Gene: SCN10A (sodium voltage-gated channel alpha subunit 10) Homo sapiens
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Symbol: SCN10A
Name: sodium voltage-gated channel alpha subunit 10
Description: The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FEPS2; hPN3; Nav1.8; OTTHUMP00000045936; peripheral nerve sodium channel 3; PN3; SNS; sodium channel protein type 10 subunit alpha; sodium channel protein type X subunit alpha; sodium channel, voltage gated, type X alpha subunit; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; voltage-gated sodium channel subunit alpha Nav1.8
Orthologs:
Mus musculus (house mouse) : Scn10a (sodium channel, voltage-gated, type X, alpha)  MGI
Rattus norvegicus (Norway rat) : Scn10a (sodium voltage-gated channel alpha subunit 10)
Chinchilla lanigera (long-tailed chinchilla) : Scn10a (sodium voltage-gated channel alpha subunit 10)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN10A (sodium voltage-gated channel alpha subunit 10)
Canis lupus familiaris (dog) : SCN10A (sodium voltage-gated channel alpha subunit 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn10a (sodium voltage-gated channel alpha subunit 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,697,110 - 38,794,010 (-)NCBIGRCh38hg38GRCh38
GRCh37338,738,837 - 38,835,501 (-)NCBIGRCh37hg19GRCh37
Build 36338,713,841 - 38,810,505 (-)NCBINCBI36hg18NCBI36
Build 34338,713,840 - 38,810,505NCBI
Celera338,677,898 - 38,774,543 (-)NCBI
Cytogenetic Map3p22.2NCBImapview
HuRef338,781,159 - 38,877,645 (-)NCBI
CHM1_1338,690,433 - 38,787,099 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SCN10A
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
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Vista + UCSC

RGD Object Information
RGD ID: 1349086
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2017-09-05
Status: ACTIVE