Enables retinol binding activity. Involved in several processes, including response to ethanol; response to muscle activity; and retinol transport. Located in extracellular space. Part of protein-containing complex. Biomarker of atherosclerosis; hypertension; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease and type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4); PARTICIPATES IN retinoic acid metabolic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol.
[Progesterone co-treated with Estradiol] results in increased expression of RBP4 mRNA and Estradiol results in increased expression of and results in increased secretion of RBP4 protein
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RBP4 mRNA
[Fenretinide binds to RBP4 protein] inhibits the reaction [RBP4 protein binds to TTR protein] and Fenretinide analog inhibits the reaction [Vitamin A promotes the reaction [RBP4 protein binds to TTR protein]]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RBP4 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of RBP4 mRNA
RBP4 protein promotes the reaction [[mono-(2-ethylhexyl)phthalate results in decreased activity of INS protein] which results in decreased phosphorylation of GSK3B protein] more ...
[Progesterone results in increased activity of PGR protein] which results in decreased expression of RBP4 mRNA and Mifepristone inhibits the reaction [Progesterone results in decreased expression of RBP4 mRNA]
Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study.
Increased levels of retinol binding protein 4 in patients with advanced heart failure correct after hemodynamic improvement through ventricular assist device placement.
Elevated serum retinol-binding protein 4 concentrations are associated with chronic kidney disease but not with the higher carotid intima-media thickness in type 2 diabetic subjects.
Association of retinol binding protein 4 and transthyretin with triglyceride levels and insulin resistance in rural thais with high type 2 diabetes risk.
Studies on the transport and cellular distribution of vitamin A in normal and vitamin A-deficient rats with special reference to the vitamin A-binding plasma protein.
Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue.
The inverse association between fasting blood glucose and the occurrence of gallbladder cancer in type 2 diabetes mellitus patients: a case-control study.