Prkar1a (protein kinase cAMP-dependent type I regulatory subunit alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prkar1a (protein kinase cAMP-dependent type I regulatory subunit alpha) Rattus norvegicus
Analyze
Symbol: Prkar1a
Name: protein kinase cAMP-dependent type I regulatory subunit alpha
RGD ID: 3391
Description: Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in female meiotic nuclear division and negative regulation of meiotic nuclear division. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease 1. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cAMP-dependent protein kinase type I-alpha regulatory subunit; Protein kinase cAMP dependent regulatory type 1; protein kinase cAMP-dependent type 1 regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type I, alpha; Protein kinase, cAMP dependent, regulatory, type 1; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; RIIA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Prkar1a-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: On NCBI's build 4.2, GeneID 25725 (Prkar1a) was annotated incorrectly on chromosome X of the reference assembly but annotated correctly on chromosome 10 of the alternate Celera assembly. The chromosome X location appears to be a Prkar1a pseudogene now represented by GeneID 100510791 and the Reference Sequence NG_027837. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,120,537 - 95,139,028 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1095,120,487 - 95,139,025 (+)EnsemblGRCr8
mRatBN7.21094,621,042 - 94,639,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1094,620,039 - 94,639,041 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1099,678,564 - 99,695,215 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,141,642 - 99,158,293 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01094,551,627 - 94,568,234 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01097,940,705 - 97,959,199 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)Ensemblrn6Rnor6.0
Rnor_5.01097,655,261 - 97,671,804 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410148,642,200 - 148,642,454 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1093,279,500 - 93,296,131 (+)NCBICelera
RGSC_v3.11099,121,411 - 99,121,777 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
deguelin  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
lead diacetate  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylparaben  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
ochratoxin A  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
procymidone  (EXP)
propiconazole  (ISO)
quinoline  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
apoptotic cell death pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin signaling pathway  (IEA)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway   (ISO)
protein kinase A (PKA) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
2. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. Groussin L, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4324-9.
6. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Kirschner LS, etal., Nat Genet. 2000 Sep;26(1):89-92.
7. Expression and modification of PKA and AKAPs during meiosis in rat oocytes. Kovo M, etal., Mol Cell Endocrinol 2002 Jun 28;192(1-2):105-13.
8. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
9. Molecular cloning and cDNA structure of the regulatory subunit of type I cAMP-dependent protein kinase from rat brain. Kuno T, etal., Biochem Biophys Res Commun 1987 Jul 31;146(2):878-83.
10. cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes. Lazar S, etal., Mol Endocrinol 2002 Feb;16(2):331-41.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Clustered distribution of cAMP-dependent protein kinase regulatory isoform RI alpha during the development of the rat brain. Mucignat-Caretta C and Caretta A, J Comp Neurol. 2002 Sep 30;451(4):324-33.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, etal., BMC Cell Biol. 2011 May 10;12:18. doi: 10.1186/1471-2121-12-18.
23. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. Vigil D, etal., J Biol Chem. 2005 Oct 21;280(42):35521-7. Epub 2005 Aug 17.
Additional References at PubMed
PMID:7775586   PMID:8794865   PMID:12004056   PMID:12475942   PMID:12815184   PMID:15299028   PMID:15381255   PMID:17895835   PMID:17911601   PMID:18316483   PMID:19946888   PMID:20581396  
PMID:21423175   PMID:21502359   PMID:21812984   PMID:22674394   PMID:24307699   PMID:24413018   PMID:24501172   PMID:25097019   PMID:25587115   PMID:30026308   PMID:30053369  


Genomics

Comparative Map Data
Prkar1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,120,537 - 95,139,028 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1095,120,487 - 95,139,025 (+)EnsemblGRCr8
mRatBN7.21094,621,042 - 94,639,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1094,620,039 - 94,639,041 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1099,678,564 - 99,695,215 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,141,642 - 99,158,293 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01094,551,627 - 94,568,234 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01097,940,705 - 97,959,199 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)Ensemblrn6Rnor6.0
Rnor_5.01097,655,261 - 97,671,804 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410148,642,200 - 148,642,454 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1093,279,500 - 93,296,131 (+)NCBICelera
RGSC_v3.11099,121,411 - 99,121,777 (+)NCBI
Cytogenetic Map10q32.1NCBI
PRKAR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381768,413,623 - 68,551,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1768,511,780 - 68,551,319 (+)Ensemblhg38GRCh38
GRCh371766,409,764 - 66,547,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,019,705 - 64,040,506 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341764,020,137 - 64,040,503NCBI
Celera1763,079,899 - 63,100,701 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1761,893,655 - 61,933,191 (+)NCBIHuRef
CHM1_11766,572,677 - 66,612,184 (+)NCBICHM1_1
T2T-CHM13v2.01769,290,146 - 69,428,169 (+)NCBIT2T-CHM13v2.0
Prkar1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911109,539,849 - 109,560,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11109,540,231 - 109,560,482 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811109,649,023 - 109,669,663 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11109,649,405 - 109,669,656 (+)Ensemblmm10GRCm38
MGSCv3711109,512,263 - 109,530,962 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611109,467,039 - 109,485,738 (+)NCBIMGSCv36mm8
Celera11121,389,458 - 121,408,159 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1172.33NCBI
Prkar1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554784,241,283 - 4,263,087 (-)Ensembl
ChiLan1.0NW_0049554784,241,283 - 4,262,119 (-)NCBIChiLan1.0ChiLan1.0
PRKAR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21984,540,117 - 84,579,940 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11789,361,347 - 89,382,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01762,448,718 - 62,488,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11767,838,484 - 67,859,610 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1767,838,484 - 67,877,943 (+)EnsemblpanPan2panpan1.1
PRKAR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,180,940 - 15,203,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,181,393 - 15,200,683 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha916,073,435 - 16,095,493 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0916,843,167 - 16,864,963 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl916,843,199 - 16,864,958 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1915,788,124 - 15,809,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0911,723,365 - 11,745,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0911,723,316 - 11,745,376 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Prkar1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560211,330,929 - 11,348,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365417,845,676 - 7,863,709 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365417,845,876 - 7,863,677 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1211,662,347 - 11,681,373 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11211,662,344 - 11,681,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,130,798 - 12,147,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12p14NCBI
PRKAR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11653,021,666 - 53,042,594 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1653,023,963 - 53,042,493 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607723,949,350 - 23,970,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkar1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248703,552,745 - 3,574,880 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248703,552,608 - 3,575,461 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Prkar1a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1969,477,329 - 69,496,563 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Prkar1a
114 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:122
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000071153
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH131422  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81095,119,892 - 95,120,052 (+)Marker Load Pipeline
mRatBN7.21094,620,396 - 94,620,556 (+)MAPPERmRatBN7.2
Rnor_6.01097,940,061 - 97,940,220NCBIRnor6.0
Rnor_5.01097,654,617 - 97,654,776UniSTSRnor5.0
Celera1093,278,856 - 93,279,015UniSTS
Cytogenetic Map10q32.1UniSTS
RH94506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21094,637,555 - 94,637,650 (+)MAPPERmRatBN7.2
mRatBN7.2X141,340,349 - 141,340,444 (-)MAPPERmRatBN7.2
mRatBN7.2X141,340,349 - 141,340,444 (+)MAPPERmRatBN7.2
mRatBN7.21094,637,555 - 94,637,650 (-)MAPPERmRatBN7.2
Rnor_6.01097,957,221 - 97,957,315NCBIRnor6.0
Rnor_6.0X146,072,848 - 146,072,942NCBIRnor6.0
Rnor_5.0X146,083,937 - 146,084,031UniSTSRnor5.0
Rnor_5.01097,671,689 - 97,671,783UniSTSRnor5.0
RGSC_v3.4X148,642,221 - 148,642,315UniSTSRGSC3.4
RGSC_v3.41099,107,292 - 99,107,386UniSTSRGSC3.4
Celera1093,296,016 - 93,296,110UniSTS
CeleraX137,322,754 - 137,322,848UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic MapXq36UniSTS
BM386718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21094,629,142 - 94,629,292 (+)MAPPERmRatBN7.2
Rnor_6.01097,948,808 - 97,948,957NCBIRnor6.0
Rnor_5.01097,663,276 - 97,663,425UniSTSRnor5.0
Celera1093,287,603 - 93,287,752UniSTS
RH 3.4 Map101071.29UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071153   ⟹   ENSRNOP00000067771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1095,120,596 - 95,139,025 (+)Ensembl
mRatBN7.2 Ensembl1094,621,469 - 94,639,036 (+)Ensembl
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094613   ⟹   ENSRNOP00000095855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1095,121,110 - 95,139,025 (+)Ensembl
mRatBN7.2 Ensembl1094,621,440 - 94,639,036 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095989   ⟹   ENSRNOP00000080176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1095,120,487 - 95,138,475 (+)Ensembl
mRatBN7.2 Ensembl1094,628,962 - 94,639,041 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119272   ⟹   ENSRNOP00000088358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1095,120,536 - 95,138,475 (+)Ensembl
mRatBN7.2 Ensembl1094,620,039 - 94,639,041 (+)Ensembl
RefSeq Acc Id: NM_013181   ⟹   NP_037313
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,120,537 - 95,137,165 (+)NCBI
mRatBN7.21094,621,042 - 94,637,671 (+)NCBI
Rnor_6.01097,940,705 - 97,957,336 (+)NCBI
Rnor_5.01097,655,261 - 97,671,804 (+)NCBI
RGSC_v3.410148,642,200 - 148,642,454 (-)RGD
Celera1093,279,500 - 93,296,131 (+)RGD
Sequence:
RefSeq Acc Id: XM_008768311   ⟹   XP_008766533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,120,735 - 95,139,028 (+)NCBI
mRatBN7.21094,621,406 - 94,639,534 (+)NCBI
Rnor_6.01097,941,074 - 97,959,199 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085298   ⟹   XP_038941226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,121,428 - 95,139,028 (+)NCBI
mRatBN7.21094,622,044 - 94,639,534 (+)NCBI
RefSeq Acc Id: XM_063268486   ⟹   XP_063124556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,121,122 - 95,139,028 (+)NCBI
RefSeq Acc Id: NP_037313   ⟸   NM_013181
- UniProtKB: P09456 (UniProtKB/Swiss-Prot),   A6HKB8 (UniProtKB/TrEMBL),   A0A8I5ZQ48 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766533   ⟸   XM_008768311
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A621 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000067771   ⟸   ENSRNOT00000071153
RefSeq Acc Id: XP_038941226   ⟸   XM_039085298
- Peptide Label: isoform X3
- UniProtKB: P09456 (UniProtKB/Swiss-Prot),   A6HKB8 (UniProtKB/TrEMBL),   A0A8I5ZQ48 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088358   ⟸   ENSRNOT00000119272
Ensembl Acc Id: ENSRNOP00000095855   ⟸   ENSRNOT00000094613
Ensembl Acc Id: ENSRNOP00000080176   ⟸   ENSRNOT00000095989
RefSeq Acc Id: XP_063124556   ⟸   XM_063268486
- Peptide Label: isoform X2
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09456-F1-model_v2 AlphaFold P09456 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697862
Promoter ID:EPDNEW_R8386
Type:initiation region
Name:Prkar1a_1
Description:protein kinase cAMP-dependent type 1 regulatory subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01097,940,720 - 97,940,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3391 AgrOrtholog
BioCyc Gene G2FUF-22827 BioCyc
Ensembl Genes ENSRNOG00000049876 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071153 ENTREZGENE
  ENSRNOT00000094613 ENTREZGENE
  ENSRNOT00000119272 ENTREZGENE
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/Swiss-Prot
InterPro cAMP-dep_kinase_reg_chain UniProtKB/Swiss-Prot
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot
  cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:25725 UniProtKB/Swiss-Prot
NCBI Gene 25725 ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN UniProtKB/Swiss-Prot
  CAMP-DEPENDENT PROTEIN KINASE TYPE I-ALPHA REGULATORY SUBUNIT UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  RIIa UniProtKB/Swiss-Prot
PhenoGen Prkar1a PhenoGen
PRINTS CAMPKINASE UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot
  CNMP_BINDING_2 UniProtKB/Swiss-Prot
  CNMP_BINDING_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049876 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
  RIIa UniProtKB/Swiss-Prot
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/Swiss-Prot
  SSF51206 UniProtKB/Swiss-Prot
TIGR TC216814
UniProt A0A8I5ZQ48 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A621 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AKN7_RAT UniProtKB/TrEMBL
  A0A8L2QZB9_RAT UniProtKB/TrEMBL
  A6HKB8 ENTREZGENE, UniProtKB/TrEMBL
  KAP0_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Prkar1a  protein kinase cAMP-dependent type I regulatory subunit alpha  Prkar1a  protein kinase cAMP-dependent type 1 regulatory subunit alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prkar1a  protein kinase cAMP-dependent type 1 regulatory subunit alpha  Prkar1a  protein kinase, cAMP-dependent, regulatory subunit type I alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkar1a  protein kinase, cAMP-dependent, regulatory subunit type I alpha  Prkar1a  protein kinase, cAMP-dependent, regulatory, type I, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Prkar1a  Protein kinase, cAMP dependent, regulatory, type 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds and inactivates the catalytic subunit of the PKA enzyme; targets different PKA isoenzymes to various subcellular loci and specific substrates 633705
gene_physical_interaction interacts with A-kinase anchoring proteins (AKAPs) 633705