RETINOID CYCLE METABOLIC PATHWAY (PW:0001005)

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Description

The retinoid cycle metabolic pathway, also known as the visual cycle, represents the set of enzymatic reactions underlying the regeneration of vitamin A derived chromophore 11-cis retinal which assures the continued visual phototransduction response to light. The chromophore is covalently bound to the G-protein coupled (GPCR) photoreceptors; the linkage is supplied by a protonated Schiff base to a lysine residue. In the absence of light 11-cis retinal acts as an inverse agonist by constraining t

Pathway Diagram:

Ariadne Genomics Inc. 11-cis-retinal --+> visual phototransduction pathway 11-cis-retinal ---> all-trans-retinal light 11-cis-retinal NADH NAD+ 11-cis-retinol retinyl ester phosphatidylcholine all-trans-retinol all-trans-retinal NADP+ NADPH ATP ADP Rho cone opsins visual phototransduction pathway Rlbp1 11-cis-retinal ---- Rlbp1 Rbp1 Lrat Rpe65 NAD+ ---> NADH 11-cis-retinol ---> 11-cis-retinal NADPH ---> NADP+ all-trans-retinal ---> all-trans-retinol Abca4 ATP ---> ADP light --+> 11-cis-retinal all-trans-retinol ---> retinyl ester Rdh8 Rdh12 Abca4 ---> all-trans-retinal Abca4 ---- all-trans-retinal retinyl ester ---> 11-cis-retinol all-trans-retinol ---- Rbp1 11-cis-retinal ---- Rho 11-cis-retinal ---- cone opsins Rdh10 Rdh11 Rdh5 all-trans-retinol ---- Rbp3 Rbp3 phosphatidylcholine ---> retinyl ester
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Genes in Pathway:

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retinoid cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca4 ATP binding cassette subfamily A member 4 JBrowse link 2 225,645,539 225,783,288 RGD:6893650
G Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) JBrowse link 2 181,896,304 181,905,366 RGD:6893650
G Opn1mw opsin 1 (cone pigments), medium-wave-sensitive JBrowse link X 156,569,683 156,589,907 RGD:6893536
G Opn1sw opsin 1, short wave sensitive JBrowse link 4 56,653,840 56,656,980 RGD:6893536
G Rbp1 retinol binding protein 1 JBrowse link 8 106,449,321 106,470,842 RGD:6893650
G Rbp3 retinol binding protein 3 JBrowse link 16 10,277,775 10,286,243 RGD:6893650
G Rdh10 retinol dehydrogenase 10 JBrowse link 5 2,605,265 2,631,905 RGD:6893650
G Rdh11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) JBrowse link 6 102,356,498 102,372,618 RGD:6893650
G Rdh12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) JBrowse link 6 102,392,828 102,405,750 RGD:6893650
G Rdh5 retinol dehydrogenase 5 JBrowse link 7 3,335,681 3,342,573 RGD:6893650
G Rdh8 retinol dehydrogenase 8 (all-trans) JBrowse link 8 21,835,065 21,842,374 RGD:6893650
G Rho rhodopsin JBrowse link 4 147,832,136 147,837,298 RGD:6893536
G Rlbp1 retinaldehyde binding protein 1 JBrowse link 1 141,097,789 141,111,375 RGD:6903223
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:6893650
RGD:6893661
altered retinoid cycle metabolic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca4 ATP binding cassette subfamily A member 4 JBrowse link 2 225,645,539 225,783,288 RGD:8547536
G Lrat lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) JBrowse link 2 181,896,304 181,905,366 RGD:8547536
G Rbp3 retinol binding protein 3 JBrowse link 16 10,277,775 10,286,243 RGD:8547536
G Rdh12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis) JBrowse link 6 102,392,828 102,405,750 RGD:8547536
G Rlbp1 retinaldehyde binding protein 1 JBrowse link 1 141,097,789 141,111,375 RGD:8547536
G Rpe65 RPE65, retinoid isomerohydrolase JBrowse link 2 266,141,581 266,169,197 RGD:8547536

Pathway Gene Annotations

Disease Annotations Associated with Genes in the retinoid cycle metabolic pathway
Disease TermsGene Symbols
Amaurosis Congenita of Leber, Type 2Rpe65
Autoimmune DiseasesRbp3
BlindnessAbca4 , Rpe65
Blue Cone MonochromatismOpn1mw
Bothnia Retinal DystrophyRlbp1
CarcinomaRbp1
Carcinoma, Basal CellRpe65
Carcinoma, Ductal, BreastLrat
Carcinoma, Squamous CellRpe65
Cleft LipAbca4
Colorblindness, Partial, Deutan SeriesOpn1mw
Colorectal NeoplasmsAbca4
Cone-Rod Dystrophy 3Abca4
Congenital AbnormalitiesRdh5
Craniofacial AbnormalitiesRdh10
Diabetes Mellitus, ExperimentalRpe65
Drug-Induced Liver InjuryLrat , Rbp1
Eye Diseases, HereditaryLrat , Rlbp1 , Rpe65
Fetal DeathRdh10
Fundus AlbipunctatusRdh5 , Rho , Rlbp1
Leber Congenital AmaurosisLrat , Rbp1 , Rpe65
Leber Congenital Amaurosis 13Rdh12
Leber Congenital Amaurosis 14Lrat
Leber Congenital Amaurosis 3Rdh12
Liver Cirrhosis, ExperimentalLrat , Rdh10
Macular DegenerationAbca4
Macular Degeneration, Age-Related, 2Abca4
Macular Dystrophy, Concentric AnnularAbca4
Mammary Neoplasms, AnimalRbp1
Mammary Neoplasms, ExperimentalRbp1
Mandibulofacial Dysostosis with Mental DeficiencyAbca4
MyopiaRdh5
Newfoundland Rod-Cone DystrophyRlbp1
Night BlindnessRdh5 , Rho , Rlbp1
Night Blindness, Congenital StationaryRho
Night Blindness, Congenital Stationary, Autosomal Dominant 1Rho
Optic Atrophy, Hereditary, LeberLrat , Rdh12 , Rpe65
Peripheral Nervous System DiseasesAbca4
Pleomorphic Xanthoastrocytoma Opn1sw
Retinal DegenerationAbca4 , Rdh12 , Rho , Rpe65
Retinal DystrophiesAbca4 , Lrat , Rbp3 , Rdh12 , Rdh5 , Rpe65
Retinal Dystrophy, Early Onset SevereAbca4
RETINAL DYSTROPHY, JUVENILE CATARACTS, AND SHORT STATURE SYNDROMERdh11
Retinitis PigmentosaAbca4 , Lrat , Rbp3 , Rdh12 , Rho , Rlbp1 , Rpe65
Retinitis Pigmentosa 19Abca4
Retinitis Pigmentosa 20Rpe65
Retinitis Pigmentosa 4Rho
Retinitis Pigmentosa 66Rbp3
Stargardt Disease 1Abca4
Stomach NeoplasmsRbp1
TritanopiaOpn1sw
UveitisRbp3
Uveitis, Autoimmune, ExperimentalRpe65
Vision DisordersAbca4
Vitamin A DeficiencyLrat
Pathway Annotations Associated with Genes in the retinoid cycle metabolic pathway

References Associated with the retinoid cycle metabolic pathway:

Ontology Path Diagram:

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