RBP4 (retinol binding protein 4) - Rat Genome Database

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Gene: RBP4 (retinol binding protein 4) Canis lupus familiaris
Analyze
Symbol: RBP4
Name: retinol binding protein 4
RGD ID: 12264551
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); retinol binding (ortholog); INVOLVED IN cardiac muscle tissue development (ortholog); detection of light stimulus involved in visual perception (ortholog); embryonic organ morphogenesis (ortholog); PARTICIPATES IN retinoic acid metabolic pathway; ASSOCIATED WITH Microphthalmia/Coloboma 10; Acute Coronary Syndrome (ortholog); acute pyelonephritis (ortholog); FOUND IN extracellular space (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinol-binding protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,822,936 - 7,830,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,822,944 - 7,830,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,999,367 - 8,007,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,083,216 - 8,090,965 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,083,226 - 8,090,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,802,939 - 7,810,708 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,832,158 - 7,839,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,002,083 - 8,009,832 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute pyelonephritis  (ISO)
Alcoholic Liver Diseases  (ISO)
Animal Mammary Neoplasms  (ISO)
Anophthalmia  (ISO)
anterior segment dysgenesis  (ISO)
aortic disease  (ISO)
Arteriovenous Fistula  (ISO)
atherosclerosis  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Carotid Atherosclerosis  (ISO)
cerebral infarction  (ISO)
chronic kidney disease  (ISO)
coloboma  (ISO)
colon adenoma  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (ISO)
Dyslipidemias  (ISO)
essential hypertension  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
Eye Abnormalities  (ISO)
familial hypercholesterolemia  (ISO)
familial temporal lobe epilepsy 1  (ISO)
gallbladder cancer  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
Insulin Resistance  (ISO)
Jaundice  (ISO)
keratomalacia  (ISO)
kidney disease  (ISO)
liver cirrhosis  (ISO)
Metabolic Syndrome  (ISO)
microphthalmia  (ISO)
Microphthalmia/Coloboma 10  (IAGP,ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
obesity  (ISO)
Pediatric Obesity  (ISO)
polycystic ovary syndrome  (ISO)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (ISO)
Prehypertension  (ISO)
proliferative diabetic retinopathy  (ISO)
psoriasis  (ISO)
Retinal Dystrophy, Iris Coloboma, and Comedogenic Acne Syndrome  (ISO)
severe pre-eclampsia  (ISO)
Spontaneous Abortions  (ISO)
Stable Angina  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
type 2 diabetes mellitus  (ISO)
Vision Disorders  (ISO)
Vitamin A Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:29847795   PMID:30032202  


Genomics

Comparative Map Data
RBP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,822,936 - 7,830,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,822,944 - 7,830,750 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,999,367 - 8,007,133 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0288,083,216 - 8,090,965 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl288,083,226 - 8,090,980 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,802,939 - 7,810,708 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,832,158 - 7,839,906 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0288,002,083 - 8,009,832 (-)NCBIUU_Cfam_GSD_1.0
RBP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381093,591,694 - 93,601,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1093,591,687 - 93,601,744 (-)EnsemblGRCh38hg38GRCh38
GRCh371095,351,451 - 95,361,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361095,341,583 - 95,350,983 (-)NCBINCBI36Build 36hg18NCBI36
Build 341095,341,583 - 95,350,983NCBI
Celera1089,092,718 - 89,102,118 (-)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,979,353 - 88,988,753 (-)NCBIHuRef
CHM1_11095,634,147 - 95,643,547 (-)NCBICHM1_1
T2T-CHM13v2.01094,471,646 - 94,481,695 (-)NCBIT2T-CHM13v2.0
Rbp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391938,105,068 - 38,113,769 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1938,105,077 - 38,113,729 (-)EnsemblGRCm39 Ensembl
GRCm381938,116,620 - 38,125,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1938,116,629 - 38,125,281 (-)EnsemblGRCm38mm10GRCm38
MGSCv371938,191,110 - 38,199,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361938,181,773 - 38,190,392 (-)NCBIMGSCv36mm8
Celera1938,908,311 - 38,919,212 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.75NCBI
Rbp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81245,306,349 - 245,313,551 (-)NCBIGRCr8
mRatBN7.21235,893,917 - 235,901,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,893,917 - 235,901,399 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,315,318 - 244,322,517 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01251,211,097 - 251,218,299 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,049,331 - 244,056,533 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,806,476 - 256,813,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,806,472 - 256,813,711 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01264,286,998 - 264,294,396 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,443,795 - 242,450,997 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11242,637,193 - 242,644,147 (-)NCBI
Celera1232,987,269 - 232,994,470 (-)NCBICelera
RH 3.4 Map11581.5RGD
Cytogenetic Map1q53NCBI
Rbp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955507108,669 - 120,584 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955507112,342 - 120,050 (-)NCBIChiLan1.0ChiLan1.0
RBP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28105,629,725 - 105,639,359 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110105,635,040 - 105,644,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01090,337,879 - 90,347,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11093,848,166 - 93,857,679 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1093,848,166 - 93,857,887 (-)Ensemblpanpan1.1panPan2
Rbp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721339,768,612 - 39,777,592 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366011,402,691 - 1,410,208 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366011,401,215 - 1,410,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14105,037,464 - 105,044,765 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114105,037,360 - 105,044,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214114,769,053 - 114,775,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RBP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1986,831,042 - 86,840,668 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl986,830,957 - 86,840,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604847,606,135 - 47,615,805 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247374,791,628 - 4,800,989 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247374,795,054 - 4,800,830 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RBP4
156 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 9 6 6 3
Medium 2 13 1 6 12 10 3
Low 3 5 5 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012608   ⟹   ENSCAFP00000011675
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl287,823,017 - 7,830,750 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000082556   ⟹   ENSCAFP00000052651
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl287,822,944 - 7,830,741 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034364   ⟹   ENSCAFP00845026904
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl288,083,226 - 8,090,971 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845034407   ⟹   ENSCAFP00845026944
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl288,083,300 - 8,090,980 (-)Ensembl
RefSeq Acc Id: XM_038439954   ⟹   XP_038295882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0288,083,216 - 8,090,965 (-)NCBI
RefSeq Acc Id: XM_038514567   ⟹   XP_038370495
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1287,802,939 - 7,810,708 (-)NCBI
RefSeq Acc Id: XM_038578212   ⟹   XP_038434140
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0288,002,083 - 8,009,832 (-)NCBI
RefSeq Acc Id: XM_038642378   ⟹   XP_038498306
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0287,832,158 - 7,839,906 (-)NCBI
RefSeq Acc Id: XM_534969   ⟹   XP_534969
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,822,936 - 7,830,735 (-)NCBI
Dog10K_Boxer_Tasha287,999,367 - 8,007,133 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_534969   ⟸   XM_534969
- Sequence:
RefSeq Acc Id: ENSCAFP00000052651   ⟸   ENSCAFT00000082556
RefSeq Acc Id: ENSCAFP00000011675   ⟸   ENSCAFT00000012608
RefSeq Acc Id: XP_038370495   ⟸   XM_038514567
RefSeq Acc Id: XP_038498306   ⟸   XM_038642378
RefSeq Acc Id: XP_038295882   ⟸   XM_038439954
RefSeq Acc Id: XP_038434140   ⟸   XM_038578212
RefSeq Acc Id: ENSCAFP00845026944   ⟸   ENSCAFT00845034407
RefSeq Acc Id: ENSCAFP00845026904   ⟸   ENSCAFT00845034364
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Promoters
RGD ID:13688269
Promoter ID:EPDNEW_C6337
Type:initiation region
Name:RBP4_1
Description:retinol binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,830,369 - 7,830,429EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007893 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040021615 UniProtKB/TrEMBL
  ENSCAFG00845019496 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012608.5 UniProtKB/TrEMBL
  ENSCAFT00000082556.2 UniProtKB/TrEMBL
  ENSCAFT00040040119.1 UniProtKB/TrEMBL
  ENSCAFT00040040156.1 UniProtKB/TrEMBL
  ENSCAFT00845034364.1 UniProtKB/TrEMBL
  ENSCAFT00845034407.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/TrEMBL
InterPro Calycin UniProtKB/TrEMBL
  Lipocalin_ApoD UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/TrEMBL
  Retinol-bd/Purpurin UniProtKB/TrEMBL
NCBI Gene RBP4 ENTREZGENE
PANTHER PTHR11873 UniProtKB/TrEMBL
  RETINOL-BINDING PROTEIN 4 UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/TrEMBL
PIRSF Lipocalin_ApoD UniProtKB/TrEMBL
  RBP_purpurin UniProtKB/TrEMBL
PRINTS LIPOCALIN UniProtKB/TrEMBL
  RETINOLBNDNG UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/TrEMBL
UniProt A0A8C0TEJ5_CANLF UniProtKB/TrEMBL
  A0A8C0TFD3_CANLF UniProtKB/TrEMBL
  A0A8I3PAG4_CANLF UniProtKB/TrEMBL
  A0A8I3S143_CANLF UniProtKB/TrEMBL
  A0A8P0T552_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:45432 ENTREZGENE