Ppp2cb Rat Gene (protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform)

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Keyword

Gene:
Ppp2cb ( Rattus norvegicus )
protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform
Description: catalytic subunit of multimeric serine/threonine phosphatase; involved in insulin signal transduction; negatively regulates the Ras/MAP kinase pathway by binding to Shc, inhibiting tyrosine phosphorylation
Synonyms: Pp2a2; MGC94855; Protein phosphatase 2 (formerly 2A) catalytic subunit beta isoform; protein phosphatase 2a, catalytic subunit, beta isoform;  (details...)
ArrayIDs: 1397349_at; 6221380; 6507732; X16044cds_s_at; 1367827_at; 6447962; 6669222; 6610965; M23591mRNA#2_at; A_43_P11789; 5707674; 6348613; 6708358; A_44_P650986; 6396214; 6659504; 5689573; 6560429; 6306812; 6603189; 6267029; GE20297; A_44_P251804; 6540943; 6215594; 5812226; 5946938; 6548780;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: PPP2CB     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Ppp2cb     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Ppp2cb genome assembly 3.1 16 62330587 - 62352043
Rat Celera Assembly 16 56593787 - 56615293
RGSC genome assembly v3.4 16 62330513 - 62351968
Cytogenetic 16 q12.3
Mus musculus Ppp2cb Mouse genome assembly build 36.1 8 34710093 - 34730276
Cytogenetic 8 8 A4
Homo sapiens PPP2CB human genome assembly 8 30762668 - 30789894
Human genome assembly build 36.2 8 30762668 - 30789894
Cytogenetic 8 p12

View comparative maps:      NCBI MapViewer

Genome
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Annotation
Molecular Function

Gene Ontology

iron ion binding,  protein domain specific binding,  protein heterodimerization activity ... (details...)
Biological Process

Gene Ontology

regulation of gene expression,  response to hydrogen peroxide,  protein amino acid dephosphorylation ... (details...)
Cellular Component

Gene Ontology

nucleus,  chromosome, centromeric region,  protein phosphatase type 2A complex ... (details...)
Physical interaction

Note Reference

forms complex with Shc by interacting with Shc PTB domain 729591

External Links
Databases
DATABASE ID SOURCE
SMART: PP2Ac IPI
PROSITE: SER_THR_PHOSPHATASE IPI
UNIPARC: UPI000049AFD9 IPI
UNIPARC: UPI0000501EE9 IPI
UNIPARC: UPI0000000CC2 IPI
KEGG Report: rno:24673 ENTREZGENE
HomoloGene Group ID: 37889 ENTREZGENE
Germonline: 3381
Pfam: Metallophos IPI
KEGG Pathway: 04530 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 04350 ENTREZGENE
KEGG Pathway: 04730 ENTREZGENE
InterPro: Ser/Thr-sp_prot-phosphatase. IPI
InterPro: M-pesterase. IPI
Ensembl Protein: ENSRNOP00000020663 IPI
Ensembl Protein: ENSRNOP00000049835 IPI
IPI: IPI00900491 IPI
IPI: IPI00949614 IPI
IPI: IPI00561107 IPI
Entrez Gene: Ppp2cb ENTREZGENE
IMAGE_CLONE: IMAGE:7109733 IMAGE-MGC_LOAD
MGC_CLONE: MGC:94855 IMAGE-MGC_LOAD
UniProt: PP2AB_RAT IPI
UniProt: Q5MKL3_RAT IPI
Ensembl Genes: ENSRNOG00000015182 IPI
RatMap: 34318 ENTREZGENE
PANTHER: T_phtase_apaH IPI
PRINTS: STPHPHTASE. IPI
Sequences
Nucleotide: M23591 Get FASTA Search GEO Profiles
Nucleotide: AY749432 Get FASTA Search GEO Profiles
Nucleotide: X14087 Get FASTA Search GEO Profiles
Nucleotide: NM_017040 Get FASTA Search GEO Profiles
Nucleotide: X16044 Get FASTA Search GEO Profiles
Nucleotide: CH473970 Get FASTA Search GEO Profiles
Nucleotide: XM_001067962 Get FASTA Search GEO Profiles
Nucleotide: BC085926 Get FASTA Search GEO Profiles
(View all 8 Nucleotide Accessions)
Protein: NP_058736 Get FASTA
Protein: XP_001067962 Get FASTA
Protein: AAV91199 Get FASTA
Protein: EDM09140 Get FASTA
Protein: AAH85926 Get FASTA
Protein: AAA41912 Get FASTA
Protein: CAA32249 Get FASTA
Protein: CAA34167 Get FASTA
Protein: P62716 Get FASTA
Protein: Q5MKL3 Get FASTA
(View all 10 Protein Accessions)
Clusters
UniGene: 977

References
Curated References
7 references in RGD related to Ppp2cb

Other References
14 other references at PubMed related to Ppp2cb

Database Information
RGD ID 3381
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

30-MAR-06: Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform protein phosphatase 2a, catalytic subunit, beta isoform APPROVED Name updated 1299863

10-JUN-02: Ppp2cb Protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform APPROVED Symbol and Name status set to approved 70586