Ptpra (protein tyrosine phosphatase, receptor type, A) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ptpra (protein tyrosine phosphatase, receptor type, A) Rattus norvegicus
Analyze
Symbol: Ptpra
Name: protein tyrosine phosphatase, receptor type, A
RGD ID: 3450
Description: Enables protein tyrosine phosphatase activity. Involved in oligodendrocyte differentiation and positive regulation of oligodendrocyte differentiation. Predicted to be located in focal adhesion and membrane. Predicted to be part of receptor complex. Predicted to be active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human PTPRA (protein tyrosine phosphatase receptor type A); PARTICIPATES IN insulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LRP; MGC93561; protein tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; R-PTP-alpha; receptor-type tyrosine-protein phosphatase alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: PtpraTn(sb-T2/Bart3)2.261Mcwi
Genetic Models: F344-PtpraTn(sb-T2/Bart3)2.261Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,103,261 - 138,212,835 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,098,110 - 138,213,126 (+)EnsemblGRCr8
mRatBN7.23117,650,146 - 117,759,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,650,183 - 117,759,728 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3121,547,451 - 121,654,208 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,143,111 - 130,251,468 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,803,579 - 127,910,341 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,976,066 - 123,084,585 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,976,104 - 123,084,863 (+)Ensemblrn6Rnor6.0
Rnor_5.03129,475,237 - 129,582,992 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,061,713 - 118,171,300 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3116,464,194 - 116,570,590 (+)NCBICelera
RGSC_v3.13118,022,615 - 118,077,164 (+)NCBI
Cytogenetic Map3q36NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamics of protein-tyrosine phosphatases in rat adipocytes. Calera MR, etal., J Biol Chem. 2000 Mar 3;275(9):6308-12.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. SRC binding to the cytoskeleton, triggered by growth cone attachment to laminin, is protein tyrosine phosphatase-dependent. Helmke S, etal., J Cell Sci. 1998 Aug;111 ( Pt 16):2465-75.
5. Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. Lei G, etal., EMBO J. 2002 Jun 17;21(12):2977-89.
6. Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. Lin D, etal., J Biol Chem. 2008 Mar 21;283(12):7674-81. Epub 2008 Jan 22.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. cDNA cloning of rat LRP, a receptor like protein tyrosine phosphatase, and evidence for its gene regulation in cultured rat mesangial cells. Moriyama T, etal., Biochem Biophys Res Commun 1992 Oct 15;188(1):34-9.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Receptor tyrosine phosphatase R-PTP-alpha is tyrosine-phosphorylated and associated with the adaptor protein Grb2. Su J, etal., J Biol Chem. 1994 Jul 22;269(29):18731-4.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. Protein tyrosine phosphatase Alpha (PTP{alpha}) acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination. Wang PS, etal., J Biol Chem. 2009 Oct 6.
18. Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. Wu CW, etal., Cancer Lett. 2006 Oct 8;242(1):95-103. doi: 10.1016/j.canlet.2005.10.046. Epub 2005 Dec 7.
Additional References at PubMed
PMID:12826681   PMID:12912911   PMID:14733908   PMID:15978577   PMID:16899073   PMID:18768480   PMID:20458337   PMID:23382219   PMID:25951993  


Genomics

Comparative Map Data
Ptpra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,103,261 - 138,212,835 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3138,098,110 - 138,213,126 (+)EnsemblGRCr8
mRatBN7.23117,650,146 - 117,759,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,650,183 - 117,759,728 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3121,547,451 - 121,654,208 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,143,111 - 130,251,468 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,803,579 - 127,910,341 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,976,066 - 123,084,585 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,976,104 - 123,084,863 (+)Ensemblrn6Rnor6.0
Rnor_5.03129,475,237 - 129,582,992 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43118,061,713 - 118,171,300 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3116,464,194 - 116,570,590 (+)NCBICelera
RGSC_v3.13118,022,615 - 118,077,164 (+)NCBI
Cytogenetic Map3q36NCBI
PTPRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38202,864,184 - 3,038,669 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl202,870,754 - 3,039,247 (+)Ensemblhg38GRCh38
GRCh37202,844,830 - 3,019,315 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36202,792,841 - 2,967,315 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34202,851,852 - 2,967,314NCBI
Celera202,907,196 - 3,081,302 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef202,793,748 - 2,965,653 (+)NCBIHuRef
CHM1_1202,844,843 - 3,014,144 (+)NCBICHM1_1
T2T-CHM13v2.0202,895,030 - 3,069,415 (+)NCBIT2T-CHM13v2.0
Ptpra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,292,198 - 130,396,220 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,292,198 - 130,398,044 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382130,450,278 - 130,554,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,450,278 - 130,556,124 (+)Ensemblmm10GRCm38
MGSCv372130,276,014 - 130,380,036 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362130,194,915 - 130,245,464 (+)NCBIMGSCv36mm8
Celera2131,674,730 - 131,778,720 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.23NCBI
Ptpra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541513,819,717 - 13,967,068 (+)Ensembl
ChiLan1.0NW_00495541513,819,934 - 13,967,068 (+)NCBIChiLan1.0ChiLan1.0
PTPRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,843,586 - 4,005,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1203,840,405 - 4,002,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0202,962,701 - 3,125,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1202,726,657 - 2,888,195 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl202,801,905 - 2,888,195 (+)EnsemblpanPan2panpan1.1
PTPRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,224,355 - 18,395,650 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,224,801 - 18,296,350 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2418,052,684 - 18,223,899 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02418,643,403 - 18,815,534 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,643,403 - 18,815,666 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,236,577 - 18,408,752 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,349,051 - 18,519,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,677,051 - 18,848,067 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ptpra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,313,690 - 167,441,022 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648515,744,205 - 15,872,995 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648515,745,054 - 15,872,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,637,932 - 32,797,104 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11732,638,494 - 32,797,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,008,987 - 37,167,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,559,634 - 33,724,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,559,697 - 33,722,137 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607110,789,232 - 10,956,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,075,101 - 4,155,130 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247413,997,853 - 4,155,130 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptpra
739 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:249
Count of miRNA genes:171
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000055801
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3136091420155634702Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
BE108511  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,759,831 - 117,760,025 (+)MAPPERmRatBN7.2
Rnor_6.03123,084,673 - 123,084,866NCBIRnor6.0
Rnor_5.03129,582,801 - 129,582,994UniSTSRnor5.0
RGSC_v3.43118,171,401 - 118,171,594UniSTSRGSC3.4
Celera3116,570,691 - 116,570,884UniSTS
RH 3.4 Map31001.2UniSTS
Cytogenetic Map3q36UniSTS
AU047115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,731,453 - 117,731,719 (+)MAPPERmRatBN7.2
Rnor_6.03123,058,055 - 123,058,320NCBIRnor6.0
Rnor_5.03129,556,183 - 129,556,448UniSTSRnor5.0
RGSC_v3.43118,143,790 - 118,144,055UniSTSRGSC3.4
Celera3116,545,174 - 116,545,439UniSTS
Cytogenetic Map3q36UniSTS
RH134950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23117,711,190 - 117,711,386 (+)MAPPERmRatBN7.2
Rnor_6.03123,037,794 - 123,037,989NCBIRnor6.0
Rnor_5.03129,535,922 - 129,536,117UniSTSRnor5.0
RGSC_v3.43118,123,530 - 118,123,725UniSTSRGSC3.4
Celera3116,524,913 - 116,525,108UniSTS
RH 3.4 Map31000.7UniSTS
Cytogenetic Map3q36UniSTS


Genetic Models
This gene Ptpra is modified in the following models/strains:
F344-PtpraTn(sb-T2/Bart3)2.261Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000055801   ⟹   ENSRNOP00000052657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,103,279 - 138,212,832 (+)Ensembl
mRatBN7.2 Ensembl3117,650,183 - 117,759,728 (+)Ensembl
Rnor_6.0 Ensembl3122,976,104 - 123,084,569 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080379   ⟹   ENSRNOP00000069583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,103,523 - 138,213,123 (+)Ensembl
mRatBN7.2 Ensembl3117,650,183 - 117,759,728 (+)Ensembl
Rnor_6.0 Ensembl3123,031,307 - 123,084,863 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147780   ⟹   ENSRNOP00000103665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,103,523 - 138,213,123 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000159514   ⟹   ENSRNOP00000106708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,098,110 - 138,205,063 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162829   ⟹   ENSRNOP00000109915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3138,103,437 - 138,213,126 (+)Ensembl
RefSeq Acc Id: NM_012763   ⟹   NP_036895
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,103,295 - 138,212,835 (+)NCBI
mRatBN7.23117,650,183 - 117,759,731 (+)NCBI
Rnor_6.03122,976,104 - 123,084,572 (+)NCBI
Rnor_5.03129,475,237 - 129,582,992 (+)NCBI
RGSC_v3.43118,061,713 - 118,171,300 (+)RGD
Celera3116,464,194 - 116,570,590 (+)RGD
Sequence:
RefSeq Acc Id: XM_006235006   ⟹   XP_006235068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,103,261 - 138,212,810 (+)NCBI
mRatBN7.23117,650,146 - 117,759,744 (+)NCBI
Rnor_6.03122,976,066 - 123,084,585 (+)NCBI
Rnor_5.03129,475,237 - 129,582,992 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104340   ⟹   XP_038960268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,103,314 - 138,212,810 (+)NCBI
mRatBN7.23117,650,203 - 117,759,744 (+)NCBI
RefSeq Acc Id: XM_063283139   ⟹   XP_063139209
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83138,177,357 - 138,212,810 (+)NCBI
RefSeq Acc Id: NP_036895   ⟸   NM_012763
- Peptide Label: precursor
- UniProtKB: Q03348 (UniProtKB/Swiss-Prot),   Q66HJ7 (UniProtKB/TrEMBL),   F1M833 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235068   ⟸   XM_006235006
- Peptide Label: isoform X1
- UniProtKB: Q03348 (UniProtKB/Swiss-Prot),   A0A8J8YBN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069583   ⟸   ENSRNOT00000080379
Ensembl Acc Id: ENSRNOP00000052657   ⟸   ENSRNOT00000055801
RefSeq Acc Id: XP_038960268   ⟸   XM_039104340
- Peptide Label: isoform X1
- UniProtKB: Q03348 (UniProtKB/Swiss-Prot),   A0A8J8YBN3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139209   ⟸   XM_063283139
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000103665   ⟸   ENSRNOT00000147780
Ensembl Acc Id: ENSRNOP00000106708   ⟸   ENSRNOT00000159514
Ensembl Acc Id: ENSRNOP00000109915   ⟸   ENSRNOT00000162829
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q03348-F1-model_v2 AlphaFold Q03348 1-796 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692434
Promoter ID:EPDNEW_R2958
Type:multiple initiation site
Name:Ptpra_1
Description:protein tyrosine phosphatase, receptor type, A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03122,976,086 - 122,976,146EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3450 AgrOrtholog
BioCyc Gene G2FUF-47855 BioCyc
Ensembl Genes ENSRNOG00000021223 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000147780 ENTREZGENE
  ENSRNOT00000162829 ENTREZGENE
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107006 IMAGE-MGC_LOAD
InterPro Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot
  Protein-Tyr_Phosphatase UniProtKB/Swiss-Prot
  PTPase_domain UniProtKB/Swiss-Prot
  Tyr_Pase_AS UniProtKB/Swiss-Prot
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  Tyr_Pase_rcpt_a/e-type UniProtKB/Swiss-Prot
  Tyr_Pase_rcpt_alpha UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:93561 IMAGE-MGC_LOAD
NCBI Gene 25167 ENTREZGENE
PANTHER PTHR19134:SF433 UniProtKB/Swiss-Prot
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
Pfam Y_phosphatase UniProtKB/Swiss-Prot
PhenoGen Ptpra PhenoGen
PIRSF PTPR_alpha UniProtKB/Swiss-Prot
  PTPR_alpha_epsilon UniProtKB/Swiss-Prot
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021223 RatGTEx
SMART PTPc UniProtKB/Swiss-Prot
  PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot
TIGR TC229590
UniProt A0A0G2JVR0_RAT UniProtKB/TrEMBL
  A0A8J8YBN3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L3A4_RAT UniProtKB/TrEMBL
  A0ABK0L8U4_RAT UniProtKB/TrEMBL
  A0ABK0M4N9_RAT UniProtKB/TrEMBL
  F1M833 ENTREZGENE
  PTPRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q66HJ7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ptpra  Protein tyrosine phosphatase, receptor type, A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has two intracellular PTPase domains 633823
gene_regulation expression is inhibited by treatment with Il6 or Il1 633823