RGD Reference Report - Mercury influences rat liver tyrosine aminotransferase activity and induction by dexamethasone. - Rat Genome Database

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Mercury influences rat liver tyrosine aminotransferase activity and induction by dexamethasone.

Authors: Dundjerski, J  Brkljacic, J  Elakovic, I  Manitasevic, S  Matic, G 
Citation: Dundjerski J, etal., J Appl Toxicol. 2006 Mar-Apr;26(2):187-90.
RGD ID: 1600129
Pubmed: PMID:16307467   (View Abstract at PubMed)
DOI: DOI:10.1002/jat.1123   (Journal Full-text)

The effects of mercury (Hg) on basal and dexamethasone-induced tyrosine aminotransferase (TAT) activity in rat liver were studied. Comparison of TAT activity after in vitro and in vivo mercury application revealed the influence of the metal only when applied in vivo, suggesting that the effects are expressed at the level of TAT gene transcription. Intraperitoneal administration of mercury at 1, 2 or 3 mg Hg kg(-1) b.w. 4 h before decapitation was shown to stimulate the basal activity of TAT. The most prominent increase was observed 4 h after the metal administration. When applied at 1 and 2 mg Hg kg(-1) b.w. mercury was also shown to reduce partially the extent of the enzyme induction by dexamethasone, which was injected intraperitoneally at 5 mg kg(-1) b.w. 5 h before death. The highest dose of mercury (3 mg Hg kg(-1) b.w.) almost completely abolished the dexamethasone effect. The finding that mercury increases basal activity of the enzyme while decreasing its induction by dexamethasone suggests that stimulatory effects of this metal on TAT activity are probably mediated by factors other than glucocorticoids.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to glucocorticoid  IDA 1600129 RGD 
response to mercury ion  IDA 1600129 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tat  (tyrosine aminotransferase)


Additional Information