Ntf4 (neurotrophin 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ntf4 (neurotrophin 4) Rattus norvegicus
Analyze
Symbol: Ntf4
Name: neurotrophin 4
RGD ID: 3212
Description: Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including ameloblast differentiation; cell surface receptor signaling pathway; and nervous system development. Predicted to act upstream of or within negative regulation of programmed cell death; nervous system development; and taste bud development. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Orthologous to human NTF4 (neurotrophin 4); PARTICIPATES IN mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neurotrophin 5; Neurotrophin 5 (neurotrophin 4/5); neurotrophin 5 (neurotrophin 4/5); neurotrophin-4; neurotrophin-5; neutrophic factor 4; NT-4; NT-5; NT4P; Ntf5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,030,035 - 105,032,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,029,764 - 105,034,038 (+)EnsemblGRCr8
mRatBN7.2195,893,560 - 95,896,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,278,986 - 101,281,817 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,751,663 - 109,754,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,042,063 - 103,044,894 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,405,314 - 101,408,145 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,484,724 - 102,487,555 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,885,577 - 95,888,408 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,149,153 - 90,151,984 (+)NCBICelera
RGSC_v3.1195,963,687 - 95,966,519 (+)NCBI
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Berkemeier LR, etal., Neuron 1991 Nov;7(5):857-66.
2. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. Botchkarev VA, etal., FASEB J. 1999 Feb;13(2):395-410.
3. Dissociation equilibrium constant of beta nerve growth factor. Bothwell MA and Shooter EM, J Biol Chem. 1977 Dec 10;252(23):8532-6.
4. Increased neurotrophin production in a Penicillium chrysogenum-induced allergic asthma model in mice. Chung YJ, etal., J Toxicol Environ Health A. 2007 Jun;70(12):1020-6.
5. Alteration in messenger RNA neurotrophin 4 and tyrosine kinase receptors B expression levels following spinal cord injury. Esmaeili A, etal., J Neurosurg Sci. 2018 Apr;62(2):146-152. doi: 10.23736/S0390-5616.16.03106-4. Epub 2014 Dec 5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Levels of brain-derived neurotrophic factor and neurotrophin-4 in lumbar motoneurons after low-thoracic spinal cord hemisection. Gulino R, etal., Brain Res 2004 Jul 9;1013(2):174-81.
9. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Ip NY, etal., Proc Natl Acad Sci U S A 1992 Apr 1;89(7):3060-4.
10. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
11. NT4/5 mutant mice have deficiency in gustatory papillae and taste bud formation. Liebl DJ, etal., Dev Biol. 1999 Sep 15;213(2):378-89.
12. Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Liebl DJ, etal., Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2297-302.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
21. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Xie CW, etal., Proc Natl Acad Sci U S A 2000 Jul 5;97(14):8116-21.
Additional References at PubMed
PMID:10908605   PMID:12376548   PMID:12970359   PMID:14519521   PMID:14622146   PMID:15376326   PMID:15703301   PMID:18045880   PMID:18957307   PMID:21273656   PMID:21767604   PMID:23526925  
PMID:24378336   PMID:35086088   PMID:39125587  


Genomics

Comparative Map Data
Ntf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,030,035 - 105,032,866 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,029,764 - 105,034,038 (+)EnsemblGRCr8
mRatBN7.2195,893,560 - 95,896,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,278,986 - 101,281,817 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,751,663 - 109,754,494 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,042,063 - 103,044,894 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,405,314 - 101,408,145 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)Ensemblrn6Rnor6.0
Rnor_5.01102,484,724 - 102,487,555 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,885,577 - 95,888,408 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,149,153 - 90,151,984 (+)NCBICelera
RGSC_v3.1195,963,687 - 95,966,519 (+)NCBI
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
NTF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,058,284 - 49,065,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,061,066 - 49,065,076 (-)Ensemblhg38GRCh38
GRCh371949,564,385 - 49,568,292 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,256,209 - 54,260,047 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341954,256,210 - 54,258,937NCBI
Celera1946,431,605 - 46,435,443 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,941,069 - 45,943,797 (-)NCBIHuRef
CHM1_11949,566,638 - 49,569,366 (-)NCBICHM1_1
T2T-CHM13v2.01952,053,068 - 52,059,823 (-)NCBIT2T-CHM13v2.0
Ntf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,063,119 - 45,066,603 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,063,119 - 45,066,603 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,413,695 - 45,417,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,413,695 - 45,417,179 (+)Ensemblmm10GRCm38
MGSCv37752,669,065 - 52,672,549 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,281,737 - 45,285,221 (+)NCBIMGSCv36mm8
Celera740,869,726 - 40,873,213 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Ntf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,647,685 - 1,650,553 (+)Ensembl
ChiLan1.0NW_0049555591,647,685 - 1,650,553 (+)NCBIChiLan1.0ChiLan1.0
NTF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,175,303 - 55,179,596 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,094,760 - 57,099,077 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1954,995,009 - 54,995,641 (-)EnsemblpanPan2panpan1.1
NTF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,371,335 - 107,377,238 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,371,335 - 107,376,987 (+)EnsemblcanFam3CanFam3.1
ROS_Cfam_1.01107,895,849 - 107,901,840 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,895,849 - 107,901,548 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,563,703 - 107,569,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,209,908 - 107,215,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,045,520 - 108,051,170 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ntf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,398,887 - 21,401,144 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,017,323 - 3,017,955 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,017,108 - 3,017,955 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,271,246 - 54,274,092 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,271,244 - 54,288,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,039,657 - 50,057,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,254,693 - 42,284,899 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,279,190 - 42,279,822 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607322,170,689 - 22,171,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,007,801 - 5,008,451 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248325,005,935 - 5,008,694 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ntf4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12154,092,641 - 154,096,058 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ntf4
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:61
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000028194
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
Ntf5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,895,659 - 95,895,908 (+)MAPPERmRatBN7.2
Rnor_6.01101,407,414 - 101,407,662NCBIRnor6.0
Rnor_5.01102,486,824 - 102,487,072UniSTSRnor5.0
RGSC_v3.4195,887,677 - 95,887,925UniSTSRGSC3.4
Celera190,151,253 - 90,151,501UniSTS
Cytogenetic Map1q22UniSTS
RH94573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2195,895,910 - 95,895,992 (+)MAPPERmRatBN7.2
Rnor_6.01101,407,665 - 101,407,746NCBIRnor6.0
Rnor_5.01102,487,075 - 102,487,156UniSTSRnor5.0
RGSC_v3.4195,887,928 - 95,888,009UniSTSRGSC3.4
Celera190,151,504 - 90,151,585UniSTS
RH 3.4 Map1909.3UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 141 85 88 57 67 57 6 318 161 11 117 76 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000028194   ⟹   ENSRNOP00000028195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,030,209 - 105,034,038 (+)Ensembl
mRatBN7.2 Ensembl195,893,915 - 95,896,146 (+)Ensembl
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095694   ⟹   ENSRNOP00000093109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,029,764 - 105,033,928 (+)Ensembl
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)Ensembl
RefSeq Acc Id: NM_013184   ⟹   NP_037316
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,030,035 - 105,032,866 (+)NCBI
mRatBN7.2195,893,560 - 95,896,391 (+)NCBI
Rnor_6.01101,405,314 - 101,408,145 (+)NCBI
Rnor_5.01102,484,724 - 102,487,555 (+)NCBI
RGSC_v3.4195,885,577 - 95,888,408 (+)RGD
Celera190,149,153 - 90,151,984 (+)RGD
Sequence:
RefSeq Acc Id: XM_039102250   ⟹   XP_038958178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,030,168 - 105,032,627 (+)NCBI
mRatBN7.2195,893,679 - 95,896,152 (+)NCBI
RefSeq Acc Id: NP_037316   ⟸   NM_013184
- Peptide Label: precursor
- UniProtKB: P34131 (UniProtKB/Swiss-Prot),   A6JB25 (UniProtKB/TrEMBL),   A6JB26 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028195   ⟸   ENSRNOT00000028194
RefSeq Acc Id: XP_038958178   ⟸   XM_039102250
- Peptide Label: isoform X1
- UniProtKB: P34131 (UniProtKB/Swiss-Prot),   A6JB25 (UniProtKB/TrEMBL),   A6JB26 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093109   ⟸   ENSRNOT00000095694
Protein Domains
Nerve growth factor-related

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P34131-F1-model_v2 AlphaFold P34131 1-209 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690037
Promoter ID:EPDNEW_R561
Type:multiple initiation site
Name:Ntf4_1
Description:neurotrophin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,405,279 - 101,405,339EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3212 AgrOrtholog
BioCyc Gene G2FUF-59687 BioCyc
Ensembl Genes ENSRNOG00000020783 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028194 ENTREZGENE
  ENSRNOT00000028194.3 UniProtKB/Swiss-Prot
  ENSRNOT00000095694 ENTREZGENE
  ENSRNOT00000095694.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  Nerve_growth_factor-like UniProtKB/Swiss-Prot
  Nerve_growth_factor-rel UniProtKB/Swiss-Prot
  Nerve_growth_factor_CS UniProtKB/Swiss-Prot
  Neurotrophin-4 UniProtKB/Swiss-Prot
KEGG Report rno:25730 UniProtKB/Swiss-Prot
NCBI Gene 25730 ENTREZGENE
PANTHER PTHR11589 UniProtKB/Swiss-Prot
  PTHR11589:SF8 UniProtKB/Swiss-Prot
Pfam NGF UniProtKB/Swiss-Prot
PhenoGen Ntf4 PhenoGen
PIRSF NGF UniProtKB/Swiss-Prot
PRINTS NEUROTROPHN4 UniProtKB/Swiss-Prot
  NGF UniProtKB/Swiss-Prot
PROSITE NGF_1 UniProtKB/Swiss-Prot
  NGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020783 RatGTEx
SMART NGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
TIGR TC202021
UniProt A6JB25 ENTREZGENE, UniProtKB/TrEMBL
  A6JB26 ENTREZGENE, UniProtKB/TrEMBL
  NTF4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-12 Ntf4  neurotrophin 4  Ntf5  neurotrophin 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ntf5  Neurotrophin 5 (neurotrophin 4/5)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process activates two trk-related tyrosine kinase receptors 729138