RGD Reference Report - Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization. - Rat Genome Database

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Urocortin I inhibits the effects of ghrelin and neuropeptide Y on feeding and energy substrate utilization.

Authors: Currie, PJ  Coiro, CD  Duenas, R  Guss, JL  Mirza, A  Tal, N 
Citation: Currie PJ, etal., Brain Res. 2011 Apr 18;1385:127-34. doi: 10.1016/j.brainres.2011.01.114.
RGD ID: 10448958
Pubmed: PMID:21303672   (View Abstract at PubMed)
PMCID: PMC3167471   (View Article at PubMed Central)
DOI: DOI:10.1016/j.brainres.2011.01.114   (Journal Full-text)

The corticotropin releasing hormone-related ligand, urocortin-I (UcnI), suppresses food intake when injected into multiple hypothalamic and extrahypothalamic areas. UcnI also alters energy substrate utilization, specifically via enhanced fat oxidation as reflected in reductions in respiratory quotient (RQ). In the present study we compared the feeding and metabolic effects of ghrelin and NPY following pretreatment with UcnI. Direct PVN injections of NPY (50 pmol) and ghrelin (50 pmol) were orexigenic while UcnI (10-40 pmol) reliably suppressed food intake. Both ghrelin and NPY increased RQ, indicating enhanced utilization of carbohydrates and the preservation of fat stores. UcnI alone suppressed RQ responses. PVN UcnI attenuated the effects of both ghrelin and NPY on food intake and energy substrate utilization. While ghrelin (5 pmol) potentiated the effect of NPY (25 pmol) on RQ and food intake, these responses were inhibited by pretreatment with UcnI (10 pmol). In conclusion, PVN NPY and ghrelin stimulate eating and promote carbohydrate oxidation while inhibiting fat utilization. These effects are blocked by UcnI which alone suppresses appetite and promotes fat oxidation. Overall these findings are consistent with a possible interactive role of PVN NPY, ghrelin and urocortin in the modulation of appetite and energy metabolism.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of eating behavior  IDA 10448958 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Npy  (neuropeptide Y)


Additional Information