Ptpra (protein tyrosine phosphatase receptor type A) - Rat Genome Database

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Gene: Ptpra (protein tyrosine phosphatase receptor type A) Ictidomys tridecemlineatus
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Symbol: Ptpra
Name: protein tyrosine phosphatase receptor type A
RGD ID: 12715738
Description: ENCODES a protein that exhibits protein tyrosine phosphatase activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); oligodendrocyte differentiation (ortholog); positive regulation of oligodendrocyte differentiation (ortholog); PARTICIPATES IN insulin signaling pathway; ASSOCIATED WITH Dystonia 30 (ortholog); gastric adenocarcinoma (ortholog); genetic disease (ortholog); FOUND IN Schaffer collateral - CA1 synapse (ortholog); synaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor-type tyrosine-protein phosphatase alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,313,690 - 167,441,022 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648515,744,205 - 15,872,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648515,745,054 - 15,872,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Ptpra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640167,313,690 - 167,441,022 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648515,744,205 - 15,872,995 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648515,745,054 - 15,872,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38202,864,184 - 3,038,669 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl202,873,420 - 3,039,076 (+)EnsemblGRCh38hg38GRCh38
GRCh37202,844,830 - 3,019,315 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36202,792,841 - 2,967,315 (+)NCBINCBI36Build 36hg18NCBI36
Build 34202,851,852 - 2,967,314NCBI
Celera202,907,196 - 3,081,302 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef202,793,748 - 2,965,653 (+)NCBIHuRef
CHM1_1202,844,843 - 3,014,144 (+)NCBICHM1_1
T2T-CHM13v2.0202,895,030 - 3,069,415 (+)NCBIT2T-CHM13v2.0
Ptpra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392130,292,198 - 130,396,220 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2130,292,198 - 130,398,044 (+)EnsemblGRCm39 Ensembl
GRCm382130,450,278 - 130,554,300 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2130,450,278 - 130,556,124 (+)EnsemblGRCm38mm10GRCm38
MGSCv372130,276,014 - 130,380,036 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,194,915 - 130,245,464 (+)NCBIMGSCv36mm8
Celera2131,674,730 - 131,778,720 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.23NCBI
Ptpra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,103,261 - 138,212,835 (+)NCBIGRCr8
mRatBN7.23117,650,146 - 117,759,744 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3117,650,183 - 117,759,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3121,547,451 - 121,654,208 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,143,111 - 130,251,468 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03127,803,579 - 127,910,341 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03122,976,066 - 123,084,585 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3122,976,104 - 123,084,863 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03129,475,237 - 129,582,992 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,061,713 - 118,171,300 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,022,615 - 118,077,164 (+)NCBI
Celera3116,464,194 - 116,570,590 (+)NCBICelera
Cytogenetic Map3q36NCBI
Ptpra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541513,819,717 - 13,967,068 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541513,819,934 - 13,967,068 (+)NCBIChiLan1.0ChiLan1.0
PTPRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2213,843,586 - 4,005,991 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1203,840,405 - 4,002,816 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0202,962,701 - 3,125,282 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1202,726,657 - 2,888,195 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl202,801,905 - 2,888,195 (+)Ensemblpanpan1.1panPan2
PTPRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12418,224,355 - 18,395,650 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2418,224,801 - 18,296,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2418,052,684 - 18,223,899 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02418,643,403 - 18,815,534 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2418,643,403 - 18,815,666 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12418,236,577 - 18,408,752 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02418,349,051 - 18,519,508 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,677,051 - 18,848,067 (-)NCBIUU_Cfam_GSD_1.0
PTPRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1732,637,932 - 32,797,104 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11732,638,494 - 32,797,110 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21737,008,987 - 37,167,722 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1233,559,634 - 33,724,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl233,559,697 - 33,722,137 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607110,789,232 - 10,956,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,075,101 - 4,155,130 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247413,997,853 - 4,155,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSSTOT00000024562   ⟹   ENSSTOP00000021338
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648515,744,205 - 15,872,995 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000028049   ⟹   ENSSTOP00000022162
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648515,744,205 - 15,872,995 (-)Ensembl
RefSeq Acc Id: XM_005320535   ⟹   XP_005320592
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,440,873 (-)NCBI
SpeTri2.0NW_00493648515,745,054 - 15,872,377 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013356486   ⟹   XP_013211940
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,440,873 (-)NCBI
SpeTri2.0NW_00493648515,745,054 - 15,872,377 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723207   ⟹   XP_021578882
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,406,500 (-)NCBI
SpeTri2.0NW_00493648515,745,054 - 15,837,870 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723208   ⟹   XP_021578883
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,363,544 (-)NCBI
SpeTri2.0NW_00493648515,745,054 - 15,794,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021723211   ⟹   XP_021578886
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,353,901 (-)NCBI
SpeTri2.0NW_00493648515,745,054 - 15,801,858 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040275396   ⟹   XP_040131330
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,441,022 (-)NCBI
RefSeq Acc Id: XM_040275397   ⟹   XP_040131331
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640167,313,690 - 167,441,022 (-)NCBI
RefSeq Acc Id: XP_005320592   ⟸   XM_005320535
- Peptide Label: isoform X1
- UniProtKB: I3NAE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013211940   ⟸   XM_013356486
- Peptide Label: isoform X2
- UniProtKB: I3NCR5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578882   ⟸   XM_021723207
- Peptide Label: isoform X1
- UniProtKB: I3NAE1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021578886   ⟸   XM_021723211
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_021578883   ⟸   XM_021723208
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_040131331   ⟸   XM_040275397
- Peptide Label: isoform X4
RefSeq Acc Id: XP_040131330   ⟸   XM_040275396
- Peptide Label: isoform X3
RefSeq Acc Id: ENSSTOP00000022162   ⟸   ENSSTOT00000028049
RefSeq Acc Id: ENSSTOP00000021338   ⟸   ENSSTOT00000024562

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023551 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024562.2 UniProtKB/TrEMBL
  ENSSTOT00000028049.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_rcpt_a/e-type UniProtKB/TrEMBL
  Tyr_Pase_rcpt_alpha UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene Ptpra ENTREZGENE
PANTHER PTHR19134:SF433 UniProtKB/TrEMBL
  RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PIRSF PTPR_alpha UniProtKB/TrEMBL
  PTPR_alpha_epsilon UniProtKB/TrEMBL
PRINTS PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt I3NAE1 ENTREZGENE, UniProtKB/TrEMBL
  I3NCR5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Ptpra  protein tyrosine phosphatase receptor type A    protein tyrosine phosphatase, receptor type A  Symbol and/or name change 5135510 APPROVED