Pld2 (phospholipase D2) - Rat Genome Database

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Gene: Pld2 (phospholipase D2) Rattus norvegicus
Analyze
Symbol: Pld2
Name: phospholipase D2
RGD ID: 3350
Description: Enables phospholipase D activity and protein kinase C binding activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of vesicle-mediated transport. Located in caveola; lamellipodium; and sarcolemma. Biomarker of congestive heart failure. Orthologous to human PLD2 (phospholipase D2); PARTICIPATES IN Arf family mediated signaling pathway; glycerophospholipid metabolic pathway; mTOR signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; PLD 2; PLD1C; Pldc; rPLD2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,754,957 - 55,772,819 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,754,988 - 55,771,435 (+)EnsemblGRCr8
mRatBN7.21055,256,326 - 55,274,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,256,359 - 55,272,808 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,936,905 - 59,954,680 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,425,411 - 59,443,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,924,519 - 54,942,294 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,161,921 - 57,181,148 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,163,174 - 57,179,730 (+)Ensemblrn6Rnor6.0
Rnor_5.01056,908,891 - 56,926,691 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41057,388,474 - 57,439,063 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1054,402,188 - 54,419,867 (+)NCBICelera
RGSC_v3.11057,402,096 - 57,452,684 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-naphthylamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
aspartame  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-endorphin  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cholesterol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
decabromodiphenyl ether  (EXP)
dimethylarsinic acid  (EXP)
ethanol  (ISO)
fentanyl  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
ganglioside GM1  (EXP)
Goe 6976  (ISO)
hydrogen peroxide  (EXP)
Ilimaquinone  (ISO)
ionomycin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
linoleic acid  (ISO)
lithocholic acid  (ISO)
loperamide  (ISO)
manganese(II) chloride  (EXP)
methadone  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
nicotine  (ISO)
ochratoxin A  (EXP)
oxybenzone  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosphatidic acid  (EXP)
potassium chloride  (EXP)
prostaglandin E2  (ISO)
reactive oxygen species  (ISO)
SB 203580  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Differential changes in phospholipase D and phosphatidate phosphohydrolase activities in ischemia-reperfusion of rat heart. Asemu G, etal., Arch Biochem Biophys. 2005 Apr 1;436(1):136-44.
2. Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells. Banno Y, etal., J Biol Chem. 2005 Apr 22;280(16):16319-24. Epub 2005 Feb 10.
3. Depolarization-induced differentiation of PC12 cells is mediated by phospholipase D2 through the transcription factor CREB pathway. Banno Y, etal., J Neurochem. 2008 Mar;104(5):1372-86. Epub 2007 Nov 14.
4. Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. Bhattacharya M, etal., J Neurosci. 2004 Oct 6;24(40):8752-61.
5. Expression of phospholipase D isozymes in scar and viable tissue in congestive heart failure due to myocardial infarction. Dent MR, etal., J Cell Mol Med. 2004 Oct-Dec;8(4):526-36.
6. Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells. Freyberg Z, etal., Mol Biol Cell. 2002 Nov;13(11):3930-42.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Stability of phospholipase D in primary astrocytes. Jin S, etal., Biochem Biophys Res Commun 2002 Sep 27;297(3):545-51.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Phospholipase D2 directly interacts with aldolase via Its PH domain. Kim JH, etal., Biochemistry. 2002 Mar 12;41(10):3414-21.
12. Differential expression of phospholipase D isozymes in the hippocampus following kainic acid-induced seizures. Kim SY, etal., J Neuropathol Exp Neurol. 2004 Aug;63(8):812-20.
13. ADP-ribosylation factor-dependent phospholipase D2 activation is required for agonist-induced mu-opioid receptor endocytosis. Koch T, etal., J Biol Chem. 2003 Mar 14;278(11):9979-85. Epub 2003 Jan 7.
14. Cloning, expression, and characterization of a novel phospholipase D complementary DNA from rat brain. Kodaki T and Yamashita S, J Biol Chem 1997 Apr 25;272(17):11408-13.
15. Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen-stimulated mast cells. Lee JH, etal., Blood. 2006 Aug 1;108(3):956-64.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Ischemic preconditioning upregulates expression of phospholipase D2 in the rat hippocampus. Min do S, etal., Acta Neuropathol. 2007 Aug;114(2):157-62. Epub 2007 Mar 29.
18. Phospholipase D is essential for keratocyte-like migration of NBT-II cells. Nagasaki A, etal., Cell Struct Funct. 2008;33(1):27-33. Epub 2008 Mar 13.
19. Molecular cloning and chromosome mapping of rat phospholipase D genes, Pld1a, Pld1b and Pld2. Nakashima S, etal., Cytogenet Cell Genet 1997;79(1-2):109-13.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. Park JB, etal., J Biol Chem. 2000 Jul 14;275(28):21295-301.
22. ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy. Parmentier JH, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H46-54. Epub 2005 Aug 19.
23. Down-regulation of phospholipase D2 mRNA in neonatal rat brainstem and cerebellum after hypoxia-ischemia. Peng JH, etal., Neurochem Res. 2006 Oct;31(10):1191-6. Epub 2006 Oct 6.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b. Powner DJ, etal., J Cell Sci. 2005 Jul 1;118(Pt 13):2975-86.
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. Singh AT, etal., Lipids. 2005 Nov;40(11):1135-40.
31. Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Sumara I, etal., Curr Biol. 2004 Oct 5;14(19):1712-22.
32. Functional implications of post-translational modifications of phospholipases D1 and D2. Xie Z, etal., Biochim Biophys Acta. 2002 Jan 30;1580(1):9-21.
33. Increased phospholipase D2 activity during hypoxia-induced death of PC12 cells: its possible anti-apoptotic role. Yamakawa H, etal., Neuroreport. 2000 Nov 9;11(16):3647-50.
34. Differential mRNA expression of phospholipase D (PLD) isozymes during cAMP-induced differentiation in C6 glioma cells. Yoshimura S, etal., Biochem Biophys Res Commun 1996 Aug 14;225(2):494-9.
35. Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Zhao Y, etal., Biochem Biophys Res Commun. 2000 Nov 11;278(1):140-3.
36. Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Zhong M, etal., Biochem Biophys Res Commun 2003 Mar 14;302(3):615-9.
Additional References at PubMed
PMID:11373276   PMID:11672434   PMID:11744693   PMID:12036299   PMID:12054584   PMID:12388770   PMID:12642902   PMID:12646582   PMID:12753082   PMID:12941779   PMID:14660552   PMID:14718562  
PMID:14744865   PMID:15036596   PMID:15210717   PMID:15581494   PMID:15598876   PMID:15616193   PMID:16024570   PMID:17110338   PMID:19010519   PMID:19666113   PMID:19794068   PMID:20664530  
PMID:20705243   PMID:21085684   PMID:21414324   PMID:21525000   PMID:22344748   PMID:29526688   PMID:30207376   PMID:37249288  


Genomics

Comparative Map Data
Pld2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,754,957 - 55,772,819 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1055,754,988 - 55,771,435 (+)EnsemblGRCr8
mRatBN7.21055,256,326 - 55,274,192 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1055,256,359 - 55,272,808 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1059,936,905 - 59,954,680 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,425,411 - 59,443,186 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,924,519 - 54,942,294 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01057,161,921 - 57,181,148 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1057,163,174 - 57,179,730 (+)Ensemblrn6Rnor6.0
Rnor_5.01056,908,891 - 56,926,691 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41057,388,474 - 57,439,063 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1054,402,188 - 54,419,867 (+)NCBICelera
RGSC_v3.11057,402,096 - 57,452,684 (+)NCBI
Cytogenetic Map10q24NCBI
PLD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38174,807,152 - 4,823,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl174,807,117 - 4,823,434 (+)Ensemblhg38GRCh38
GRCh37174,710,447 - 4,726,725 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,657,378 - 4,673,694 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34174,657,391 - 4,673,694NCBI
Celera174,725,830 - 4,742,140 (+)NCBICelera
Cytogenetic Map17p13.2NCBI
HuRef174,598,848 - 4,615,181 (+)NCBIHuRef
CHM1_1174,719,366 - 4,735,679 (+)NCBICHM1_1
T2T-CHM13v2.0174,697,008 - 4,713,290 (+)NCBIT2T-CHM13v2.0
Pld2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,430,318 - 70,448,936 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,430,890 - 70,448,936 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381170,539,492 - 70,558,110 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,540,064 - 70,558,110 (+)Ensemblmm10GRCm38
MGSCv371170,353,666 - 70,371,612 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361170,356,359 - 70,374,305 (+)NCBIMGSCv36mm8
Celera1178,088,483 - 78,106,417 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Pld2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,239,177 - 10,250,890 (+)Ensembl
ChiLan1.0NW_00495546710,239,177 - 10,250,516 (+)NCBIChiLan1.0ChiLan1.0
PLD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21912,415,539 - 12,432,079 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11714,383,741 - 14,400,414 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0174,853,919 - 4,870,254 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1174,843,095 - 4,858,991 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,843,217 - 4,858,425 (+)EnsemblpanPan2panpan1.1
PLD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,755,881 - 31,767,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,756,433 - 31,767,066 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha531,895,467 - 31,907,045 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0531,861,137 - 31,872,703 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl531,859,919 - 31,872,701 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1531,827,405 - 31,838,971 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0531,787,088 - 31,798,653 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0531,963,496 - 31,975,051 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pld2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560253,017,042 - 53,030,311 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366772,870,660 - 2,883,567 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366772,870,664 - 2,883,545 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,073,914 - 52,087,809 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,073,913 - 52,087,804 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,192,761 - 54,204,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,283,248 - 4,298,034 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl164,283,521 - 4,298,632 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605917,339,077 - 17,355,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pld2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247868,690,461 - 8,702,771 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247868,690,968 - 8,702,213 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pld2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1950,154,899 - 50,171,322 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pld2
165 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:169
Interacting mature miRNAs:211
Transcripts:ENSRNOT00000056998
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Wox42  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21055,273,696 - 55,273,877 (+)MAPPERmRatBN7.2
Rnor_6.01057,180,653 - 57,180,833NCBIRnor6.0
Rnor_5.01056,926,196 - 56,926,376UniSTSRnor5.0
RGSC_v3.41057,438,568 - 57,438,748UniSTSRGSC3.4
Celera1054,419,372 - 54,419,552UniSTS
Cytogenetic Map10q23.3-q24UniSTS
D10Wox41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21055,273,338 - 55,273,646 (+)MAPPERmRatBN7.2
Rnor_6.01057,180,295 - 57,180,602NCBIRnor6.0
Rnor_5.01056,925,838 - 56,926,145UniSTSRnor5.0
RGSC_v3.41057,438,210 - 57,438,517UniSTSRGSC3.4
Celera1054,419,014 - 54,419,321UniSTS
Cytogenetic Map10q23.3-q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000056998   ⟹   ENSRNOP00000053831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,754,988 - 55,771,435 (+)Ensembl
mRatBN7.2 Ensembl1055,256,359 - 55,272,808 (+)Ensembl
Rnor_6.0 Ensembl1057,163,174 - 57,179,730 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096590   ⟹   ENSRNOP00000094259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1055,754,988 - 55,771,435 (+)Ensembl
mRatBN7.2 Ensembl1055,256,359 - 55,272,808 (+)Ensembl
RefSeq Acc Id: NM_033299   ⟹   NP_150641
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,754,996 - 55,772,819 (+)NCBI
mRatBN7.21055,256,367 - 55,274,192 (+)NCBI
Rnor_6.01057,162,605 - 57,181,148 (+)NCBI
Rnor_5.01056,908,891 - 56,926,691 (+)NCBI
RGSC_v3.41057,388,474 - 57,439,063 (+)RGD
Celera1054,402,188 - 54,419,867 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085250   ⟹   XP_038941178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,754,958 - 55,772,819 (+)NCBI
mRatBN7.21055,256,328 - 55,274,192 (+)NCBI
RefSeq Acc Id: XM_039085252   ⟹   XP_038941180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,754,957 - 55,769,554 (+)NCBI
mRatBN7.21055,256,326 - 55,270,928 (+)NCBI
RefSeq Acc Id: XM_063268454   ⟹   XP_063124524
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81055,764,652 - 55,772,819 (+)NCBI
RefSeq Acc Id: NP_150641   ⟸   NM_033299
- UniProtKB: O08768 (UniProtKB/Swiss-Prot),   P70498 (UniProtKB/Swiss-Prot),   A6HG64 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053831   ⟸   ENSRNOT00000056998
RefSeq Acc Id: XP_038941180   ⟸   XM_039085252
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038941178   ⟸   XM_039085250
- Peptide Label: isoform X1
- UniProtKB: P70498 (UniProtKB/Swiss-Prot),   O08768 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000094259   ⟸   ENSRNOT00000096590
RefSeq Acc Id: XP_063124524   ⟸   XM_063268454
- Peptide Label: isoform X3
Protein Domains
PH   PLD phosphodiesterase   PX

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70498-F1-model_v2 AlphaFold P70498 1-933 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3350 AgrOrtholog
BioCyc Gene G2FUF-24453 BioCyc
Ensembl Genes ENSRNOG00000019604 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000056998 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.30.1520.10 UniProtKB/Swiss-Prot
  Endonuclease Chain A UniProtKB/Swiss-Prot
InterPro PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Phox UniProtKB/Swiss-Prot
  PLD-like_dom UniProtKB/Swiss-Prot
  PLipase_D/transphosphatidylase UniProtKB/Swiss-Prot
  PLipase_D_euk UniProtKB/Swiss-Prot
  PLipase_D_fam UniProtKB/Swiss-Prot
  PX_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25097 UniProtKB/Swiss-Prot
NCBI Gene 25097 ENTREZGENE
PANTHER PHOSPHOLIPASE D2 UniProtKB/Swiss-Prot
  PTHR18896 UniProtKB/Swiss-Prot
Pfam PF00787 UniProtKB/Swiss-Prot
  PLDc UniProtKB/Swiss-Prot
  PLDc_2 UniProtKB/Swiss-Prot
PhenoGen Pld2 PhenoGen
PIRSF Phospholipase_D_euk UniProtKB/Swiss-Prot
PROSITE PLD UniProtKB/Swiss-Prot
  PS50195 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019604 RatGTEx
SMART PLDc UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
  SM00312 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  Phospholipase D/nuclease UniProtKB/Swiss-Prot
  SSF64268 UniProtKB/Swiss-Prot
UniProt A0A8I6ALR6_RAT UniProtKB/TrEMBL
  A6HG64 ENTREZGENE, UniProtKB/TrEMBL
  F1LPQ4_RAT UniProtKB/TrEMBL
  O08768 ENTREZGENE
  P70498 ENTREZGENE, UniProtKB/Swiss-Prot
  Q8K4D5_RAT UniProtKB/TrEMBL
UniProt Secondary O08768 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pld2  Phoshpolipase D gene 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation stimulated by PIP2, inhibited by oleate; not affected by ARF1 or RhoA 729617