Sp1 (Sp1 transcription factor) - Rat Genome Database

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Gene: Sp1 (Sp1 transcription factor) Rattus norvegicus
Analyze
Symbol: Sp1
Name: Sp1 transcription factor
RGD ID: 3738
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and cellular response to zinc ion starvation. Located in chromatin and nucleus. Part of protein-DNA complex. Orthologous to human SP1 (Sp1 transcription factor); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; forkhead class A signaling pathway; hypoxia inducible factor pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: trans-acting transcription factor 1; transcription factor Sp1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,419,864 - 135,450,513 (+)NCBIGRCr8
mRatBN7.27133,541,302 - 133,571,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,298,300 - 135,327,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,527,694 - 137,557,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,513,816 - 137,543,172 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
Celera7129,968,890 - 129,999,257 (+)NCBICelera
RH 3.4 Map71062.1RGD
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Sp1RatCarotid Artery Injuries  IEP 9854624protein:increased phosphorylation:smooth muscle cell:RGD 
Sp1RatPlaque, Atherosclerotic  ISOSP1 (Homo sapiens)9854624protein:increased phosphorylation:smooth muscle cell:RGD 
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Sp1RatNeurodevelopmental Disorders  ISOSP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Object Symbol
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Original Reference(s)
Sp1RatColorectal Neoplasms  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Sp1RatDisease Progression  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35072892
Sp1Rathyperglycemia  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11696579
Sp1RatNeoplasm Invasiveness  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26317792 and PMID:35072892
Sp1RatNeoplasm Metastasis  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12538496 and PMID:35072892
Sp1RatNeoplastic Cell Transformation  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22009531
Sp1RatSkin Neoplasms  ISOSP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22009531

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Original Reference(s)
Sp1Rat(+)-catechin increases expressionISOSP1 (Homo sapiens)6480464Catechin results in increased expression of SP1 proteinCTDPMID:28768059
Sp1Rat(+)-catechin multiple interactionsISOSP1 (Homo sapiens)6480464Catechin inhibits the reaction [arsenic trioxide results in decreased expression of SP1 protein]CTDPMID:28768059
Sp1Rat(-)-demecolcine decreases expressionISOSP1 (Homo sapiens)6480464Demecolcine results in decreased expression of SP1 mRNACTDPMID:23649840
Sp1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSP1 (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [EGF protein results in increased activity of SP1 protein]CTDPMID:12931129
Sp1Rat(20S)-ginsenoside Rg3 multiple interactionsISOSP1 (Homo sapiens)6480464ginsenoside Rg3 inhibits the reaction [cagA protein and Helicobacter pylori results in decreased expression of SP1 protein]CTDPMID:26427350
Sp1Rat(R)-lipoic acid multiple interactionsISOSp1 (Mus musculus)6480464Thioctic Acid results in increased phosphorylation of and results in decreased activity of SP1 proteinCTDPMID:21351249
Sp1Rat(S)-nicotine multiple interactionsISOSP1 (Homo sapiens)6480464Nicotine promotes the reaction [[GATA4 protein binds to SP1 protein] which binds to CHRNA7 protein] more ...CTDPMID:24089524
Sp1Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of SP1 mRNACTDPMID:32387197
Sp1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionEXP 64804641-Methyl-4-phenyl-1 more ...CTDPMID:23538867
Sp1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine affects response to substanceISOSp1 (Mus musculus)6480464SP1 affects the susceptibility to 1-Methyl-4-phenyl-1 more ...CTDPMID:25851821
Sp1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsEXP 64804641-Methyl-4-phenyl-1 more ...CTDPMID:23538867
Sp1Rat17alpha-ethynylestradiol multiple interactionsISOSP1 (Homo sapiens)6480464SP1 protein promotes the reaction [Ethinyl Estradiol results in increased expression of AGER mRNA]CTDPMID:15878629
Sp1Rat17alpha-ethynylestradiol increases activityISOSP1 (Homo sapiens)6480464Ethinyl Estradiol results in increased activity of SP1 proteinCTDPMID:15878629
Sp1Rat17beta-estradiol multiple interactionsISOSP1 (Homo sapiens)6480464[Estradiol co-treated with bisphenol A] results in increased expression of SP1 mRNA more ...CTDPMID:16675542 more ...
Sp1Rat17beta-estradiol decreases expressionISOSP1 (Homo sapiens)6480464Estradiol results in decreased expression of SP1 mRNACTDPMID:29783106
Sp1Rat17beta-estradiol increases activityISOSP1 (Homo sapiens)6480464Estradiol results in increased activity of SP1 proteinCTDPMID:17088408
Sp1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303
Sp1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:27291303
Sp1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOSp1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNACTDPMID:14708085 and PMID:24058054
Sp1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SP1 mRNACTDPMID:33387578

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Biological Process
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Original Reference(s)
Sp1Ratcellular response to estrogen stimulus  IEP 152177689 RGD 
Sp1Ratcellular response to insulin stimulus involved_inIDA 11059577PMID:26908121ParkinsonsUK-UCL 
Sp1Ratcellular response to wortmannin  IEP 152177689 RGD 
Sp1Ratcellular response to zinc ion starvation  IEP 151667428 RGD 
Sp1Ratdefinitive hemopoiesis acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratembryonic camera-type eye morphogenesis acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratembryonic placenta development acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratembryonic process involved in female pregnancy acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratembryonic skeletal system development acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratenucleate erythrocyte differentiation acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratin utero embryonic development acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratliver development acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratlung development acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratmegakaryocyte differentiation acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1RatmRNA transcription by RNA polymerase II acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291 PMID:22331133RGDPMID:22331133
Sp1Ratmyeloid progenitor cell differentiation acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratneuron differentiation acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291 PMID:29781215RGDPMID:29781215
Sp1Ratossification acts_upstream_of_or_withinISOSp1 (Mus musculus)1624291MGI:1277166 PMID:17584888RGDPMID:17584888
Sp1Ratpositive regulation by host of viral transcription involved_inIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1Ratpositive regulation of amyloid-beta formation acts_upstream_ofISOSP1 (Homo sapiens)1624291 PMID:14701757RGDPMID:14701757
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Cellular Component
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Original Reference(s)
Sp1Ratchromatin located_inIDA 11059577PMID:26908121ParkinsonsUK-UCL 
Sp1Ratchromatin located_inISOSp1 (Mus musculus)1624291 PMID:21029371RGDPMID:21029371
Sp1Ratchromatin located_inISOSP1 (Homo sapiens)1624291 PMID:15831516 more ...RGDPMID:15831516 more ...
Sp1Ratchromatin located_inIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Sp1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Sp1Rateuchromatin is_active_inISOSP1 (Homo sapiens)1624291 PMID:14701757RGDPMID:14701757
Sp1Rateuchromatin is_active_inIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1Ratnucleoplasm located_inISOSP1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Sp1Ratnucleoplasm located_inIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1Ratnucleoplasm located_inISOSP1 (Homo sapiens)1624291 PMID:12498690RGDPMID:12498690
Sp1Ratnucleus located_inISOSp1 (Mus musculus)1624291 PMID:11004506 more ...RGDPMID:11004506 more ...
Sp1Ratnucleus located_inIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Sp1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Sp1Ratnucleus located_inISOSP1 (Homo sapiens)1624291 PMID:12169688RGDPMID:12169688
Sp1Ratnucleus located_inIDA 10047233PMID:14979875UniProt 
Sp1Ratprotein-DNA complex  IDA 2316171 RGD 
Sp1Ratprotein-DNA complex part_ofIPIUniProtKB:A0A0G2K5M1 and UniProtKB:A0A0G2QC0913506263PMID:10362258ARUK-UCL 
Sp1Rattranscription repressor complex part_ofISOSP1 (Homo sapiens)1624291 PMID:16691198RGDPMID:16691198
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Molecular Function
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Sp1RatbHLH transcription factor binding enablesISOSp1 (Mus musculus)1624291UniProtKB:Q99PV5 and PMID:12657651RGDPMID:12657651
Sp1Ratcis-regulatory region sequence-specific DNA binding enablesISOSp1 (Mus musculus)1624291 PMID:15511642 more ...RGDPMID:15511642 more ...
Sp1RatDNA binding enablesISOSP1 (Homo sapiens)1624291 PMID:12560508RGDPMID:12560508
Sp1RatDNA binding enablesISOSp1 (Mus musculus)1624291 PMID:12119294 more ...RGDPMID:12119294 more ...
Sp1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Sp1RatDNA binding enablesIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSP1 (Homo sapiens)1624291 PMID:14701757 more ...RGDPMID:14701757 more ...
Sp1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSp1 (Mus musculus)1624291 PMID:19943855RGDPMID:19943855
Sp1RatDNA-binding transcription factor activity enablesISOSP1 (Homo sapiens)1624291 PMID:12169688 and PMID:12560508RGDPMID:12169688 and PMID:12560508
Sp1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1RatDNA-binding transcription factor activity enablesISOSp1 (Mus musculus)1624291 PMID:12119294 more ...RGDPMID:12119294 more ...
Sp1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOSP1 (Homo sapiens)1624291 PMID:18293083RGDPMID:18293083
Sp1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOSp1 (Mus musculus)1624291 PMID:22331133RGDPMID:22331133
Sp1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0000233 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sp1Ratdouble-stranded DNA binding  IDA 1626488 RGD 
Sp1Ratdouble-stranded DNA binding enablesISOSp1 (Mus musculus)1624291 PMID:15282343RGDPMID:15282343
Sp1Ratdouble-stranded DNA binding enablesIEAUniProtKB:P08047 and ensembl:ENSP000003293571600115GO_REF:0000107EnsemblGO_REF:0000107
Sp1Ratdouble-stranded DNA binding enablesISOSP1 (Homo sapiens)1624291 PMID:20371611RGDPMID:20371611
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RGD Manual Annotations


  
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Original Reference(s)
Sp1Ratphosphatidylinositol 3-kinase-Akt signaling pathway   IMP 152177689 RGD 

Imported Annotations - KEGG (archival)

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Sp1RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Sp1Rattransforming growth factor-beta superfamily mediated signaling pathway  IEA 6907045 KEGGrno:04350

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Alfonso-Jaume MA, etal., Biochem J. 2004 Jun 15;380(Pt 3):735-47.
2. Hyperglycemia and hyperlipidemia blunts the Insulin-Inpp5f negative feedback loop in the diabetic heart. Bai D, etal., Sci Rep. 2016 Feb 24;6:22068. doi: 10.1038/srep22068.
3. Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. Billon N, etal., Oncogene. 1999 May 6;18(18):2872-82. doi: 10.1038/sj.onc.1202712.
4. Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. D'Addario M, etal., J Biol Chem 2002 Dec 6;277(49):47541-50.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, etal., Endocrinology 2004 Feb;145(2):901-12. Epub 2003 Oct 23.
8. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
9. Synergistic activation of the rat laminin gamma1 chain promoter by the gut-enriched Kruppel-like factor (GKLF/KLF4) and Sp1. Higaki Y, etal., Nucleic Acids Res 2002 Jun 1;30(11):2270-9.
10. Alterations in the DNA binding activity of transcriptional factors activator protein-1, Sp1, and hepatocyte nuclear factor-1 in rat jejunum during starvation and refeeding. Ihara T, etal., J Gastroenterol Hepatol. 2003 Jun;18(6):705-11.
11. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. Imataka H, etal., EMBO J 1992 Oct;11(10):3663-71.
12. Sp1 inhibits proliferation and induces apoptosis in vascular smooth muscle cells by repressing p21WAF1/Cip1 transcription and cyclin D1-Cdk4-p21WAF1/Cip1 complex formation. Kavurma MM and Khachigian LM, J Biol Chem 2003 Aug 29;278(35):32537-43. Epub 2003 Jun 9.
13. Insulin-responsive nuclear proteins facilitate Sp1 interactions with the insulin-like growth factor-I gene. Kaytor EN, etal., J Biol Chem 2001 Oct 5;276(40):36896-901. Epub 2001 Jul 16.
14. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
15. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
16. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Sp1 and Egr1 regulate transcription of the Dmrt1 gene in Sertoli cells. Lei N and Heckert LL, Biol Reprod 2002 Mar;66(3):675-84.
18. Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. Marinova Z, etal., J Neurochem. 2009 Nov;111(4):976-87. Epub 2009 Sep 18.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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PMID:1524678   PMID:2833704   PMID:8617793   PMID:9705320   PMID:9738004   PMID:10816420   PMID:11004506   PMID:11022037   PMID:11071760   PMID:11688998   PMID:11897710   PMID:12093818  
PMID:12119294   PMID:12153142   PMID:12498690   PMID:12529372   PMID:12560508   PMID:12640146   PMID:12657651   PMID:12700237   PMID:12736330   PMID:12771217   PMID:12850056   PMID:12900380  
PMID:14563703   PMID:14580349   PMID:14593115   PMID:14604767   PMID:14630713   PMID:14643899   PMID:14667815   PMID:14701757   PMID:14744869   PMID:14988427   PMID:14988433   PMID:15016652  
PMID:15094381   PMID:15282343   PMID:15330762   PMID:15389873   PMID:15511642   PMID:15561949   PMID:15589828   PMID:15663180   PMID:15670758   PMID:15721292   PMID:15817708   PMID:15831516  
PMID:15860735   PMID:16052526   PMID:16141233   PMID:16158334   PMID:16189269   PMID:16332679   PMID:16365142   PMID:16378599   PMID:16403775   PMID:16582099   PMID:16595660   PMID:16638616  
PMID:16691198   PMID:16751776   PMID:16886906   PMID:16931573   PMID:17109817   PMID:17379926   PMID:17449871   PMID:17584888   PMID:17628354   PMID:17660393   PMID:17670746   PMID:17827154  
PMID:17872376   PMID:18004997   PMID:18192274   PMID:18293083   PMID:18348986   PMID:18367547   PMID:18434628   PMID:18443233   PMID:18543254   PMID:18568943   PMID:18655767   PMID:18850004  
PMID:19127542   PMID:19168719   PMID:19263243   PMID:19302822   PMID:19307576   PMID:19728174   PMID:19808779   PMID:19943855   PMID:20371611   PMID:20381604   PMID:20392694   PMID:20699577  
PMID:20716579   PMID:20882567   PMID:21029371   PMID:21115498   PMID:21179468   PMID:21289081   PMID:21518763   PMID:21645329   PMID:21659522   PMID:22049076   PMID:22253285   PMID:22282354  
PMID:22331133   PMID:22337869   PMID:22504846   PMID:22511764   PMID:22582096   PMID:22975163   PMID:23093703   PMID:23611784   PMID:23633075   PMID:23802567   PMID:23806282   PMID:23814049  
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Sp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87135,419,864 - 135,450,513 (+)NCBIGRCr8
mRatBN7.27133,541,302 - 133,571,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7135,298,300 - 135,327,653 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,527,694 - 137,557,048 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,513,816 - 137,543,172 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,014,173 - 144,044,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,805,281 - 141,836,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47141,164,180 - 141,194,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17141,240,616 - 141,265,690 (+)NCBI
Celera7129,968,890 - 129,999,257 (+)NCBICelera
RH 3.4 Map71062.1RGD
Cytogenetic Map7q36NCBI
SP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381253,380,176 - 53,416,446 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1253,380,176 - 53,416,446 (+)EnsemblGRCh38hg38GRCh38
GRCh371253,773,960 - 53,810,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361252,060,246 - 52,096,497 (+)NCBINCBI36Build 36hg18NCBI36
Build 341252,060,245 - 52,096,491NCBI
Celera1253,423,138 - 53,460,427 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,814,656 - 50,850,614 (+)NCBIHuRef
CHM1_11253,741,140 - 53,777,425 (+)NCBICHM1_1
T2T-CHM13v2.01253,346,223 - 53,382,489 (+)NCBIT2T-CHM13v2.0
Sp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915102,314,751 - 102,344,839 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15102,314,578 - 102,344,839 (+)EnsemblGRCm39 Ensembl
GRCm3815102,406,316 - 102,436,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15102,406,143 - 102,436,404 (+)EnsemblGRCm38mm10GRCm38
MGSCv3715102,236,747 - 102,266,835 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615102,234,362 - 102,260,713 (+)NCBIMGSCv36mm8
Celera15104,563,277 - 104,594,207 (+)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1557.55NCBI
Sp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458644,378 - 677,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955458644,435 - 677,360 (+)NCBIChiLan1.0ChiLan1.0
SP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21040,770,223 - 40,809,774 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11240,766,986 - 40,806,525 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01235,338,492 - 35,374,462 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11236,122,583 - 36,158,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1236,127,681 - 36,158,356 (-)Ensemblpanpan1.1panPan2
SP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,802,587 - 1,861,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,805,184 - 1,847,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2744,404,740 - 44,448,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0271,804,038 - 1,848,490 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl271,804,038 - 1,848,385 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1271,823,470 - 1,867,184 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0271,807,708 - 1,852,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,805,663 - 44,849,851 (+)NCBIUU_Cfam_GSD_1.0
Sp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,467,059 - 62,509,967 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,655,349 - 10,693,042 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,655,116 - 10,693,025 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,588,758 - 18,630,089 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,588,763 - 18,633,177 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2519,024,941 - 19,070,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11149,484,459 - 49,516,941 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1149,484,518 - 49,512,541 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037196,540,987 - 196,574,325 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249041,475,664 - 1,507,588 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sp1
82 total Variants

Predicted Target Of
Summary Value
Count of predictions:711
Count of miRNA genes:272
Interacting mature miRNAs:383
Transcripts:ENSRNOT00000019403
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 12 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat

1 to 10 of 12 rows
D18Mit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81879,484,311 - 79,484,461 (+)Marker Load Pipeline
mRatBN7.21877,209,694 - 77,209,844 (+)MAPPERmRatBN7.2
Rnor_6.01880,696,226 - 80,696,375NCBIRnor6.0
Rnor_5.01879,748,238 - 79,748,387UniSTSRnor5.0
RGSC_v3.41880,370,367 - 80,370,517RGDRGSC3.4
RGSC_v3.41880,370,368 - 80,370,517UniSTSRGSC3.4
RGSC_v3.11880,443,810 - 80,444,102RGD
Celera1875,835,913 - 75,836,062UniSTS
RH 3.4 Map18814.4UniSTS
RH 3.4 Map18814.4RGD
RH 2.0 Map1853.0RGD
SHRSP x BN Map1849.0499RGD
FHH x ACI Map1860.7699RGD
Cytogenetic Map7q36UniSTS
D7Rat105  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,432,666 - 135,432,835 (+)Marker Load Pipeline
mRatBN7.27133,554,112 - 133,554,281 (+)MAPPERmRatBN7.2
Rnor_6.07144,026,790 - 144,026,958NCBIRnor6.0
Rnor_5.07141,818,660 - 141,818,828UniSTSRnor5.0
RGSC_v3.47141,176,663 - 141,176,832RGDRGSC3.4
RGSC_v3.47141,176,664 - 141,176,832UniSTSRGSC3.4
RGSC_v3.17141,253,101 - 141,253,269RGD
RH 3.4 Map71062.4UniSTS
RH 3.4 Map71062.4RGD
RH 2.0 Map7793.5RGD
SHRSP x BN Map788.51RGD
Cytogenetic Map7q36UniSTS
X60136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,566,700 - 133,566,776 (+)MAPPERmRatBN7.2
Rnor_6.07144,039,375 - 144,039,450NCBIRnor6.0
Rnor_5.07141,831,244 - 141,831,319UniSTSRnor5.0
RGSC_v3.47141,189,249 - 141,189,324UniSTSRGSC3.4
Celera7129,993,997 - 129,994,072UniSTS
Cytogenetic Map7q36UniSTS
RH131903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,571,569 - 133,571,754 (+)MAPPERmRatBN7.2
Rnor_6.07144,044,244 - 144,044,428NCBIRnor6.0
Rnor_5.07141,836,113 - 141,836,297UniSTSRnor5.0
RGSC_v3.47141,194,118 - 141,194,302UniSTSRGSC3.4
Celera7129,998,866 - 129,999,050UniSTS
RH 3.4 Map71062.9UniSTS
Cytogenetic Map7q36UniSTS
RH132106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,558,497 - 133,558,715 (+)MAPPERmRatBN7.2
Rnor_6.07144,031,174 - 144,031,391NCBIRnor6.0
Rnor_5.07141,823,043 - 141,823,260UniSTSRnor5.0
RGSC_v3.47141,181,048 - 141,181,265UniSTSRGSC3.4
Celera7129,985,797 - 129,986,014UniSTS
RH 3.4 Map71062.9UniSTS
Cytogenetic Map7q36UniSTS
RH133875  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr87135,446,173 - 135,446,369 (+)Marker Load Pipeline
mRatBN7.27133,567,621 - 133,567,817 (+)MAPPERmRatBN7.2
Rnor_6.07144,040,296 - 144,040,491NCBIRnor6.0
Rnor_5.07141,832,165 - 141,832,360UniSTSRnor5.0
RGSC_v3.47141,190,170 - 141,190,365UniSTSRGSC3.4
Celera7129,994,918 - 129,995,113UniSTS
RH 3.4 Map71062.7UniSTS
Cytogenetic Map7q36UniSTS
BE105685  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,571,147 - 133,571,349 (+)MAPPERmRatBN7.2
Rnor_6.07144,043,822 - 144,044,023NCBIRnor6.0
Rnor_5.07141,835,691 - 141,835,892UniSTSRnor5.0
RGSC_v3.47141,193,696 - 141,193,897UniSTSRGSC3.4
Celera7129,998,444 - 129,998,645UniSTS
RH 3.4 Map71063.3UniSTS
Cytogenetic Map7q36UniSTS
PMC114562P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,543,747 - 133,544,278 (+)MAPPERmRatBN7.2
Rnor_6.07144,016,430 - 144,016,960NCBIRnor6.0
Rnor_5.07141,808,299 - 141,808,829UniSTSRnor5.0
RGSC_v3.47141,166,303 - 141,166,833UniSTSRGSC3.4
Celera7129,971,108 - 129,971,638UniSTS
Cytogenetic Map7q36UniSTS
RH94510  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map71062.1UniSTS
Cytogenetic Map7q36UniSTS
RH141474  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,569,621 - 133,569,819 (+)MAPPERmRatBN7.2
Rnor_6.07144,042,296 - 144,042,493NCBIRnor6.0
Rnor_5.07141,834,165 - 141,834,362UniSTSRnor5.0
RGSC_v3.47141,192,170 - 141,192,367UniSTSRGSC3.4
Celera7129,996,918 - 129,997,115UniSTS
RH 3.4 Map71065.7UniSTS
Cytogenetic Map7q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000019403   ⟹   ENSRNOP00000019403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,541,491 - 133,571,961 (+)Ensembl
Rnor_6.0 Ensembl7144,014,173 - 144,044,629 (+)Ensembl
RefSeq Acc Id: NM_012655   ⟹   NP_036787
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,420,050 - 135,450,513 (+)NCBI
mRatBN7.27133,541,491 - 133,571,961 (+)NCBI
Rnor_6.07144,014,173 - 144,044,635 (+)NCBI
Rnor_5.07141,805,281 - 141,836,504 (+)NCBI
RGSC_v3.47141,164,180 - 141,194,509 (+)RGD
Celera7129,968,890 - 129,999,257 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078431   ⟹   XP_038934359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,420,239 - 135,450,513 (+)NCBI
mRatBN7.27133,541,803 - 133,571,961 (+)NCBI
RefSeq Acc Id: XM_039078432   ⟹   XP_038934360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87135,419,864 - 135,450,513 (+)NCBI
mRatBN7.27133,541,302 - 133,571,961 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_036787 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934359 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934360 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAP72036 (Get FASTA)   NCBI Sequence Viewer  
  BAA02235 (Get FASTA)   NCBI Sequence Viewer  
  BAC05486 (Get FASTA)   NCBI Sequence Viewer  
  EDL86841 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019403
  ENSRNOP00000019403.5
GenBank Protein Q01714 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_036787   ⟸   NM_012655
- UniProtKB: Q8K4R0 (UniProtKB/Swiss-Prot),   Q01714 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019403   ⟸   ENSRNOT00000019403
RefSeq Acc Id: XP_038934360   ⟸   XM_039078432
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038934359   ⟸   XM_039078431
- Peptide Label: isoform X1
- UniProtKB: A6KCV1 (UniProtKB/TrEMBL)
C2H2-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q01714-F1-model_v2 AlphaFold Q01714 1-786 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695699
Promoter ID:EPDNEW_R6224
Type:initiation region
Name:Sp1_1
Description:Sp1 transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07144,014,095 - 144,014,155EPDNEW


1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31937 BioCyc
Ensembl Genes ENSRNOG00000014084 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019403 ENTREZGENE
  ENSRNOT00000019403.7 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:24790 UniProtKB/Swiss-Prot
NCBI Gene 24790 ENTREZGENE
PANTHER KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
  TRANSCRIPTION FACTOR SP1 UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Sp1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014084 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
TIGR TC226427
UniProt A6KCV1 ENTREZGENE, UniProtKB/TrEMBL
  Q01714 ENTREZGENE
  Q8K4R0 ENTREZGENE
  SP1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q8K4R0 UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Sp1  Sp1 transcription factor  Sp1  trans-acting transcription factor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sp1  trans-acting transcription factor 1  Sp1  Sp1 transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sp1  Sp1 transcription factor      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_physical_interaction may interact with the insulin responsive binding protein IRBP to promote transcription of the IGF-1 gene 737656