Ppp1cc (protein phosphatase 1 catalytic subunit gamma) - Rat Genome Database

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Gene: Ppp1cc (protein phosphatase 1 catalytic subunit gamma) Rattus norvegicus
Analyze
Symbol: Ppp1cc
Name: protein phosphatase 1 catalytic subunit gamma
RGD ID: 3377
Description: Enables lamin binding activity; protein domain specific binding activity; and protein phosphatase 1 binding activity. Involved in positive regulation of glial cell proliferation. Acts upstream of or within neuron differentiation. Located in dendritic spine. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of congestive heart failure. Orthologous to human PPP1CC (protein phosphatase 1 catalytic subunit gamma); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; dopamine signaling pathway; glycogen biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium acetate; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PP-1G; Ppp1cc1; protein phosphatase 1 catalytic subunit gamma isoform; protein phosphatase 1 catalytic subunit gamma isoform 1; Protein phosphatase 1 catalytic subunit gamma isoform 1 (possible existence of an alternative gene product Ppp1cc2); protein phosphatase 1, catalytic subunit, gamma isoform; protein phosphatase 1, catalytic subunit, gamma isozyme; protein phosphatase 1C catalytic subunit; protein serine-threonine phosphatase catalytic subunit PP-1b; serine/threonine-protein phosphatase PP1-gamma catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Lnnr1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,043,822 - 40,061,301 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,043,822 - 40,061,341 (-)EnsemblGRCr8
mRatBN7.21234,383,072 - 34,400,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,555,467 - 35,572,955 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,166,698 - 36,184,182 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,219,154 - 35,236,638 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,864,302 - 39,882,030 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,864,295 - 39,882,030 (-)Ensemblrn6Rnor6.0
Rnor_5.01241,744,531 - 41,762,059 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,580,169 - 35,598,249 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,054,251 - 36,071,363 (-)NCBICelera
RGSC_v3.11235,443,556 - 35,461,637 (-)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
all-trans-retinoic acid  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
ampicillin  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calyculin A  (ISO)
cannabidiol  (EXP)
carbon nanotube  (ISO)
clofibric acid  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyproconazole  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
microcystin-LR  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
neomycin  (EXP)
nitrates  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
roflumilast  (EXP)
rotenone  (EXP,ISO)
salubrinal  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium azide  (EXP)
Tautomycin  (EXP,ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61.
2. Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Burén S, etal., Cancer Cell. 2016 Aug 8;30(2):290-307. doi: 10.1016/j.ccell.2016.06.023.
3. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
4. Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Ceulemans H and Bollen M, Physiol Rev. 2004 Jan;84(1):1-39.
5. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Cid C, etal., Proteomics. 2007 Sep;7(17):3207-18.
6. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Protein Phosphatase 1c Associated with the Cardiac Sodium Calcium Exchanger 1 Regulates Its Activity by Dephosphorylating Serine 68-phosphorylated Phospholemman. Hafver TL, etal., J Biol Chem. 2016 Feb 26;291(9):4561-79. doi: 10.1074/jbc.M115.677898. Epub 2015 Dec 14.
9. Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases. Ishida A, etal., Br J Pharmacol. 2008 Jun;154(4):729-40. doi: 10.1038/bjp.2008.127. Epub 2008 May 5.
10. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. Li T, etal., J Biol Chem. 2007 Mar 2;282(9):6619-28. Epub 2007 Jan 3.
11. PPP1CC is associated with astrocyte and microglia proliferation after traumatic spinal cord injury in rats. Liu X, etal., Pathol Res Pract. 2017 Nov;213(11):1355-1364. doi: 10.1016/j.prp.2017.09.020. Epub 2017 Sep 28.
12. Regulation of neurabin I interaction with protein phosphatase 1 by phosphorylation. McAvoy T, etal., Biochemistry. 1999 Sep 28;38(39):12943-9.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines. Ouimet CC, etal., Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3396-400.
16. Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1. Patel KG, etal., J Neurosci 2001 Oct 15;21(20):7954-68.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. Santos M, etal., PLoS One. 2013 Oct 7;8(10):e76788. doi: 10.1371/journal.pone.0076788. eCollection 2013.
21. Identification of members of the protein phosphatase 1 gene family in the rat and enhanced expression of protein phosphatase 1 alpha gene in rat hepatocellular carcinomas. Sasaki K, etal., Jpn J Cancer Res 1990 Dec;81(12):1272-80.
22. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. Smith FD, etal., J Biol Chem 1999 Jul 9;274(28):19894-900.
23. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
24. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. Terry-Lorenzo RT, etal., J Biol Chem 2002 Aug 2;277(31):27716-24.
25. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. Terry-Lorenzo RT, etal., J Biol Chem 2002 Nov 29;277(48):46535-43. Epub 2002 Sep 21.
26. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1653777   PMID:2174876   PMID:9755872   PMID:10585469   PMID:10880350   PMID:11739654   PMID:12065664   PMID:12931191   PMID:14640981   PMID:15016827   PMID:15247246   PMID:15908465  
PMID:16629905   PMID:17369396   PMID:17936702   PMID:18372251   PMID:20124353   PMID:20516061   PMID:21423176   PMID:21630459   PMID:21700703   PMID:21712997   PMID:21930935   PMID:22681889  
PMID:22801782   PMID:23531501   PMID:23612982   PMID:23789093   PMID:24270157   PMID:28131823  


Genomics

Comparative Map Data
Ppp1cc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,043,822 - 40,061,301 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1240,043,822 - 40,061,341 (-)EnsemblGRCr8
mRatBN7.21234,383,072 - 34,400,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1235,555,467 - 35,572,955 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,166,698 - 36,184,182 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,219,154 - 35,236,638 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,864,302 - 39,882,030 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,864,295 - 39,882,030 (-)Ensemblrn6Rnor6.0
Rnor_5.01241,744,531 - 41,762,059 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41235,580,169 - 35,598,249 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1236,054,251 - 36,071,363 (-)NCBICelera
RGSC_v3.11235,443,556 - 35,461,637 (-)NCBI
Cytogenetic Map12q16NCBI
PPP1CC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812110,708,376 - 110,742,891 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12110,719,680 - 110,742,939 (-)Ensemblhg38GRCh38
GRCh3712111,157,485 - 111,180,696 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612109,642,127 - 109,665,050 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3412109,620,463 - 109,643,387NCBI
Celera12110,784,396 - 110,807,538 (-)NCBICelera
Cytogenetic Map12q24.11NCBI
HuRef12108,174,950 - 108,198,121 (-)NCBIHuRef
CHM1_112111,125,280 - 111,148,449 (-)NCBICHM1_1
T2T-CHM13v2.012110,686,068 - 110,720,600 (-)NCBIT2T-CHM13v2.0
Ppp1cc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,296,338 - 122,313,336 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,296,341 - 122,313,336 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385122,154,967 - 122,175,273 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,158,278 - 122,175,273 (+)Ensemblmm10GRCm38
MGSCv375122,608,288 - 122,625,278 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365122,418,896 - 122,435,886 (+)NCBIMGSCv36mm8
Celera5119,247,786 - 119,264,874 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.2NCBI
Ppp1cc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,578,782 - 7,606,132 (-)Ensembl
ChiLan1.0NW_0049554827,582,605 - 7,605,340 (-)NCBIChiLan1.0ChiLan1.0
PPP1CC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210118,779,075 - 118,802,152 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112118,775,480 - 118,798,509 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012108,288,158 - 108,311,128 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112111,682,248 - 111,705,658 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12111,681,611 - 111,705,658 (-)EnsemblpanPan2panpan1.1
PPP1CC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,497,350 - 8,518,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,495,067 - 8,518,675 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha268,661,768 - 8,681,361 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0268,755,953 - 8,777,439 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,755,955 - 8,778,039 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,715,062 - 8,734,635 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,777,244 - 8,796,945 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,730,033 - 8,749,642 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1cc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,827,747 - 155,847,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,630,561 - 3,651,786 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,631,794 - 3,651,754 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1CC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,070,545 - 32,091,499 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11432,071,472 - 32,091,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,994,041 - 34,013,840 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1CC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111105,962,182 - 105,986,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037139,130,369 - 139,154,783 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1cc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,191,150 - 21,213,544 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474721,191,165 - 21,212,521 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1cc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11631,655,532 - 31,672,668 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1cc
74 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000048851
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB740494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV727747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM102812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM122849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN803249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000048851   ⟹   ENSRNOP00000047912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,822 - 40,061,301 (-)Ensembl
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)Ensembl
Rnor_6.0 Ensembl1239,864,302 - 39,882,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078761   ⟹   ENSRNOP00000071829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,822 - 40,061,301 (-)Ensembl
mRatBN7.2 Ensembl1234,383,072 - 34,400,553 (-)Ensembl
Rnor_6.0 Ensembl1239,864,302 - 39,882,030 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083296   ⟹   ENSRNOP00000069518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,822 - 40,060,612 (-)Ensembl
mRatBN7.2 Ensembl1234,383,072 - 34,399,864 (-)Ensembl
Rnor_6.0 Ensembl1239,864,295 - 39,881,352 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094425   ⟹   ENSRNOP00000081567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,822 - 40,051,095 (-)Ensembl
mRatBN7.2 Ensembl1234,383,072 - 34,390,345 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118479   ⟹   ENSRNOP00000076436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,822 - 40,061,341 (-)Ensembl
mRatBN7.2 Ensembl1234,383,072 - 34,390,369 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119439   ⟹   ENSRNOP00000083502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1240,043,822 - 40,050,826 (-)Ensembl
mRatBN7.2 Ensembl1234,383,072 - 34,390,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000120201   ⟹   ENSRNOP00000089719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,383,072 - 34,391,103 (-)Ensembl
RefSeq Acc Id: NM_001270983   ⟹   NP_001257912
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,043,822 - 40,061,301 (-)NCBI
mRatBN7.21234,383,072 - 34,400,553 (-)NCBI
Rnor_6.01239,864,302 - 39,882,030 (-)NCBI
Rnor_5.01241,744,531 - 41,762,059 (-)NCBI
Celera1236,054,251 - 36,071,363 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022498   ⟹   NP_071943
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,043,822 - 40,061,301 (-)NCBI
mRatBN7.21234,383,072 - 34,400,553 (-)NCBI
Rnor_6.01239,864,302 - 39,882,030 (-)NCBI
Rnor_5.01241,744,531 - 41,762,059 (-)NCBI
RGSC_v3.41235,580,169 - 35,598,249 (-)RGD
Celera1236,054,251 - 36,071,363 (-)NCBI
Sequence:
RefSeq Acc Id: NP_071943   ⟸   NM_022498
- Peptide Label: isoform 1
- UniProtKB: P63088 (UniProtKB/Swiss-Prot),   A6J1B7 (UniProtKB/TrEMBL),   A0A8I5ZJ60 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257912   ⟸   NM_001270983
- Peptide Label: isoform 2
- UniProtKB: Q6AYZ4 (UniProtKB/TrEMBL),   A0A0G2JVK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069518   ⟸   ENSRNOT00000083296
Ensembl Acc Id: ENSRNOP00000047912   ⟸   ENSRNOT00000048851
Ensembl Acc Id: ENSRNOP00000071829   ⟸   ENSRNOT00000078761
Ensembl Acc Id: ENSRNOP00000081567   ⟸   ENSRNOT00000094425
Ensembl Acc Id: ENSRNOP00000083502   ⟸   ENSRNOT00000119439
Ensembl Acc Id: ENSRNOP00000076436   ⟸   ENSRNOT00000118479
Ensembl Acc Id: ENSRNOP00000089719   ⟸   ENSRNOT00000120201
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63088-F1-model_v2 AlphaFold P63088 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698651
Promoter ID:EPDNEW_R9176
Type:multiple initiation site
Name:Ppp1cc_1
Description:protein phosphatase 1 catalytic subunit gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,881,971 - 39,882,031EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3377 AgrOrtholog
BIND 130595
  130599
BioCyc Gene G2FUF-19237 BioCyc
Ensembl Genes ENSRNOG00000001269 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048851 ENTREZGENE
  ENSRNOT00000048851.4 UniProtKB/Swiss-Prot
  ENSRNOT00000078761 ENTREZGENE
  ENSRNOT00000078761.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112668 IMAGE-MGC_LOAD
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  PP1_catalytic_subunit UniProtKB/Swiss-Prot
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot
  STPPase_N UniProtKB/Swiss-Prot
KEGG Report rno:24669 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93440 IMAGE-MGC_LOAD
NCBI Gene 24669 ENTREZGENE
PANTHER SERINE/THREONINE PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
  SERINE_THREONINE-PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
  STPPase_N UniProtKB/Swiss-Prot
PhenoGen Ppp1cc PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001269 RatGTEx
SMART PP2Ac UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt A0A0G2JVK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZJ60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSW1_RAT UniProtKB/TrEMBL
  A0A8I5ZX24_RAT UniProtKB/TrEMBL
  A6J1B7 ENTREZGENE, UniProtKB/TrEMBL
  P63088 ENTREZGENE, UniProtKB/Swiss-Prot
  Q6AYZ4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O09186 UniProtKB/Swiss-Prot
  O09189 UniProtKB/Swiss-Prot
  P37139 UniProtKB/Swiss-Prot
  Q64679 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp1cc  protein phosphatase 1 catalytic subunit gamma  Ppp1cc  protein phosphatase 1, catalytic subunit, gamma isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ppp1cc  protein phosphatase 1, catalytic subunit, gamma isozyme  Ppp1cc  protein phosphatase 1, catalytic subunit, gamma isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ppp1cc  Protein phosphatase 1, catalytic subunit, gamma isoform 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization recruited to the synapse by binding with neurabins, which are protein phosphatase-1 subunit targeting proteins 729440
gene_expression expressed in the dendrite spines, localized in PSD (post-synaptic density) 625568
gene_function phosphorylates receptors, ion channels, and signaling proteins 625568
gene_process interacts with neurabins to regulate synaptic activity 625568