RGD Reference Report - The uncoupling protein-1 gene -3826A/G polymorphism and hypertension in Japanese subjects. - Rat Genome Database

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The uncoupling protein-1 gene -3826A/G polymorphism and hypertension in Japanese subjects.

Authors: Kotani, K  Sakane, N  Saiga, K  Tsuzaki, K  Shimohiro, H  Tabata, M  Kurozawa, Y 
Citation: Kotani K, etal., Clin Chem Lab Med. 2007;45(9):1186-9.
RGD ID: 2313626
Pubmed: PMID:17635070   (View Abstract at PubMed)
DOI: DOI:10.1515/CCLM.2007.253   (Journal Full-text)

BACKGROUND: The possible effects of the uncoupling protein-1 (UCP-1) gene -3826A/G polymorphism on hypertension (HT) have yet to be elucidated. METHODS: A total of 578 Japanese subjects (231 males and 347 females, mean age 58.4 years) were enrolled in the study to investigate the association between HT and the -3826A/G polymorphism by genomic PCR and Bcl1-restriction fragment length polymorphism methods. RESULTS: Multivariate logistic regression analysis for HT, adjusted for genotype (recessive model, AA+AG vs. GG) and other covariates such as cardiovascular risk factors [e.g., smoking, body mass index (BMI), dyslipidemia and diabetes] showed age [odds ratio (OR) 1.11 (95% confidence interval 1.08-1.13)] and BMI [OR 1.13 (1.06-1.21)] as independent significant factors. In the subgroup analysis, as well as age and BMI, GG genotype [OR 2.32 (1.08-4.99)] was also an independent significant factor for HT in males. Similarly, as well as age and BMI, GG genotype [OR 1.89 (1.00-3.57)] was also an independent significant factor for HT in the relatively older subgroup (> or =60 years). CONCLUSIONS: The results suggest that the GG genotype may be associated with the presence of HT in Japanese males and older subjects. Further investigation is needed to confirm our hypothesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 2313626DNA:polymorphism: :-3826A>G (human)RGD 
hypertension  ISOUCP1 (Homo sapiens)2313626; 2313626DNA:polymorphism: :-3826A>G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ucp1  (uncoupling protein 1)

Genes (Mus musculus)
Ucp1  (uncoupling protein 1 (mitochondrial, proton carrier))

Genes (Homo sapiens)
UCP1  (uncoupling protein 1)


Additional Information