Zeb1 (zinc finger E-box binding homeobox 1) - Rat Genome Database

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Gene: Zeb1 (zinc finger E-box binding homeobox 1) Rattus norvegicus
Analyze
Symbol: Zeb1
Name: zinc finger E-box binding homeobox 1
RGD ID: 3831
Description: Enables chromatin binding activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; regulation of transcription by RNA polymerase II; and response to activity. Predicted to be located in nucleus. Biomarker of acute myocardial infarction; hypospadias; and rheumatic heart disease. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deltaEF1; TCF-8; Tcf8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); zfhep; Zfhx1a; zinc finger E-box-binding homeobox 1; zinc finger homeodomain enhancer-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eae33
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81756,644,397 - 56,811,155 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1756,644,397 - 56,810,745 (-)EnsemblGRCr8
mRatBN7.21751,948,948 - 52,116,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,948,948 - 52,115,214 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1755,134,749 - 55,300,937 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01759,137,668 - 59,303,854 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01753,287,135 - 53,453,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01754,656,627 - 54,714,920 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,658,463 - 54,714,914 (-)Ensemblrn6Rnor6.0
Rnor_5.01752,353,064 - 52,373,420 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41760,177,150 - 60,198,584 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1747,960,914 - 48,019,394 (-)NCBICelera
RGSC_v3.11760,187,896 - 60,245,300 (-)NCBI
Cytogenetic Map17q12.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(S)-nicotine  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2-acetamidofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-Nitrobenzanthrone  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
camphor  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chlormequat chloride  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cycloastragenol  (EXP)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
embelin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
galaxolide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glabridin  (ISO)
hexadecanoic acid  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ionomycin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
LY294002  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
MK-2206  (ISO)
monensin A  (ISO)
monocrotaline  (ISO)
N-methyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
PD 0325901  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
Rebamipide  (EXP)
resveratrol  (ISO)
sabinene  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
spathulenol  (ISO)
sulforaphane  (ISO)
testosterone enanthate  (ISO)
thalidomide  (ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
warfarin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleolus  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Alternative splicing gives rise to two isoforms of Zfhep, a zinc finger/homeodomain protein that binds T3-response elements. Cabanillas AM and Darling DS, DNA Cell Biol 1996 Aug;15(8):643-51.
2. T3-activation of the rat growth hormone gene is inhibited by a zinc finger/homeodomain protein. Cabanillas AM, etal., Mol Cell Endocrinol. 2001 Jul 5;181(1-2):131-7.
3. Altered expression and insulin-induced trafficking of Na+-K+-ATPase in rat skeletal muscle: effects of high-fat diet and exercise. Galuska D, etal., Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E38-49. Epub 2009 Apr 14.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Nishimura G, etal., Dev Cell. 2006 Jul;11(1):93-104.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. Ponticos M, etal., Mol Cell Biol. 2004 Jul;24(14):6151-61.
11. Molecular Mechanism of MicroRNA-200c Regulating Transforming Growth Factor-β (TGF-β)/SMAD Family Member 3 (SMAD3) Pathway by Targeting Zinc Finger E-Box Binding Homeobox 1 (ZEB1) in Hypospadias in Rats. Qian C, etal., Med Sci Monit. 2016 Oct 29;22:4073-4081. doi: 10.12659/msm.896958.
12. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats. Ren YS, etal., J Proteomics. 2020 Jun 30;222:103691. doi: 10.1016/j.jprot.2020.103691. Epub 2020 Feb 14.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. Xian S, etal., Mol Med Rep. 2021 Jan;23(1):10. doi: 10.3892/mmr.2020.11648. Epub 2020 Nov 12.
18. Developmental and functional evidence of a role for Zfhep in neural cell development. Yen G, etal., Brain Res Mol Brain Res. 2001 Nov 30;96(1-2):59-67.
Additional References at PubMed
PMID:9126927   PMID:9389660   PMID:11681996   PMID:12193549   PMID:12937339   PMID:14643678   PMID:14672405   PMID:16598713   PMID:17392792   PMID:18192284   PMID:18436818   PMID:19194497  
PMID:20346398   PMID:20418909   PMID:20548288   PMID:20705680   PMID:20856809   PMID:21478908   PMID:21980308   PMID:22012804   PMID:23765923   PMID:23814079   PMID:24735878   PMID:25190660  
PMID:25391656   PMID:26934489   PMID:29150958   PMID:29323698   PMID:30549040   PMID:32278027   PMID:33846788   PMID:34032956   PMID:36123704   PMID:37246926   PMID:37391399  


Genomics

Comparative Map Data
Zeb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81756,644,397 - 56,811,155 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1756,644,397 - 56,810,745 (-)EnsemblGRCr8
mRatBN7.21751,948,948 - 52,116,018 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1751,948,948 - 52,115,214 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1755,134,749 - 55,300,937 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01759,137,668 - 59,303,854 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01753,287,135 - 53,453,509 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01754,656,627 - 54,714,920 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1754,658,463 - 54,714,914 (-)Ensemblrn6Rnor6.0
Rnor_5.01752,353,064 - 52,373,420 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41760,177,150 - 60,198,584 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1747,960,914 - 48,019,394 (-)NCBICelera
RGSC_v3.11760,187,896 - 60,245,300 (-)NCBI
Cytogenetic Map17q12.1NCBI
ZEB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381031,318,417 - 31,529,804 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1031,318,495 - 31,529,814 (+)Ensemblhg38GRCh38
GRCh371031,607,346 - 31,818,732 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361031,648,148 - 31,856,742 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341031,648,147 - 31,856,740NCBI
Celera1031,373,372 - 31,583,958 (+)NCBICelera
Cytogenetic Map10p11.22NCBI
HuRef1031,330,231 - 31,538,974 (+)NCBIHuRef
CHM1_11031,608,067 - 31,818,701 (+)NCBICHM1_1
T2T-CHM13v2.01031,348,155 - 31,559,554 (+)NCBIT2T-CHM13v2.0
Zeb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39185,591,330 - 5,775,468 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl185,591,860 - 5,775,467 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38185,591,327 - 5,775,468 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl185,591,860 - 5,775,467 (+)Ensemblmm10GRCm38
MGSCv37185,591,889 - 5,774,909 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36185,591,889 - 5,774,909 (+)NCBIMGSCv36mm8
Celera185,749,281 - 5,819,757 (+)NCBICelera
Cytogenetic Map18A1NCBI
cM Map184.42NCBI
Zeb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542923,010,790 - 23,198,250 (+)Ensembl
ChiLan1.0NW_00495542923,011,627 - 23,198,188 (+)NCBIChiLan1.0ChiLan1.0
ZEB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2843,969,716 - 44,179,649 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11043,974,837 - 44,184,975 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01031,449,202 - 31,659,534 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11032,043,863 - 32,253,550 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1032,046,491 - 32,253,550 (+)EnsemblpanPan2panpan1.1
ZEB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1215,300,401 - 15,481,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl215,299,723 - 15,481,495 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha212,788,320 - 12,969,363 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0213,536,487 - 13,717,784 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl213,501,815 - 13,717,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1212,976,357 - 13,157,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0212,866,906 - 13,048,214 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0213,140,991 - 13,322,104 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Zeb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934410,517,823 - 10,676,265 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493657417,684 - 178,293 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493657417,643 - 175,762 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZEB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1042,013,084 - 42,214,205 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11042,013,114 - 42,216,139 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21046,547,219 - 46,726,896 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZEB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1930,674,893 - 30,862,682 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl930,674,578 - 30,863,250 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605639,637,685 - 39,830,491 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Zeb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248053,964,450 - 4,042,527 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248053,964,448 - 4,044,546 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Zeb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11431,958,007 - 32,114,227 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zeb1
921 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir200crno-miR-200c-3pMirtarbaseexternal_infoWestern blotFunctional MTI19167416
Mir200crno-miR-200c-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)20705680

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:70
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000024336, ENSRNOT00000046013
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174949693265155015Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)174238816487388164Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)173310464578104645Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1354654Spl7Serum phospholipid level QTL 75.5blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)173803135483031354Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)175482950393515804Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174096801789341781Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
1354629Scl31Serum cholesterol level QTL 314.1blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)173803135483031354Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
1600398Edcs5Endometrial carcinoma susceptibility QTL 52.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)173544694975762341Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)173803135483031354Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173803135483031354Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)173310464578104645Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)174238816487388164Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)174605012691050126Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175560459793006569Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)174265489587654895Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)173768787782687877Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)174106235286062352Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173219953486201342Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173604553781045537Rat

Markers in Region
BE118897  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21751,950,801 - 51,950,985 (+)MAPPERmRatBN7.2
Rnor_6.01754,658,479 - 54,658,662NCBIRnor6.0
Rnor_5.01752,353,080 - 52,353,263UniSTSRnor5.0
RGSC_v3.41760,177,166 - 60,177,349UniSTSRGSC3.4
Celera1747,962,767 - 47,962,950UniSTS
RH 3.4 Map17535.49UniSTS
Cytogenetic Map17q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024336   ⟹   ENSRNOP00000024336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1756,644,397 - 56,808,832 (-)Ensembl
mRatBN7.2 Ensembl1751,948,948 - 52,115,214 (-)Ensembl
Rnor_6.0 Ensembl1754,658,463 - 54,714,914 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000046013   ⟹   ENSRNOP00000049343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1756,646,232 - 56,662,352 (-)Ensembl
mRatBN7.2 Ensembl1751,950,784 - 51,966,904 (-)Ensembl
Rnor_6.0 Ensembl1754,658,463 - 54,678,710 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096837   ⟹   ENSRNOP00000086424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1756,644,397 - 56,810,745 (-)Ensembl
mRatBN7.2 Ensembl1751,948,948 - 52,114,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139666   ⟹   ENSRNOP00000105892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1756,646,232 - 56,666,682 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000173987   ⟹   ENSRNOP00000100713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1756,644,397 - 56,810,707 (-)Ensembl
RefSeq Acc Id: NM_001308265   ⟹   NP_001295194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81756,644,397 - 56,810,653 (-)NCBI
mRatBN7.21751,948,948 - 52,115,214 (-)NCBI
Rnor_6.01754,656,627 - 54,714,920 (-)NCBI
Celera1747,960,914 - 48,019,394 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039095402   ⟹   XP_038951330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81756,644,397 - 56,809,651 (-)NCBI
mRatBN7.21751,948,948 - 52,113,738 (-)NCBI
RefSeq Acc Id: XM_039095404   ⟹   XP_038951332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81756,644,397 - 56,809,978 (-)NCBI
mRatBN7.21751,948,948 - 52,114,523 (-)NCBI
RefSeq Acc Id: XM_063276113   ⟹   XP_063132183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81756,644,397 - 56,811,155 (-)NCBI
RefSeq Acc Id: XM_063276114   ⟹   XP_063132184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81756,644,397 - 56,717,430 (-)NCBI
RefSeq Acc Id: NP_001295194   ⟸   NM_001308265
- UniProtKB: Q62948 (UniProtKB/Swiss-Prot),   Q62947 (UniProtKB/Swiss-Prot),   F8WG35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000049343   ⟸   ENSRNOT00000046013
Ensembl Acc Id: ENSRNOP00000024336   ⟸   ENSRNOT00000024336
RefSeq Acc Id: XP_038951332   ⟸   XM_039095404
- Peptide Label: isoform X1
- UniProtKB: A6K9E4 (UniProtKB/TrEMBL),   F8WG35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951330   ⟸   XM_039095402
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3L9 (UniProtKB/TrEMBL),   F8WG35 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086424   ⟸   ENSRNOT00000096837
RefSeq Acc Id: XP_063132183   ⟸   XM_063276113
- Peptide Label: isoform X1
- UniProtKB: A6K9E4 (UniProtKB/TrEMBL),   F8WG35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132184   ⟸   XM_063276114
- Peptide Label: isoform X1
- UniProtKB: A6K9E4 (UniProtKB/TrEMBL),   F8WG35 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105892   ⟸   ENSRNOT00000139666
Ensembl Acc Id: ENSRNOP00000100713   ⟸   ENSRNOT00000173987
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62947-F1-model_v2 AlphaFold Q62947 1-1109 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3831 AgrOrtholog
BioCyc Gene G2FUF-9039 BioCyc
Ensembl Genes ENSRNOG00000017863 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024336 ENTREZGENE
  ENSRNOT00000024336.8 UniProtKB/Swiss-Prot
  ENSRNOT00000096837 ENTREZGENE
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
  Homeodomain-like UniProtKB/Swiss-Prot
InterPro Di19_Zn_binding_dom UniProtKB/Swiss-Prot
  Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
  ZnF_E-box_Homeobox UniProtKB/Swiss-Prot
KEGG Report rno:25705 UniProtKB/Swiss-Prot
NCBI Gene 25705 ENTREZGENE
PANTHER HISTONE H4 TRANSCRIPTION FACTOR-RELATED UniProtKB/Swiss-Prot
  ZINC FINGER E-BOX-BINDING HOMEOBOX 1 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
  zf-Di19 UniProtKB/Swiss-Prot
PhenoGen Zeb1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017863 RatGTEx
SMART HOX UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
TIGR TC220274
UniProt A0A8I6A3L9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LC75_RAT UniProtKB/TrEMBL
  A6K9E4 ENTREZGENE, UniProtKB/TrEMBL
  E9PT24_RAT UniProtKB/TrEMBL
  F8WG35 ENTREZGENE, UniProtKB/TrEMBL
  Q62947 ENTREZGENE
  Q62948 ENTREZGENE
  Q7TP68_RAT UniProtKB/TrEMBL
  ZEB1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q62948 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-11-13 Zeb1  zinc finger E-box binding homeobox 1  Tcf8  transcription factor 8  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-11-17 Tcf8  transcription factor 8      Name updated 1299863 APPROVED
2004-09-10 Tcf8  transcription factor 8 (represses interleukin 2 expression)    transcription factor 8  Name updated 1299863 APPROVED
2003-04-09 Tcf8  transcription factor 8    Transcription factor 8  Symbol and Name updated 629477 APPROVED
2002-06-10 Tcf8  Transcription factor 8      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains two separate zinc finger domains, ZD1 and ZD2, and a homeodomain 730026
gene_function binds DNA 730026