Tat (tyrosine aminotransferase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tat (tyrosine aminotransferase) Rattus norvegicus
Analyze
Symbol: Tat
Name: tyrosine aminotransferase
RGD ID: 3820
Description: Enables L-tyrosine-2-oxoglutarate transaminase activity and amino acid binding activity. Involved in several processes, including cellular response to retinoic acid; liver regeneration; and response to glucocorticoid. Located in cytosol. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: L-tyrosine:2-oxoglutarate aminotransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,856,604 - 54,867,168 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,856,563 - 54,867,482 (+)EnsemblGRCr8
mRatBN7.21937,947,153 - 37,957,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,947,112 - 37,958,031 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,759,466 - 44,770,043 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,412,802 - 45,423,379 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,722,404 - 47,732,988 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,675,639 - 41,686,195 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,675,355 - 41,686,229 (-)Ensemblrn6Rnor6.0
Rnor_5.01952,499,259 - 52,509,759 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,854,163 - 39,865,060 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1937,350,682 - 37,361,246 (+)NCBICelera
RGSC_v3.11939,859,002 - 39,870,255 (+)NCBI
RH 3.4 Map19448.1RGD
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (EXP)
3-methyl-4'-dimethylaminoazobenzene  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
acephate  (EXP)
acetic acid  (ISO)
actinomycin D  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldosterone  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atropine  (EXP)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[b]fluorene  (EXP)
beryllium sulfate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
corn oil  (EXP)
corticosterone  (EXP)
cortisol  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (EXP)
dichlorvos  (EXP)
diethylstilbestrol  (EXP)
diphenyl diselenide  (EXP)
disulfiram  (EXP)
ebselen  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
imidacloprid  (EXP)
inulin  (ISO)
ketoconazole  (ISO)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
melatonin  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylprednisolone aceponate  (ISO)
miconazole  (EXP,ISO)
mifepristone  (EXP,ISO)
mirex  (EXP)
mometasone furoate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nevirapine  (ISO)
nimesulide  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ortho-Aminoazotoluene  (ISO)
Ortho-topolin riboside  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
prednisolone  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sphingosine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolylfluanid  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
withaferin A  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Structural and immunochemical properties of rat liver tyrosine aminotransferase. Dietrich JB, etal., Biochimie 1988 May;70(5):673-9.
2. Mercury influences rat liver tyrosine aminotransferase activity and induction by dexamethasone. Dundjerski J, etal., J Appl Toxicol. 2006 Mar-Apr;26(2):187-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Complete complementary DNA of rat tyrosine aminotransferase messenger RNA. Deduction of the primary structure of the enzyme. Grange T, etal., J Mol Biol 1985 Jul 20;184(2):347-50.
6. The structure of tyrosine aminotransferase. Evidence for domains involved in catalysis and enzyme turnover. Hargrove JL, etal., J Biol Chem 1989 Jan 5;264(1):45-53.
7. Role of Glucocorticoid Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and NADPH-Cytochrome P450 Oxidoreductase. Hunter SR, etal., Drug Metab Dispos. 2017 Feb;45(2):118-129. doi: 10.1124/dmd.116.073833. Epub 2016 Nov 16.
8. Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells. Johansson M, etal., Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):309-15.
9. [Glucose-fatty acids cycle in cobalt chloride-induced oxidative stress in rats] Kaliman PA and Okhrimenko SM, Ukr Biokhim Zh. 2005 Mar-Apr;77(2):154-8.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Subcellular distribution of tyrosine aminotransferase in rat brain. Miller JE and Litwack G, Arch Biochem Biophys. 1969 Oct;134(1):149-59.
14. Regulation of tyrosine aminotransferase by insulin and cyclic AMP: similar effects on activity but opposite effects on transcription. Moore PS and Koontz JW, Mol Endocrinol. 1989 Nov;3(11):1724-32. doi: 10.1210/mend-3-11-1724.
15. Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Natt E, etal., Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9297-301.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Rat liver tryptophan pyrrolase activity and gene expression during alcohol withdrawal. Oretti RG, etal., Alcohol Alcohol. 2000 Sep-Oct;35(5):427-34. doi: 10.1093/alcalc/35.5.427.
19. Inhibition of tyrosine aminotransferase gene expression by retinoic acid. Pan CJ, etal., Mol Endocrinol. 1992 Apr;6(4):572-80. doi: 10.1210/mend.6.4.1350056.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Stabilization of tyrosine aminotransferase and ornithine decarboxylase in regenerating rat liver by ethanol treatment. Pösö H and Pösö AR, FEBS Lett. 1980 May 5;113(2):211-4. doi: 10.1016/0014-5793(80)80593-x.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Acute ethanol effects on rat liver tryptophan oxygenase and tyrosine aminotransferase. Rouach H, etal., Pharmacol Biochem Behav. 1980;13 Suppl 1:139-43. doi: 10.1016/s0091-3057(80)80022-0.
28. Induction of tyrosine aminotransferase mRNA by glucocorticoids and cAMP in fetal rat liver. Ruiz-Bravo N and Ernest MJ, Proc Natl Acad Sci U S A. 1982 Jan;79(2):365-8. doi: 10.1073/pnas.79.2.365.
29. Isolation and characterization of the rat tyrosine aminotransferase gene. Shinomiya T, etal., Proc Natl Acad Sci U S A 1984 Mar;81(5):1346-50.
30. Involvement of conserved asparagine and arginine residues from the N-terminal region in the catalytic mechanism of rat liver and Trypanosoma cruzi tyrosine aminotransferases. Sobrado VR, etal., Protein Sci. 2003 May;12(5):1039-50.
31. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
32. Down-regulation of glucocorticoid receptor and its relationship to the induction of rat liver tyrosine aminotransferase. Yang YL, etal., J Steroid Biochem. 1989 Jan;32(1A):99-104. doi: 10.1016/0022-4731(89)90020-4.
Additional References at PubMed
PMID:1299072   PMID:1682164   PMID:1983704   PMID:7999802   PMID:12477932   PMID:14651853   PMID:17170234   PMID:21153519   PMID:25502805   PMID:31515488  


Genomics

Comparative Map Data
Tat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81954,856,604 - 54,867,168 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1954,856,563 - 54,867,482 (+)EnsemblGRCr8
mRatBN7.21937,947,153 - 37,957,717 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1937,947,112 - 37,958,031 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1944,759,466 - 44,770,043 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01945,412,802 - 45,423,379 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01947,722,404 - 47,732,988 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01941,675,639 - 41,686,195 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1941,675,355 - 41,686,229 (-)Ensemblrn6Rnor6.0
Rnor_5.01952,499,259 - 52,509,759 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41939,854,163 - 39,865,060 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1937,350,682 - 37,361,246 (+)NCBICelera
RGSC_v3.11939,859,002 - 39,870,255 (+)NCBI
RH 3.4 Map19448.1RGD
Cytogenetic Map19q12NCBI
TAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381671,565,660 - 71,577,092 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1671,565,660 - 71,577,095 (-)Ensemblhg38GRCh38
GRCh371671,599,563 - 71,610,995 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361670,158,255 - 70,168,496 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341670,158,254 - 70,168,496NCBI
Celera1655,916,606 - 55,926,850 (-)NCBICelera
Cytogenetic Map16q22.2NCBI
HuRef1657,368,735 - 57,378,980 (-)NCBIHuRef
CHM1_11673,013,576 - 73,023,820 (-)NCBICHM1_1
T2T-CHM13v2.01677,382,852 - 77,394,286 (-)NCBIT2T-CHM13v2.0
Tat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398110,712,710 - 110,726,436 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8110,717,069 - 110,726,435 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388109,986,078 - 109,999,804 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8109,990,437 - 109,999,803 (+)Ensemblmm10GRCm38
MGSCv378112,514,336 - 112,523,704 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368112,879,586 - 112,888,930 (+)NCBIMGSCv36mm8
Celera8114,212,364 - 114,221,732 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map857.38NCBI
Tat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554844,276,953 - 4,287,627 (-)Ensembl
ChiLan1.0NW_0049554844,278,083 - 4,287,535 (-)NCBIChiLan1.0ChiLan1.0
TAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21882,583,247 - 82,594,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11688,514,074 - 88,524,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01653,434,028 - 53,443,624 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11671,402,560 - 71,414,013 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1671,404,399 - 71,413,886 (-)EnsemblpanPan2panpan1.1
TAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1577,365,589 - 77,378,474 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl577,366,138 - 77,378,419 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha577,327,228 - 77,340,137 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0577,804,675 - 77,817,578 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl577,804,680 - 77,817,500 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1577,624,765 - 77,637,663 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0577,447,892 - 77,460,816 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0577,946,897 - 77,959,805 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934937,389,275 - 37,399,429 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647522,189,728 - 22,199,672 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647522,190,282 - 22,199,398 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl614,570,589 - 14,583,177 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1614,571,311 - 14,583,203 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2614,064,566 - 14,076,459 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1554,695,342 - 54,749,291 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl554,693,458 - 54,705,082 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604717,503,474 - 17,512,808 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474613,790,440 - 13,803,202 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474613,793,593 - 13,803,227 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tat
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11729,691,162 - 29,701,619 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tat
93 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:102
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000022721
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat

Markers in Region
D19Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81954,865,240 - 54,865,383 (+)Marker Load Pipeline
mRatBN7.21937,955,789 - 37,955,932 (-)MAPPERmRatBN7.2
Rnor_6.01941,677,424 - 41,677,566NCBIRnor6.0
Rnor_5.01952,501,044 - 52,501,186UniSTSRnor5.0
RGSC_v3.41939,863,132 - 39,863,275RGDRGSC3.4
RGSC_v3.41939,863,133 - 39,863,275UniSTSRGSC3.4
Celera1937,359,319 - 37,359,461UniSTS
RGSC_v3.11939,868,013 - 39,868,156RGD
RH 3.4 Map19442.9UniSTS
RH 3.4 Map19442.9RGD
RH 2.0 Map19488.7RGD
FHH x ACI Map1930.2099RGD
Cytogenetic Map19q11-q12UniSTS
D19Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81954,856,658 - 54,856,850 (+)Marker Load Pipeline
mRatBN7.21937,947,207 - 37,947,399 (-)MAPPERmRatBN7.2
Rnor_6.01941,685,949 - 41,686,140NCBIRnor6.0
Rnor_5.01952,509,513 - 52,509,704UniSTSRnor5.0
RGSC_v3.41939,854,217 - 39,854,409RGDRGSC3.4
RGSC_v3.41939,854,218 - 39,854,409UniSTSRGSC3.4
Celera1937,350,737 - 37,350,926UniSTS
RGSC_v3.11939,859,098 - 39,859,290RGD
RH 3.4 Map19441.8UniSTS
RH 3.4 Map19441.8RGD
RH 2.0 Map19482.6RGD
Cytogenetic Map19q11-q12UniSTS
D19Wox6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81954,846,619 - 54,846,941 (+)Marker Load Pipeline
mRatBN7.21937,937,168 - 37,937,490 (-)MAPPERmRatBN7.2
Rnor_6.01941,695,858 - 41,696,179NCBIRnor6.0
Rnor_5.01952,519,422 - 52,519,743UniSTSRnor5.0
RGSC_v3.41939,844,178 - 39,844,500RGDRGSC3.4
RGSC_v3.41939,844,179 - 39,844,500UniSTSRGSC3.4
Celera1937,340,698 - 37,341,019UniSTS
RGSC_v3.11939,849,059 - 39,849,381RGD
RH 3.4 Map19431.7RGD
RH 3.4 Map19431.7UniSTS
RH 2.0 Map19471.8RGD
Cytogenetic Map19q11-q12UniSTS
D19Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map19454.5UniSTS
RH 3.4 Map19454.5RGD
Cytogenetic Map19q11-q12UniSTS
D19Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81954,856,563 - 54,856,860 (+)Marker Load Pipeline
mRatBN7.21937,947,112 - 37,947,409 (-)MAPPERmRatBN7.2
Rnor_6.01941,685,939 - 41,686,235NCBIRnor6.0
Rnor_5.01952,509,503 - 52,509,799UniSTSRnor5.0
RGSC_v3.41939,854,122 - 39,854,419RGDRGSC3.4
RGSC_v3.41939,854,123 - 39,854,419UniSTSRGSC3.4
Celera1937,350,642 - 37,350,936UniSTS
RGSC_v3.11939,859,003 - 39,859,300RGD
Cytogenetic Map19q11-q12UniSTS
Tat  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81954,856,673 - 54,856,853 (+)Marker Load Pipeline
mRatBN7.21937,947,222 - 37,947,402 (-)MAPPERmRatBN7.2
Rnor_6.01941,685,946 - 41,686,125NCBIRnor6.0
Rnor_5.01952,509,510 - 52,509,689UniSTSRnor5.0
RGSC_v3.41939,854,233 - 39,854,412UniSTSRGSC3.4
Celera1937,350,752 - 37,350,929UniSTS
Cytogenetic Map19q11-q12UniSTS
RH94607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21937,957,511 - 37,957,647 (-)MAPPERmRatBN7.2
Rnor_6.01941,675,709 - 41,675,844NCBIRnor6.0
Rnor_5.01952,499,329 - 52,499,464UniSTSRnor5.0
RGSC_v3.41939,864,855 - 39,864,990UniSTSRGSC3.4
Celera1937,361,041 - 37,361,176UniSTS
RH 3.4 Map19448.1UniSTS
Cytogenetic Map19q11-q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 7 16 59 80 81 55 21 55 6 159 52 42 38 52 26 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000022721   ⟹   ENSRNOP00000022721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1954,856,563 - 54,867,482 (+)Ensembl
mRatBN7.2 Ensembl1937,947,112 - 37,958,031 (+)Ensembl
Rnor_6.0 Ensembl1941,675,355 - 41,686,229 (-)Ensembl
RefSeq Acc Id: NM_012668   ⟹   NP_036800
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81954,856,604 - 54,867,168 (+)NCBI
mRatBN7.21937,947,153 - 37,957,717 (+)NCBI
Rnor_6.01941,675,639 - 41,686,195 (-)NCBI
Rnor_5.01952,499,259 - 52,509,759 (-)NCBI
RGSC_v3.41939,854,163 - 39,865,060 (+)RGD
Celera1937,350,682 - 37,361,246 (+)RGD
Sequence:
RefSeq Acc Id: NP_036800   ⟸   NM_012668
- UniProtKB: Q5EBB6 (UniProtKB/Swiss-Prot),   P04694 (UniProtKB/Swiss-Prot),   A6IZ42 (UniProtKB/TrEMBL),   Q9QWS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022721   ⟸   ENSRNOT00000022721
Protein Domains
Aminotransferase class I/classII large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04694-F1-model_v2 AlphaFold P04694 1-454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701131
Promoter ID:EPDNEW_R11655
Type:single initiation site
Name:Tat_1
Description:tyrosine aminotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01941,686,236 - 41,686,296EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3820 AgrOrtholog
BioCyc Gene G2FUF-5702 BioCyc
BioCyc Pathway PWY-5886 [3-(4-hydroxyphenyl)pyruvate biosynthesis] BioCyc
  TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image PWY-5886 BioCyc
  TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000016348 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022721 ENTREZGENE
  ENSRNOT00000022721.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7372826 IMAGE-MGC_LOAD
InterPro Aminotransferase_I/II UniProtKB/Swiss-Prot
  NHTrfase_class1_PyrdxlP-BS UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
  Tyr_aminoTrfase_ubiquitination UniProtKB/Swiss-Prot
  TyrNic_aminoTrfase UniProtKB/Swiss-Prot
  Tyrosine_aminoTrfase UniProtKB/Swiss-Prot
KEGG Report rno:24813 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108738 IMAGE-MGC_LOAD
NCBI Gene 24813 ENTREZGENE
PANTHER TYROSINE AMINOTRANSFERASE UniProtKB/Swiss-Prot
  TYROSINE AMINOTRANSFERASE UniProtKB/Swiss-Prot
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot
  TAT_ubiq UniProtKB/Swiss-Prot
PhenoGen Tat PhenoGen
PIRSF Tyr_transaminase UniProtKB/Swiss-Prot
PROSITE AA_TRANSFER_CLASS_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016348 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A6IZ42 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ43_RAT UniProtKB/TrEMBL
  A6IZ44_RAT UniProtKB/TrEMBL
  A6IZ45_RAT UniProtKB/TrEMBL
  ATTY_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5EBB6 ENTREZGENE
  Q9QWS4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q5EBB6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Tat  tyrosine aminotransferase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate