Rgs4 (regulator of G-protein signaling 4) - Rat Genome Database

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Gene: Rgs4 (regulator of G-protein signaling 4) Rattus norvegicus
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Symbol: Rgs4
Name: regulator of G-protein signaling 4
RGD ID: 3567
Description: Enables G-protein alpha-subunit binding activity; GTPase activator activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of transmembrane transport; and regulation of signal transduction. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human RGS4 (regulator of G protein signaling 4); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; calcium signaling pathway via the calcium-sensing receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: RGP4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,469,593 - 84,475,884 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1384,469,593 - 84,475,884 (-)EnsemblGRCr8
mRatBN7.21381,936,775 - 81,943,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1384,564,610 - 84,570,879 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,857,386 - 85,863,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,089,853 - 83,096,122 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)Ensemblrn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (EXP)
(S)-timolol (anhydrous)  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4,5,3',4',5'-Hexachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cytarabine  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
eticlopride(1+)  (EXP)
flavonoids  (EXP)
formaldehyde  (ISO)
haloperidol  (EXP)
hydrogen cyanide  (ISO)
irinotecan  (EXP)
kenpaullone  (EXP)
ketamine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
prednisolone  (EXP,ISO)
progesterone  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
reserpine  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
Soman  (EXP)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The physiology, signaling, and pharmacology of dopamine receptors. Beaulieu JM and Gainetdinov RR, Pharmacol Rev. 2011 Mar;63(1):182-217. doi: 10.1124/pr.110.002642. Epub 2011 Feb 8.
2. Selectivity and anti-Parkinson's potential of thiadiazolidinone RGS4 inhibitors. Blazer LL, etal., ACS Chem Neurosci. 2015 Jun 17;6(6):911-9. doi: 10.1021/acschemneuro.5b00063. Epub 2015 Apr 20.
3. Development of a bimolecular luminescence complementation assay for RGS: G protein interactions in cells. Bodle CR, etal., Anal Biochem. 2017 Apr 1;522:10-17. doi: 10.1016/j.ab.2017.01.013. Epub 2017 Jan 20.
4. A region-specific increase in Galphaq and Galpha11 proteins in brains of rats during cocaine withdrawal. Carrasco GA, etal., J Pharmacol Exp Ther. 2003 Dec;307(3):1012-9. Epub 2003 Oct 8.
5. RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. Chen IS, etal., J Physiol. 2014 Mar 15;592(6):1237-48. doi: 10.1113/jphysiol.2013.269803. Epub 2014 Jan 13.
6. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Costigan M, etal., Mol Cell Neurosci. 2003 Sep;24(1):106-16.
7. RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Ding J, etal., Nat Neurosci. 2006 Jun;9(6):832-42. doi: 10.1038/nn1700. Epub 2006 May 14.
8. Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family. Druey KM, etal., Nature 1996 Feb 22;379(6567):742-6.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Regulation of RGS proteins by chronic morphine in rat locus coeruleus. Gold SJ, etal., Eur J Neurosci. 2003 Mar;17(5):971-80.
11. Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizures. Gold SJ, etal., J Neurochem. 2002 Aug;82(4):828-38.
12. RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia. Gu Z, etal., Mol Pharmacol. 2007 Apr;71(4):1030-9. doi: 10.1124/mol.106.032490. Epub 2007 Jan 12.
13. Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. Ho AM, etal., Brain Res. 2010 Jun 22;1340:1-9. doi: 10.1016/j.brainres.2010.04.049. Epub 2010 Apr 27.
14. CASK associates with glutamate receptor interacting protein and signaling molecules. Hong CJ and Hsueh YP, Biochem Biophys Res Commun. 2006 Dec 22;351(3):771-6. Epub 2006 Oct 30.
15. Expression of RGS2, RGS4 and RGS7 in the developing postnatal brain. Ingi T and Aoki Y, Eur J Neurosci. 2002 Mar;15(5):929-36.
16. RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells. Ji M, etal., Brain Res. 2011 Sep 9;1411:1-8. doi: 10.1016/j.brainres.2011.07.008. Epub 2011 Jul 13.
17. RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease. Ko WK, etal., Neurobiol Dis. 2014 Oct;70:138-48. doi: 10.1016/j.nbd.2014.06.013. Epub 2014 Jun 24.
18. EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins. Koelle MR and Horvitz HR, Cell 1996 Jan 12;84(1):115-25.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Rapid kinetics of regulator of G-protein signaling (RGS)-mediated Galphai and Galphao deactivation. Galpha specificity of RGS4 AND RGS7. Lan KL, etal., J Biol Chem. 2000 Oct 27;275(43):33497-503. doi: 10.1074/jbc.M005785200.
21. Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence. Lin TC, etal., Epilepsy Behav. 2009 Feb;14(2):316-23. doi: 10.1016/j.yebeh.2008.12.005. Epub 2009 Jan 4.
22. Chronic intermittent ethanol exposure selectively alters the expression of Ga subunit isoforms and RGS subtypes in rat prefrontal cortex. Luessen DJ, etal., Brain Res. 2017 Oct 1;1672:106-112. doi: 10.1016/j.brainres.2017.07.014. Epub 2017 Jul 21.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. RGS4 exerts inhibitory activities on the signaling of dopamine D2 receptor and D3 receptor through the N-terminal region. Min C, etal., Pharmacol Res. 2012 Feb;65(2):213-20. doi: 10.1016/j.phrs.2011.08.008. Epub 2011 Aug 31.
25. The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat. Namvar S, etal., J Neurol Sci. 2017 Apr 15;375:450-459. doi: 10.1016/j.jns.2017.02.047. Epub 2017 Feb 22.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Pi M, etal., Endocrinology. 2002 Oct;143(10):3830-8.
29. GOA pipeline RGD automated data pipeline
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Differential regulation of RGS proteins in the prefrontal cortex of short- and long-term human opiate abusers. Rivero G, etal., Neuropharmacology. 2012 Feb;62(2):1044-51. doi: 10.1016/j.neuropharm.2011.10.015. Epub 2011 Oct 31.
32. Allosteric inhibition of the regulator of G protein signaling-Galpha protein-protein interaction by CCG-4986. Roman DL, etal., Mol Pharmacol. 2010 Sep;78(3):360-5. doi: 10.1124/mol.109.063388. Epub 2010 Jun 7.
33. Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum. Schwendt M, etal., Neuroreport. 2007 Aug 6;18(12):1261-5. doi: 10.1097/WNR.0b013e328240507a.
34. Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes. Serazin-Leroy V, etal., Biochim Biophys Acta. 2001 Nov 26;1550(1):37-51.
35. Mechanism of RGS4, a GTPase-activating protein for G protein alpha subunits. Srinivasa SP, etal., J Biol Chem. 1998 Jan 16;273(3):1529-33.
36. RGS Proteins in Heart: Brakes on the Vagus. Stewart A, etal., Front Physiol. 2012 Apr 13;3:95. doi: 10.3389/fphys.2012.00095. eCollection 2012.
37. The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration. Sun H, etal., Neuroscience. 2015 Oct 29;307:253-61. doi: 10.1016/j.neuroscience.2015.08.053. Epub 2015 Aug 28.
38. A new model of nerve injury in the rat reveals a role of Regulator of G protein Signaling 4 in tactile hypersensitivity. Taccola G, etal., Exp Neurol. 2016 Dec;286:1-11. doi: 10.1016/j.expneurol.2016.09.008. Epub 2016 Sep 15.
39. RGS4 inhibits G-protein signaling in cardiomyocytes. Tamirisa P, etal., Circulation. 1999 Jan 26;99(3):441-7.
40. Striatal gene expression of RGS2 and RGS4 is specifically mediated by dopamine D1 and D2 receptors: clues for RGS2 and RGS4 functions. Taymans JM, etal., J Neurochem 2003 Mar;84(5):1118-27.
41. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
42. Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Tesmer JJ, etal., Cell. 1997 Apr 18;89(2):251-61.
43. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Wang L, etal., Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3220-5.
44. Identification of potential therapeutic targets in hypertension-associated bladder dysfunction. Yono M, etal., BJU Int. 2010 Mar;105(6):877-83. doi: 10.1111/j.1464-410X.2009.08809.x. Epub 2009 Aug 18.
45. Antihypertensive effects of peroxisome proliferator-activated receptor-beta activation in spontaneously hypertensive rats. Zarzuelo MJ, etal., Hypertension. 2011 Oct;58(4):733-43. doi: 10.1161/HYPERTENSIONAHA.111.174490. Epub 2011 Aug 8.
Additional References at PubMed
PMID:9353196   PMID:10702309   PMID:10791963   PMID:12604710   PMID:15793568   PMID:16539683   PMID:17060050   PMID:18207159   PMID:19324084   PMID:20630860   PMID:21367864   PMID:22193724  
PMID:22970249   PMID:23977258   PMID:26119705   PMID:26478461   PMID:32779957   PMID:34450404   PMID:36793204  


Genomics

Comparative Map Data
Rgs4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81384,469,593 - 84,475,884 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1384,469,593 - 84,475,884 (-)EnsemblGRCr8
mRatBN7.21381,936,775 - 81,943,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1384,564,610 - 84,570,879 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01385,857,386 - 85,863,677 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01383,089,853 - 83,096,122 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01388,054,817 - 88,061,108 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)Ensemblrn6Rnor6.0
Rnor_5.01392,682,956 - 92,689,247 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41385,533,882 - 85,540,173 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1381,602,391 - 81,608,682 (-)NCBICelera
RGSC_v3.11385,548,069 - 85,554,361 (-)NCBI
RH 3.4 Map13510.9RGD
Cytogenetic Map13q24NCBI
RGS4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381163,068,871 - 163,076,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1163,068,775 - 163,076,802 (+)Ensemblhg38GRCh38
GRCh371163,038,661 - 163,046,592 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,305,285 - 161,313,216 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341159,770,808 - 159,778,036NCBI
Celera1136,142,715 - 136,150,908 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1134,283,724 - 134,291,924 (+)NCBIHuRef
CHM1_11164,461,279 - 164,469,481 (+)NCBICHM1_1
T2T-CHM13v2.01162,413,422 - 162,421,357 (+)NCBIT2T-CHM13v2.0
Rgs4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,569,046 - 169,575,211 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,569,046 - 169,575,211 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,741,477 - 169,747,642 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,741,477 - 169,747,642 (-)Ensemblmm10GRCm38
MGSCv371171,671,608 - 171,677,773 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361171,578,350 - 171,584,295 (-)NCBIMGSCv36mm8
Celera1172,167,498 - 172,173,650 (-)NCBICelera
Cytogenetic Map1H2.3NCBI
cM Map176.84NCBI
Rgs4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546213,338,960 - 13,347,610 (-)Ensembl
ChiLan1.0NW_00495546213,340,812 - 13,347,598 (-)NCBIChiLan1.0ChiLan1.0
RGS4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2186,701,675 - 86,709,417 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1186,370,272 - 86,378,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01138,488,317 - 138,496,497 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11142,284,040 - 142,292,225 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1142,284,040 - 142,292,225 (+)EnsemblpanPan2panpan1.1
RGS4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13819,771,454 - 19,778,917 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3819,771,441 - 19,779,190 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3819,826,659 - 19,834,129 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03819,854,868 - 19,862,329 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3819,824,617 - 19,862,433 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13819,830,174 - 19,837,642 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03820,181,940 - 20,189,434 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03820,473,021 - 20,480,491 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rgs4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344103,671,010 - 103,678,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937238102,061 - 109,474 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004937238101,948 - 109,513 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGS4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl487,383,345 - 87,390,893 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1487,383,336 - 87,390,478 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2495,096,206 - 95,103,332 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGS4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12565,729,344 - 65,735,278 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2565,726,394 - 65,735,381 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605567,526,009 - 67,532,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgs4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248261,569,854 - 1,579,627 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248261,570,143 - 1,577,300 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rgs4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11048,935,024 - 48,941,287 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rgs4
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:207
Interacting mature miRNAs:254
Transcripts:ENSRNOT00000003774
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH133702  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81384,471,519 - 84,471,703 (+)Marker Load Pipeline
mRatBN7.21381,938,701 - 81,938,885 (+)MAPPERmRatBN7.2
Rnor_6.01388,056,744 - 88,056,927NCBIRnor6.0
Rnor_5.01392,684,883 - 92,685,066UniSTSRnor5.0
RGSC_v3.41385,535,809 - 85,535,992UniSTSRGSC3.4
Celera1381,604,318 - 81,604,501UniSTS
RH 3.4 Map13516.8UniSTS
Cytogenetic Map13q24UniSTS
RH142220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,937,024 - 81,937,191 (+)MAPPERmRatBN7.2
Rnor_6.01388,055,067 - 88,055,233NCBIRnor6.0
Rnor_5.01392,683,206 - 92,683,372UniSTSRnor5.0
RGSC_v3.41385,534,132 - 85,534,298UniSTSRGSC3.4
Celera1381,602,641 - 81,602,807UniSTS
RH 3.4 Map13510.9UniSTS
Cytogenetic Map13q24UniSTS
RH140719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,937,579 - 81,937,708 (+)MAPPERmRatBN7.2
Rnor_6.01388,055,622 - 88,055,750NCBIRnor6.0
Rnor_5.01392,683,761 - 92,683,889UniSTSRnor5.0
RGSC_v3.41385,534,687 - 85,534,815UniSTSRGSC3.4
Celera1381,603,196 - 81,603,324UniSTS
RH 3.4 Map13510.9UniSTS
Cytogenetic Map13q24UniSTS
RH141357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,937,094 - 81,937,295 (+)MAPPERmRatBN7.2
Rnor_6.01388,055,137 - 88,055,337NCBIRnor6.0
Rnor_5.01392,683,276 - 92,683,476UniSTSRnor5.0
RGSC_v3.41385,534,202 - 85,534,402UniSTSRGSC3.4
Celera1381,602,711 - 81,602,911UniSTS
RH 3.4 Map13513.5UniSTS
Cytogenetic Map13q24UniSTS
AA004315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21381,939,015 - 81,939,116 (+)MAPPERmRatBN7.2
Rnor_6.01388,057,058 - 88,057,158NCBIRnor6.0
Rnor_5.01392,685,197 - 92,685,297UniSTSRnor5.0
RGSC_v3.41385,536,123 - 85,536,223UniSTSRGSC3.4
Celera1381,604,632 - 81,604,732UniSTS
Cytogenetic Map13q24UniSTS
MARC_16101-16102:1018026133:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81384,472,477 - 84,473,463 (+)Marker Load Pipeline
mRatBN7.21381,939,658 - 81,940,647 (+)MAPPERmRatBN7.2
Rnor_6.01388,057,701 - 88,058,687NCBIRnor6.0
Rnor_5.01392,685,840 - 92,686,826UniSTSRnor5.0
RGSC_v3.41385,536,766 - 85,537,752UniSTSRGSC3.4
Celera1381,605,275 - 81,606,261UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 43 59 6 299 143 11 141 73 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003774   ⟹   ENSRNOP00000003774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,469,593 - 84,475,884 (-)Ensembl
mRatBN7.2 Ensembl1381,936,775 - 81,943,068 (-)Ensembl
Rnor_6.0 Ensembl1388,054,817 - 88,061,108 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098564   ⟹   ENSRNOP00000076439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,469,593 - 84,473,853 (-)Ensembl
mRatBN7.2 Ensembl1381,936,775 - 81,941,037 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117519   ⟹   ENSRNOP00000089881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1384,471,953 - 84,475,884 (-)Ensembl
mRatBN7.2 Ensembl1381,939,135 - 81,943,068 (-)Ensembl
RefSeq Acc Id: NM_017214   ⟹   NP_058910
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81384,469,593 - 84,475,884 (-)NCBI
mRatBN7.21381,936,775 - 81,943,068 (-)NCBI
Rnor_6.01388,054,817 - 88,061,108 (-)NCBI
Rnor_5.01392,682,956 - 92,689,247 (-)NCBI
RGSC_v3.41385,533,882 - 85,540,173 (-)RGD
Celera1381,602,391 - 81,608,682 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058910 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52367 (Get FASTA)   NCBI Sequence Viewer  
  AAC52440 (Get FASTA)   NCBI Sequence Viewer  
  AAD12065 (Get FASTA)   NCBI Sequence Viewer  
  EDM09268 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003774
  ENSRNOP00000003774.2
GenBank Protein P49799 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058910   ⟸   NM_017214
- UniProtKB: P49799 (UniProtKB/Swiss-Prot),   A6IDM9 (UniProtKB/TrEMBL),   A0A8I5Y8W6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003774   ⟸   ENSRNOT00000003774
Ensembl Acc Id: ENSRNOP00000076439   ⟸   ENSRNOT00000098564
Ensembl Acc Id: ENSRNOP00000089881   ⟸   ENSRNOT00000117519
Protein Domains
RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49799-F1-model_v2 AlphaFold P49799 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698980
Promoter ID:EPDNEW_R9505
Type:single initiation site
Name:Rgs4_1
Description:regulator of G-protein signaling 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01388,061,119 - 88,061,179EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3567 AgrOrtholog
BioCyc Gene G2FUF-17491 BioCyc
Ensembl Genes ENSRNOG00000002773 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003774 ENTREZGENE
  ENSRNOT00000003774.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.167.10 UniProtKB/Swiss-Prot
  1.10.196.10 UniProtKB/Swiss-Prot
InterPro RGS UniProtKB/Swiss-Prot
  RGS_RGS4 UniProtKB/Swiss-Prot
  RGS_sf UniProtKB/Swiss-Prot
  RGS_subdom1/3 UniProtKB/Swiss-Prot
  RGS_subdomain_2 UniProtKB/Swiss-Prot
KEGG Report rno:29480 UniProtKB/Swiss-Prot
NCBI Gene 29480 ENTREZGENE
PANTHER PTHR10845:SF184 UniProtKB/Swiss-Prot
  REGULATOR OF G PROTEIN SIGNALING UniProtKB/Swiss-Prot
Pfam RGS UniProtKB/Swiss-Prot
PhenoGen Rgs4 PhenoGen
PRINTS RGSPROTEIN UniProtKB/Swiss-Prot
PROSITE RGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002773 RatGTEx
SMART RGS UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48097 UniProtKB/Swiss-Prot
TIGR TC216573
UniProt A0A8I5Y8W6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIG2_RAT UniProtKB/TrEMBL
  A6IDM9 ENTREZGENE, UniProtKB/TrEMBL
  P49799 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rgs4  regulator of G-protein signaling 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function may interact with heterotrimeric G protein alpha subunits and function as a GAP 69961