Npy (neuropeptide Y) - Rat Genome Database

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Gene: Npy (neuropeptide Y) Rattus norvegicus
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Symbol: Npy
Name: neuropeptide Y
RGD ID: 3197
Description: Enables neuropeptide Y receptor binding activity. Involved in several processes, including adult feeding behavior; positive regulation of ERK1 and ERK2 cascade; and positive regulation of metabolic process. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and terminal bouton. Is active in neuronal dense core vesicle. Used to study absence epilepsy; alcohol use disorder; depressive disorder; and hypertension. Biomarker of several diseases, including cerebral infarction; median neuropathy; neurodegenerative disease (multiple); obesity; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; alcohol use disorder; artery disease (multiple); and epilepsy (multiple). Orthologous to human NPY (neuropeptide Y); PARTICIPATES IN neuropeptide Y metabolic pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; (S)-nicotine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: LOC100912228; NPY02; pro-neuropeptide Y; pro-neuropeptide Y-like; RATNPY; RATNPY02
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Npyem6Sage
Genetic Models: iNP-Npyem6Sage/Iusm ; iNP-Npyem6Sage-/-/Iusm ; iNP-Npyem6Sage+/-/Iusm
Is Marker For: Strains:   BB.SHR-(D4Mit6-Spr)/K ; iP/Iusm ; iNP/Iusm ; NP.P-(D4Rat119-D4Rat55)/Iusm ; SHR.BN-(Il6-Npy)
QTLs:   Bp21   Bp135  
Candidate Gene For: Eau1 Scwia1 Aia3 Alc18 Bp79 Sach4 Alc16 Alc14 Bw40 Alc21 Alc22 Bp330 Bw126
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,212,111 - 80,219,310 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl480,212,111 - 80,219,310 (+)EnsemblGRCr8
mRatBN7.2478,881,294 - 78,888,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl478,881,264 - 78,888,495 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,098,422 - 84,105,619 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0479,873,911 - 79,881,112 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,314,242 - 78,321,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,557,856 - 79,565,059 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,557,854 - 79,565,097 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl479,573,998 - 79,581,208 (+)Ensemblrn6Rnor6.0
Rnor_5.04144,233,753 - 144,240,956 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,038,013 - 78,045,187 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera473,795,148 - 73,802,371 (+)NCBICelera
RGSC_v3.1478,314,142 - 78,321,317 (+)NCBI
RH 3.4 Map4507.8RGD
RH 3.4 Map4508.6RGD
Cytogenetic Map4q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP,ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (EXP)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-deoxy-D-glucose  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acarbose  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
AM-251  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (EXP)
ATP  (ISO)
Aurothioglucose  (ISO)
Azoxymethane  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bucladesine  (EXP)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP)
cannabidiol  (EXP)
cannabigerol  (EXP)
capsaicin  (EXP)
capsazepine  (ISO)
carbachol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorisondamine  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (EXP)
cocaine  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
cyanocob(III)alamin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
diprotium oxide  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
fructose  (EXP,ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
Glutathione ethyl ester  (EXP)
glycidol  (EXP)
guanethidine  (EXP,ISO)
haloperidol  (EXP)
Hexamethonium  (EXP)
kainic acid  (EXP,ISO)
ketamine  (ISO)
L-methionine  (ISO)
limonene  (EXP,ISO)
linalool  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
masoprocol  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methylmercury chloride  (ISO)
monosodium L-glutamate  (EXP,ISO)
morphine  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
nickel atom  (EXP)
nicotine  (EXP)
nitroglycerin  (EXP)
olanzapine  (EXP,ISO)
orlistat  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP)
Oxotremorine  (EXP)
ozone  (EXP)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (ISO)
paricalcitol  (ISO)
pentobarbital  (ISO)
perfluorooctanoic acid  (EXP)
phenacetin  (EXP)
phenformin  (EXP)
phenylephrine  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (EXP,ISO)
potassium chloride  (EXP)
prazosin  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP)
quinpirole  (ISO)
RES-701-1  (EXP)
reserpine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
ruthenium red  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
SKF 38393  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
succimer  (ISO)
tauroursodeoxycholic acid  (ISO)
terbutaline  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetrodotoxin  (EXP)
thioacetamide  (EXP)
thiopental  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
tribromoethanol  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
undecane  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
veratridine  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
water  (EXP)
XL147  (ISO)
yohimbine  (EXP)
zalcitabine  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
adult feeding behavior  (IDA)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
central nervous system neuron development  (IEA,ISO)
cerebral cortex development  (IEA,ISO)
chemical synaptic transmission  (IDA)
developmental growth  (IMP)
drinking behavior  (IMP)
feeding behavior  (IBA)
G protein-coupled receptor signaling pathway  (IEA,ISO)
innate immune response  (ISO)
monocyte activation  (IDA)
negative regulation of acute inflammatory response to antigenic stimulus  (IDA)
negative regulation of blood pressure  (IMP)
negative regulation of cellular process  (IDA)
negative regulation of somatostatin secretion  (ISO)
neuron projection development  (IEA,ISO)
neuropeptide signaling pathway  (IBA,IEA,IMP)
positive regulation of appetite  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of cell-substrate adhesion  (IDA)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of dopamine metabolic process  (IDA)
positive regulation of eating behavior  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of somatostatin secretion  (ISO)
regulation of blood pressure  (ISO)
regulation of nerve growth factor production  (IDA)
regulation of nitric oxide biosynthetic process  (IDA)
regulation of presynaptic cytosolic calcium ion concentration  (EXP,IDA)
regulation of synaptic vesicle exocytosis  (EXP,IDA)
short-day photoperiodism  (IEP)
synaptic signaling via neuropeptide  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Muller cells. Alvaro AR, etal., Neurochem Int. 2007 Apr;50(5):757-63. Epub 2007 Feb 8.
2. Differential modulation of synaptic transmission by neuropeptide Y in rat neocortical neurons. Bacci A, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):17125-30.
3. Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. Beal MF, etal., J Neurosci. 1991 Jun;11(6):1649-59.
4. Somatostatin and neuropeptide Y immunoreactivity in Parkinson's disease dementia with Alzheimer's changes. Beal MF, etal., Synapse. 1988;2(4):463-7.
5. NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization. Bedoui S, etal., J Neuroimmunol 2002 Nov;132(1-2):25-33.
6. Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4. Bharat V, etal., Cell Rep. 2017 Nov 21;21(8):2118-2133. doi: 10.1016/j.celrep.2017.10.084.
7. The antidepressant effects of running and escitalopram are associated with levels of hippocampal NPY and Y1 receptor but not cell proliferation in a rat model of depression. Bjornebekk A, etal., Hippocampus. 2010 Jul;20(7):820-8. doi: 10.1002/hipo.20683.
8. Nerve stimulation induced overflow of neuropeptide Y and modulation by angiotensin II in spontaneously hypertensive rats. Byku M, etal., Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2188-97. doi: 10.1152/ajpheart.00384.2008. Epub 2008 Oct 3.
9. Renal and cardiac neuropeptide Y and NPY receptors in a rat model of congestive heart failure. Callanan EY, etal., Am J Physiol Renal Physiol. 2007 Dec;293(6):F1811-7. Epub 2007 Sep 5.
10. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Calvino C, etal., Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.
11. The feeding response to melanin-concentrating hormone is attenuated by antagonism of the NPY Y(1)-receptor in the rat. Chaffer CL and Morris MJ, Endocrinology 2002 Jan;143(1):191-7.
12. Pertussis toxin inhibits neuropeptide Y-induced feeding in rats. Chance WT, etal., Peptides. 1989 Nov-Dec;10(6):1283-6. doi: 10.1016/0196-9781(89)90022-3.
13. Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. Chance WT, etal., Peptides. 2007 Feb;28(2):295-301. Epub 2007 Jan 17.
14. Neuropeptide Y protects rat cortical neurons against beta-amyloid toxicity and re-establishes synthesis and release of nerve growth factor. Croce N, etal., ACS Chem Neurosci. 2012 Apr 18;3(4):312-8. doi: 10.1021/cn200127e. Epub 2012 Jan 30.
15. Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization. Currie PJ, etal., Brain Res. 2011 Apr 18;1385:127-34. doi: 10.1016/j.brainres.2011.01.114.
16. The anti-inflammatory effect of neuropeptide Y (NPY) in rats is dependent on dipeptidyl peptidase 4 (DP4) activity and age. Dimitrijevic M, etal., Peptides. 2008 Dec;29(12):2179-87. doi: 10.1016/j.peptides.2008.08.017. Epub 2008 Sep 3.
17. Support for involvement of glutamate decarboxylase 1 and neuropeptide y in anxiety susceptibility. Donner J, etal., Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):316-27. doi: 10.1002/ajmg.b.32029. Epub 2012 Feb 10.
18. The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury. Duan H, etal., J Surg Res. 2013 Oct;184(2):1006-12. doi: 10.1016/j.jss.2013.03.096. Epub 2013 Apr 18.
19. Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. Dube C, etal., J Mol Neurosci. 2005;25(3):275-84.
20. Long-term valproate treatment increases brain neuropeptide Y expression and decreases seizure expression in a genetic rat model of absence epilepsy. Elms J, etal., PLoS One. 2013 Sep 9;8(9):e73505. doi: 10.1371/journal.pone.0073505. eCollection 2013.
21. Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis. Fekete C, etal., Endocrinology 2002 Dec;143(12):4513-9.
22. Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Fraley GS and Ritter S, Endocrinology 2003 Jan;144(1):75-83.
23. Neuropeptide Y level in paraventricular nucleus of experimental diabetic rats: correlation with sympathetic activity and body weight. Ganguly PK Int J Gen Med. 2010 Oct 5;3:321-5. doi: 10.2147/IJGM.S7749.
24. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. Garcia MC, etal., FASEB J 2003 Aug;17(11):1392-400.
25. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
26. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
27. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. Heilig M, etal., J Psychiatr Res 2004 Mar-Apr;38(2):113-21.
28. Neuropeptide Y is expressed by rat mononuclear blood leukocytes and strongly down-regulated during inflammation. Holler J, etal., J Immunol. 2008 Nov 15;181(10):6906-12.
29. Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease. Hult Lundh S, etal., Hum Mol Genet. 2013 Sep 1;22(17):3485-97. doi: 10.1093/hmg/ddt203. Epub 2013 May 22.
30. Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats. Husum H, etal., Neuropharmacology 2002 May;42(6):798-806.
31. Neuropeptide y and neuropeptide y y5 receptor interaction restores impaired growth potential of aging bone marrow stromal cells. Igura K, etal., Rejuvenation Res. 2011 Aug;14(4):393-403. doi: 10.1089/rej.2010.1129. Epub 2011 May 19.
32. Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men. Karvonen MK, etal., Atherosclerosis. 2001 Nov;159(1):145-51.
33. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. Kawahito Y, etal., J Immunol 1998 Oct 15;161(8):4411-9
34. Changes in neuropeptide Y protein expression following photothrombotic brain infarction and epileptogenesis. Kharlamov EA, etal., Brain Res. 2007 Jan 5;1127(1):151-62. Epub 2006 Nov 22.
35. Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. Kloster E, etal., J Mol Med (Berl). 2014 Feb;92(2):177-84.
36. Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Koban M, etal., Endocrinology. 2006 Jan;147(1):421-31. doi: 10.1210/en.2005-0695. Epub 2005 Oct 6.
37. Plasma neuropeptide Y is reduced in patients with Alzheimer's disease. Koide S, etal., Neurosci Lett. 1995 Sep 29;198(2):149-51.
38. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Kovanen L, etal., Alcohol Alcohol. 2010 Jul-Aug;45(4):303-11. doi: 10.1093/alcalc/agq035. Epub 2010 Jun 16.
39. Hypothalamic CART is a new anorectic peptide regulated by leptin. Kristensen P, etal., Nature. 1998 May 7;393(6680):72-6.
40. Differential susceptibility of interneurons expressing neuropeptide Y or parvalbumin in the aged hippocampus to acute seizure activity. Kuruba R, etal., PLoS One. 2011;6(9):e24493. doi: 10.1371/journal.pone.0024493. Epub 2011 Sep 6.
41. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
42. A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Lappalainen J, etal., Arch Gen Psychiatry. 2002 Sep;59(9):825-31.
43. Of mice and men: neuropeptide Y and its receptors are associated with atherosclerotic lesion burden and vulnerability. Li L, etal., J Cardiovasc Transl Res. 2011 Jun;4(3):351-62. doi: 10.1007/s12265-011-9271-5. Epub 2011 Apr 6.
44. Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexia. Makarenko IG, etal., Brain Res 2003 Jan 24;961(1):100-8.
45. Increased neuropeptide Y-like immunoreactivity in cerebrospinal fluid and plasma of human immunodeficiency virus-infected patients: relationship to HIV encephalopathy. Malessa R, etal., J Neurol Sci. 1996 Mar;136(1-2):154-8.
46. Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. Melas PA, etal., Peptides. 2012 May;35(1):49-55. doi: 10.1016/j.peptides.2012.02.020. Epub 2012 Mar 3.
47. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
48. Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism. Michalkiewicz M, etal., Hypertension 2005 Apr;45(4):780-5. Epub 2005 Feb 7.
49. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Morris MJ, etal., Eur J Neurosci. 2007 Feb;25(4):1136-43.
50. Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling. Morrison CD, etal., Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E1051-7. Epub 2005 Jul 26.
51. Reduced tissue immigration of monocytes by neuropeptide Y during endotoxemia is associated with Y2 receptor activation. Nave H, etal., J Neuroimmunol. 2004 Oct;155(1-2):1-12.
52. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
53. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Noe F, etal., Brain. 2008 Jun;131(Pt 6):1506-15. doi: 10.1093/brain/awn079. Epub 2008 May 13.
54. Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men. Nordman S, etal., Exp Clin Endocrinol Diabetes. 2005 May;113(5):282-7.
55. Amelioration of dextran sulfate sodium-induced colitis by neuropeptide Y antisense oligodeoxynucleotide. Pang XH, etal., Int J Colorectal Dis. 2010 Sep;25(9):1047-53. doi: 10.1007/s00384-010-0964-z. Epub 2010 Jun 5.
56. Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn. Polgar E, etal., J Comp Neurol. 2011 Apr 15;519(6):1007-23. doi: 10.1002/cne.22570.
57. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Proulx K, etal., Endocrinology 2002 Dec;143(12):4683-92.
58. Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. Qiu B, etal., J Genet Genomics. 2016 Jul 20;43(7):421-30. doi: 10.1016/j.jgg.2016.04.010. Epub 2016 Apr 29.
59. Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease. Rangani RJ, etal., Peptides. 2012 Feb;33(2):317-28. doi: 10.1016/j.peptides.2012.01.004. Epub 2012 Jan 16.
60. GOA pipeline RGD automated data pipeline
61. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
62. Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth. Ross AW, etal., J Neuroendocrinol. 2009 Jul;21(7):610-9. Epub 2009 Apr 13.
63. A biometrical genome search in rats reveals the multigenic basis of blood pressure variation. Schork NJ, etal., Genome Res 1995 Sep;5(2):164-72
64. Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression. Sohn EH, etal., Endocrinology 2002 Mar;143(3):954-63.
65. Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP. Sorensen AT, etal., Exp Neurol. 2009 Feb;215(2):328-33. doi: 10.1016/j.expneurol.2008.10.015. Epub 2008 Nov 10.
66. Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine. Sorensen G, etal., Neuroreport. 2009 Jul 15;20(11):1023-6.
67. Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. Spence JP, etal., Neuroscience 2005;131(4):871-6.
68. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, etal., Cell Rep. 2018 Jul 17;24(3):685-700. doi: 10.1016/j.celrep.2018.06.071.
69. Identification of genomic regions controlling experimental autoimmune uveoretinitis in rats. Sun SH, etal., Int Immunol 1999 Apr;11(4):529-34
70. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
71. Neuropeptide Y receptor Y2 gene polymorphism interacts with plasma neuropeptide Y levels in predicting left ventricular hypertrophy in dialysis patients. Testa A, etal., J Hypertens. 2010 Aug;28(8):1745-51.
72. Ultrastructural Characterization of Corticotropin-Releasing Factor and Neuropeptide Y in the Rat Locus Coeruleus: Anatomical Evidence for Putative Interactions. Theisen CC, etal., Neuroscience. 2018 Aug 1;384:21-40. doi: 10.1016/j.neuroscience.2018.04.043. Epub 2018 May 22.
73. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Thorsell A, etal., Proc Natl Acad Sci U S A 2000 Nov 7;97(23):12852-7.
74. Neuropeptide Y modulates c-Fos protein expression in the cuneate nucleus and contributes to mechanical hypersensitivity following rat median nerve injury. Tsai YJ, etal., J Neurotrauma. 2009 Sep;26(9):1609-21. doi: 10.1089/neu.2008.0642.
75. Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla. Tumer N, etal., Neurosci Lett. 2013 Jun 7;544:62-7. doi: 10.1016/j.neulet.2013.03.042. Epub 2013 Apr 6.
76. Involvement of neuropeptide Y in the acute, chronic and withdrawal responses of morphine in nociception in neuropathic rats: behavioral and neuroanatomical correlates. Upadhya MA, etal., Neuropeptides. 2009 Aug;43(4):303-14. doi: 10.1016/j.npep.2009.05.003. Epub 2009 Jun 24.
77. Difference of NPY and its receptor gene expressions between obesity and obesity-resistant rats in response to high-fat diet. Wang C, etal., Horm Metab Res. 2007 Apr;39(4):262-7.
78. Activation of neuropeptide Y Y1 receptors inhibits glutamate release through reduction of voltage-dependent Ca2+ entry in the rat cerebral cortex nerve terminals: suppression of this inhibitory effect by the protein kinase C-dependent facilitatory pathway. Wang SJ, Neuroscience. 2005;134(3):987-1000. doi: 10.1016/j.neuroscience.2005.04.053.
79. Localization in rats of genetic loci regulating susceptibility to experimental erosive arthritis and related autoimmune diseases. Wilder RL, etal., Transplant Proc 1999 May;31(3):1585-8
80. Transcellular induction of neuropeptide Y expression by NT4 and BDNF. Wirth MJ, etal., Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3064-9. Epub 2005 Feb 9.
81. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue Xu ZQ, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Apr;16(4):218-20.
82. Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells. Zhao FL, etal., Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11100-5. Epub 2005 Jul 22.
83. [Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats]. Zhiguo W, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Feb;34(2):93-8.
Additional References at PubMed
PMID:2834371   PMID:3031663   PMID:3031687   PMID:3413293   PMID:8837218   PMID:9067840   PMID:9623984   PMID:9756788   PMID:10698177   PMID:11738809   PMID:11856342   PMID:11897270  
PMID:11914579   PMID:11932938   PMID:12030805   PMID:12069594   PMID:12093484   PMID:12429884   PMID:12450741   PMID:12450742   PMID:12576193   PMID:12590942   PMID:12686755   PMID:12727330  
PMID:12782392   PMID:12786976   PMID:12842868   PMID:12895522   PMID:12902638   PMID:12914981   PMID:12919938   PMID:14551170   PMID:14617575   PMID:15123022   PMID:15127943   PMID:15245875  
PMID:15567472   PMID:15576634   PMID:15582708   PMID:15618885   PMID:15619124   PMID:15652508   PMID:15680466   PMID:15716245   PMID:15716408   PMID:15789763   PMID:15926937   PMID:16051880  
PMID:16087729   PMID:16154634   PMID:16195495   PMID:16198490   PMID:16266747   PMID:16336998   PMID:16383008   PMID:16387449   PMID:16426702   PMID:16675522   PMID:16721031   PMID:16728494  
PMID:16867179   PMID:16888209   PMID:16965293   PMID:17011171   PMID:17023531   PMID:17081520   PMID:17154253   PMID:17289093   PMID:17388940   PMID:17400722   PMID:17462823   PMID:17464216  
PMID:17467917   PMID:17684035   PMID:17690163   PMID:17976913   PMID:17989139   PMID:18001323   PMID:18032527   PMID:18094253   PMID:18164503   PMID:18242853   PMID:18308474   PMID:18323405  
PMID:18331583   PMID:18384674   PMID:18389390   PMID:18467436   PMID:18502321   PMID:18504079   PMID:18535107   PMID:18539096   PMID:18544708   PMID:18573184   PMID:18573695   PMID:18588949  
PMID:18598846   PMID:18603306   PMID:18835268   PMID:18937973   PMID:18955035   PMID:19009650   PMID:19017729   PMID:19036961   PMID:19063928   PMID:19095023   PMID:19151514   PMID:19183337  
PMID:19211911   PMID:19229719   PMID:19255506   PMID:19295167   PMID:19383429   PMID:19497417   PMID:19553928   PMID:19559985   PMID:19609086   PMID:19620061   PMID:19671088   PMID:19817504  
PMID:19818818   PMID:19877509   PMID:19879928   PMID:19934016   PMID:19968967   PMID:20012021   PMID:20028355   PMID:20051529   PMID:20179883   PMID:20219870   PMID:20335227   PMID:20531438  
PMID:20610828   PMID:20633633   PMID:20814066   PMID:20817751   PMID:20836657   PMID:20846339   PMID:20945070   PMID:21061149   PMID:21079358   PMID:21162274   PMID:21179736   PMID:21428728  
PMID:21453769   PMID:21473895   PMID:21527271   PMID:21558160   PMID:21589937   PMID:21799827   PMID:21821286   PMID:21855588   PMID:22365383   PMID:22437342   PMID:22461566   PMID:22474320  
PMID:22513398   PMID:22527118   PMID:22643238   PMID:22659471   PMID:22708658   PMID:22832533   PMID:22917777   PMID:22938859   PMID:22964363   PMID:23024812   PMID:23090692   PMID:23123350  
PMID:23271280   PMID:23303411   PMID:23312492   PMID:23313404   PMID:23321476   PMID:23457218   PMID:23526718   PMID:23644054   PMID:23652932   PMID:23680526   PMID:24094067   PMID:24183962  
PMID:24291064   PMID:24308227   PMID:24444822   PMID:24549602   PMID:24582971   PMID:24779394   PMID:24829502   PMID:25011012   PMID:25109664   PMID:25146309   PMID:25197671   PMID:25241802  
PMID:25482245   PMID:25561025   PMID:25635612   PMID:25775546   PMID:25825358   PMID:25952775   PMID:25993471   PMID:26012590   PMID:26047956   PMID:26086271   PMID:26188175   PMID:26490304  
PMID:26514659   PMID:26541912   PMID:26561644   PMID:26589184   PMID:26702900   PMID:26707636   PMID:26779765   PMID:27805869   PMID:27855650   PMID:28062253   PMID:28065829   PMID:28097455  
PMID:28438668   PMID:28575455   PMID:28914170   PMID:29425286   PMID:29442423   PMID:29519725   PMID:29777700   PMID:29850786   PMID:30146352   PMID:30227410   PMID:30950054   PMID:31915051  
PMID:32200588   PMID:33044017   PMID:33966606   PMID:34666848   PMID:35008014   PMID:35313782   PMID:36565980   PMID:37653540  


Genomics

Comparative Map Data
Npy
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8480,212,111 - 80,219,310 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl480,212,111 - 80,219,310 (+)EnsemblGRCr8
mRatBN7.2478,881,294 - 78,888,495 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl478,881,264 - 78,888,495 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx484,098,422 - 84,105,619 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0479,873,911 - 79,881,112 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0478,314,242 - 78,321,437 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0479,557,856 - 79,565,059 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl479,557,854 - 79,565,097 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl479,573,998 - 79,581,208 (+)Ensemblrn6Rnor6.0
Rnor_5.04144,233,753 - 144,240,956 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4478,038,013 - 78,045,187 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera473,795,148 - 73,802,371 (+)NCBICelera
RGSC_v3.1478,314,142 - 78,321,317 (+)NCBI
RH 3.4 Map4507.8RGD
RH 3.4 Map4508.6RGD
Cytogenetic Map4q24NCBI
NPY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38724,284,190 - 24,291,862 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl724,284,188 - 24,291,862 (+)Ensemblhg38GRCh38
GRCh37724,323,809 - 24,331,481 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36724,290,334 - 24,298,002 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34724,097,048 - 24,104,717NCBI
Celera724,312,617 - 24,320,302 (+)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef724,208,802 - 24,216,490 (+)NCBIHuRef
CHM1_1724,325,406 - 24,333,092 (+)NCBICHM1_1
T2T-CHM13v2.0724,422,184 - 24,429,876 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2724,375,683 - 24,383,371 (+)NCBI
Npy
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39649,799,690 - 49,806,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl649,799,690 - 49,806,487 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38649,822,710 - 49,829,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl649,822,710 - 49,829,507 (+)Ensemblmm10GRCm38
MGSCv37649,772,728 - 49,779,506 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36649,752,315 - 49,759,093 (+)NCBIMGSCv36mm8
Celera650,334,213 - 50,340,981 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map624.04NCBI
Npy
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541026,348,504 - 26,355,297 (+)Ensembl
ChiLan1.0NW_00495541026,348,388 - 26,355,232 (+)NCBIChiLan1.0ChiLan1.0
NPY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2629,145,106 - 29,152,854 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1777,469,833 - 77,477,581 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0724,963,056 - 24,970,803 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1724,566,963 - 24,574,657 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl724,568,041 - 24,574,657 (+)EnsemblpanPan2panpan1.1
NPY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11437,824,579 - 37,831,289 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1437,823,861 - 37,831,443 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1437,373,133 - 37,380,851 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01437,758,052 - 37,765,788 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1437,758,938 - 37,765,943 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11437,872,113 - 37,879,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01437,564,477 - 37,572,202 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01437,908,665 - 37,916,390 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Npy
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511882,077,623 - 82,085,085 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364781,290,505 - 1,296,874 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364781,289,437 - 1,296,819 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1847,985,725 - 47,992,667 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11847,985,796 - 47,993,726 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21852,929,745 - 52,937,666 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12134,068,533 - 34,076,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2134,068,530 - 34,075,127 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604270,564,869 - 70,572,551 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npy
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247396,277,612 - 6,285,397 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247396,277,704 - 6,285,454 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Npy
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1691,247,542 - 91,254,873 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Npy
63 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:106
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000013145
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317586Eae25Experimental allergic encephalomyelitis QTL 259.300000190734863nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)48021363484338055Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)480216705104243248Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
D4Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,213,634 - 80,213,769 (+)Marker Load Pipeline
mRatBN7.2478,882,817 - 78,882,954 (+)MAPPERmRatBN7.2
Rnor_6.0479,575,534 - 79,575,667NCBIRnor6.0
Rnor_6.0479,559,380 - 79,559,514NCBIRnor6.0
Rnor_5.04144,235,277 - 144,235,411UniSTSRnor5.0
Rnor_5.04144,249,326 - 144,249,459UniSTSRnor5.0
RGSC_v3.4478,039,510 - 78,039,646UniSTSRGSC3.4
RGSC_v3.4478,039,509 - 78,039,646RGDRGSC3.4
Celera473,796,672 - 73,796,816UniSTS
RGSC_v3.1478,315,639 - 78,315,776RGD
RH 3.4 Map4504.2UniSTS
RH 3.4 Map4504.2RGD
RH 2.0 Map4547.5RGD
Cytogenetic Map4q24UniSTS
D4Hri1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,213,634 - 80,213,760 (+)Marker Load Pipeline
mRatBN7.2478,882,817 - 78,882,945 (+)MAPPERmRatBN7.2
Rnor_6.0479,575,534 - 79,575,658NCBIRnor6.0
Rnor_6.0479,559,380 - 79,559,505NCBIRnor6.0
Rnor_5.04144,235,277 - 144,235,402UniSTSRnor5.0
Rnor_5.04144,249,326 - 144,249,450UniSTSRnor5.0
RGSC_v3.4478,039,510 - 78,039,637UniSTSRGSC3.4
RGSC_v3.4478,039,509 - 78,039,637RGDRGSC3.4
Celera473,796,672 - 73,796,807UniSTS
Cytogenetic Map4q24UniSTS
D4Mgh4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,878,504 - 78,878,711 (+)MAPPERmRatBN7.2
Rnor_6.0479,570,971 - 79,571,177NCBIRnor6.0
Rnor_6.0479,555,067 - 79,555,273NCBIRnor6.0
Rnor_5.04144,230,964 - 144,231,170UniSTSRnor5.0
Rnor_5.04144,244,763 - 144,244,969UniSTSRnor5.0
RGSC_v3.4478,035,196 - 78,035,403RGDRGSC3.4
RGSC_v3.4478,035,197 - 78,035,403UniSTSRGSC3.4
Celera473,792,358 - 73,792,564UniSTS
RGSC_v3.1478,311,326 - 78,311,533RGD
RH 3.4 Map4504.3UniSTS
RH 3.4 Map4504.3RGD
RH 2.0 Map4551.7RGD
SHRSP x BN Map437.38RGD
FHH x ACI Map446.9099RGD
Cytogenetic Map4q24UniSTS
D4Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,216,804 - 80,216,952 (+)Marker Load Pipeline
mRatBN7.2478,885,989 - 78,886,137 (+)MAPPERmRatBN7.2
Rnor_6.0479,578,703 - 79,578,854NCBIRnor6.0
Rnor_6.0479,562,550 - 79,562,701NCBIRnor6.0
Rnor_5.04144,238,447 - 144,238,598UniSTSRnor5.0
Rnor_5.04144,252,495 - 144,252,646UniSTSRnor5.0
RGSC_v3.4478,042,682 - 78,042,833UniSTSRGSC3.4
RGSC_v3.4478,042,681 - 78,042,833RGDRGSC3.4
Celera473,799,852 - 73,800,013UniSTS
RGSC_v3.1478,318,811 - 78,318,963RGD
RH 3.4 Map4508.4UniSTS
RH 3.4 Map4508.4RGD
RH 2.0 Map4543.9RGD
Cytogenetic Map4q24UniSTS
D4Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,216,682 - 80,216,972 (+)Marker Load Pipeline
mRatBN7.2478,885,867 - 78,886,157 (+)MAPPERmRatBN7.2
Rnor_6.0479,562,428 - 79,562,721NCBIRnor6.0
Rnor_6.0479,578,581 - 79,578,874NCBIRnor6.0
Rnor_5.04144,252,373 - 144,252,666UniSTSRnor5.0
Rnor_5.04144,238,325 - 144,238,618UniSTSRnor5.0
RGSC_v3.4478,042,559 - 78,042,853RGDRGSC3.4
RGSC_v3.4478,042,560 - 78,042,853UniSTSRGSC3.4
Celera473,799,730 - 73,800,033UniSTS
RGSC_v3.1478,318,689 - 78,318,983RGD
FHH x ACI Map446.9099RGD
FHH x ACI Map446.9099UniSTS
Cytogenetic Map4q24UniSTS
D4Mit7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,216,705 - 80,217,004 (+)Marker Load Pipeline
mRatBN7.2478,885,890 - 78,886,189 (+)MAPPERmRatBN7.2
Rnor_6.0479,562,451 - 79,562,753RGDRnor6.0
D4Mit24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,882,815 - 78,882,945 (+)MAPPERmRatBN7.2
Rnor_6.0479,575,532 - 79,575,658NCBIRnor6.0
Rnor_6.0479,559,378 - 79,559,505NCBIRnor6.0
Rnor_5.04144,235,275 - 144,235,402UniSTSRnor5.0
Rnor_5.04144,249,324 - 144,249,450UniSTSRnor5.0
RGSC_v3.4478,039,507 - 78,039,637RGDRGSC3.4
RGSC_v3.4478,039,508 - 78,039,637UniSTSRGSC3.4
Celera473,796,670 - 73,796,807UniSTS
RGSC_v3.1478,315,637 - 78,315,767RGD
RH 3.4 Map4500.0RGD
RH 3.4 Map4500.0UniSTS
RH 2.0 Map4554.5RGD
Cytogenetic Map4q24UniSTS
D4Arb35  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,213,632 - 80,213,779 (+)Marker Load Pipeline
mRatBN7.2478,882,815 - 78,882,964 (+)MAPPERmRatBN7.2
Rnor_6.0479,559,378 - 79,559,524NCBIRnor6.0
Rnor_6.0479,575,532 - 79,575,677NCBIRnor6.0
Rnor_5.04144,249,324 - 144,249,469UniSTSRnor5.0
Rnor_5.04144,235,275 - 144,235,421UniSTSRnor5.0
RGSC_v3.4478,039,507 - 78,039,656RGDRGSC3.4
RGSC_v3.4478,039,508 - 78,039,656UniSTSRGSC3.4
Celera473,796,670 - 73,796,826UniSTS
RGSC_v3.1478,315,637 - 78,315,786RGD
FHH x ACI Map446.34RGD
FHH x ACI Map446.34UniSTS
Cytogenetic Map4q24UniSTS
D14Mit29  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,216,705 - 80,217,004 (+)Marker Load Pipeline
mRatBN7.2478,885,890 - 78,886,189 (+)MAPPERmRatBN7.2
Rnor_6.0479,562,451 - 79,562,753NCBIRnor6.0
Rnor_6.0479,578,604 - 79,578,906NCBIRnor6.0
Rnor_5.04144,252,396 - 144,252,698UniSTSRnor5.0
Rnor_5.04144,238,348 - 144,238,650UniSTSRnor5.0
RGSC_v3.4478,042,583 - 78,042,885UniSTSRGSC3.4
Celera473,799,753 - 73,800,065UniSTS
Cytogenetic Map4q24UniSTS
RH94804  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,886,166 - 78,886,421 (+)MAPPERmRatBN7.2
Rnor_6.0479,578,884 - 79,579,138NCBIRnor6.0
Rnor_6.0479,562,731 - 79,562,985NCBIRnor6.0
Rnor_5.04144,252,676 - 144,252,930UniSTSRnor5.0
Rnor_5.04144,238,628 - 144,238,882UniSTSRnor5.0
RGSC_v3.4478,042,863 - 78,043,117UniSTSRGSC3.4
Celera473,800,043 - 73,800,297UniSTS
RH 3.4 Map4508.6UniSTS
Cytogenetic Map4q24UniSTS
D14Mit29.1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2478,885,833 - 78,885,943 (+)MAPPERmRatBN7.2
Rnor_6.0479,578,547 - 79,578,656NCBIRnor6.0
Rnor_6.0479,562,394 - 79,562,503NCBIRnor6.0
Rnor_5.04144,238,291 - 144,238,400UniSTSRnor5.0
Rnor_5.04144,252,339 - 144,252,448UniSTSRnor5.0
RGSC_v3.4478,042,526 - 78,042,635UniSTSRGSC3.4
Celera473,799,696 - 73,799,805UniSTS
Cytogenetic Map4q24UniSTS
RH94574  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8480,219,176 - 80,219,275 (+)Marker Load Pipeline
mRatBN7.2478,888,361 - 78,888,460 (+)MAPPERmRatBN7.2
Rnor_6.0479,564,926 - 79,565,024NCBIRnor6.0
Rnor_6.0479,581,079 - 79,581,177NCBIRnor6.0
Rnor_5.04144,254,871 - 144,254,969UniSTSRnor5.0
Rnor_5.04144,240,823 - 144,240,921UniSTSRnor5.0
RGSC_v3.4478,045,058 - 78,045,156UniSTSRGSC3.4
Celera473,802,238 - 73,802,336UniSTS
Cytogenetic Map4q24UniSTS


Related Rat Strains
The following Strains have been annotated to Npy
BB.SHR-(D4Mit6-Spr)/K     iNP/Iusm     iP/Iusm     NP.P-(D4Rat119-D4Rat55)/Iusm     SHR.BN-(Il6-Npy)    


Genetic Models
This gene Npy is modified in the following models/strains:
iNP-Npyem6Sage/Iusm     iNP-Npyem6Sage-/-/Iusm     iNP-Npyem6Sage+/-/Iusm    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
18 1 30 111 67 59 35 80 35 12 250 144 11 86 53 60 24 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000013145   ⟹   ENSRNOP00000013146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl479,557,854 - 79,565,097 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074351   ⟹   ENSRNOP00000066713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl480,212,111 - 80,219,310 (+)Ensembl
mRatBN7.2 Ensembl478,881,264 - 78,888,495 (+)Ensembl
Rnor_6.0 Ensembl479,573,998 - 79,581,208 (+)Ensembl
RefSeq Acc Id: NM_012614   ⟹   NP_036746
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8480,212,111 - 80,219,310 (+)NCBI
mRatBN7.2478,881,294 - 78,888,495 (+)NCBI
Rnor_6.0479,557,856 - 79,565,059 (+)NCBI
Rnor_5.04144,233,753 - 144,240,956 (+)NCBI
RGSC_v3.4478,038,013 - 78,045,187 (+)RGD
Celera473,795,148 - 73,802,371 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036746   ⟸   NM_012614
- Peptide Label: preproprotein
- UniProtKB: P07808 (UniProtKB/Swiss-Prot),   F2W8A6 (UniProtKB/TrEMBL),   M0RAZ3 (UniProtKB/TrEMBL),   F2W8A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013146   ⟸   ENSRNOT00000013145
Ensembl Acc Id: ENSRNOP00000066713   ⟸   ENSRNOT00000074351

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07808-F1-model_v2 AlphaFold P07808 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693045
Promoter ID:EPDNEW_R3565
Type:single initiation site
Name:Npy_1
Description:neuropeptide Y
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0479,574,024 - 79,574,084EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3197 AgrOrtholog
BIND 133988
BioCyc Gene G2FUF-44903 BioCyc
Ensembl Genes ENSRNOG00000009768 Ensembl
  ENSRNOG00000046449 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000074351 ENTREZGENE
Gene3D-CATH 6.10.250.900 UniProtKB/Swiss-Prot
InterPro Pancreatic_hormone-like UniProtKB/Swiss-Prot
  Pancreatic_hormone-like_CS UniProtKB/Swiss-Prot
KEGG Report rno:24604 UniProtKB/Swiss-Prot
NCBI Gene 24604 ENTREZGENE
PANTHER PRO-NEUROPEPTIDE Y UniProtKB/Swiss-Prot
  PTHR10533 UniProtKB/Swiss-Prot
Pfam Hormone_3 UniProtKB/Swiss-Prot
PharmGKB NPY RGD
PhenoGen Npy PhenoGen
PRINTS PANCHORMONE UniProtKB/Swiss-Prot
PROSITE PANCREATIC_HORMONE_1 UniProtKB/Swiss-Prot
  PANCREATIC_HORMONE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009768 RatGTEx
  ENSRNOG00000046449 RatGTEx
SMART PAH UniProtKB/Swiss-Prot
TIGR TC232176
UniProt A0A8L2QXP1_RAT UniProtKB/TrEMBL
  F2W8A6 ENTREZGENE, UniProtKB/TrEMBL
  F2W8A7 ENTREZGENE, UniProtKB/TrEMBL
  M0RAZ3 ENTREZGENE
  NPY_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Npy  neuropeptide Y  LOC100912228  pro-neuropeptide Y-like  Data merged from RGD:6487865 737654 PROVISIONAL
2012-07-05 LOC100912228  pro-neuropeptide Y-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Npy  Neuropeptide Y      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression present in the hypothalamus of obese rats, especially in the paraventricular nucleus 70437
gene_expression abundant in central and peripheral nervous system 628512
gene_expression expressed throughout nervous system; increased expression in brain areas undergoing seizures 628420
gene_function hypothalamic-derived neuropeptide 628420
gene_function hypothalamic-derived neuropeptide 628512
gene_function inhibitory neurotransmitter that controls blood pressure 1357410
gene_other exogenous Npy has long-lasting effects on postsynaptic current amplitude in neocortex 628420
gene_physical_interaction binds to G protein coupled pancreatic polypeptide (Pp) receptors Y1,Y2 and Y5 628420
gene_process regulates appetite 70437
gene_process activates G-protein coupled receptors 70437
gene_process may function as an endogenous antiepileptic agent 628512
gene_process involved in energy homeostasis 628420
gene_process may be involved in modulation of Ca2+ dependent GABA release onto pyramidal neurons 628420
gene_process involved in modulation of feeding behaviour, anxiety, memory consolidation, and regulation of blood pressure; may decrease excitatory postsynaptic current and increase monosynaptic inhibitory postsynaptic current 628420
gene_process mediates effects of leptin on energy homeostasis; may influence hypothalamic-pituitary-thyroid axis (HPT axis) 628420
gene_process mediates the control of stress and fear related behavior 1357416
gene_regulation decrease in hypothalamic NPY innervation observed in anorectic TB rats 727497
gene_transcript polymorphism at position +4666 defined by microsatellite marker D4Mit7, contributes to reduced levels of mRNA expression in brain regions of alcohol preferring (iP) rats 1357412