Neu1 (neuraminidase 1) - Rat Genome Database

Name: Neu1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Neu1 (neuraminidase 1) Chinchilla lanigera

Analyze

Symbol:

Neu1

Name:

neuraminidase 1

RGD ID:

8855845

Description:

ENCODES a protein that exhibits alpha-sialidase activity (ortholog); exo-alpha-sialidase activity (ortholog); INVOLVED IN oligosaccharide catabolic process (ortholog); positive regulation of neuron projection development (ortholog); regulation of myoblast proliferation (ortholog); ASSOCIATED WITH genetic disease (ortholog); glycoproteinosis (ortholog); Hydrops Fetalis (ortholog); FOUND IN cell junction (ortholog); cell surface (ortholog); intracellular membrane-bounded organelle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sialidase 1 (lysosomal sialidase); sialidase-1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NEU1 (neuraminidase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NEU1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Neu1 (neuraminidase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	378,708 - 383,085 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	378,708 - 383,076 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

glycoproteinosis (ISO)

Hydrops Fetalis (ISO)

Neuraminidase Deficiency (ISO)

progressive myoclonus epilepsy (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

oligosaccharide catabolic process (ISO)

positive regulation of neuron projection development (ISO)

regulation of myoblast proliferation (ISO)

Cellular Component

cell junction (ISO)

cell surface (ISO)

intracellular membrane-bounded organelle (ISO)

lysosome (ISO)

Molecular Function

alpha-sialidase activity (ISO)

exo-alpha-sialidase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Neu1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	378,708 - 383,085 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	378,708 - 383,076 (-)	NCBI	ChiLan1.0	ChiLan1.0

NEU1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,857,659 - 31,862,821 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,857,659 - 31,862,905 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,825,436 - 31,830,598 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	31,934,931 - 31,938,662 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	31,934,931 - 31,938,662	NCBI
Celera	6	33,425,415 - 33,429,295 (-)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,612,642 - 31,616,522 (-)	NCBI		HuRef
CHM1_1	6	31,828,970 - 31,832,850 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,710,899 - 31,716,061 (-)	NCBI		T2T-CHM13v2.0

Neu1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,150,229 - 35,156,273 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,150,229 - 35,154,929 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,931,253 - 34,937,297 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,931,253 - 34,935,953 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	35,068,198 - 35,074,242 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,539,435 - 34,543,377 (+)	NCBI		MGSCv36	mm8
Celera	17	38,027,486 - 38,033,530 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.48	NCBI

Neu1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,902,120 - 3,906,383 (-)	NCBI		GRCr8
mRatBN7.2	20	3,897,480 - 3,901,745 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,897,480 - 3,901,745 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,597,480 - 4,601,727 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	3,959,222 - 3,963,469 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,496,415 - 4,500,659 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,610,995 - 4,615,258 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,610,995 - 4,615,247 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,690,982 - 6,695,245 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	3,999,317 - 4,003,800 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	3,999,977 - 4,003,886 (-)	NCBI
Celera	20	4,127,729 - 4,131,992 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

NEU1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,338,259 - 46,342,058 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,299,753 - 42,303,551 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,522,392 - 31,526,097 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,409,217 - 32,412,971 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	32,409,217 - 32,412,971 (-)	Ensembl	panpan1.1		panPan2

NEU1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,323,659 - 1,327,989 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,323,877 - 1,328,520 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,458,231 - 1,463,184 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,465,128 - 1,470,088 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,465,833 - 1,469,900 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,322,829 - 1,327,813 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,390,787 - 1,395,741 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,455,970 - 1,460,945 (-)	NCBI		UU_Cfam_GSD_1.0

Neu1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,874,214 - 35,878,035 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,683,204 - 1,688,883 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,683,283 - 1,687,130 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NEU1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	23,947,061 - 23,958,666 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	23,953,721 - 23,958,659 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	27,853,642 - 27,858,581 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NEU1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,158,530 - 40,162,254 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,158,679 - 40,161,723 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,773,648 - 31,777,370 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Neu1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,382,467 - 24,387,874 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,382,509 - 24,386,410 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005389390	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01034127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01034128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01136897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000012446 ⟹ ENSCLAP00000012303

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955437	378,708 - 383,085 (-)	Ensembl

RefSeq Acc Id:

XM_005389390 ⟹ XP_005389447

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955437	378,708 - 383,076 (-)	NCBI

Sequence:

show sequence

TGTCCGGCGTGGGGCCGGTTTGGAGGCCGCTTCTGAGCTGCTTAAAGAGCCAGGTCAGCTGACC
GGCCCCAGACCGTCGCCTCTGCAGCGCGAAGGTGAGGTCGGCGCGCGGAACCGGCACGCCGGCA
TGCCGCGCTCCTGCGAAGGCGCGAGGGCGCGGGCGCTGGCCGCCGTCTTCCCGCTGCTCCTGTC
CCTGGCCGGGCTGGAGGCGAGGGCTAAGGACGACTTCAGCCAGGTGCAGCCGCTGGTGACCCTG
GAGCAGCTGCTGTGGGTGAGCGGCCGGCAGATCGGCGCCGTGGACACCTTCCGCATCCCGCTCA
TCGCGGCCACGCCGCGGGGCACCCTGCTTGCCTTCGCCGAGGCCCGGAAGATGTCCGCGTCCGA
CGAGGGCGCCAAGTTCATCGCCCTGCGGAGGTCCACGGACCAAGGCAGCACCTGGTCCTCCACA
GCGTTCATCGTGGACGACGGGGAGGCCCCCGACGGGCTGAACCTGGGGGCCGTGGTGAGCGATG
CGGAGACAGGAGTTGTGTTTCTCTTCTACACGCTCTGTGCGCACAAGTTCCGCTGCCAGGTGGC
CTCCACCATGTTGGTGTGGAGCAAGGACGACGGCGTCTCCTGGAGCCCGCCCCGGAACCTGTCC
GTGGACATCGGCACCGAGATGTTTGCTCCTGGGCCGGGCTCCGGCATTCAGAAAAGGTGGGAGC
CGCGGAAGGGCCGGCTTATCACGTGTGGCCACGGGACGCTGGAGCGGGACGGGGTCTTCTGTCT
CCTCAGCGATGACCACGGGGCCACCTGGCGCTACGGGACTGGGGTCAGCGGCATTCCGTACGGC
CAGCCCAAGGTGGAGAACGACTTCAACCCGGACGAGTGCCAGCCCTACGAGCTCCCAGATGGCT
CGGTCATCATCAACGCCCGGAACCAGAACAACTACCACTGCCGCTGCCGCATCATCCTCCGCAG
CTATGACGCCTGTGACACGCTGCGGCCCCGGGACGTGACCTTCGACCACGAGCTCGTGGACCCT
GTGGTGGCCGCGGGCGCCATAGCCACCAGCTCTGGGATTATCTTCTTCTCCAACCCGGCCCACC
CGGAGTTCCGAGTGAACCTGACGCTGCGCTGGAGCTTCAGCAACGGCACCTCGTGGCAGAAAGA
GAAGGTCCAGCTGTGGCCAGGGCCCAGCGGCTACTCGTCCCTGACCGCCCTGGAGAGCAGCAGG
GGCGGGGAGAACGAGGCGCCGCAGCTCTACGTCCTGTATGAGAAAGGCCTGAGCCGCTACACGG
AGAGCATCTCCATGGCCAAAGTCAGCATCTACGGCACGCTCTGAGCGGCGGGCGGGCGGGGCGT
CGGGCCGCTCCTGCAGGGCCGGGGCTCTGGGGCCGCTGCGGACGCCTACGAGGCGGCGCCACCT
TCCTTTGGACTCTGCAAAGTCAAGCTCTCTTTGCCAGAGAAATGAATCCGTTAGGATGGAAAGA
ACACTTTCCTCTCCCACGCGGAAGCTCTGCCCTCACCTGAGAACTTGCGCTTCCTTCCCGCGCG
GAGGCCCCGGCGCCCCCAGGACCCCAGGACGGGCCGGCTCTCCCCAGGCGGGGCTGGGTGCGTC
TGTAGAGCTGCGGAACTGTGAACTCGGGGCCCTGGGGGAGCCGGGCTCCCTCTAGGTGCTGGGA
GGAGACGCGGGCTTTGGAGCTGCTTGGTGAAAGTCAGCTGGGGCGGGATGTTTGGTTTAAGGGT
GAGGAACTAAGTAGGCTGTCGCCCTTAACTATTTATGGATCAGATGTTCACAGTGTGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005389447	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012303
	ENSCLAP00000012303.1

RefSeq Acc Id:

XP_005389447 ⟸ XM_005389390

- UniProtKB:

A0A8C2VGE4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRSCEGARARALAAVFPLLLSLAGLEARAKDDFSQVQPLVTLEQLLWVSGRQIGAVDTFRIPL
IAATPRGTLLAFAEARKMSASDEGAKFIALRRSTDQGSTWSSTAFIVDDGEAPDGLNLGAVVSD
AETGVVFLFYTLCAHKFRCQVASTMLVWSKDDGVSWSPPRNLSVDIGTEMFAPGPGSGIQKRWE
PRKGRLITCGHGTLERDGVFCLLSDDHGATWRYGTGVSGIPYGQPKVENDFNPDECQPYELPDG
SVIINARNQNNYHCRCRIILRSYDACDTLRPRDVTFDHELVDPVVAAGAIATSSGIIFFSNPAH
PEFRVNLTLRWSFSNGTSWQKEKVQLWPGPSGYSSLTALESSRGGENEAPQLYVLYEKGLSRYT
ESISMAKVSIYGTL

hide sequence

RefSeq Acc Id:

ENSCLAP00000012303 ⟸ ENSCLAT00000012446

Protein Domains

Sialidase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008497	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012446	ENTREZGENE
	ENSCLAT00000012446.1	UniProtKB/TrEMBL
Gene3D-CATH	2.120.10.10	UniProtKB/TrEMBL
InterPro	Sialidase	UniProtKB/TrEMBL
	Sialidase_fam	UniProtKB/TrEMBL
	Sialidase_sf	UniProtKB/TrEMBL
NCBI Gene	Neu1	ENTREZGENE
PANTHER	PTHR10628	UniProtKB/TrEMBL
	SIALIDASE-1	UniProtKB/TrEMBL
Pfam	BNR_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50939	UniProtKB/TrEMBL
UniProt	A0A8C2VGE4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-09	Neu1	neuraminidase 1		sialidase 1 (lysosomal sialidase)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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