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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3117 Species: Rattus norvegicus RGD Object: Gene Symbol: Mt1a Name: metallothionein 1a

Acc ID: CHEBI:32509 Term: pirinixic acid Definition: An aryl sulfide that has formula C14H14ClN3O2S. CasRN: 50892-23-4 Chemical ID: MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:10922	6480464	CTD	pirinixic acid affects the expression of MT1 mRNA	PMID:11798191
multiple interactions	ISO	RGD:10922	6480464	CTD	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MT1 mRNA	PMID:19710929
decreases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in decreased expression of MT1 mRNA	PMID:20813756 PMID:16221962 PMID:17321000
multiple interactions	ISO	RGD:10922	6480464	CTD	PPARA protein affects the reaction [pirinixic acid results in decreased expression of MT1 mRNA]	PMID:17321000
increases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in increased expression of MT1 mRNA	PMID:17426115 PMID:18301758 PMID:18445702
decreases expression	EXP		6480464	CTD	pirinixic acid results in decreased expression of MT1A mRNA	PMID:19162173 PMID:15890375
decreases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in decreased expression of MT1 mRNA	PMID:17321000 PMID:20813756 PMID:16221962
increases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in increased expression of MT1 mRNA	PMID:18301758 PMID:18445702 PMID:17426115
decreases expression	EXP		6480464	CTD	pirinixic acid results in decreased expression of MT1A mRNA	PMID:15890375 PMID:19162173
decreases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in decreased expression of MT1 mRNA	PMID:16221962 PMID:17321000 PMID:20813756
increases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in increased expression of MT1 mRNA	PMID:17426115 PMID:18445702 PMID:18301758
increases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in increased expression of MT1 mRNA	PMID:18301758 PMID:17426115 PMID:18445702
decreases expression	ISO	RGD:10922	6480464	CTD	pirinixic acid results in decreased expression of MT1 mRNA	PMID:20813756 PMID:17321000 PMID:16221962
decreases expression	EXP		6480464	CTD	pirinixic acid results in decreased expression of MT1A mRNA	PMID:15890375 PMID:19162173 PMID:22484513