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Gene: Neu1 (neuraminidase 1) Rattus norvegicus

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Symbol:

Neu1

Name:

neuraminidase 1

RGD ID:

3163

Description:

Enables exo-alpha-sialidase activity. Involved in positive regulation of neuron projection development and regulation of myoblast proliferation. Located in cell surface. Human ortholog(s) of this gene implicated in mucolipidosis. Orthologous to human NEU1 (neuraminidase 1); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

lysosomal sialidase; N-acetyl-alpha-neuraminidase 1; sialidase 1 (lysosomal sialidase); sialidase-1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEU1 (neuraminidase 1)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Neu1 (neuraminidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	NEU1 (neuraminidase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	neu1 (neuraminidase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	neu1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,902,120 - 3,906,383 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	3,902,120 - 3,906,383 (-)	Ensembl				GRCr8
mRatBN7.2	20	3,897,480 - 3,901,745 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,897,480 - 3,901,745 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	4,597,480 - 4,601,727 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	3,959,222 - 3,963,469 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,496,415 - 4,500,659 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,610,995 - 4,615,258 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,610,995 - 4,615,247 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	6,690,982 - 6,695,245 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	3,999,317 - 4,003,800 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	4,127,729 - 4,131,992 (+)	NCBI		Celera
RGSC_v3.1	20	3,999,977 - 4,003,886 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Desbuquois dysplasia (ISO)

genetic disease (ISO)

glycoproteinosis (ISO,ISS)

Hydrops Fetalis (ISO)

Neuraminidase Deficiency (ISO)

progressive myoclonus epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

2-methylcholine (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

Bufotalin (ISO)

Butylbenzyl phthalate (ISO)

butyric acid (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

cisplatin (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

DDE (ISO)

deoxynivalenol (ISO)

dexamethasone (ISO)

diuron (EXP)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

fluoxetine (ISO)

folic acid (ISO)

formaldehyde (ISO)

gemcitabine (ISO)

gentamycin (EXP)

hydrogen cyanide (ISO)

indometacin (ISO)

isobutanol (ISO)

leflunomide (EXP)

Licochalcone B (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mocetinostat (ISO)

nickel sulfate (ISO)

okadaic acid (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phorone (EXP)

pirinixic acid (ISO)

potassium cyanide (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

rotenone (EXP)

serpentine asbestos (ISO)

sevoflurane (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulindac (ISO)

sunitinib (ISO)

tacedinaline (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Yessotoxin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ganglioside catabolic process (IBA)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

oligosaccharide catabolic process (IBA,IEA,ISO,ISS)

positive regulation of neuron projection development (IMP)

regulation of myoblast proliferation (IMP)

Cellular Component

cell junction (IEA,ISO)

cell surface (IDA)

cytoplasm (IBA)

cytoplasmic vesicle (IEA)

lysosomal lumen (IEA)

lysosomal membrane (IEA)

lysosome (IBA,IEA,ISO)

membrane (IBA)

plasma membrane (IEA)

Molecular Function

alpha-sialidase activity (IEA,ISO)

exo-alpha-sialidase activity (IBA,IDA,IEA,ISO)

hydrolase activity (IEA)

hydrolase activity, acting on glycosyl bonds (IEA)

protein binding (IPI,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

sphingolipid metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Desialylation of insulin receptors and IGF-1 receptors by neuraminidase-1 controls the net proliferative response of L6 myoblasts to insulin.	Arabkhari M, etal., Glycobiology. 2010 May;20(5):603-16. doi: 10.1093/glycob/cwq010. Epub 2010 Jan 24.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Differential expression of three sialidase genes in rat development.	Hasegawa T, etal., Biochem Biophys Res Commun 2001 Jan 26;280(3):726-32.
5.	Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling.	Jayanth P, etal., Cell Signal. 2010 Aug;22(8):1193-205. doi: 10.1016/j.cellsig.2010.03.011. Epub 2010 Mar 25.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Biochemical characteristics and subcellular localizations of rat liver neuraminidase isozymes: a paradox resolved.	Samollow PB, etal., Biochem Genet. 1990 Jun;28(5-6):283-98.
15.	Uncultured adipose-derived regenerative cells promote peripheral nerve regeneration.	Suganuma S, etal., J Orthop Sci. 2013 Jan;18(1):145-51. doi: 10.1007/s00776-012-0306-9. Epub 2012 Sep 5.

Additional References at PubMed

PMID:8985184	PMID:9425240	PMID:12477932	PMID:19199708	PMID:23376485	PMID:23533145	PMID:25153125	PMID:28500071	PMID:29277445	PMID:33608771	PMID:35002528

Genomics

Comparative Map Data

Neu1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,902,120 - 3,906,383 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	20	3,902,120 - 3,906,383 (-)	Ensembl				GRCr8
mRatBN7.2	20	3,897,480 - 3,901,745 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,897,480 - 3,901,745 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	20	4,597,480 - 4,601,727 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	3,959,222 - 3,963,469 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,496,415 - 4,500,659 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,610,995 - 4,615,258 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,610,995 - 4,615,247 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	20	6,690,982 - 6,695,245 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	20	3,999,317 - 4,003,800 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	20	4,127,729 - 4,131,992 (+)	NCBI		Celera
RGSC_v3.1	20	3,999,977 - 4,003,886 (-)	NCBI
Cytogenetic Map	20	p12	NCBI

NEU1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,857,659 - 31,862,821 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,857,063 - 31,862,905 (-)	Ensembl			hg38	GRCh38
GRCh37	6	31,825,436 - 31,830,598 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	31,934,931 - 31,938,662 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	6	31,934,931 - 31,938,662	NCBI
Celera	6	33,425,415 - 33,429,295 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,612,642 - 31,616,522 (-)	NCBI		HuRef
CHM1_1	6	31,828,970 - 31,832,850 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,710,899 - 31,716,061 (-)	NCBI		T2T-CHM13v2.0

Neu1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,150,229 - 35,156,273 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,150,229 - 35,154,929 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	17	34,931,253 - 34,937,297 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,931,253 - 34,935,953 (+)	Ensembl			mm10	GRCm38
MGSCv37	17	35,068,198 - 35,074,242 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,539,435 - 34,543,377 (+)	NCBI		MGSCv36	mm8
Celera	17	38,027,486 - 38,033,530 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.48	NCBI

Neu1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	378,708 - 383,085 (-)	Ensembl
ChiLan1.0	NW_004955437	378,708 - 383,076 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEU1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,338,259 - 46,342,058 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,299,753 - 42,303,551 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,522,392 - 31,526,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,409,217 - 32,412,971 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,409,217 - 32,412,971 (-)	Ensembl			panPan2	panpan1.1

NEU1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,323,659 - 1,327,989 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,323,877 - 1,328,520 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,458,231 - 1,463,184 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,465,128 - 1,470,088 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,465,833 - 1,469,900 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,322,829 - 1,327,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,390,787 - 1,395,741 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,455,970 - 1,460,945 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Neu1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,874,214 - 35,878,035 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,683,204 - 1,688,883 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,683,283 - 1,687,130 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEU1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	23,953,499 - 23,958,638 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	23,953,721 - 23,958,659 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	27,853,642 - 27,858,581 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEU1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,158,530 - 40,162,254 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,158,679 - 40,161,723 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666044	31,773,648 - 31,777,370 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Neu1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,382,467 - 24,387,874 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624754	24,382,509 - 24,386,410 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Neu1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	18	7,523,007 - 7,527,201 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Neu1
52 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	118
Count of miRNA genes:	95
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000049344
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1533200	5306452	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	1	6693431	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	1	26925056	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1	33724594	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26128279	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600300	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1533083	46533083	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24164241	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	1	34066551	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3626323	10078622	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29193376	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	6693431	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	1	27341128	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3626323	9244918	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29193376	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29193376	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29193376	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29193376	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1	14100378	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27341128	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578510	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600300	Rat

Markers in Region

D20Yum55

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,897,521 - 3,897,682 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	4,615,056 - 4,615,216	NCBI	Rnor6.0
Rnor_5.0	20	6,695,043 - 6,695,203	UniSTS	Rnor5.0
RGSC_v3.4	20	3,999,359 - 3,999,519	UniSTS	RGSC3.4
Celera	20	4,131,790 - 4,131,950	UniSTS
Cytogenetic Map	20	p12	UniSTS

RH140193

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,897,681 - 3,897,875 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	4,614,863 - 4,615,056	NCBI	Rnor6.0
Rnor_5.0	20	6,694,850 - 6,695,043	UniSTS	Rnor5.0
RGSC_v3.4	20	3,999,519 - 3,999,712	UniSTS	RGSC3.4
Celera	20	4,131,597 - 4,131,790	UniSTS
RH 3.4 Map	20	52.42	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	92	59	6	356	192	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB035722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC100639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000049344 ⟹ ENSRNOP00000050614

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	20	3,902,120 - 3,906,383 (-)	Ensembl
mRatBN7.2 Ensembl	20	3,897,480 - 3,901,745 (-)	Ensembl
Rnor_6.0 Ensembl	20	4,610,995 - 4,615,247 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082410

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,611,999 - 4,614,246 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083430

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,611,706 - 4,612,522 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083987

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,611,631 - 4,612,413 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087470 ⟹ ENSRNOP00000070867

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,611,273 - 4,614,214 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087912

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	4,613,588 - 4,614,349 (+)	Ensembl

RefSeq Acc Id:

NM_031522 ⟹ NP_113710

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	3,902,120 - 3,906,383 (-)	NCBI
mRatBN7.2	20	3,897,480 - 3,901,745 (-)	NCBI
Rnor_6.0	20	4,610,995 - 4,615,258 (+)	NCBI
Rnor_5.0	20	6,690,982 - 6,695,245 (+)	NCBI
RGSC_v3.4	20	3,999,317 - 4,003,800 (-)	RGD
Celera	20	4,127,729 - 4,131,992 (+)	RGD

Sequence:

show sequence

CTCTGGGTCACATGCGGATGTCGGACAGCTGGGTGGACTAATTGGAGTCGCGGCAGCGTGGACC
AAGGCCCCCTCCAAGGGGAGGGTTCGGAGTGACGTGCGCGCTTTTAAAGGGTCGAGGTCAGCTG
ACCGCTTGCCACCGGTGACCACTTCGTGGACGGGGATTGGGGATTGCGGGGAGCCATGGTGGGG
GCAGAGCCAAGCAGACCCCCGGGACCACCGAGCTACTGGACAGGCCGGCGGGGTCAGGGGCTCG
CAGCGATCTTCCTGCTCCTGGTGTCCGCGGCGGGATCAGAGGCCAGGACAGAGGATGACTTCAG
CCTGGTGCAGCCGCTGGTGACCATGGAGCAATTGCTGTGGGTGAGCGGGAAGCAGATCGGCTCC
GTAGACACTTTTCGAATCCCGCTCATCACAGCCACCCCTCGGGGCACGCTCCTGGCCTTCGCTG
AGGCTAGGAAAAAGTCTGCATCCGATGAGGGGGCCAAGTTCATCGCTATGAGGAGGTCCACAGA
CCAGGGTAGCACGTGGTCCTCTACGGCTTTCATTGTAGACGACGGGGAGGCCTCCGATGGGCTG
AACCTGGGGGCTGTGGTGAACGACGTAGACACAGGAGTGGTGTTCCTCATCTATACCCTCTGTG
CTCACAAGGTCAACTGCCAGGTGGCCTCTACCATGCTGGTTTGGAGTAAGGATGACGGCGTTTC
CTGGAGCCCACCGCGGAATCTCTCCGTGGATATTGGCACAGAGATGTTTGCCCCTGGACCCGGC
TCTGGCATTCAGAAACAGCGGGAGCCTTGGAAGGGCCGGCTCATTGTGTGTGGACACGGGACGC
TGGAGCGAGATGGGGTCTTCTGTCTCCTCAGTGATGACCACGGTGCCTCCTGGCACTATGGGAC
TGGAGTGAGCGGCATTCCCTTCGGCCAGCCCAAACACGATCACGATTTCAACCCCGACGAGTGC
CAGCCCTACGAGCTTCCAGACGGCTCAGTCATCATCAACGCCCGGAACCAGAATAACTACCACT
GCCGCTGCAGGATCGTCCTCCGCAGCTATGACGCCTGTGACACCCTCAGGCCCCGGGATGTGAC
CTTCGACCCTGAGCTCGTGGACCCTGTGGTAGCTGCAGGAGCGCTAGCCACCAGCTCCGGCATT
GTCTTCTTCTCCAATCCAGCCCATCCCGAGTACCGAGTGAACCTGACCCTGCGCTGGAGCTTCA
GCAATGGCACATCCTGGCAGAAGGAGAGGGTCCAGTTGTGGCCGGGACCCAGCGGCTACTCATC
CCTGACAGCCCTGGAAAACAGCACGGACGGGAAGAAGCAGCCCCCGCAGCTGTTCGTTCTGTAC
GAGAAAGGACTGAACCGGTACACGGAGAGCATCTCCATGGTCAAAATCAGCGTCTACGGCACGC
TCTGAGCCGCGCGCCTAAGGACACCAAGTCCTGGACCCTGACTTCACAGCTCTCTGGACCGTGT
GCAGAGGGTGCCTGAAACACAGCTCTTCCTCCGAATTCCCCTTCAACGGGGAAGTCACTCCGTT
ATGACTTAACGCCCAGCTTCCTCTTCCCAGAGAGGAAGTCCCTCCCTCACCAGGAACACTGTTT
TTCCAGAATGTTGGGGATGGTCCCTGTCCATTCTCCTCCAGGACAGCGGAGCTGTTCCTTTCTG
GGACAGGATGGGGGAGGGGCTCCCCCTGGAGAGGTGAATAGATATGAACTCAGGGAACTGGGAA
GGCCTGGTGTCCTAGGGTATTGGAGGCAGGTACTAGATGTGATTGCTGAAAGTCCCCGGGGCAG
AGTGTCCTTTCAGTGCAAGGATAAACACACACACACACACACACACACACACACACACACATGT
GCACCCCCTGATTATTTATGAATCGAAATATTTGTGACTTAAAATTTTTAATGCAAAAAAAAAA
GTGTTTGTGGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113710	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00640	(Get FASTA)	NCBI Sequence Viewer
	BAB21443	(Get FASTA)	NCBI Sequence Viewer
	CAE83976	(Get FASTA)	NCBI Sequence Viewer
	EDL83468	(Get FASTA)	NCBI Sequence Viewer
	EDL83469	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000050614
GenBank Protein	Q99PW3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_113710 ⟸ NM_031522
- Peptide Label:	precursor
- UniProtKB:	Q99PW3 (UniProtKB/Swiss-Prot), Q6MG70 (UniProtKB/TrEMBL), D3ZB63 (UniProtKB/TrEMBL), A0A9K3Y7Q5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVGAEPSRPPGPPSYWTGRRGQGLAAIFLLLVSAAGSEARTEDDFSLVQPLVTMEQLLWVSGKQ IGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEAS DGLNLGAVVNDVDTGVVFLIYTLCAHKVNCQVASTMLVWSKDDGVSWSPPRNLSVDIGTEMFAP GPGSGIQKQREPWKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNP DECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATS SGIVFFSNPAHPEYRVNLTLRWSFSNGTSWQKERVQLWPGPSGYSSLTALENSTDGKKQPPQLF VLYEKGLNRYTESISMVKISVYGTL hide sequence

Ensembl Acc Id:

ENSRNOP00000070867 ⟸ ENSRNOT00000087470

Ensembl Acc Id:

ENSRNOP00000050614 ⟸ ENSRNOT00000049344

Protein Domains

Sialidase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PW3-F1-model_v2	AlphaFold	Q99PW3	1-409	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701362

Promoter ID:

EPDNEW_R11885

Type:

multiple initiation site

Name:

Neu1_1

Description:

neuraminidase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	4,611,133 - 4,611,193	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3163	AgrOrtholog
BioCyc Gene	G2FUF-4613	BioCyc
Ensembl Genes	ENSRNOG00000032942	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000049344	ENTREZGENE
Gene3D-CATH	2.120.10.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7929913	IMAGE-MGC_LOAD
InterPro	Sialidase	UniProtKB/Swiss-Prot
	Sialidase_fam	UniProtKB/Swiss-Prot
	Sialidase_sf	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124600	IMAGE-MGC_LOAD
NCBI Gene	24591	ENTREZGENE
PANTHER	PTHR10628	UniProtKB/Swiss-Prot
	SIALIDASE-1	UniProtKB/Swiss-Prot
Pfam	BNR_2	UniProtKB/Swiss-Prot
PhenoGen	Neu1	PhenoGen
RatGTEx	ENSRNOG00000032942	RatGTEx
Superfamily-SCOP	SSF50939	UniProtKB/Swiss-Prot
UniProt	A0A9K3Y7Q5	ENTREZGENE, UniProtKB/TrEMBL
	A6KTN9_RAT	UniProtKB/TrEMBL
	D3ZB63	ENTREZGENE
	NEUR1_RAT	UniProtKB/Swiss-Prot
	Q6MG70	ENTREZGENE, UniProtKB/TrEMBL
	Q99PW3	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-04-17	Neu1	neuraminidase 1	Neu1	sialidase 1 (lysosomal sialidase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Neu1	sialidase 1 (lysosomal sialidase)	Neu1	neuraminidase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Neu1	Neuraminidase 1			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_mapping	found within the rat major histocompatibility RT1 complex	1300431

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)