Scn10a (sodium voltage-gated channel alpha subunit 10) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Scn10a (sodium voltage-gated channel alpha subunit 10) Rattus norvegicus
Analyze
Symbol: Scn10a
Name: sodium voltage-gated channel alpha subunit 10
RGD ID: 3629
Description: Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential and voltage-gated sodium channel activity. Involved in odontogenesis of dentin-containing tooth and sodium ion transport. Located in axon. Part of clathrin complex. Is active in glutamatergic synapse and presynaptic membrane. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-trans-(S)-allethrin; allethrin; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Na(V)1.8; Nav1.8; peripheral nerve sodium channel 3; PN3; sensory neuron sodium channel; sodium channel protein type 10 subunit alpha; sodium channel protein type X subunit alpha; sodium channel type X alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type X, alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,228,424 - 128,340,749 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8128,228,424 - 128,340,298 (-)EnsemblGRCr8
mRatBN7.28119,350,723 - 119,462,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,350,724 - 119,462,614 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,932,439 - 125,044,084 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,131,466 - 123,243,120 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,965,215 - 121,076,407 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,298,593 - 128,416,896 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,298,594 - 128,416,650 (-)Ensemblrn6Rnor6.0
Rnor_5.08127,503,061 - 127,620,197 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,578,222 - 124,690,458 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,500,856 - 118,611,564 (-)NCBICelera
RGSC_v3.18124,597,959 - 124,710,195 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lidocaine pharmacokinetics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Akopian AN, etal., Nature 1996 Jan 18;379(6562):257-62.
2. Odontoblasts in developing, mature and ageing rat teeth have multiple phenotypes that variably express all nine voltage-gated sodium channels. Byers MR and Westenbroek RE, Arch Oral Biol. 2011 Nov;56(11):1199-220.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. Gold MS, etal., J Neurosci 2003 Jan 1;23(1):158-66.
6. Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. Joshi SK, etal., J Pain. 2009 Mar;10(3):306-15. Epub 2008 Dec 13.
7. CAP-1A is a novel linker that binds clathrin and the voltage-gated sodium channel Na(v)1.8. Liu C, etal., Mol Cell Neurosci 2005 Apr;28(4):636-49.
8. Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8. Malik-Hall M, etal., Brain Res Mol Brain Res. 2003 Feb 20;110(2):298-304.
9. Functional tetrodotoxin-resistant Na(+) channels are expressed presynaptically in rat dorsal root ganglia neurons. Medvedeva YV, etal., Neuroscience. 2009 Mar 17;159(2):559-69. doi: 10.1016/j.neuroscience.2008.12.029. Epub 2008 Dec 30.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Annexin II light chain regulates sensory neuron-specific sodium channel expression. Okuse K, etal., Nature. 2002 Jun 6;417(6889):653-6.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. Sodium-calcium exchanger and multiple sodium channel isoforms in intra-epidermal nerve terminals. Persson AK, etal., Mol Pain. 2010 Nov 30;6:84. doi: 10.1186/1744-8069-6-84.
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Relationship of axonal voltage-gated sodium channel 1.8 (NaV1.8) mRNA accumulation to sciatic nerve injury-induced painful neuropathy in rats. Ruangsri S, etal., J Biol Chem. 2011 Nov 18;286(46):39836-47. Epub 2011 Sep 30.
20. Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons. Sangameswaran L, etal., J Biol Chem 1996 Mar 15;271(11):5953-6.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Differential modulation of Nav1.7 and Nav1.8 channels by antidepressant drugs. Thériault O, etal., Eur J Pharmacol. 2015 Oct 5;764:395-403. doi: 10.1016/j.ejphar.2015.06.053. Epub 2015 Jul 14.
Additional References at PubMed
PMID:9450690   PMID:9839820   PMID:11487631   PMID:14759526   PMID:14960304   PMID:15047701   PMID:15178439   PMID:16029194   PMID:16545521   PMID:17108087   PMID:17568746   PMID:17950013  
PMID:18552876   PMID:18782866   PMID:19056867   PMID:19164297   PMID:19269275   PMID:19320998   PMID:19575990   PMID:19607921   PMID:19953341   PMID:20028484   PMID:20062061   PMID:20482896  
PMID:20720009   PMID:21041692   PMID:21276017   PMID:21562192   PMID:21572961   PMID:22127815   PMID:22225591   PMID:22342308   PMID:23064159   PMID:23139220   PMID:23449670   PMID:24606981  
PMID:24724624   PMID:24763188   PMID:24990156   PMID:24998131   PMID:25503076   PMID:26005195   PMID:26597700   PMID:26764239   PMID:27327156   PMID:27631681   PMID:27905525   PMID:29956586  
PMID:30860870   PMID:33998011   PMID:34798136  


Genomics

Comparative Map Data
Scn10a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,228,424 - 128,340,749 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8128,228,424 - 128,340,298 (-)EnsemblGRCr8
mRatBN7.28119,350,723 - 119,462,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,350,724 - 119,462,614 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,932,439 - 125,044,084 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,131,466 - 123,243,120 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,965,215 - 121,076,407 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,298,593 - 128,416,896 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,298,594 - 128,416,650 (-)Ensemblrn6Rnor6.0
Rnor_5.08127,503,061 - 127,620,197 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,578,222 - 124,690,458 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,500,856 - 118,611,564 (-)NCBICelera
RGSC_v3.18124,597,959 - 124,710,195 (-)NCBI
Cytogenetic Map8q32NCBI
SCN10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,696,807 - 38,816,217 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,696,802 - 38,816,286 (-)Ensemblhg38GRCh38
GRCh37338,738,298 - 38,857,708 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,713,841 - 38,810,505 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34338,713,840 - 38,810,505NCBI
Celera338,677,898 - 38,774,543 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,781,159 - 38,877,645 (-)NCBIHuRef
CHM1_1338,690,433 - 38,787,099 (-)NCBICHM1_1
T2T-CHM13v2.0338,709,028 - 38,828,431 (-)NCBIT2T-CHM13v2.0
Scn10a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,437,522 - 119,548,388 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,437,522 - 119,548,388 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,608,456 - 119,719,322 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,608,456 - 119,719,322 (-)Ensemblmm10GRCm38
MGSCv379119,517,584 - 119,603,478 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369119,457,165 - 119,543,058 (-)NCBIMGSCv36mm8
Celera9120,082,167 - 120,168,344 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Scn10a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,157,179 - 25,243,473 (+)Ensembl
ChiLan1.0NW_00495542725,157,179 - 25,244,020 (+)NCBIChiLan1.0ChiLan1.0
SCN10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,649,419 - 38,747,494 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,654,181 - 38,752,256 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,593,765 - 38,691,172 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,876,068 - 38,972,247 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,876,068 - 38,972,247 (-)EnsemblpanPan2panpan1.1
SCN10A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,420,468 - 8,527,414 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,420,472 - 8,527,383 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha238,460,551 - 8,567,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,708,298 - 8,817,466 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,709,728 - 8,817,466 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,523,267 - 8,630,160 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,664,475 - 8,771,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,658,580 - 8,765,552 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scn10a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,871,017 - 194,982,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,010,123 - 28,102,124 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,010,123 - 28,102,124 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN10A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,481,255 - 23,570,379 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11323,481,537 - 23,570,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,726,454 - 25,805,806 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115624,962 - 724,018 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15625,742 - 721,963 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660639,354,464 - 9,451,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn10a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,254,445 - 2,355,738 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247312,254,445 - 2,356,174 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Scn10a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18110,850,399 - 110,963,140 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:72
Count of miRNA genes:62
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000046864
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
D8Rat4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88128,311,709 - 128,311,858 (+)Marker Load Pipeline
mRatBN7.28119,434,019 - 119,434,168 (+)MAPPERmRatBN7.2
Rnor_6.08128,388,056 - 128,388,204NCBIRnor6.0
Rnor_5.08127,591,320 - 127,591,468UniSTSRnor5.0
RGSC_v3.48124,661,862 - 124,662,011RGDRGSC3.4
RGSC_v3.48124,661,863 - 124,662,011UniSTSRGSC3.4
Celera8118,582,992 - 118,583,140UniSTS
RGSC_v3.18124,681,600 - 124,681,748RGD
RH 3.4 Map81286.3UniSTS
RH 3.4 Map81286.3RGD
RH 2.0 Map81002.9RGD
SHRSP x BN Map880.7899RGD
Cytogenetic Map8q32UniSTS
D8Got185  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,429,949 - 119,430,216 (+)MAPPERmRatBN7.2
Rnor_6.08128,383,986 - 128,384,252NCBIRnor6.0
Rnor_5.08127,587,250 - 127,587,516UniSTSRnor5.0
RGSC_v3.48124,657,792 - 124,658,059RGDRGSC3.4
RGSC_v3.48124,657,793 - 124,658,059UniSTSRGSC3.4
Celera8118,578,924 - 118,579,186UniSTS
RGSC_v3.18124,677,530 - 124,677,796RGD
RH 3.4 Map81285.0UniSTS
RH 3.4 Map81285.0RGD
RH 2.0 Map81023.5RGD
Cytogenetic Map8q32UniSTS
BE096280  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,350,741 - 119,350,905 (+)MAPPERmRatBN7.2
Rnor_6.08128,298,612 - 128,298,775NCBIRnor6.0
Rnor_5.08127,503,080 - 127,503,243UniSTSRnor5.0
RGSC_v3.48124,578,241 - 124,578,404UniSTSRGSC3.4
Celera8118,500,875 - 118,501,038UniSTS
RH 3.4 Map81285.3UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 51 118 32 31 5 65 5 6 166 143 8 94 10 51 26 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000046864   ⟹   ENSRNOP00000047944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,228,424 - 128,340,298 (-)Ensembl
mRatBN7.2 Ensembl8119,350,724 - 119,462,614 (-)Ensembl
Rnor_6.0 Ensembl8128,298,594 - 128,416,650 (-)Ensembl
RefSeq Acc Id: NM_017247   ⟹   NP_058943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,228,424 - 128,340,298 (-)NCBI
mRatBN7.28119,350,723 - 119,462,614 (-)NCBI
Rnor_6.08128,298,593 - 128,416,650 (-)NCBI
Rnor_5.08127,503,061 - 127,620,197 (-)NCBI
RGSC_v3.48124,578,222 - 124,690,458 (-)RGD
Celera8118,500,856 - 118,611,564 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080963   ⟹   XP_038936891
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,237,629 - 128,290,946 (-)NCBI
mRatBN7.28119,359,931 - 119,413,213 (-)NCBI
RefSeq Acc Id: XM_039080964   ⟹   XP_038936892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,228,424 - 128,340,749 (-)NCBI
mRatBN7.28119,350,723 - 119,462,882 (-)NCBI
RefSeq Acc Id: NP_058943   ⟸   NM_017247
- UniProtKB: Q63554 (UniProtKB/Swiss-Prot),   Q62968 (UniProtKB/Swiss-Prot),   Q6EWG6 (UniProtKB/Swiss-Prot),   A6I3X6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047944   ⟸   ENSRNOT00000046864
RefSeq Acc Id: XP_038936892   ⟸   XM_039080964
- Peptide Label: isoform X2
- UniProtKB: A6I3X6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936891   ⟸   XM_039080963
- Peptide Label: isoform X1
Protein Domains
Ion transport   IQ   Sodium ion transport-associated

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62968-F1-model_v2 AlphaFold Q62968 1-1956 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3629 AgrOrtholog
BioCyc Gene G2FUF-28784 BioCyc
Ensembl Genes ENSRNOG00000032473 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046864 ENTREZGENE
  ENSRNOT00000046864.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  iswi atpase UniProtKB/Swiss-Prot
InterPro Ion_trans_dom UniProtKB/Swiss-Prot
  Na_channel_asu UniProtKB/Swiss-Prot
  Na_chnl_inactivation_gate UniProtKB/Swiss-Prot
  Na_trans_assoc UniProtKB/Swiss-Prot
  VGCC_Ca_Na UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29571 UniProtKB/Swiss-Prot
NCBI Gene 29571 ENTREZGENE
PANTHER PTHR10037 UniProtKB/Swiss-Prot
  PTHR10037:SF208 UniProtKB/Swiss-Prot
Pfam Ion_trans UniProtKB/Swiss-Prot
  IQ_SCN5A_C UniProtKB/Swiss-Prot
  Na_trans_assoc UniProtKB/Swiss-Prot
PhenoGen Scn10a PhenoGen
PRINTS NACHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032473 RatGTEx
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC208312
UniProt A6I3X6 ENTREZGENE, UniProtKB/TrEMBL
  Q0Q789_RAT UniProtKB/TrEMBL
  Q62968 ENTREZGENE
  Q63554 ENTREZGENE
  Q6EWG6 ENTREZGENE
  SCNAA_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63554 UniProtKB/Swiss-Prot
  Q6EWG6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Scn10a  sodium voltage-gated channel alpha subunit 10  Scn10a  sodium channel, voltage-gated, type X, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-16 Scn10a  sodium channel, voltage-gated, type X, alpha subunit  Scn10a  sodium channel, voltage-gated, type X, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Scn10a  sodium channel, voltage-gated, type X, alpha  Scn10a  sodium channel, voltage-gated, type X, alpha subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Scn10a  sodium channel, voltage-gated, type X, alpha subunit  Scn10a  sodium channel, voltage-gated, type X, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-13 Scn10a  sodium channel, voltage-gated, type X, alpha  Scn10a  sodium channel, voltage-gated, type 10, alpha polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Scn10a  sodium channel, voltage-gated, type 10, alpha polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Scn10a  sodium channel, voltage-gated, type 10, alpha polypeptide      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed primarily in small sensory neurons of the peripheral nervous system 69978