAPPERmRatBN7.2
mRatBN7.21924,813,116 - 24,813,393 (+)MAPPERmRatBN7.2
Rnor_6.01929,400,398 - 29,400,674NCBIRnor6.0
Rnor_6.01924,460,436 - 24,460,712NCBIRnor6.0
Rnor_5.01935,438,440 - 35,438,716UniSTSRnor5.0
Rnor_5.01940,308,557 - 40,308,833UniSTSRnor5.0
RGSC_v3.41926,531,884 - 26,532,160UniSTSRGSC3.4
RGSC_v3.41926,531,883 - 26,532,160RGDRGSC3.4
Celera1924,352,781 - 24,353,057UniSTS
RGSC_v3.11926,536,709 - 26,536,986RGD
SHRSP x BN Map1918.5999RGD
SHRSP x BN Map1918.5999UniSTS
FHH x ACI Map1921.16RGD
Cytogenetic Map19p11-q11UniSTS
AI385626  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,612 - 24,816,715 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,114 - 24,457,216NCBIRnor6.0
Rnor_5.01935,435,118 - 35,435,220UniSTSRnor5.0
RGSC_v3.41926,535,382 - 26,535,484UniSTSRGSC3.4
Celera1924,356,277 - 24,356,379UniSTS
Cytogenetic Map19p11-q11UniSTS
RH94828  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,815,082 - 24,815,182 (-)MAPPERmRatBN7.2
Rnor_6.01924,458,647 - 24,458,746NCBIRnor6.0
Rnor_5.01935,436,651 - 35,436,750UniSTSRnor5.0
RGSC_v3.41926,533,850 - 26,533,949UniSTSRGSC3.4
Celera1924,354,747 - 24,354,846UniSTS
Cytogenetic Map19p11-q11UniSTS
RH94640  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81941,720,092 - 41,720,258 (+)Marker Load Pipeline
mRatBN7.21924,815,524 - 24,815,690 (-)MAPPERmRatBN7.2
Rnor_6.01924,458,139 - 24,458,304NCBIRnor6.0
Rnor_5.01935,436,143 - 35,436,308UniSTSRnor5.0
RGSC_v3.41926,534,292 - 26,534,457UniSTSRGSC3.4
Celera1924,355,189 - 24,355,354UniSTS
Cytogenetic Map19p11-q11UniSTS
RH94528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,808,802 - 24,808,876 (-)MAPPERmRatBN7.2
mRatBN7.21924,808,802 - 24,808,876 (+)MAPPERmRatBN7.2
Rnor_6.01924,464,714 - 24,464,787NCBIRnor6.0
Rnor_6.01929,396,084 - 29,396,157NCBIRnor6.0
Rnor_5.01940,304,243 - 40,304,316UniSTSRnor5.0
Rnor_5.01935,442,718 - 35,442,791UniSTSRnor5.0
RGSC_v3.41926,527,568 - 26,527,641UniSTSRGSC3.4
Celera1924,348,465 - 24,348,538UniSTS
Cytogenetic Map19p11-q11UniSTS
Ucp1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81941,720,342 - 41,721,199 (+)Marker Load Pipeline
mRatBN7.21924,815,774 - 24,816,631 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,198 - 24,458,054NCBIRnor6.0
Rnor_5.01935,435,202 - 35,436,058UniSTSRnor5.0
RGSC_v3.41926,534,542 - 26,535,400UniSTSRGSC3.4
Celera1924,355,439 - 24,356,295UniSTS
Cytogenetic Map19p11-q11UniSTS
D19Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21924,816,042 - 24,816,202 (-)MAPPERmRatBN7.2
Rnor_6.01924,457,627 - 24,457,786NCBIRnor6.0
Rnor_5.01935,435,631 - 35,435,790UniSTSRnor5.0
RGSC_v3.41926,534,810 - 26,534,971UniSTSRGSC3.4
Celera1924,355,707 - 24,355,866UniSTS
Cytogenetic Map15p11UniSTS
Cytogenetic Map19p11-q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 9 24 37 44 41 12 22 12 4 130 64 1 21 39 42 29 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000004900   ⟹   ENSRNOP00000004900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1941,713,351 - 41,721,420 (-)Ensembl
mRatBN7.2 Ensembl1924,808,783 - 24,816,852 (-)Ensembl
Rnor_6.0 Ensembl1924,456,976 - 24,464,807 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000072100   ⟹   ENSRNOP00000065918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1929,396,157 - 29,400,355 (-)Ensembl
RefSeq Acc Id: NM_012682   ⟹   NP_036814
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81941,713,350 - 41,721,421 (-)NCBI
mRatBN7.21924,808,782 - 24,816,853 (-)NCBI
Rnor_6.01924,456,976 - 24,464,808 (+)NCBI
Rnor_5.01935,434,980 - 35,442,812 (+)NCBI
RGSC_v3.41926,527,548 - 26,535,621 (-)RGD
Celera1924,348,444 - 24,356,517 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036814   ⟸   NM_012682
- UniProtKB: P04633 (UniProtKB/Swiss-Prot),   A6IYF5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004900   ⟸   ENSRNOT00000004900
Ensembl Acc Id: ENSRNOP00000065918   ⟸   ENSRNOT00000072100

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8W3-F1-model_v2 AlphaFold M0R8W3 1-196 view protein structure
AF-P04633-F1-model_v2 AlphaFold P04633 1-307 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700995
Promoter ID:EPDNEW_R11518
Type:single initiation site
Name:Ucp1_1
Description:uncoupling protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01924,456,978 - 24,457,038EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3931 AgrOrtholog
BioCyc Gene G2FUF-6005 BioCyc
Ensembl Genes ENSRNOG00000003580 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000046239 Ensembl
Ensembl Transcript ENSRNOT00000004900 ENTREZGENE
  ENSRNOT00000004900.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.50.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7380759 IMAGE-MGC_LOAD
InterPro Mit_carrier UniProtKB/Swiss-Prot
  Mito_Metabolite_Transporter UniProtKB/Swiss-Prot
  Mitochondrial_sb/sol_carrier UniProtKB/Swiss-Prot
  Mt_carrier_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24860 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108736 IMAGE-MGC_LOAD
NCBI Gene 24860 ENTREZGENE
PANTHER MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED UniProtKB/Swiss-Prot
Pfam Mito_carr UniProtKB/Swiss-Prot
PhenoGen Ucp1 PhenoGen
PRINTS MTUNCOUPLING UniProtKB/Swiss-Prot
PROSITE SOLCAR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003580 RatGTEx
  ENSRNOG00000046239 RatGTEx
Superfamily-SCOP SSF103506 UniProtKB/Swiss-Prot
TIGR TC218948
UniProt A6IYF5 ENTREZGENE, UniProtKB/TrEMBL
  A6IYF6_RAT UniProtKB/TrEMBL
  P04633 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ucp1  uncoupling protein 1  LOC100909612  mitochondrial brown fat uncoupling protein 1-like  Data merged from RGD:6502621 737654 PROVISIONAL
2016-05-05 Ucp1  uncoupling protein 1  Ucp1  uncoupling protein 1 (mitochondrial, proton carrier)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909612  mitochondrial brown fat uncoupling protein 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Ucp1  uncoupling protein 1 (mitochondrial, proton carrier)    uncoupling protein 1  Name updated 1299863 APPROVED
2004-12-14 Ucp1  uncoupling protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Ucp1  uncoupling protein 1      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in the inner mitochondrial membrane of brown adipocytes 70670
gene_function inner mitochondrial membrane transporter 70670
gene_pathway increased mRNA expression is induced by activation of the retinoic acid and retinoid X receptors and occurs via activation of a MAP kinase signaling pathway 730207
gene_process T3 by itself induces the transcription of Ucp1 70670
gene_process uncouples electron transport from oxidative phosphorylation 70670
gene_regulation aFGF and bFGF increase the expression, EGF and vasopressin decrease the expression 70670
gene_regulation triiodothyronine (T3) inhibits the mitogenic activity of aFGF and bFGF 70670
gene_regulation mRNA expression is upregulated by leptin 631305