Plin1 (perilipin 1) - Rat Genome Database

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Gene: Plin1 (perilipin 1) Rattus norvegicus
Analyze
Symbol: Plin1
Name: perilipin 1
RGD ID: 3351
Description: Predicted to be involved in lipid catabolic process and negative regulation of lipid catabolic process. Predicted to act upstream of or within cellular response to cold. Located in lipid droplet. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 4 and obesity. Orthologous to human PLIN1 (perilipin 1); INTERACTS WITH (+)-schisandrin B; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lipid droplet-associated protein; PERI; PERIA; perilipin; perilipin-1; Plin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,073,612 - 143,086,199 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,074,214 - 143,086,206 (-)EnsemblGRCr8
mRatBN7.21133,664,294 - 133,676,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,664,892 - 133,676,828 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,574,304 - 141,586,247 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,743,695 - 148,755,636 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,661,405 - 141,673,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,458,907 - 141,470,927 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,458,181 - 141,471,010 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,419,793 - 142,432,199 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,497,431 - 135,509,926 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1125,728,269 - 125,740,447 (-)NCBICelera
RGSC_v3.11135,575,836 - 135,588,332 (-)NCBI
Cytogenetic Map1q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(R)-lipoic acid  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3'-Dimethylbisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP,ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine 6-sulfate  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
celastrol  (ISO)
chlorpyrifos  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
fenofibrate  (ISO)
fentin hydroxide  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
hexadecanoic acid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
leupeptin  (ISO)
Licarin A  (ISO)
linoleic acid  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
malathion  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methylnicotinate  (ISO)
nelfinavir  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phosphatidylcholine  (ISO)
phoxim  (ISO)
pioglitazone  (ISO)
propanal  (ISO)
quercetin  (ISO)
quinoxyfen  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
terbufos  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
titanium dioxide  (ISO)
tolclofos-methyl  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell periphery  (ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA)
lipid droplet  (IBA,IDA,IEA,ISO,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. Corella D, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5121-6. Epub 2005 Jun 28.
2. Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression. Forcheron F, etal., Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1711-7. Epub 2005 Jun 16.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Greenberg AS, etal., Proc Natl Acad Sci U S A 1993 Dec 15;90(24):12035-9.
5. Heat shock protein 70 is translocated to lipid droplets in rat adipocytes upon heat stimulation. Jiang H, etal., Biochim Biophys Acta. 2007 Jan;1771(1):66-74. Epub 2006 Nov 15.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Tansey JT, etal., Proc Natl Acad Sci U S A 2001 May 22;98(11):6494-9.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. Yamaguchi T, etal., J Biol Chem 2004 Jul 16;279(29):30490-7. Epub 2004 May 10.
Additional References at PubMed
PMID:9755872   PMID:16571721   PMID:19299455   PMID:21420243   PMID:21701568  


Genomics

Comparative Map Data
Plin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,073,612 - 143,086,199 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,074,214 - 143,086,206 (-)EnsemblGRCr8
mRatBN7.21133,664,294 - 133,676,854 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1133,664,892 - 133,676,828 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1141,574,304 - 141,586,247 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01148,743,695 - 148,755,636 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,661,405 - 141,673,342 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01141,458,907 - 141,470,927 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1141,458,181 - 141,471,010 (-)Ensemblrn6Rnor6.0
Rnor_5.01142,419,793 - 142,432,199 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41135,497,431 - 135,509,926 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1125,728,269 - 125,740,447 (-)NCBICelera
RGSC_v3.11135,575,836 - 135,588,332 (-)NCBI
Cytogenetic Map1q31NCBI
PLIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381589,664,367 - 89,679,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1589,664,365 - 89,679,450 (-)Ensemblhg38GRCh38
GRCh371590,207,598 - 90,222,598 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,008,602 - 88,023,595 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341588,008,601 - 88,023,595NCBI
Celera1566,610,375 - 66,625,424 (-)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1566,320,556 - 66,335,605 (-)NCBIHuRef
CHM1_11590,048,432 - 90,063,481 (-)NCBICHM1_1
T2T-CHM13v2.01587,420,250 - 87,435,249 (-)NCBIT2T-CHM13v2.0
Plin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,370,912 - 79,382,652 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl779,369,966 - 79,382,651 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38779,721,164 - 79,732,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,720,218 - 79,732,903 (-)Ensemblmm10GRCm38
MGSCv37786,866,050 - 86,877,662 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36779,594,677 - 79,605,684 (-)NCBIMGSCv36mm8
Celera777,120,535 - 77,132,138 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.11NCBI
Plin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541615,533,268 - 15,549,772 (+)Ensembl
ChiLan1.0NW_00495541615,538,309 - 15,549,275 (+)NCBIChiLan1.0ChiLan1.0
PLIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,214,027 - 79,231,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11582,918,147 - 82,936,512 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01568,357,815 - 68,375,062 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11587,565,468 - 87,579,467 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,565,468 - 87,577,301 (-)EnsemblpanPan2panpan1.1
PLIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,657,178 - 52,670,573 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,658,427 - 52,671,196 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha355,291,156 - 55,304,527 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,073,572 - 53,086,957 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,074,803 - 53,087,586 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1352,595,775 - 52,609,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0352,805,669 - 52,819,039 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,145,820 - 53,159,427 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,853,950 - 130,877,219 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648315,457,297 - 15,470,350 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648315,457,299 - 15,470,674 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,236,348 - 55,250,797 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1755,237,517 - 55,250,797 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,125,368 - 60,142,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7q11-q14NCBI
PLIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,204,071 - 8,219,974 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,202,035 - 8,215,921 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605938,584,169 - 38,609,434 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476816,735,905 - 16,760,326 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476816,736,435 - 16,750,150 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plin1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12120,513,622 - 120,524,852 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plin1
119 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:57
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000065759
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
AI406700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21133,674,890 - 133,674,997 (+)MAPPERmRatBN7.2
Rnor_6.01141,468,990 - 141,469,096NCBIRnor6.0
Rnor_5.01142,430,211 - 142,430,317UniSTSRnor5.0
RGSC_v3.41135,508,536 - 135,508,642UniSTSRGSC3.4
Celera1125,738,510 - 125,738,616UniSTS
RH 3.4 Map11062.9UniSTS
Cytogenetic Map1q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 12 30 78 53 52 21 26 21 6 178 89 11 52 51 84 31 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000065759   ⟹   ENSRNOP00000061809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,074,214 - 143,086,206 (-)Ensembl
mRatBN7.2 Ensembl1133,664,892 - 133,676,828 (-)Ensembl
Rnor_6.0 Ensembl1141,458,993 - 141,470,380 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082164   ⟹   ENSRNOP00000068793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1143,074,214 - 143,083,547 (-)Ensembl
mRatBN7.2 Ensembl1133,664,892 - 133,674,227 (-)Ensembl
Rnor_6.0 Ensembl1141,458,181 - 141,471,010 (-)Ensembl
RefSeq Acc Id: NM_001308145   ⟹   NP_001295074
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,074,214 - 143,086,148 (-)NCBI
mRatBN7.21133,664,892 - 133,676,828 (-)NCBI
Rnor_6.01141,458,993 - 141,470,927 (-)NCBI
Celera1125,728,269 - 125,740,447 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759499   ⟹   XP_008757721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81143,073,612 - 143,086,199 (-)NCBI
mRatBN7.21133,664,294 - 133,676,854 (-)NCBI
Rnor_6.01141,458,907 - 141,470,905 (-)NCBI
Sequence:
RefSeq Acc Id: XP_008757721   ⟸   XM_008759499
- Peptide Label: isoform X1
- UniProtKB: P43884 (UniProtKB/Swiss-Prot),   F1LSF5 (UniProtKB/TrEMBL),   A6JC64 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295074   ⟸   NM_001308145
- UniProtKB: P43884 (UniProtKB/Swiss-Prot),   F1LSF5 (UniProtKB/TrEMBL),   A6JC64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068793   ⟸   ENSRNOT00000082164
Ensembl Acc Id: ENSRNOP00000061809   ⟸   ENSRNOT00000065759

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43884-F1-model_v2 AlphaFold P43884 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690133
Promoter ID:EPDNEW_R654
Type:initiation region
Name:Plin1_1
Description:perilipin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01141,470,955 - 141,471,015EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3351 AgrOrtholog
BioCyc Gene G2FUF-58777 BioCyc
Ensembl Genes ENSRNOG00000015086 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000065759 ENTREZGENE
InterPro Perilipin UniProtKB/Swiss-Prot
  PLIN1 UniProtKB/Swiss-Prot
NCBI Gene 25629 ENTREZGENE
PANTHER PERILIPIN-1 UniProtKB/Swiss-Prot
  PTHR47138 UniProtKB/Swiss-Prot
Pfam Perilipin UniProtKB/Swiss-Prot
PhenoGen Plin1 PhenoGen
PIRSF PAT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015086 RatGTEx
TIGR TC228085
UniProt A0A0G2JTP6_RAT UniProtKB/TrEMBL
  A6JC64 ENTREZGENE, UniProtKB/TrEMBL
  F1LSF5 ENTREZGENE, UniProtKB/TrEMBL
  P43884 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Plin1  perilipin 1  Plin  perilipin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Plin  Perilipin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to lipid storage droplets 729463
gene_transcript perilipin A and perilipin B are products of alternative splicing 729463