RBL2 (RB transcriptional corepressor like 2) - Rat Genome Database

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Gene: RBL2 (RB transcriptional corepressor like 2) Canis lupus familiaris
Analyze
Symbol: RBL2
Name: RB transcriptional corepressor like 2
RGD ID: 12346065
Description: ENCODES a protein that exhibits promoter-specific chromatin binding (inferred); RNA polymerase II transcription regulatory region sequence-specific DNA binding (inferred); INVOLVED IN negative regulation of gene expression (ortholog); PARTICIPATES IN G1/S transition pathway; ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); BRUNET-WAGNER NEURODEVELOPMENTAL SYNDROME (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: retinoblastoma-like 2 (p130); retinoblastoma-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1262,263,974 - 62,315,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl262,265,293 - 62,315,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,897,038 - 58,948,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0262,805,721 - 62,857,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,805,721 - 62,857,245 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,629,354 - 59,680,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0260,649,922 - 60,701,093 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,532,307 - 61,583,705 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RBL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1262,263,974 - 62,315,371 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl262,265,293 - 62,315,425 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha258,897,038 - 58,948,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0262,805,721 - 62,857,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl262,805,721 - 62,857,245 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,629,354 - 59,680,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0260,649,922 - 60,701,093 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,532,307 - 61,583,705 (-)NCBIUU_Cfam_GSD_1.0
RBL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381653,434,471 - 53,491,648 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1653,433,977 - 53,491,648 (+)EnsemblGRCh38hg38GRCh38
GRCh371653,468,383 - 53,525,560 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361652,025,901 - 52,083,061 (+)NCBINCBI36Build 36hg18NCBI36
Build 341652,025,900 - 52,083,060NCBI
Celera1637,983,164 - 38,040,371 (+)NCBICelera
Cytogenetic Map16q12.2NCBI
HuRef1639,355,821 - 39,413,031 (+)NCBIHuRef
CHM1_11654,875,514 - 54,932,695 (+)NCBICHM1_1
T2T-CHM13v2.01659,232,279 - 59,289,452 (+)NCBIT2T-CHM13v2.0
Rbl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39891,796,685 - 91,850,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl891,796,685 - 91,850,472 (+)EnsemblGRCm39 Ensembl
GRCm38891,070,057 - 91,123,844 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl891,070,057 - 91,123,844 (+)EnsemblGRCm38mm10GRCm38
MGSCv37893,593,993 - 93,647,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36890,825,998 - 90,879,586 (+)NCBIMGSCv36mm8
MGSCv36893,960,214 - 94,013,949 (+)NCBIMGSCv36mm8
Celera895,389,485 - 95,438,924 (+)NCBICelera
Cytogenetic Map8C4NCBI
cM Map844.25NCBI
Rbl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81932,049,690 - 32,096,467 (-)NCBIGRCr8
mRatBN7.21915,876,852 - 15,923,632 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1915,876,853 - 15,923,572 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1917,565,460 - 17,612,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01922,760,015 - 22,806,716 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01925,707,582 - 25,754,278 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01917,300,088 - 17,346,865 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1917,300,089 - 17,346,808 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01928,364,200 - 28,410,959 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41917,045,131 - 17,092,597 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11917,049,956 - 17,097,423 (-)NCBI
Celera1915,782,149 - 15,828,852 (-)NCBICelera
Cytogenetic Map19p11NCBI
Rbl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543311,185,077 - 11,237,645 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543311,185,726 - 11,237,645 (+)NCBIChiLan1.0ChiLan1.0
RBL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21862,869,133 - 62,937,383 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11668,787,777 - 68,855,993 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01633,674,751 - 33,731,308 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11652,759,290 - 52,815,685 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1652,759,290 - 52,816,175 (+)Ensemblpanpan1.1panPan2
Rbl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934953,434,852 - 53,501,832 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364756,086,584 - 6,144,067 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364756,087,055 - 6,140,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RBL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl631,748,739 - 31,802,022 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1631,757,718 - 31,802,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RBL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1539,225,797 - 39,283,550 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl539,225,844 - 39,282,190 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604737,097,718 - 37,155,647 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rbl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247573,295,479 - 3,351,928 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247573,295,471 - 3,351,539 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RBL2
393 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 21 5 6 5 6 6 12 5 10 6
Low 1 1 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000015343   ⟹   ENSCAFP00000014197
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl262,265,293 - 62,315,425 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000072455   ⟹   ENSCAFP00000058501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl262,265,293 - 62,315,425 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845006112   ⟹   ENSCAFP00845004860
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl262,805,721 - 62,857,245 (-)Ensembl
RefSeq Acc Id: XM_038461032   ⟹   XP_038316960
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha258,898,357 - 58,944,308 (-)NCBI
RefSeq Acc Id: XM_038470215   ⟹   XP_038326143
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1259,629,354 - 59,680,520 (-)NCBI
RefSeq Acc Id: XM_038470216   ⟹   XP_038326144
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1259,630,673 - 59,676,375 (-)NCBI
RefSeq Acc Id: XM_038531039   ⟹   XP_038386967
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0261,532,307 - 61,583,705 (-)NCBI
RefSeq Acc Id: XM_038531040   ⟹   XP_038386968
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0261,533,626 - 61,579,576 (-)NCBI
RefSeq Acc Id: XM_038595255   ⟹   XP_038451183
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0260,649,922 - 60,701,093 (-)NCBI
RefSeq Acc Id: XM_038595256   ⟹   XP_038451184
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0260,651,241 - 60,696,941 (-)NCBI
RefSeq Acc Id: XM_038659344   ⟹   XP_038515272
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0262,805,721 - 62,857,135 (-)NCBI
RefSeq Acc Id: XM_038659345   ⟹   XP_038515273
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0262,807,040 - 62,853,007 (-)NCBI
RefSeq Acc Id: XM_535303   ⟹   XP_535303
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1262,263,974 - 62,315,371 (-)NCBI
Dog10K_Boxer_Tasha258,897,038 - 58,948,437 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_535303   ⟸   XM_535303
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MJZ3 (UniProtKB/TrEMBL),   A0A8I3N5E1 (UniProtKB/TrEMBL),   A0A8C0MJQ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014197   ⟸   ENSCAFT00000015343
RefSeq Acc Id: ENSCAFP00000058501   ⟸   ENSCAFT00000072455
RefSeq Acc Id: XP_038326143   ⟸   XM_038470215
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038326144   ⟸   XM_038470216
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451183   ⟸   XM_038595255
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451184   ⟸   XM_038595256
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038515272   ⟸   XM_038659344
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MJZ3 (UniProtKB/TrEMBL),   A0A8I3N5E1 (UniProtKB/TrEMBL),   A0A8C0MJQ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515273   ⟸   XM_038659345
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JPB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038316960   ⟸   XM_038461032
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JPB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386967   ⟸   XM_038531039
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MJQ4 (UniProtKB/TrEMBL),   A0A8C0MJZ3 (UniProtKB/TrEMBL),   A0A8I3N5E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038386968   ⟸   XM_038531040
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JPB8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845004860   ⟸   ENSCAFT00845006112
Protein Domains
Cyclin-like   Retinoblastoma-associated protein A-box   Retinoblastoma-associated protein C-terminal   Retinoblastoma-associated protein N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000009654 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030006784 UniProtKB/TrEMBL
  ENSCAFG00040010713 UniProtKB/TrEMBL
  ENSCAFG00845003441 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000015343.5 UniProtKB/TrEMBL
  ENSCAFT00030012506.1 UniProtKB/TrEMBL
  ENSCAFT00030012629.1 UniProtKB/TrEMBL
  ENSCAFT00030012718.1 UniProtKB/TrEMBL
  ENSCAFT00040019821.1 UniProtKB/TrEMBL
  ENSCAFT00845006112 ENTREZGENE
  ENSCAFT00845006112.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.472.140 UniProtKB/TrEMBL
  Cyclin-like UniProtKB/TrEMBL
InterPro Cyclin-like UniProtKB/TrEMBL
  Cyclin-like_sf UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
  RB_C UniProtKB/TrEMBL
  RB_fam UniProtKB/TrEMBL
  RB_N UniProtKB/TrEMBL
NCBI Gene RBL2 ENTREZGENE
PANTHER PTHR13742 UniProtKB/TrEMBL
  PTHR13742:SF8 UniProtKB/TrEMBL
Pfam DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  RB_B UniProtKB/TrEMBL
SMART CYCLIN UniProtKB/TrEMBL
  DUF3452 UniProtKB/TrEMBL
  RB_A UniProtKB/TrEMBL
  Rb_C UniProtKB/TrEMBL
Superfamily-SCOP SSF47954 UniProtKB/TrEMBL
UniProt A0A8C0JPB8 ENTREZGENE
  A0A8C0MFU0_CANLF UniProtKB/TrEMBL
  A0A8C0MJQ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MJZ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N5E1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45403 ENTREZGENE