RGD Reference Report - Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats. - Rat Genome Database

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Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats.

Authors: Chance, WT  Xiao, C  Dayal, R  Sheriff, S 
Citation: Chance WT, etal., Peptides. 2007 Feb;28(2):295-301. Epub 2007 Jan 17.
RGD ID: 10448965
Pubmed: PMID:17234300   (View Abstract at PubMed)
DOI: DOI:10.1016/j.peptides.2006.10.018   (Journal Full-text)

Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VMA). To better assess specific intra-area alterations of NPY, Y(1) receptor (Y(1) R), and agouti-related peptide (AgRP) in TB rats, we used radioimmunoassay, quantitative real-time RT-PCR, and immunohistochemistry. We found that NPY and AgRP mRNA were elevated significantly in whole hypothalamus of anorectic TB rats, while Y(1) R mRNA was decreased. Based on two replicates of four pooled samples each, both NPY and AgRP mRNA appeared to be elevated in the VMA of anorectic TB rats, while only AgRP exhibited a similar increase in the DMA. Levels of NPY were elevated in the VMA of both TB and pair-fed (PF) rats, but in the DMA only PF rats exhibited a significant NPY increase. NPY and Y(1) R immunohistochemistry revealed reduced NPY staining in PVN and ARC nucleus of TB and PF rats. Y(1) R immunostaining was also reduced in the ARC and PVN of TB rats, while PF rats exhibited elevated immunostaining in the PVN. These results continue to implicate dysfunction of NPY feeding systems in experimental cancer anorexia and suggest down-regulation of Y(1) R receptors as well as possible problems in NPY translation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Anorexia  ISONpy (Rattus norvegicus)10448965; 10448965associated with NeoplasmsRGD 
Anorexia  ISONpy1r (Rattus norvegicus)10448965; 10448965associated with Neoplasms more ...RGD 
Anorexia  IEP 10448965associated with NeoplasmsRGD 
Anorexia  IEP 10448965associated with Neoplasms more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Npy  (neuropeptide Y)
Npy1r  (neuropeptide Y receptor Y1)

Genes (Mus musculus)
Npy  (neuropeptide Y)
Npy1r  (neuropeptide Y receptor Y1)

Genes (Homo sapiens)
NPY  (neuropeptide Y)
NPY1R  (neuropeptide Y receptor Y1)


Additional Information