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Strain Registration

Strain: iNP/Iusm

Symbol: iNP/Iusm
Strain: iNP
Substrain: Iusm
Full Name: alcohol-nonpreferring
RGD ID: 634381
Citation ID: RRID:RGD_634381
Ontology ID: RS:0000610
Alleles: Npy
Also Known As: alcohol-nonpreferring
Type: inbred
Available Source: Not Available
Origination: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Description: These were inbred alcohol-nonpreferring rats developed from outbred alcohol-nonpreferring rats (Iusm:NP) at generation 30 at Indiana University for high-alcohol-nonpreferring behavior. Inbred rats utilized for the development of alcohol-preferring, alcohol-nonpreferring congenic strains were in the27th generation of inbreeding.
Last Known Status: Unknown





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
iNP/Iusm  IEA 7241799 RGD 
Iusm:NP  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
consumption behavior trait  EXP 631229 RGD 
drinking behavior trait  EXP 69704; 61483 RGD 

References

References - curated
# Reference Title Reference Citation
1. Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines. Bice P, etal., Mamm Genome 1998 Dec;9(12):949-55.
2. A quantitative trait locus for alcohol consumption in selectively bred rat lines. Carr LG, etal., Alcohol Clin Exp Res 1998 Jun;22(4):884-7
3. Mapping of QTL influencing saccharin consumption in the selectively bred alcohol-preferring and -nonpreferring rat lines. Foroud T, etal., Behav Genet 2002 Jan;32(1):57-67.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Effect of polymorphism on expression of the neuropeptide Y gene in inbred alcohol-preferring and -nonpreferring rats. Spence JP, etal., Neuroscience 2005;131(4):871-6.
6. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Worst TJ, etal., J Neurosci Res 2005 May 15;80(4):529-38.

Region

Strain QTL Data
Symbol Name Trait
Alc18 Alcohol consumption QTL 18 drinking behavior trait   (VT:0001422)    
Alc19 Alcohol consumption QTL 19 drinking behavior trait   (VT:0001422)    
Alc20 Alcohol consumption QTL 20 drinking behavior trait   (VT:0001422)    
Alc21 Alcohol consumption QTL 21 drinking behavior trait   (VT:0001422)    
Alc8 Alcohol consumption QTL 8 consumption behavior trait   (VT:0002069)    
Sach1 Saccharin preference QTL 1 consumption behavior trait   (VT:0002069)    
Sach2 Saccharin preference QTL 2 consumption behavior trait   (VT:0002069)    
Sach3 Saccharin preference QTL 3 consumption behavior trait   (VT:0002069)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These have low voluntary oral consumption of alcohol which results in low blood alcohol. 69704
strain_other strain contains polymorphism at position +4666 in the second intron with sequence GAGAGAG; associated with differential expression level of Npy gene 1357412
strain_phys_biochem Vamp2 mRNA is downregulated in frontal cortex compared with P strain 1358772

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-01 iNP/Iusm  alcohol-nonpreferring  NP  alcohol-nonpreferring  Symbol and/or name change 68913 APPROVED