Rasa1 (RAS p21 protein activator 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rasa1 (RAS p21 protein activator 1) Rattus norvegicus
Analyze
Symbol: Rasa1
Name: RAS p21 protein activator 1
RGD ID: 3537
Description: Enables several functions, including GTPase activator activity; platelet-derived growth factor receptor binding activity; and protein kinase binding activity. Involved in several processes, including activation of GTPase activity; cellular response to epidermal growth factor stimulus; and cellular response to platelet-derived growth factor stimulus. Located in nuclear membrane. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1); PARTICIPATES IN protein kinase C (PKC) signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GAP; GAPX; GTPase-activating protein; p120GAP; ras GTPase-activating protein 1; RAS p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; Rasa; rasGAP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8217,593,136 - 17,676,707 (-)NCBIGRCr8
mRatBN7.2215,857,704 - 15,940,757 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl215,857,980 - 15,940,854 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx222,959,727 - 23,040,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0221,059,980 - 21,140,482 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0215,733,780 - 15,814,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0213,617,021 - 13,696,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl213,616,822 - 13,696,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0213,470,580 - 13,551,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4214,203,815 - 14,287,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1214,124,183 - 14,208,193 (-)NCBI
Celera212,124,725 - 12,204,755 (-)NCBICelera
Cytogenetic Map2q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
fenthion  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
GTP  (ISO)
indometacin  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lipopolysaccharide  (ISO)
methidathion  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP)
rofecoxib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
nuclear membrane  (IDA)
plasma membrane  (IEA,ISO)
ruffle  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. RASA1: variable phenotype with capillary and arteriovenous malformations. Boon LM, etal., Curr Opin Genet Dev. 2005 Jun;15(3):265-9.
2. GTPase-activating protein interactions with the viral and cellular Src kinases. Brott BK, etal., Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):755-9.
3. Two regions with differential growth-modulating activity in the N-terminal domain of ras GTPase-activating protein (p120GAP) src homology and Gly-Ala-Pro-rich regions. Chang JS, etal., Eur J Biochem. 1995 Sep 15;232(3):691-9.
4. Dysregulation of HSG triggers vascular proliferative disorders. Chen KH, etal., Nat Cell Biol 2004 Sep;6(9):872-83. Epub 2004 Aug 22.
5. Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. Chow A, etal., FEBS Lett. 2000 Mar 3;469(1):88-92.
6. Sequence of the cDNA encoding Ras GTPase-activating protein from rat. Davis MM, etal., Gene 1993 Dec 8;134(2):305-6.
7. Capillary malformation-arteriovenous malformation, a new clinical and genetic disorder caused by RASA1 mutations. Eerola I, etal., Am J Hum Genet 2003 Dec;73(6):1240-9.
8. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. Friedman E, etal., Nat Genet 1993 Nov;5(3):242-7.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. PDGF-induced glycosaminoglycan synthesis is mediated via phosphatidylinositol 3-kinase. Liu J, etal., Am J Physiol. 1998 May;274(5 Pt 1):L702-13.
12. Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites. Lundby A, etal., Cell. 2019 Oct 3;179(2):543-560.e26. doi: 10.1016/j.cell.2019.09.008.
13. Purification of a novel ras GTPase-activating protein from rat brain. Maekawa M, etal., J Biol Chem. 1993 Oct 25;268(30):22948-52.
14. Insulin signal transduction in rat small intestine: role of MAP kinases in expression of mucosal hydrolases. Marandi S, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G229-40.
15. The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion. McGlade J, etal., EMBO J. 1993 Aug;12(8):3073-81.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein. Moran MF, etal., Mol Cell Biol. 1991 Apr;11(4):1804-12.
18. Alterations in the subcellular distribution of p21ras-GTPase activating protein in proliferating rat acinar cells. Nakagawa Y, etal., Biochem Biophys Res Commun. 1992 Sep 16;187(2):1172-9.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart. Queiros AM, etal., Int J Cardiol. 2013 Nov 20;169(5):331-8. doi: 10.1016/j.ijcard.2013.09.002. Epub 2013 Oct 5.
24. Sodium butyrate inhibits platelet-derived growth factor-induced proliferation of vascular smooth muscle cells. Ranganna K, etal., Arterioscler Thromb Vasc Biol. 1995 Dec;15(12):2273-83.
25. GOA pipeline RGD automated data pipeline
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. miR-335 is involved in the rat epididymal development by targeting the mRNA of RASA1. Wang J and Ruan K, Biochem Biophys Res Commun. 2010 Nov 12;402(2):222-7. doi: 10.1016/j.bbrc.2010.10.002. Epub 2010 Oct 8.
30. Neuroprotective gene expression profiles in ischemic cortical cultures preconditioned with IGF-1 or bFGF. Yoshida E, etal., Brain Res Mol Brain Res. 2004 Nov 24;131(1-2):33-50.
31. Ras GTPase-activating protein binds to Akt and is required for its activation. Yue Y, etal., J Biol Chem. 2004 Mar 26;279(13):12883-9. Epub 2004 Jan 5.
Additional References at PubMed
PMID:1756860   PMID:2122974   PMID:2157284   PMID:2176151   PMID:7478585   PMID:8183574   PMID:8798684   PMID:11970986   PMID:12008030   PMID:14643014   PMID:15542850   PMID:15860730  
PMID:16046410   PMID:20624904   PMID:22206666   PMID:23687085   PMID:34165173  


Genomics

Comparative Map Data
Rasa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8217,593,136 - 17,676,707 (-)NCBIGRCr8
mRatBN7.2215,857,704 - 15,940,757 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl215,857,980 - 15,940,854 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx222,959,727 - 23,040,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0221,059,980 - 21,140,482 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0215,733,780 - 15,814,284 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0213,617,021 - 13,696,531 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl213,616,822 - 13,696,426 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0213,470,580 - 13,551,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4214,203,815 - 14,287,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1214,124,183 - 14,208,193 (-)NCBI
Celera212,124,725 - 12,204,755 (-)NCBICelera
Cytogenetic Map2q11NCBI
RASA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38587,267,883 - 87,391,916 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl587,267,883 - 87,391,931 (+)EnsemblGRCh38hg38GRCh38
GRCh37586,563,700 - 86,687,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36586,599,907 - 86,723,489 (+)NCBINCBI36Build 36hg18NCBI36
Build 34586,600,521 - 86,723,488NCBI
Celera582,456,373 - 82,579,983 (+)NCBICelera
Cytogenetic Map5q14.3NCBI
HuRef581,768,403 - 81,891,908 (+)NCBIHuRef
CHM1_1585,997,132 - 86,120,771 (+)NCBICHM1_1
T2T-CHM13v2.0587,749,006 - 87,873,021 (+)NCBIT2T-CHM13v2.0
Rasa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391385,362,893 - 85,437,487 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1385,362,899 - 85,437,249 (-)EnsemblGRCm39 Ensembl
GRCm381385,214,699 - 85,289,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1385,214,780 - 85,289,130 (-)EnsemblGRCm38mm10GRCm38
MGSCv371385,354,304 - 85,429,091 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361385,689,136 - 85,729,574 (-)NCBIMGSCv36mm8
Celera1387,446,946 - 87,523,497 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1345.05NCBI
Rasa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541823,807,740 - 23,897,707 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541823,807,740 - 23,897,699 (-)NCBIChiLan1.0ChiLan1.0
RASA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2428,003,513 - 28,131,187 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1526,157,126 - 26,284,812 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0527,980,907 - 28,104,368 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1528,115,159 - 28,239,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl528,115,159 - 28,240,321 (-)Ensemblpanpan1.1panPan2
RASA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1321,068,182 - 21,177,288 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl321,054,930 - 21,176,757 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha322,433,878 - 22,542,367 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0320,976,854 - 21,085,576 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl320,963,599 - 21,086,379 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1320,947,976 - 21,056,165 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0320,910,527 - 21,018,703 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0321,202,248 - 21,310,549 (-)NCBIUU_Cfam_GSD_1.0
Rasa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213176,687,034 - 176,786,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364695,839,743 - 5,932,021 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364695,839,560 - 5,933,049 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl294,878,911 - 94,993,450 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1294,879,615 - 94,992,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2297,399,815 - 97,512,972 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RASA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1481,249,851 - 81,371,486 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl481,249,805 - 81,370,453 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604930,268,183 - 30,393,793 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247436,788,108 - 6,882,223 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247436,750,476 - 6,882,556 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasa1
618 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir212rno-miR-212-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22431733
Mir132rno-miR-132-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22431733

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:20
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000046251
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000046251   ⟹   ENSRNOP00000047300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl215,857,980 - 15,940,854 (-)Ensembl
Rnor_6.0 Ensembl213,616,822 - 13,696,426 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095572   ⟹   ENSRNOP00000088606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl215,857,980 - 15,940,854 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101798   ⟹   ENSRNOP00000092393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl215,857,980 - 15,940,854 (-)Ensembl
RefSeq Acc Id: NM_013135   ⟹   NP_037267
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8217,593,136 - 17,676,161 (-)NCBI
mRatBN7.2215,857,706 - 15,940,738 (-)NCBI
Rnor_6.0213,617,021 - 13,696,531 (-)NCBI
Rnor_5.0213,470,580 - 13,551,782 (-)NCBI
RGSC_v3.4214,203,815 - 14,287,824 (-)RGD
Celera212,124,725 - 12,204,755 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101802   ⟹   XP_038957730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8217,593,136 - 17,676,707 (-)NCBI
mRatBN7.2215,857,704 - 15,940,757 (-)NCBI
RefSeq Acc Id: NP_037267   ⟸   NM_013135
- UniProtKB: G3V9H0 (UniProtKB/TrEMBL),   A6I4M1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047300   ⟸   ENSRNOT00000046251
RefSeq Acc Id: XP_038957730   ⟸   XM_039101802
- Peptide Label: isoform X1
- UniProtKB: A6I4L9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088606   ⟸   ENSRNOT00000095572
Ensembl Acc Id: ENSRNOP00000092393   ⟸   ENSRNOT00000101798
Protein Domains
C2   PH   Ras-GAP   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50904-F1-model_v2 AlphaFold P50904 1-1038 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3537 AgrOrtholog
BioCyc Gene G2FUF-54930 BioCyc
Ensembl Genes ENSRNOG00000029185 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055004033 UniProtKB/Swiss-Prot
  ENSRNOG00060000743 UniProtKB/Swiss-Prot
  ENSRNOG00065005513 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046251.3 UniProtKB/TrEMBL
  ENSRNOT00000095572.1 UniProtKB/TrEMBL
  ENSRNOT00000101798.1 UniProtKB/TrEMBL
  ENSRNOT00055006446 UniProtKB/Swiss-Prot
  ENSRNOT00060000872 UniProtKB/Swiss-Prot
  ENSRNOT00065008164 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_C_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_N_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25676 UniProtKB/Swiss-Prot
NCBI Gene 25676 ENTREZGENE
PANTHER PTHR10194 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rasa1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029185 RatGTEx
  ENSRNOG00055004033 RatGTEx
  ENSRNOG00060000743 RatGTEx
  ENSRNOG00065005513 RatGTEx
SMART RasGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC220708
UniProt A0A8I6A6I6_RAT UniProtKB/TrEMBL
  A0A8I6AHF7_RAT UniProtKB/TrEMBL
  A6I4L9 ENTREZGENE, UniProtKB/TrEMBL
  A6I4M0_RAT UniProtKB/TrEMBL
  A6I4M1 ENTREZGENE, UniProtKB/TrEMBL
  G3V9H0 ENTREZGENE, UniProtKB/TrEMBL
  P50904 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Rasa1  RAS p21 protein activator 1  Rasa1  RAS p21 protein activator (GTPase activating protein) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rasa1  RAS p21 protein activator (GTPase activating protein) 1  Rasa1  RAS p21 protein activator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2000-11-11 Rasa1  RAS p21 protein activator 1      Symbol updated 61033 APPROVED
2000-11-11 Rasa  RAS p21 protein activator      Symbol withdrawn 61033 WITHDRAWN