Rbl2 (RB transcriptional corepressor like 2) - Rat Genome Database

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Gene: Rbl2 (RB transcriptional corepressor like 2) Rattus norvegicus
Analyze
Symbol: Rbl2
Name: RB transcriptional corepressor like 2
RGD ID: 3541
Description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation and negative regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within negative regulation of gene expression. Located in chromatin. Orthologous to human RBL2 (RB transcriptional corepressor like 2); PARTICIPATES IN G1/S transition pathway; cell cycle pathway, mitotic; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 130 kDa retinoblastoma-associated protein; P130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; Rb2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related; Retinoblastoma-related gene; retinoblastoma-related protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81932,049,690 - 32,096,467 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1932,049,691 - 32,096,411 (-)EnsemblGRCr8
mRatBN7.21915,876,852 - 15,923,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,876,853 - 15,923,572 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1917,565,460 - 17,612,163 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,760,015 - 22,806,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,707,582 - 25,754,278 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01917,300,088 - 17,346,865 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1917,300,089 - 17,346,808 (-)Ensemblrn6Rnor6.0
Rnor_5.01928,364,200 - 28,410,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41917,045,131 - 17,092,597 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1915,782,149 - 15,828,852 (-)NCBICelera
RGSC_v3.11917,049,956 - 17,097,423 (-)NCBI
Cytogenetic Map19p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calmidazolium  (ISO)
calyculin A  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
Clasto-Lactacystin beta-lactone  (ISO)
clomipramine  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
dieldrin  (EXP)
digitonin  (ISO)
dimercaprol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
imipramine  (EXP)
isoprenaline  (ISO)
ketoconazole  (EXP)
lamivudine  (ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nicotine  (ISO)
O-methyleugenol  (EXP)
okadaic acid  (ISO)
oleanolic acid  (ISO)
ozone  (EXP)
p-menthan-3-ol  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
procymidone  (EXP)
promethazine  (EXP)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
resveratrol  (ISO)
riddelliine  (ISO)
ritonavir  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IDA)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
transcription regulator complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Mammalian cyclin-dependent kinases. Malumbres M and Barbacid M, Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Rodriguez JL, etal., Biochem J. 2006 Sep 15;398(3):431-7.
11. Cloning and characterization of the rat p130, a member of the retinoblastoma gene family. Sawada Y, etal., Biochim Biophys Acta 1997 Jul 10;1361(1):20-7.
Additional References at PubMed
PMID:9697699   PMID:10082561   PMID:12189208   PMID:12477932   PMID:15174090   PMID:15459751   PMID:15769944   PMID:16123778   PMID:16286473   PMID:16513252   PMID:18818403   PMID:19056867  
PMID:19099372   PMID:25100735  


Genomics

Comparative Map Data
Rbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81932,049,690 - 32,096,467 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1932,049,691 - 32,096,411 (-)EnsemblGRCr8
mRatBN7.21915,876,852 - 15,923,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,876,853 - 15,923,572 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1917,565,460 - 17,612,163 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,760,015 - 22,806,716 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,707,582 - 25,754,278 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01917,300,088 - 17,346,865 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1917,300,089 - 17,346,808 (-)Ensemblrn6Rnor6.0
Rnor_5.01928,364,200 - 28,410,959 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41917,045,131 - 17,092,597 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1915,782,149 - 15,828,852 (-)NCBICelera
RGSC_v3.11917,049,956 - 17,097,423 (-)NCBI
Cytogenetic Map19p11NCBI
RBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,434,471 - 53,491,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,433,977 - 53,491,649 (+)Ensemblhg38GRCh38
GRCh371653,468,383 - 53,525,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,025,901 - 52,083,061 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341652,025,900 - 52,083,060NCBI
Celera1637,983,164 - 38,040,371 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1639,355,821 - 39,413,031 (+)NCBIHuRef
CHM1_11654,875,514 - 54,932,695 (+)NCBICHM1_1
T2T-CHM13v2.01659,232,279 - 59,289,452 (+)NCBIT2T-CHM13v2.0
Rbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39891,796,685 - 91,850,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl891,796,685 - 91,850,472 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38891,070,057 - 91,123,844 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,070,057 - 91,123,844 (+)Ensemblmm10GRCm38
MGSCv37893,593,993 - 93,647,743 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36890,825,998 - 90,879,586 (+)NCBIMGSCv36mm8
MGSCv36893,960,214 - 94,013,949 (+)NCBIMGSCv36mm8
Celera895,389,485 - 95,438,924 (+)NCBICelera
Cytogenetic Map8C4NCBI
cM Map844.25NCBI
Rbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543311,185,077 - 11,237,645 (+)Ensembl
ChiLan1.0NW_00495543311,185,726 - 11,237,645 (+)NCBIChiLan1.0ChiLan1.0
RBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21862,869,133 - 62,937,383 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11668,787,777 - 68,855,993 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01633,674,751 - 33,731,308 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11652,759,290 - 52,815,685 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1652,759,290 - 52,816,175 (+)EnsemblpanPan2panpan1.1
RBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1262,263,974 - 62,315,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl262,265,293 - 62,315,425 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha258,897,038 - 58,948,437 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0262,805,721 - 62,857,135 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,805,721 - 62,857,245 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,629,354 - 59,680,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0260,649,922 - 60,701,093 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,532,307 - 61,583,705 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rbl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934953,434,852 - 53,501,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364756,086,584 - 6,144,067 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364756,087,055 - 6,140,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,748,739 - 31,802,022 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1631,757,718 - 31,802,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1539,225,797 - 39,283,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl539,225,844 - 39,282,190 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604737,097,718 - 37,155,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247573,295,479 - 3,351,928 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247573,295,471 - 3,351,539 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Rbl2
275 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:547
Count of miRNA genes:248
Interacting mature miRNAs:303
Transcripts:ENSRNOT00000017361
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
BE112852  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,882,368 - 15,882,536 (+)MAPPERmRatBN7.2
Rnor_6.01917,305,605 - 17,305,772NCBIRnor6.0
Rnor_5.01928,369,717 - 28,369,884UniSTSRnor5.0
RGSC_v3.41917,050,647 - 17,050,814UniSTSRGSC3.4
Celera1915,787,666 - 15,787,833UniSTS
Cytogenetic Map19p11UniSTS
RH137786  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81932,050,545 - 32,050,748 (+)Marker Load Pipeline
mRatBN7.21915,877,707 - 15,877,910 (+)MAPPERmRatBN7.2
Rnor_6.01917,300,944 - 17,301,146NCBIRnor6.0
Rnor_5.01928,365,056 - 28,365,258UniSTSRnor5.0
RGSC_v3.41917,045,986 - 17,046,188UniSTSRGSC3.4
Celera1915,783,004 - 15,783,206UniSTS
Cytogenetic Map19p11UniSTS
RH132847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,886,368 - 15,886,551 (+)MAPPERmRatBN7.2
Rnor_6.01917,309,605 - 17,309,787NCBIRnor6.0
Rnor_5.01928,373,717 - 28,373,899UniSTSRnor5.0
RGSC_v3.41917,054,647 - 17,054,829UniSTSRGSC3.4
Celera1915,791,666 - 15,791,848UniSTS
Cytogenetic Map19p11UniSTS
RH144576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,880,747 - 15,880,897 (+)MAPPERmRatBN7.2
Rnor_6.01917,303,984 - 17,304,133NCBIRnor6.0
Rnor_5.01928,368,096 - 28,368,245UniSTSRnor5.0
RGSC_v3.41917,049,026 - 17,049,175UniSTSRGSC3.4
Celera1915,786,045 - 15,786,194UniSTS
Cytogenetic Map19p11UniSTS
BE120467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,894,112 - 15,894,262 (+)MAPPERmRatBN7.2
Rnor_6.01917,317,349 - 17,317,498NCBIRnor6.0
Rnor_5.01928,381,461 - 28,381,610UniSTSRnor5.0
RGSC_v3.41917,062,391 - 17,062,540UniSTSRGSC3.4
Celera1915,799,410 - 15,799,559UniSTS
Cytogenetic Map19p11UniSTS
RH136737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,906,944 - 15,907,064 (+)MAPPERmRatBN7.2
Rnor_6.01917,330,181 - 17,330,300NCBIRnor6.0
Rnor_5.01928,394,293 - 28,394,412UniSTSRnor5.0
RGSC_v3.41917,075,970 - 17,076,089UniSTSRGSC3.4
Celera1915,812,225 - 15,812,344UniSTS
Cytogenetic Map19p11UniSTS
RH142012  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21915,876,718 - 15,876,928 (+)MAPPERmRatBN7.2
Rnor_6.01917,299,955 - 17,300,164NCBIRnor6.0
Rnor_5.01928,364,067 - 28,364,276UniSTSRnor5.0
RGSC_v3.41917,044,997 - 17,045,206UniSTSRGSC3.4
Celera1915,782,015 - 15,782,224UniSTS
Cytogenetic Map19p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017361   ⟹   ENSRNOP00000017361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1932,049,691 - 32,096,411 (-)Ensembl
mRatBN7.2 Ensembl1915,876,853 - 15,923,572 (-)Ensembl
Rnor_6.0 Ensembl1917,300,089 - 17,346,808 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117469   ⟹   ENSRNOP00000088993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1932,049,691 - 32,096,411 (-)Ensembl
mRatBN7.2 Ensembl1915,876,853 - 15,923,572 (-)Ensembl
RefSeq Acc Id: NM_031094   ⟹   NP_112356
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81932,049,691 - 32,096,411 (-)NCBI
mRatBN7.21915,876,853 - 15,923,572 (-)NCBI
Rnor_6.01917,300,089 - 17,346,808 (-)NCBI
Rnor_5.01928,364,200 - 28,410,959 (-)NCBI
RGSC_v3.41917,045,131 - 17,092,597 (-)RGD
Celera1915,782,149 - 15,828,852 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255199   ⟹   XP_006255261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81932,049,690 - 32,096,464 (-)NCBI
mRatBN7.21915,876,852 - 15,923,630 (-)NCBI
Rnor_6.01917,300,088 - 17,346,863 (-)NCBI
Rnor_5.01928,364,200 - 28,410,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255200   ⟹   XP_006255262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81932,057,447 - 32,096,467 (-)NCBI
mRatBN7.21915,884,717 - 15,923,632 (-)NCBI
Rnor_6.01917,308,373 - 17,346,865 (-)NCBI
Rnor_5.01928,364,200 - 28,410,959 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278309   ⟹   XP_063134379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81932,064,588 - 32,096,467 (-)NCBI
RefSeq Acc Id: NP_112356   ⟸   NM_031094
- UniProtKB: O55081 (UniProtKB/Swiss-Prot),   A6KD82 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255261   ⟸   XM_006255199
- Peptide Label: isoform X1
- UniProtKB: O55081 (UniProtKB/Swiss-Prot),   G3V7P7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255262   ⟸   XM_006255200
- Peptide Label: isoform X2
- UniProtKB: O55081 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017361   ⟸   ENSRNOT00000017361
Ensembl Acc Id: ENSRNOP00000088993   ⟸   ENSRNOT00000117469
RefSeq Acc Id: XP_063134379   ⟸   XM_063278309
- Peptide Label: isoform X3
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55081-F1-model_v2 AlphaFold O55081 1-1135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700974
Promoter ID:EPDNEW_R11497
Type:initiation region
Name:Rbl2_1
Description:RB transcriptional corepressor like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01917,346,845 - 17,346,905EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3541 AgrOrtholog
BioCyc Gene G2FUF-6359 BioCyc
Ensembl Genes ENSRNOG00000012153 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000017361 ENTREZGENE
  ENSRNOT00000117469 ENTREZGENE
Gene3D-CATH 1.10.472.140 UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
InterPro Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
  RB_C UniProtKB/Swiss-Prot
  RB_fam UniProtKB/Swiss-Prot
  RB_N UniProtKB/Swiss-Prot
KEGG Report rno:81758 UniProtKB/Swiss-Prot
NCBI Gene Rbl2 ENTREZGENE
PANTHER PTHR13742 UniProtKB/Swiss-Prot
  PTHR13742:SF8 UniProtKB/Swiss-Prot
Pfam DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  RB_B UniProtKB/Swiss-Prot
PhenoGen Rbl2 PhenoGen
RatGTEx ENSRNOG00000012153 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
  DUF3452 UniProtKB/Swiss-Prot
  RB_A UniProtKB/Swiss-Prot
  Rb_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
UniProt A0A8I6AAZ8_RAT UniProtKB/TrEMBL
  A6KD82 ENTREZGENE, UniProtKB/TrEMBL
  A6KD83_RAT UniProtKB/TrEMBL
  A6KD84_RAT UniProtKB/TrEMBL
  G3V7P7 ENTREZGENE, UniProtKB/TrEMBL
  O55081 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-03 Rbl2  RB transcriptional corepressor like 2  Rbl2  retinoblastoma-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Rbl2  retinoblastoma-like 2  Rb2  Retinoblastoma-related gene  Symbol and Name updated 629477 APPROVED
2002-06-10 Rb2  Retinoblastoma-related gene      Symbol and Name status set to approved 70586 APPROVED