NTF4 (neurotrophin 4) - Rat Genome Database

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Gene: NTF4 (neurotrophin 4) Canis lupus familiaris
Analyze
Symbol: NTF4
Name: neurotrophin 4
RGD ID: 12391863
Description: ENCODES a protein that exhibits growth factor activity (inferred); nerve growth factor receptor binding (inferred); INVOLVED IN adult locomotory behavior (ortholog); epidermis development (ortholog); ganglion mother cell fate determination (ortholog); ASSOCIATED WITH asthma (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 12 (ortholog); FOUND IN axon (inferred); dendrite (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neurotrophin 5 (neurotrophin 4/5); neurotrophin-4; NTF5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,371,335 - 107,377,238 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,371,335 - 107,376,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,895,849 - 107,901,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,895,849 - 107,901,548 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,563,703 - 107,569,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,209,908 - 107,215,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,045,520 - 108,051,170 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:22524196   PMID:30032202  


Genomics

Comparative Map Data
NTF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,371,335 - 107,377,238 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,371,335 - 107,376,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.01107,895,849 - 107,901,840 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,895,849 - 107,901,548 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,563,703 - 107,569,398 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,209,908 - 107,215,558 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,045,520 - 108,051,170 (+)NCBIUU_Cfam_GSD_1.0
NTF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,058,284 - 49,065,035 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,061,066 - 49,065,076 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,564,385 - 49,568,292 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,256,209 - 54,260,047 (-)NCBINCBI36Build 36hg18NCBI36
Build 341954,256,210 - 54,258,937NCBI
Celera1946,431,605 - 46,435,443 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,941,069 - 45,943,797 (-)NCBIHuRef
CHM1_11949,566,638 - 49,569,366 (-)NCBICHM1_1
T2T-CHM13v2.01952,053,068 - 52,059,823 (-)NCBIT2T-CHM13v2.0
Ntf5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,063,119 - 45,066,603 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,063,119 - 45,066,603 (+)EnsemblGRCm39 Ensembl
GRCm38745,413,695 - 45,417,179 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,413,695 - 45,417,179 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,669,065 - 52,672,549 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,281,737 - 45,285,221 (+)NCBIMGSCv36mm8
Celera740,869,726 - 40,873,213 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.3NCBI
Ntf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,030,035 - 105,032,866 (+)NCBIGRCr8
mRatBN7.2195,893,560 - 95,896,391 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,893,457 - 95,897,243 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,278,986 - 101,281,817 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,751,663 - 109,754,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,042,063 - 103,044,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,405,314 - 101,408,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,405,314 - 101,408,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,484,724 - 102,487,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,885,577 - 95,888,408 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1195,963,687 - 95,966,519 (+)NCBI
Celera190,149,153 - 90,151,984 (+)NCBICelera
RH 3.4 Map1909.3RGD
Cytogenetic Map1q22NCBI
Ntf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,647,685 - 1,650,553 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,647,685 - 1,650,553 (+)NCBIChiLan1.0ChiLan1.0
NTF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,175,303 - 55,179,596 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,094,760 - 57,099,077 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl1954,995,009 - 54,995,641 (-)Ensemblpanpan1.1panPan2
Ntf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,398,887 - 21,401,144 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366643,017,108 - 3,017,955 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,271,246 - 54,274,092 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,271,244 - 54,288,846 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,039,657 - 50,057,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,254,693 - 42,284,899 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,279,190 - 42,279,822 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,170,689 - 22,171,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,007,801 - 5,008,451 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,005,935 - 5,008,694 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NTF4
74 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 6
Low 5 13 5 1 5 6 5 6 7
Below cutoff 5 9 1 5 1 7 2 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000006174   ⟹   ENSCAFP00000005718
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1107,371,335 - 107,376,987 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845000638   ⟹   ENSCAFP00845000449
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1107,895,849 - 107,901,548 (+)Ensembl
RefSeq Acc Id: NM_001190429   ⟹   NP_001177358
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11107,371,335 - 107,376,987 (+)NCBI
ROS_Cfam_1.01107,895,849 - 107,901,548 (+)NCBI
UMICH_Zoey_3.11107,563,703 - 107,569,398 (+)NCBI
UNSW_CanFamBas_1.01107,209,908 - 107,215,558 (+)NCBI
UU_Cfam_GSD_1.01108,045,520 - 108,051,170 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038653564   ⟹   XP_038509492
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,899,046 - 107,901,840 (+)NCBI
RefSeq Acc Id: XM_038653565   ⟹   XP_038509493
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01107,899,227 - 107,901,840 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001177358 (Get FASTA)   NCBI Sequence Viewer  
  XP_038509492 (Get FASTA)   NCBI Sequence Viewer  
  XP_038509493 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ADI55152 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00030024064.1
  ENSCAFP00040000722.1
  ENSCAFP00845000449
  ENSCAFP00845000449.1
Reference Protein Sequences
RefSeq Acc Id: NP_001177358   ⟸   NM_001190429
- Peptide Label: precursor
- UniProtKB: A0A8C0PL35 (UniProtKB/TrEMBL),   A0A8I3MVE7 (UniProtKB/TrEMBL),   D7RJ35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000005718   ⟸   ENSCAFT00000006174
RefSeq Acc Id: XP_038509492   ⟸   XM_038653564
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LN98 (UniProtKB/TrEMBL),   D7RJ35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038509493   ⟸   XM_038653565
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LN98 (UniProtKB/TrEMBL),   D7RJ35 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845000449   ⟸   ENSCAFT00845000638
Protein Domains
Nerve growth factor-related


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000003838 Ensembl
  ENSCAFG00030014944 UniProtKB/TrEMBL
  ENSCAFG00040000492 UniProtKB/TrEMBL
  ENSCAFG00845000410 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030027577.1 UniProtKB/TrEMBL
  ENSCAFT00040000850.1 UniProtKB/TrEMBL
  ENSCAFT00845000638 ENTREZGENE
  ENSCAFT00845000638.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/TrEMBL
  Neurotrophin-4 UniProtKB/TrEMBL
NCBI Gene NTF4 ENTREZGENE
PANTHER PTHR11589 UniProtKB/TrEMBL
  PTHR11589:SF8 UniProtKB/TrEMBL
Pfam NGF UniProtKB/TrEMBL
PIRSF NGF UniProtKB/TrEMBL
PRINTS NEUROTROPHN4 UniProtKB/TrEMBL
  NGF UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/TrEMBL
  NGF_2 UniProtKB/TrEMBL
SMART NGF UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A8C0LN98 ENTREZGENE
  A0A8C0PL35 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MVE7 ENTREZGENE, UniProtKB/TrEMBL
  D7RJ35 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44003 ENTREZGENE