Mt1a (metallothionein 1A) - Rat Genome Database

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Gene: Mt1a (metallothionein 1A) Rattus norvegicus
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Symbol: Mt1a (Ensembl: AC128848.1)
Name: metallothionein 1A (Ensembl:metallothionein 1)
RGD ID: 3117
Description: Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to zinc ion. Predicted to be located in cytosol and lysosome. Predicted to be active in cytoplasm and nucleus. Biomarker of kidney failure; median neuropathy; and transient cerebral ischemia. Orthologous to several human genes including MT1F (metallothionein 1F); INTERACTS WITH 1,2,4-trimethylbenzene; 1,2-dimethylhydrazine; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Metallothionein; metallothionein 1; Metallothionein 1 A; metallothionein-1; metallothionein-I; Mt; MT-1; MT-I; Mt1
RGD Orthologs
Human
Mouse
Pig
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Mt1-ps1   Mt1-ps2   Mt1-ps3  
Allele / Splice: Mt1-ps1 ; Mt1-ps2
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,831,959 - 10,832,975 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX37,806,895 - 37,807,080 (-)EnsemblGRCr8
GRCr8 Ensembl1779,695,809 - 79,696,200 (+)EnsemblGRCr8
GRCr8 Ensembl1910,831,959 - 10,832,976 (-)EnsemblGRCr8
mRatBN7.21910,826,032 - 10,827,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,826,032 - 10,827,049 (-)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX33,998,206 - 33,998,391 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1774,786,654 - 74,787,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,794,185 - 10,795,201 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,561,039 - 11,562,055 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,848,030 - 10,849,046 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,301,991 - 11,303,007 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,793,336 - 78,793,724 (+)Ensemblrn6Rnor6.0
Rnor_5.01911,277,133 - 11,278,149 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,261,631 - 11,262,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,711,989 - 10,713,005 (-)NCBICelera
RGSC_v3.11911,266,456 - 11,267,404 (-)NCBI
RH 3.4 Map19128.1RGD
Cytogenetic Map19p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(R)-lipoic acid  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-4,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-tert-butyl-4-hydroxyanisole  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-aminonicotinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
[6]-Shogaol  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
acetohydrazide  (ISO)
acetylacetonate  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arecoline  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
Azaspiracid  (ISO)
Azoxymethane  (ISO)
bacitracin  (EXP)
barium chloride  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoic acid  (ISO)
benzyl cinnamate  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
Calcimycin  (EXP)
calmidazolium  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carrageenan  (ISO)
cefaloridine  (EXP)
cerium trichloride  (ISO)
chloroethene  (ISO)
chlorogenic acid  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
cholesterol  (ISO)
cholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
citric acid  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
corticosterone  (EXP)
cortisol  (EXP)
coumarin  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP)
cycloheximide  (ISO)
cytarabine  (ISO)
D-gluconic acid  (ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dicoumarol  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dopamine  (ISO)
doramapimod  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylenediaminetetraacetic acid  (ISO)
ethylmercuric chloride  (ISO)
etomoxir  (EXP)
EUK-134  (EXP)
fentin chloride  (EXP)
ferroheme b  (ISO)
flumequine  (ISO)
folic acid  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycerol  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
graphene oxide  (ISO)
griseofulvin  (ISO)
heme b  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP)
homocysteine  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxycitronellal  (ISO)
icariin  (ISO)
imidacloprid  (EXP)
imiprothrin  (EXP)
irinotecan  (EXP)
iron atom  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (EXP,ISO)
leflunomide  (EXP)
leupeptin  (ISO)
linsidomine  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (EXP,ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
manganese(II) sulfate  (EXP)
melatonin  (EXP)
menadione  (ISO)
Mercuric oxide  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesoporphyrin IX  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (EXP,ISO)
metyrapone  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP,ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP)
orotic acid  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentetic acid  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phalloidin  (ISO)
phenacetin  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylhydrazine  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
poly(vinylpyrrolidone)  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium dichromate  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
Ptaquiloside  (ISO)
pyrithione  (ISO)
quartz  (ISO)
quercetin  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
Ro 31-8220  (ISO)
rotenone  (EXP,ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
salicylic acid  (ISO)
SB 203580  (ISO)
selenium atom  (EXP)
serotonin  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (ISO)
sodium propionate  (EXP)
Soman  (EXP)
spironolactone  (EXP)
staurosporine  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP)
succimer  (EXP,ISO)
sulforaphane  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiosalicylic acid  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
topotecan  (EXP)
triadimefon  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trifluoperazine  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (EXP)
vancomycin  (EXP,ISO)
vanillin  (ISO)
verteporfin  (ISO)
vitamin E  (EXP,ISO)
wortmannin  (ISO)
XMU-MP-1  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISS)
cytosol  (ISO)
lysosome  (ISO)
nucleus  (IBA,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning of the rat metallothionein 1 (MT-1) mRNA sequence. Andersen RD, etal., DNA 1983;2(1):15-22.
2. Early effects of surgery on zinc and metallothionein levels in female rats. Brambila E, etal., Biol Trace Elem Res. 1999 Nov;70(2):173-82.
3. Favorable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice. Caballero B, etal., J Pineal Res. 2008 Oct;45(3):302-11. doi: 10.1111/j.1600-079X.2008.00591.x. Epub 2008 Apr 13.
4. Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. Campagne MV, etal., J Neurosci. 2000 Jul 15;20(14):5200-7.
5. Metallothionein-1 messenger RNA transcription in steroid-secreting cells of the rat ovary during the periovulatory period. Espey LL, etal., Biol Reprod 2003 May;68(5):1895-902.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Systemic imbalance of essential metals and cardiac gene expression in rats following acute pulmonary zinc exposure. Gilmour PS, etal., J Toxicol Environ Health A. 2006 Nov;69(22):2011-32.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat. Grunblatt E, etal., J Alzheimers Dis. 2006 Aug;9(3):261-71.
10. Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice. Ignacio S, etal., Ann N Y Acad Sci. 2005 Aug;1053:121-36.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effect in vivo. Lanza C, etal., J Neurochem. 2009 Sep;110(5):1674-84. Epub 2009 Jul 8.
13. Expression of antioxidant molecules after peripheral nerve injury and regeneration. Lanza C, etal., J Neurosci Res. 2012 Apr;90(4):842-8. doi: 10.1002/jnr.22778. Epub 2012 Jan 18.
14. Brain genomics of intracerebral hemorrhage. Lu A, etal., J Cereb Blood Flow Metab. 2006 Feb;26(2):230-52.
15. Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. Manso Y, etal., Cell Mol Life Sci. 2012 Nov;69(21):3665-81. doi: 10.1007/s00018-012-1045-y. Epub 2012 Jul 6.
16. Cloning of metallothionein cDNA from neonatal rat liver. Mercer JF and Hudson P, Biosci Rep 1982 Oct;2(10):761-8.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Metallothionein isoforms (I+II and III) and interleukin-6 in the hippocampus of old rats: may their concomitant increments lead to neurodegeneration? Mocchegiani E, etal., Brain Res Bull 2004 Mar 15;63(2):133-42.
19. Effect of quercetin on metallothionein, nitric oxide synthases and cyclooxygenase-2 expression on experimental chronic cadmium nephrotoxicity in rats. Morales AI, etal., Toxicol Appl Pharmacol. 2006 Jan 1;210(1-2):128-35. Epub 2005 Oct 14.
20. Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection. Mukhopadhyay D, etal., Syst Biol Reprod Med. 2009 Dec;55(5-6):188-92. doi: 10.3109/19396360903114429.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure. Piedboeuf B, etal., Am J Respir Cell Mol Biol. 1994 Feb;10(2):123-32.
23. GOA pipeline RGD automated data pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Comprehensive gene review and curation RGD comprehensive gene curation
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats. Sárközy M, etal., Cardiovasc Diabetol. 2015 Jun 28;14:85. doi: 10.1186/s12933-015-0248-6.
28. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
29. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Tsuruma K, etal., Invest Ophthalmol Vis Sci. 2012 Nov 29;53(12):7896-903. doi: 10.1167/iovs.12-10165.
Additional References at PubMed
PMID:1942051   PMID:2959527   PMID:3023830   PMID:3184190   PMID:3653102   PMID:3945804   PMID:6470004   PMID:6853483   PMID:8640230   PMID:9358851   PMID:11168427   PMID:11792622  
PMID:12130647   PMID:12458661   PMID:12692462   PMID:14690533   PMID:15033980   PMID:15062872   PMID:15126248   PMID:15475485   PMID:15489334   PMID:15623840   PMID:15650329   PMID:15884113  
PMID:16827180   PMID:17008879   PMID:17896077   PMID:17974098   PMID:18350280   PMID:18605988   PMID:19103603   PMID:19148152   PMID:19490425   PMID:19767886   PMID:20109269   PMID:20945050  
PMID:21154237   PMID:21264950   PMID:21359432   PMID:21409224   PMID:22100509   PMID:22571646   PMID:22703381   PMID:23291980   PMID:23726995   PMID:24489578   PMID:24807795   PMID:25947372  
PMID:26884304   PMID:27147436   PMID:27173051   PMID:27523482   PMID:27939232   PMID:28377323   PMID:28760087   PMID:32495853  


Genomics

Comparative Map Data
Mt1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,831,959 - 10,832,975 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX37,806,895 - 37,807,080 (-)EnsemblGRCr8
GRCr8 Ensembl1779,695,809 - 79,696,200 (+)EnsemblGRCr8
GRCr8 Ensembl1910,831,959 - 10,832,976 (-)EnsemblGRCr8
mRatBN7.21910,826,032 - 10,827,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,826,032 - 10,827,049 (-)EnsemblmRatBN7.2
mRatBN7.2 EnsemblX33,998,206 - 33,998,391 (-)EnsemblmRatBN7.2
mRatBN7.2 Ensembl1774,786,654 - 74,787,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,794,185 - 10,795,201 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,561,039 - 11,562,055 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,848,030 - 10,849,046 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,301,991 - 11,303,007 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1778,793,336 - 78,793,724 (+)Ensemblrn6Rnor6.0
Rnor_5.01911,277,133 - 11,278,149 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,261,631 - 11,262,647 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,711,989 - 10,713,005 (-)NCBICelera
RGSC_v3.11911,266,456 - 11,267,404 (-)NCBI
RH 3.4 Map19128.1RGD
Cytogenetic Map19p12NCBI
MT1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,638,666 - 56,640,087 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,638,202 - 56,640,087 (+)Ensemblhg38GRCh38
GRCh371656,672,578 - 56,673,999 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,230,079 - 55,231,500 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341655,230,081 - 55,231,498NCBI
Celera1641,170,031 - 41,171,454 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,542,032 - 42,543,455 (+)NCBIHuRef
CHM1_11658,079,506 - 58,080,929 (+)NCBICHM1_1
T2T-CHM13v2.01662,433,646 - 62,435,069 (+)NCBIT2T-CHM13v2.0
Mt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,905,214 - 94,906,955 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,905,710 - 94,906,955 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38894,178,883 - 94,180,327 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,179,082 - 94,180,327 (+)Ensemblmm10GRCm38
MGSCv37896,702,989 - 96,704,227 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36897,068,356 - 97,069,453 (+)NCBIMGSCv36mm8
Celera898,511,203 - 98,512,441 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.34NCBI
MT1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,672,001 - 18,673,672 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1618,672,016 - 18,673,673 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,383,569 - 26,411,799 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Mt1a
2 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
D19Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81910,833,618 - 10,833,895 (+)Marker Load Pipeline
mRatBN7.21910,827,691 - 10,827,970 (+)MAPPERmRatBN7.2
Rnor_6.01911,303,651 - 11,303,927NCBIRnor6.0
Celera1910,713,649 - 10,713,920UniSTS
Cytogenetic Map19p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_138826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF411318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ255899 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J00750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000038212   ⟹   ENSRNOP00000030623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1910,831,959 - 10,832,976 (-)Ensembl
mRatBN7.2 Ensembl1910,826,032 - 10,827,049 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000057898   ⟹   ENSRNOP00000054706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1779,695,809 - 79,696,200 (+)Ensembl
mRatBN7.2 Ensembl1774,786,654 - 74,787,135 (+)Ensembl
Rnor_6.0 Ensembl1778,793,336 - 78,793,724 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117036   ⟹   ENSRNOP00000088494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX37,806,895 - 37,807,080 (-)Ensembl
mRatBN7.2 EnsemblX33,998,206 - 33,998,391 (-)Ensembl
RefSeq Acc Id: NM_138826   ⟹   NP_620181
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,831,959 - 10,832,975 (-)NCBI
mRatBN7.21910,826,032 - 10,827,048 (-)NCBI
Rnor_6.01911,301,991 - 11,303,007 (-)NCBI
Rnor_5.01911,277,133 - 11,278,149 (-)NCBI
RGSC_v3.41911,261,631 - 11,262,647 (-)RGD
Celera1910,711,989 - 10,713,005 (-)RGD
Sequence:
RefSeq Acc Id: NP_620181   ⟸   NM_138826
- UniProtKB: P02803 (UniProtKB/Swiss-Prot),   Q53Z83 (UniProtKB/TrEMBL),   A0A8I6A7Y9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054706   ⟸   ENSRNOT00000057898
Ensembl Acc Id: ENSRNOP00000030623   ⟸   ENSRNOT00000038212
Ensembl Acc Id: ENSRNOP00000088494   ⟸   ENSRNOT00000117036

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02803-F1-model_v2 AlphaFold P02803 1-61 view protein structure
AF-A0A0H2UHT7-F1-model_v2 AlphaFold A0A0H2UHT7 1-115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700957
Promoter ID:EPDNEW_R11473
Type:multiple initiation site
Name:AC128848_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,303,008 - 11,303,068EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3117 AgrOrtholog
BioCyc Gene G2FUF-6477 BioCyc
Ensembl Genes ENSRNOG00000025764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000038047 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00000065877 Ensembl
Ensembl Transcript ENSRNOT00000038212 ENTREZGENE
  ENSRNOT00000038212.6 UniProtKB/Swiss-Prot
  ENSRNOT00000057898.4 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6891030 IMAGE-MGC_LOAD
InterPro Metalthion_dom_sf UniProtKB/Swiss-Prot
  Metalthion_dom_sf_vert UniProtKB/Swiss-Prot
  Metalthion_vert UniProtKB/Swiss-Prot
  Metalthion_vert_metal_BS UniProtKB/Swiss-Prot
KEGG Report rno:24567 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72674 IMAGE-MGC_LOAD
NCBI Gene 24567 ENTREZGENE
PANTHER METALLOTHIONEIN-1F UniProtKB/Swiss-Prot
  PTHR23299 UniProtKB/Swiss-Prot
Pfam Metallothio UniProtKB/Swiss-Prot
PhenoGen Mt1a PhenoGen
PRINTS MTVERTEBRATE UniProtKB/Swiss-Prot
PROSITE METALLOTHIONEIN_VRT UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000025764 RatGTEx
  ENSRNOG00000038047 RatGTEx
  ENSRNOG00000065877 RatGTEx
Superfamily-SCOP SSF57868 UniProtKB/Swiss-Prot
TIGR TC216658
  TC228990
UniProt A0A0H2UHT7_RAT UniProtKB/TrEMBL
  A0A8I6A7Y9 ENTREZGENE, UniProtKB/TrEMBL
  MT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q53Z83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-05-22 Mt1a  metallothionein 1A  Mt1  metallothionein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-02-03 Mt1  metallothionein 1  Mt1a  metallothionein 1a  Name and Symbol changed 629549 APPROVED
2005-11-16   metallothionein 1a  Mt1a  Metallothionein  Name updated 1299863 APPROVED
2002-06-10 Mt1a  Metallothionein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the vicinity of steroid-secreting areas of the ovary 633227
gene_regulation mRNA highly induced by 24 h after hCG treatment 633227