Rbp1 (retinol binding protein 1) - Rat Genome Database

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Gene: Rbp1 (retinol binding protein 1) Rattus norvegicus
Analyze
Symbol: Rbp1
Name: retinol binding protein 1
RGD ID: 3543
Description: Enables retinol binding activity. Involved in response to benzoic acid; response to retinoic acid; and retinoid metabolic process. Located in cell body. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human RBP1 (retinol binding protein 1); PARTICIPATES IN retinoic acid metabolic pathway; retinoid cycle metabolic pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cellular retinol-binding protein I; CRBP; CRBP-I; retinol binding protein 1, cellular; Retinol-binding protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88107,904,589 - 107,926,109 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8107,887,417 - 107,983,847 (+)EnsemblGRCr8
mRatBN7.2899,025,218 - 99,046,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,025,206 - 99,046,743 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8104,694,098 - 104,715,613 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08102,893,354 - 102,914,875 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08100,735,862 - 100,757,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08106,449,321 - 106,470,842 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8106,449,321 - 106,470,842 (+)Ensemblrn6Rnor6.0
Rnor_5.08105,891,160 - 105,912,681 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48103,605,870 - 103,627,390 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera898,434,714 - 98,456,228 (+)NCBICelera
RGSC_v3.18103,625,419 - 103,646,845 (+)NCBI
RH 3.4 Map81051.49RGD
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-bromohexadecanoic acid  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP,ISO)
ammonium chloride  (EXP)
arotinoid acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumarin  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrazine  (EXP)
inulin  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
N-acetyl-beta-D-glucosamine  (ISO)
N-acetyl-D-glucosamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
Soman  (EXP)
sunitinib  (ISO)
terbufos  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
toluene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell body  (IDA)
cytoplasm  (IDA,IEA)
cytosol  (IBA,IEA,ISO)
lipid droplet  (IEA,ISO,ISS)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mass spectrometry techniques for detection of ligand-dependent changes in the conformational flexibility of cellular retinol-binding protein type I localized by hydrogen/deuterium exchange. Careri M, etal., Rapid Commun Mass Spectrom. 2006;20(13):1973-80.
2. Uptake and esterification of vitamin A by RCS rat retinal pigment epithelial cells in primary culture. Cia D, etal., Vision Res. 2004 Feb;44(3):247-55.
3. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Everts HB, etal., Exp Cell Res. 2005 Aug 15;308(2):309-19.
4. Structure and backbone dynamics of Apo- and holo-cellular retinol-binding protein in solution. Franzoni L, etal., J Biol Chem 2002 Jun 14;277(24):21983-97.
5. New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers. Franzoni L, etal., J Lipid Res. 2010 Jun;51(6):1332-43. Epub 2009 Nov 25.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Localizations of visual cycle components in retinal pigment epithelium. Huang J, etal., Mol Vis. 2009;15:223-34. Epub 2009 Jan 26.
9. Global methylation analysis identifies prognostically important epigenetically inactivated tumor suppressor genes in multiple myeloma. Kaiser MF, etal., Blood. 2013 Jul 11;122(2):219-26. doi: 10.1182/blood-2013-03-487884. Epub 2013 May 22.
10. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, etal., Biochim Biophys Acta. 2012 Jan;1821(1):137-51. Epub 2011 Apr 5.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility. Lu J, etal., J Mol Biol. 2003 Jul 18;330(4):799-812.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Physiological insights into all-trans-retinoic acid biosynthesis. Napoli JL Biochim Biophys Acta. 2012 Jan;1821(1):152-67. Epub 2011 May 19.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenzanthracene. Shan L, etal., Carcinogenesis. 2002 Oct;23(10):1561-8.
20. Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. Sherman DR, etal., Proc Natl Acad Sci U S A 1987 May;84(10):3209-13.
21. All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and Testicular Cell Fate. Spade DJ, etal., Toxicol Sci. 2019 Feb 1;167(2):546-558. doi: 10.1093/toxsci/kfy260.
22. All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity. Spade DJ, etal., Toxicol Sci. 2019 Mar 1;168(1):149-159. doi: 10.1093/toxsci/kfy283.
Additional References at PubMed
PMID:2054343   PMID:3584109   PMID:4039728   PMID:6541654   PMID:6942701   PMID:7683727   PMID:11222375   PMID:12631600   PMID:15193143   PMID:15632377   PMID:15765518   PMID:18503097  
PMID:22230368   PMID:22944241   PMID:28057518   PMID:31746385  


Genomics

Comparative Map Data
Rbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88107,904,589 - 107,926,109 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8107,887,417 - 107,983,847 (+)EnsemblGRCr8
mRatBN7.2899,025,218 - 99,046,740 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl899,025,206 - 99,046,743 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8104,694,098 - 104,715,613 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08102,893,354 - 102,914,875 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08100,735,862 - 100,757,379 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08106,449,321 - 106,470,842 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8106,449,321 - 106,470,842 (+)Ensemblrn6Rnor6.0
Rnor_5.08105,891,160 - 105,912,681 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48103,605,870 - 103,627,390 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera898,434,714 - 98,456,228 (+)NCBICelera
RGSC_v3.18103,625,419 - 103,646,845 (+)NCBI
RH 3.4 Map81051.49RGD
Cytogenetic Map8q31NCBI
RBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383139,517,438 - 139,539,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3139,517,434 - 139,539,829 (-)Ensemblhg38GRCh38
GRCh373139,236,280 - 139,258,584 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363140,718,970 - 140,741,175 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343140,718,977 - 140,741,188NCBI
Celera3137,659,177 - 137,681,571 (-)NCBICelera
Cytogenetic Map3q23NCBI
HuRef3136,611,722 - 136,634,115 (-)NCBIHuRef
CHM1_13139,199,741 - 139,222,138 (-)NCBICHM1_1
T2T-CHM13v2.03142,264,863 - 142,287,171 (-)NCBIT2T-CHM13v2.0
Rbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,305,014 - 98,328,604 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl998,305,014 - 98,328,628 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38998,422,961 - 98,446,551 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl998,422,961 - 98,446,575 (+)Ensemblmm10GRCm38
MGSCv37998,323,380 - 98,346,970 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36998,232,313 - 98,255,903 (+)NCBIMGSCv36mm8
Celera997,975,569 - 97,999,047 (+)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map951.36NCBI
Rbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555086,046,316 - 6,072,288 (+)Ensembl
ChiLan1.0NW_0049555086,046,738 - 6,072,202 (+)NCBIChiLan1.0ChiLan1.0
RBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,431,555 - 137,453,940 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13137,436,285 - 137,458,668 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03136,554,315 - 136,576,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13144,153,937 - 144,176,209 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3144,153,937 - 144,176,209 (-)EnsemblpanPan2panpan1.1
RBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12335,677,844 - 35,698,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2335,679,176 - 35,698,363 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2335,665,589 - 35,686,876 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02336,214,587 - 36,235,924 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2336,214,587 - 36,236,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12335,896,788 - 35,918,084 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02335,970,311 - 35,991,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02336,212,783 - 36,234,124 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560274,860,890 - 74,886,796 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365401,600,398 - 1,626,652 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365401,600,673 - 1,626,573 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1380,380,962 - 80,407,458 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11380,380,958 - 80,407,328 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21388,047,841 - 88,073,765 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,011,664 - 51,033,963 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604123,988,481 - 24,010,687 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473016,091,863 - 16,119,591 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473016,091,863 - 16,119,591 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rbp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1889,800,189 - 89,821,304 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rbp1
105 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000018622
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
RH94499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2899,046,615 - 99,046,698 (+)MAPPERmRatBN7.2
Rnor_6.08106,470,718 - 106,470,800NCBIRnor6.0
Rnor_5.08105,912,557 - 105,912,639UniSTSRnor5.0
RGSC_v3.48103,627,266 - 103,627,348UniSTSRGSC3.4
Celera898,456,104 - 98,456,186UniSTS
RH 3.4 Map81051.49UniSTS
Cytogenetic Map8q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 29 59 6 293 129 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000018622   ⟹   ENSRNOP00000018622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8107,887,417 - 107,926,112 (+)Ensembl
mRatBN7.2 Ensembl899,025,206 - 99,046,743 (+)Ensembl
Rnor_6.0 Ensembl8106,449,321 - 106,470,842 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000018755   ⟹   ENSRNOP00000018755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8107,904,515 - 107,983,847 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000134126   ⟹   ENSRNOP00000111588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8107,904,515 - 107,930,681 (+)Ensembl
RefSeq Acc Id: NM_012733   ⟹   NP_036865
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88107,904,589 - 107,926,109 (+)NCBI
mRatBN7.2899,025,218 - 99,046,740 (+)NCBI
Rnor_6.08106,449,321 - 106,470,842 (+)NCBI
Rnor_5.08105,891,160 - 105,912,681 (+)NCBI
RGSC_v3.48103,605,870 - 103,627,390 (+)RGD
Celera898,434,714 - 98,456,228 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40962 (Get FASTA)   NCBI Sequence Viewer  
  AAA42021 (Get FASTA)   NCBI Sequence Viewer  
  EDL77465 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018622.2
GenBank Protein P02696 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036865   ⟸   NM_012733
- UniProtKB: P02696 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018622   ⟸   ENSRNOT00000018622
Ensembl Acc Id: ENSRNOP00000018755   ⟸   ENSRNOT00000018755
Ensembl Acc Id: ENSRNOP00000111588   ⟸   ENSRNOT00000134126

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02696-F1-model_v2 AlphaFold P02696 1-135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696201
Promoter ID:EPDNEW_R6726
Type:initiation region
Name:Rbp1_1
Description:retinol binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08106,449,337 - 106,449,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3543 AgrOrtholog
BioCyc Gene G2FUF-29419 BioCyc
BioCyc Pathway PWY-6857 [retinol biosynthesis] BioCyc
  PWY-6861 [the visual cycle I (vertebrates)] BioCyc
  PWY-6872 [retinoate biosynthesis I] BioCyc
  PWY-6875 [retinoate biosynthesis II] BioCyc
BioCyc Pathway Image PWY-6857 BioCyc
  PWY-6861 BioCyc
  PWY-6872 BioCyc
  PWY-6875 BioCyc
Ensembl Genes ENSRNOG00000013794 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018622.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
InterPro Calycin UniProtKB/Swiss-Prot
  CRBP1 UniProtKB/Swiss-Prot
  Fatty_acid-bd UniProtKB/Swiss-Prot
  ILBP UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
KEGG Report rno:25056 UniProtKB/Swiss-Prot
NCBI Gene 25056 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Rbp1 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot
PROSITE FABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013794 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
UniProt A0ABK0M847_RAT UniProtKB/TrEMBL
  A6I2B2_RAT UniProtKB/TrEMBL
  P02696 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Rbp1  retinol binding protein 1  Rbp1  retinol binding protein 1, cellular  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rbp1  retinol binding protein 1, cellular    retinol binding protein 1  Name updated 1299863 APPROVED
2002-06-10 Rbp1  Retinol-binding protein 1      Symbol and Name status set to approved 70586 APPROVED