RBL2 (RB transcriptional corepressor like 2) - Rat Genome Database

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Pathways
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Gene: RBL2 (RB transcriptional corepressor like 2) Sus scrofa
Analyze
Symbol: RBL2
Name: RB transcriptional corepressor like 2
RGD ID: 14007733
Description: ENCODES a protein that exhibits promoter-specific chromatin binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of gene expression (ortholog); PARTICIPATES IN G1/S transition pathway; ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); BRUNET-WAGNER NEURODEVELOPMENTAL SYNDROME (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN chromatin (ortholog); INTERACTS WITH ammonia
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinoblastoma-like 2 (p130); retinoblastoma-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,748,739 - 31,802,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1631,757,718 - 31,802,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ammonia  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IEA,ISO)
chromosome  (IEA)
cytosol  (IEA)
nucleolus  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
transcription regulator complex  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,748,739 - 31,802,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1631,757,718 - 31,802,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,434,471 - 53,491,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,433,977 - 53,491,648 (+)EnsemblGRCh38hg38GRCh38
GRCh371653,468,383 - 53,525,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,025,901 - 52,083,061 (+)NCBINCBI36Build 36hg18NCBI36
Build 341652,025,900 - 52,083,060NCBI
Celera1637,983,164 - 38,040,371 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1639,355,821 - 39,413,031 (+)NCBIHuRef
CHM1_11654,875,514 - 54,932,695 (+)NCBICHM1_1
T2T-CHM13v2.01659,232,279 - 59,289,452 (+)NCBIT2T-CHM13v2.0
Rbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39891,796,685 - 91,850,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl891,796,685 - 91,850,472 (+)EnsemblGRCm39 Ensembl
GRCm38891,070,057 - 91,123,844 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,070,057 - 91,123,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37893,593,993 - 93,647,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36890,825,998 - 90,879,586 (+)NCBIMGSCv36mm8
MGSCv36893,960,214 - 94,013,949 (+)NCBIMGSCv36mm8
Celera895,389,485 - 95,438,924 (+)NCBICelera
Cytogenetic Map8C4NCBI
cM Map844.25NCBI
Rbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81932,049,690 - 32,096,467 (-)NCBIGRCr8
mRatBN7.21915,876,852 - 15,923,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,876,853 - 15,923,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1917,565,460 - 17,612,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,760,015 - 22,806,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,707,582 - 25,754,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01917,300,088 - 17,346,865 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1917,300,089 - 17,346,808 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01928,364,200 - 28,410,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41917,045,131 - 17,092,597 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11917,049,956 - 17,097,423 (-)NCBI
Celera1915,782,149 - 15,828,852 (-)NCBICelera
Cytogenetic Map19p11NCBI
Rbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543311,185,077 - 11,237,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543311,185,726 - 11,237,645 (+)NCBIChiLan1.0ChiLan1.0
RBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21862,869,133 - 62,937,383 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11668,787,777 - 68,855,993 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01633,674,751 - 33,731,308 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11652,759,290 - 52,815,685 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1652,759,290 - 52,816,175 (+)Ensemblpanpan1.1panPan2
RBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1262,263,974 - 62,315,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl262,265,293 - 62,315,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,897,038 - 58,948,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0262,805,721 - 62,857,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,805,721 - 62,857,245 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,629,354 - 59,680,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0260,649,922 - 60,701,093 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,532,307 - 61,583,705 (-)NCBIUU_Cfam_GSD_1.0
Rbl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934953,434,852 - 53,501,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364756,086,584 - 6,144,067 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364756,087,055 - 6,140,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1539,225,797 - 39,283,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl539,225,844 - 39,282,190 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604737,097,718 - 37,155,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247573,295,479 - 3,351,928 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247573,295,471 - 3,351,539 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RBL2
431 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 2 15 2 3 3
Low 1 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000049220   ⟹   ENSSSCP00000036310
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl631,757,896 - 31,801,999 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000057336   ⟹   ENSSSCP00000032770
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl631,748,739 - 31,802,022 (-)Ensembl
RefSeq Acc Id: XM_021094167   ⟹   XP_020949826
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1631,757,718 - 31,802,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094168   ⟹   XP_020949827
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1631,757,718 - 31,802,047 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094169   ⟹   XP_020949828
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1631,757,718 - 31,802,008 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094170   ⟹   XP_020949829
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1631,757,718 - 31,802,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094171   ⟹   XP_020949830
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1631,757,718 - 31,791,962 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021094172   ⟹   XP_020949831
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1631,757,718 - 31,790,298 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020949826 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949827 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949828 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949829 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949830 (Get FASTA)   NCBI Sequence Viewer  
  XP_020949831 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000032770
  ENSSSCP00000032770.2
  ENSSSCP00005000472.1
  ENSSSCP00005000475.1
  ENSSSCP00005000485.1
  ENSSSCP00005000492.1
  ENSSSCP00015019974.1
  ENSSSCP00015020156.1
  ENSSSCP00025041042.1
  ENSSSCP00025041196.1
  ENSSSCP00025041399.1
  ENSSSCP00025041553.1
  ENSSSCP00030027184.1
  ENSSSCP00030027202.1
  ENSSSCP00030027212.1
  ENSSSCP00035027818.1
  ENSSSCP00035027821.1
  ENSSSCP00035027828.1
  ENSSSCP00035027831.1
  ENSSSCP00040024207.1
  ENSSSCP00040024318.1
  ENSSSCP00040024416.1
  ENSSSCP00040024483.1
  ENSSSCP00045006534.1
  ENSSSCP00045006540.1
  ENSSSCP00045006560.1
  ENSSSCP00045006570.1
  ENSSSCP00050011510.1
  ENSSSCP00050011519.1
  ENSSSCP00050011525.1
  ENSSSCP00055017899.1
  ENSSSCP00055017963.1
  ENSSSCP00055018054.1
  ENSSSCP00055018110.1
  ENSSSCP00060033523.1
  ENSSSCP00060033524.1
  ENSSSCP00060033531.1
  ENSSSCP00060033536.1
  ENSSSCP00065006127.1
  ENSSSCP00065006130.1
  ENSSSCP00065006138.1
  ENSSSCP00065006139.1
  ENSSSCP00070024006.1
  ENSSSCP00070024011.1
  ENSSSCP00070024024.1
Reference Protein Sequences
RefSeq Acc Id: XP_020949827   ⟸   XM_021094168
- Peptide Label: isoform X2
- UniProtKB: A0A4X1U7Z8 (UniProtKB/TrEMBL),   A0A286ZMT8 (UniProtKB/TrEMBL),   A0A8D0U288 (UniProtKB/TrEMBL),   A0A8D1CX67 (UniProtKB/TrEMBL),   A0A8D1ER96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949829   ⟸   XM_021094170
- Peptide Label: isoform X4
- UniProtKB: A0A4X1U7C9 (UniProtKB/TrEMBL),   A0A8D0U2B9 (UniProtKB/TrEMBL),   A0A8D1A830 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949826   ⟸   XM_021094167
- Peptide Label: isoform X1
- UniProtKB: A0A286ZMT8 (UniProtKB/TrEMBL),   A0A8D0U288 (UniProtKB/TrEMBL),   A0A8D1CX67 (UniProtKB/TrEMBL),   A0A8D1ER96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949828   ⟸   XM_021094169
- Peptide Label: isoform X3
- UniProtKB: A0A8D0U2B9 (UniProtKB/TrEMBL),   A0A8D1A830 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949830   ⟸   XM_021094171
- Peptide Label: isoform X5
- UniProtKB: A0A8D0HY52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020949831   ⟸   XM_021094172
- Peptide Label: isoform X6
- UniProtKB: A0A8D0HY52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036310   ⟸   ENSSSCT00000049220
RefSeq Acc Id: ENSSSCP00000032770   ⟸   ENSSSCT00000057336
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000032648 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005000701 UniProtKB/TrEMBL
  ENSSSCG00015037611 UniProtKB/TrEMBL
  ENSSSCG00025068102 UniProtKB/TrEMBL
  ENSSSCG00030042640 UniProtKB/TrEMBL
  ENSSSCG00035051600 UniProtKB/TrEMBL
  ENSSSCG00040043382 UniProtKB/TrEMBL
  ENSSSCG00045005744 UniProtKB/TrEMBL
  ENSSSCG00050020641 UniProtKB/TrEMBL
  ENSSSCG00055011562 UniProtKB/TrEMBL
  ENSSSCG00060056924 UniProtKB/TrEMBL
  ENSSSCG00065011298 UniProtKB/TrEMBL
  ENSSSCG00070014657 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000057336 ENTREZGENE
  ENSSSCT00000057336.2 UniProtKB/TrEMBL
  ENSSSCT00005000925.1 UniProtKB/TrEMBL
  ENSSSCT00005000931.1 UniProtKB/TrEMBL
  ENSSSCT00005000946.1 UniProtKB/TrEMBL
  ENSSSCT00005000957.1 UniProtKB/TrEMBL
  ENSSSCT00015050065.1 UniProtKB/TrEMBL
  ENSSSCT00015050517.1 UniProtKB/TrEMBL
  ENSSSCT00025093530.1 UniProtKB/TrEMBL
  ENSSSCT00025093890.1 UniProtKB/TrEMBL
  ENSSSCT00025094284.1 UniProtKB/TrEMBL
  ENSSSCT00025094640.1 UniProtKB/TrEMBL
  ENSSSCT00030059395.1 UniProtKB/TrEMBL
  ENSSSCT00030059430.1 UniProtKB/TrEMBL
  ENSSSCT00030059452.1 UniProtKB/TrEMBL
  ENSSSCT00035068722.1 UniProtKB/TrEMBL
  ENSSSCT00035068728.1 UniProtKB/TrEMBL
  ENSSSCT00035068748.1 UniProtKB/TrEMBL
  ENSSSCT00035068756.1 UniProtKB/TrEMBL
  ENSSSCT00040058079.1 UniProtKB/TrEMBL
  ENSSSCT00040058290.1 UniProtKB/TrEMBL
  ENSSSCT00040058460.1 UniProtKB/TrEMBL
  ENSSSCT00040058585.1 UniProtKB/TrEMBL
  ENSSSCT00045009564.1 UniProtKB/TrEMBL
  ENSSSCT00045009574.1 UniProtKB/TrEMBL
  ENSSSCT00045009611.1 UniProtKB/TrEMBL
  ENSSSCT00045009625.1 UniProtKB/TrEMBL
  ENSSSCT00050027851.1 UniProtKB/TrEMBL
  ENSSSCT00050027869.1 UniProtKB/TrEMBL
  ENSSSCT00050027878.1 UniProtKB/TrEMBL
  ENSSSCT00055022627.1 UniProtKB/TrEMBL
  ENSSSCT00055022711.1 UniProtKB/TrEMBL
  ENSSSCT00055022828.1 UniProtKB/TrEMBL
  ENSSSCT00055022909.1 UniProtKB/TrEMBL
  ENSSSCT00060077558.1 UniProtKB/TrEMBL
  ENSSSCT00060077561.1 UniProtKB/TrEMBL
  ENSSSCT00060077575.1 UniProtKB/TrEMBL
  ENSSSCT00060077584.1 UniProtKB/TrEMBL
  ENSSSCT00065015021.1 UniProtKB/TrEMBL
  ENSSSCT00065015032.1 UniProtKB/TrEMBL
  ENSSSCT00065015047.1 UniProtKB/TrEMBL
  ENSSSCT00065015050.1 UniProtKB/TrEMBL
  ENSSSCT00070028806.1 UniProtKB/TrEMBL
  ENSSSCT00070028812.1 UniProtKB/TrEMBL
  ENSSSCT00070028825.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.472.140 UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
  RB_C UniProtKB/TrEMBL
  RB_fam UniProtKB/TrEMBL
  RB_N UniProtKB/TrEMBL
NCBI Gene RBL2 ENTREZGENE
PANTHER PTHR13742 UniProtKB/TrEMBL
  PTHR13742:SF8 UniProtKB/TrEMBL
Pfam DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A286ZMT8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U7C9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U7Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U804_PIG UniProtKB/TrEMBL
  A0A8D0HLV1_PIG UniProtKB/TrEMBL
  A0A8D0HQZ7_PIG UniProtKB/TrEMBL
  A0A8D0HUV0_PIG UniProtKB/TrEMBL
  A0A8D0HY52 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0U288 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0U2B9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1A761_PIG UniProtKB/TrEMBL
  A0A8D1A830 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1A9L2_PIG UniProtKB/TrEMBL
  A0A8D1CX67 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ER96 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QCT6_PIG UniProtKB/TrEMBL
VGNC ID VGNC:92143 ENTREZGENE