Mitf (melanocyte inducing transcription factor) - Rat Genome Database

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Gene: Mitf (melanocyte inducing transcription factor) Rattus norvegicus
Analyze
Symbol: Mitf
Name: melanocyte inducing transcription factor
RGD ID: 3092
Description: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein dimerization activity. Involved in several processes, including cellular response to zinc ion starvation; osteoclast differentiation; and response to ethanol. Predicted to be located in lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Tietz syndrome; Tietze's syndrome; Waardenburg syndrome; Waardenburg syndrome type 2A; and familial melanoma. Orthologous to human MITF (melanocyte inducing transcription factor); PARTICIPATES IN interleukin-6 signaling pathway; melanoma pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: melanogenesis associated transcription factor; microphthalmia-associated transcription factor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,965,676 - 132,177,790 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4131,965,714 - 132,177,790 (+)EnsemblGRCr8
mRatBN7.24130,409,020 - 130,621,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4130,409,217 - 130,621,145 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4135,833,861 - 136,047,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04131,614,906 - 131,828,127 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04130,232,868 - 130,446,103 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04130,172,484 - 130,425,496 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4130,172,727 - 130,425,532 (+)Ensemblrn6Rnor6.0
Rnor_5.04194,667,943 - 194,921,498 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44132,534,187 - 132,745,669 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4119,282,401 - 119,497,938 (+)NCBICelera
RGSC_v3.14132,971,000 - 132,989,691 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
afzelin  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chaetocin  (ISO)
chlorpromazine  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
DDE  (ISO)
DDT  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
emodin  (ISO)
entinostat  (ISO)
fenofibrate  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
lawsone  (ISO)
lead diacetate  (ISO)
lithium chloride  (ISO)
loliolide  (ISO)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylseleninic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-phenylthiourea  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nonanedioic acid  (ISO)
okadaic acid  (ISO)
oxidopamine  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
permethrin  (EXP)
phenylmercury acetate  (ISO)
phytol  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
Ptaquiloside  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
stilbenoid  (ISO)
Sweroside  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO,ISS)
lysosomal membrane  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
4. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
5. MITF interacts with the SWI/SNF subunit, BRG1, to promote GATA4 expression in cardiac hypertrophy. Mehta G, etal., J Mol Cell Cardiol. 2015 Nov;88:101-10. doi: 10.1016/j.yjmcc.2015.09.010. Epub 2015 Sep 24.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Microphthalmia-associated transcription factor and tyrosinase as markers of melanoma cells in blood of patients with melanoma. Samija I, etal., Croat Med J. 2004 Apr;45(2):142-8.
16. Tietz syndrome (hypopigmentation/deafness) caused by mutation of MITF. Smith SD, etal., J Med Genet. 2000 Jun;37(6):446-8.
17. The mutational spectrum in Waardenburg syndrome. Tassabehji M, etal., Hum Mol Genet. 1995 Nov;4(11):2131-7.
18. Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. Weilbaecher KN, etal., J Exp Med 1998 Mar 2;187(5):775-85.
19. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Yannay-Cohen N, etal., Mol Cell. 2009 Jun 12;34(5):603-11. doi: 10.1016/j.molcel.2009.05.019.
Additional References at PubMed
PMID:2379821   PMID:8995290   PMID:9199364   PMID:9647758   PMID:11930005   PMID:12086670   PMID:12204775   PMID:12235125   PMID:14575687   PMID:14737107   PMID:15304486   PMID:15576400  
PMID:15716956   PMID:15729346   PMID:16411896   PMID:17442941   PMID:19188590   PMID:19201870   PMID:20530484   PMID:21209915   PMID:22234890   PMID:22523078   PMID:23207919   PMID:23980096  
PMID:24769727   PMID:27889061  


Genomics

Comparative Map Data
Mitf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84131,965,676 - 132,177,790 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4131,965,714 - 132,177,790 (+)EnsemblGRCr8
mRatBN7.24130,409,020 - 130,621,145 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4130,409,217 - 130,621,145 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4135,833,861 - 136,047,084 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04131,614,906 - 131,828,127 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04130,232,868 - 130,446,103 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04130,172,484 - 130,425,496 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4130,172,727 - 130,425,532 (+)Ensemblrn6Rnor6.0
Rnor_5.04194,667,943 - 194,921,498 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44132,534,187 - 132,745,669 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4119,282,401 - 119,497,938 (+)NCBICelera
RGSC_v3.14132,971,000 - 132,989,691 (+)NCBI
Cytogenetic Map4q34NCBI
MITF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38369,739,464 - 69,968,332 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl369,738,536 - 69,968,336 (+)Ensemblhg38GRCh38
GRCh37369,788,615 - 70,017,483 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36369,871,323 - 70,100,177 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34370,010,945 - 70,100,176NCBI
Celera369,715,972 - 69,944,858 (+)NCBICelera
Cytogenetic Map3p13NCBI
HuRef369,788,411 - 70,016,737 (+)NCBIHuRef
CHM1_1369,739,823 - 69,968,702 (+)NCBICHM1_1
T2T-CHM13v2.0369,776,362 - 70,005,284 (+)NCBIT2T-CHM13v2.0
Mitf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39697,783,966 - 97,998,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl697,784,013 - 97,998,310 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38697,807,002 - 98,021,360 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl697,807,052 - 98,021,349 (+)Ensemblmm10GRCm38
MGSCv37697,757,052 - 97,971,352 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36697,957,255 - 97,984,170 (+)NCBIMGSCv36mm8
Celera699,672,554 - 99,880,690 (+)NCBICelera
Cytogenetic Map6D3NCBI
cM Map645.05NCBI
Mitf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542117,947,277 - 18,154,090 (-)Ensembl
ChiLan1.0NW_00495542117,948,117 - 18,157,379 (-)NCBIChiLan1.0ChiLan1.0
MITF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2269,693,359 - 69,921,387 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1369,698,199 - 69,926,175 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0369,674,064 - 69,902,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1371,037,671 - 71,265,445 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl371,037,665 - 71,265,445 (+)EnsemblpanPan2panpan1.1
MITF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12021,772,147 - 21,873,545 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2021,612,927 - 21,870,578 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2021,826,585 - 21,857,697 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02021,883,312 - 22,101,930 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2021,886,050 - 22,101,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12021,572,611 - 21,603,715 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02021,921,161 - 21,952,266 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02021,991,588 - 22,022,704 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mitf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049421,682,409 - 1,858,295 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366031,682,513 - 1,858,173 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366031,682,411 - 1,858,295 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MITF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1351,178,203 - 51,422,093 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11351,177,356 - 51,422,096 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21356,593,519 - 56,594,255 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MITF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12230,747,747 - 30,971,951 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2230,748,440 - 30,972,168 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041135,815,967 - 136,039,769 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mitf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247734,346,007 - 4,562,969 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247734,346,072 - 4,561,218 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mitf
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1649,041,975 - 49,244,249 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mitf
957 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir182rno-miR-182Mirtarbaseexternal_infoWestern blotFunctional MTI19167416
Mir96rno-miR-96-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416

Predicted Target Of
Summary Value
Count of predictions:204
Count of miRNA genes:140
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000051121
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4117737142152833657Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4121020385148834277Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat

Markers in Region
D4Rat116  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84132,049,630 - 132,049,868 (+)Marker Load Pipeline
mRatBN7.24130,492,986 - 130,493,224 (+)MAPPERmRatBN7.2
Rnor_6.04130,297,677 - 130,297,914NCBIRnor6.0
Rnor_5.04194,793,679 - 194,793,916UniSTSRnor5.0
RGSC_v3.44132,619,018 - 132,619,344RGDRGSC3.4
RGSC_v3.44132,619,103 - 132,619,340UniSTSRGSC3.4
Celera4119,365,717 - 119,365,954UniSTS
RGSC_v3.14132,863,944 - 132,864,181RGD
RH 3.4 Map4805.7RGD
RH 3.4 Map4805.7UniSTS
RH 2.0 Map4867.2RGD
SHRSP x BN Map456.66RGD
FHH x ACI Map477.9799RGD
Cytogenetic Map4q34-q41UniSTS
D4Got97  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04194,882,087 - 194,882,230NCBIRnor5.0
Rnor_5.04194,882,086 - 194,882,230NCBIRnor5.0
Rnor_5.04194,882,127 - 194,882,230NCBIRnor5.0
Rnor_5.04194,882,126 - 194,882,230NCBIRnor5.0
RGSC_v3.44132,709,021 - 132,709,164RGDRGSC3.4
RGSC_v3.44132,709,022 - 132,709,164UniSTSRGSC3.4
RGSC_v3.44132,709,062 - 132,709,164UniSTSRGSC3.4
RGSC_v3.44132,709,061 - 132,709,164RGDRGSC3.4
Celera4119,458,562 - 119,458,656UniSTS
RGSC_v3.14132,953,863 - 132,954,005RGD
RH 3.4 Map4795.01RGD
RH 3.4 Map4795.01UniSTS
Cytogenetic Map4q34-q41UniSTS
Mitf  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,538,293 - 130,538,433 (+)MAPPERmRatBN7.2
Rnor_6.04130,342,654 - 130,342,793NCBIRnor6.0
Rnor_5.04194,838,656 - 194,838,795UniSTSRnor5.0
RGSC_v3.44132,665,646 - 132,665,785UniSTSRGSC3.4
Celera4119,410,997 - 119,411,136UniSTS
Cytogenetic Map4q34-q41UniSTS
BE097660  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,453,838 - 130,453,996 (+)MAPPERmRatBN7.2
Rnor_6.04130,217,446 - 130,217,603NCBIRnor6.0
Rnor_5.04194,712,765 - 194,712,922UniSTSRnor5.0
RGSC_v3.44132,579,691 - 132,579,848UniSTSRGSC3.4
Celera4119,326,747 - 119,326,904UniSTS
RH 3.4 Map4805.3UniSTS
Cytogenetic Map4q34-q41UniSTS
AU048069  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,561,057 - 130,561,191 (+)MAPPERmRatBN7.2
Rnor_6.04130,365,409 - 130,365,542NCBIRnor6.0
Rnor_5.04194,861,411 - 194,861,544UniSTSRnor5.0
RGSC_v3.44132,688,401 - 132,688,534UniSTSRGSC3.4
Celera4119,433,721 - 119,433,854UniSTS
Cytogenetic Map4q34-q41UniSTS
RH139322  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,489,447 - 130,489,587 (+)MAPPERmRatBN7.2
Rnor_6.04130,294,138 - 130,294,277NCBIRnor6.0
Rnor_5.04194,790,140 - 194,790,279UniSTSRnor5.0
RGSC_v3.44132,615,564 - 132,615,703UniSTSRGSC3.4
Celera4119,362,176 - 119,362,315UniSTS
RH 3.4 Map1850.2UniSTS
Cytogenetic Map4q34-q41UniSTS
UniSTS:496619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24130,586,060 - 130,587,341 (+)MAPPERmRatBN7.2
Rnor_6.04130,390,412 - 130,391,692NCBIRnor6.0
Rnor_5.04194,886,414 - 194,887,694UniSTSRnor5.0
RGSC_v3.44132,713,348 - 132,714,628UniSTSRGSC3.4
Celera4119,462,844 - 119,464,124UniSTS
Cytogenetic Map4q34-q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051121   ⟹   ENSRNOP00000044350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,965,714 - 132,177,790 (+)Ensembl
mRatBN7.2 Ensembl4130,409,217 - 130,621,145 (+)Ensembl
Rnor_6.0 Ensembl4130,172,727 - 130,422,735 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083127   ⟹   ENSRNOP00000073565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4132,084,348 - 132,177,790 (+)Ensembl
mRatBN7.2 Ensembl4130,527,867 - 130,621,145 (+)Ensembl
Rnor_6.0 Ensembl4130,332,076 - 130,425,532 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094478   ⟹   ENSRNOP00000084182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4132,141,297 - 132,177,790 (+)Ensembl
mRatBN7.2 Ensembl4130,584,902 - 130,621,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128180   ⟹   ENSRNOP00000100348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,965,731 - 132,175,027 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000171312   ⟹   ENSRNOP00000100525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4131,965,740 - 132,177,790 (+)Ensembl
RefSeq Acc Id: NM_001191089   ⟹   NP_001178018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,740 - 132,177,790 (+)NCBI
mRatBN7.24130,409,085 - 130,621,145 (+)NCBI
Rnor_6.04130,172,856 - 130,425,496 (+)NCBI
Rnor_5.04194,667,943 - 194,921,498 (+)NCBI
Celera4119,282,401 - 119,497,938 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001398550   ⟹   NP_001385479
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,740 - 132,177,790 (+)NCBI
mRatBN7.24130,409,085 - 130,621,145 (+)NCBI
RefSeq Acc Id: XM_017592478   ⟹   XP_017447967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84132,083,188 - 132,177,790 (+)NCBI
mRatBN7.24130,526,535 - 130,617,941 (+)NCBI
Rnor_6.04130,332,222 - 130,425,496 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107083   ⟹   XP_038963011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,677 - 132,177,790 (+)NCBI
mRatBN7.24130,409,020 - 130,617,941 (+)NCBI
RefSeq Acc Id: XM_039107085   ⟹   XP_038963013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,676 - 132,177,790 (+)NCBI
mRatBN7.24130,409,217 - 130,617,941 (+)NCBI
RefSeq Acc Id: XM_039107087   ⟹   XP_038963015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,984,382 - 132,177,790 (+)NCBI
mRatBN7.24130,427,689 - 130,617,941 (+)NCBI
RefSeq Acc Id: XM_039107089   ⟹   XP_038963017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,678 - 132,177,790 (+)NCBI
mRatBN7.24130,409,024 - 130,621,145 (+)NCBI
RefSeq Acc Id: XM_063285573   ⟹   XP_063141643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84132,083,187 - 132,177,790 (+)NCBI
RefSeq Acc Id: XM_063285574   ⟹   XP_063141644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,984,326 - 132,177,790 (+)NCBI
RefSeq Acc Id: XM_063285575   ⟹   XP_063141645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84131,965,678 - 132,177,790 (+)NCBI
RefSeq Acc Id: XM_063285576   ⟹   XP_063141646
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84132,142,851 - 132,177,790 (+)NCBI
RefSeq Acc Id: NP_001178018   ⟸   NM_001191089
- Peptide Label: isoform 1
- UniProtKB: F1LQV3 (UniProtKB/Swiss-Prot),   O88368 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017447967   ⟸   XM_017592478
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5U8 (UniProtKB/TrEMBL),   A0A8I5ZYC4 (UniProtKB/TrEMBL),   A6IBG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044350   ⟸   ENSRNOT00000051121
Ensembl Acc Id: ENSRNOP00000073565   ⟸   ENSRNOT00000083127
RefSeq Acc Id: XP_038963011   ⟸   XM_039107083
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038963017   ⟸   XM_039107089
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038963013   ⟸   XM_039107085
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038963015   ⟸   XM_039107087
- Peptide Label: isoform X5
- UniProtKB: A0A8L2ULS4 (UniProtKB/TrEMBL),   A0A8I5ZYC4 (UniProtKB/TrEMBL),   A6IBG2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084182   ⟸   ENSRNOT00000094478
RefSeq Acc Id: NP_001385479   ⟸   NM_001398550
- Peptide Label: isoform 2
RefSeq Acc Id: XP_063141645   ⟸   XM_063285575
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063141644   ⟸   XM_063285574
- Peptide Label: isoform X5
- UniProtKB: A0A8I5ZYC4 (UniProtKB/TrEMBL),   A6IBG2 (UniProtKB/TrEMBL),   A0A8L2ULS4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141643   ⟸   XM_063285573
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141646   ⟸   XM_063285576
- Peptide Label: isoform X8
- UniProtKB: A0A8I5ZYC4 (UniProtKB/TrEMBL),   A6IBG2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100525   ⟸   ENSRNOT00000171312
Ensembl Acc Id: ENSRNOP00000100348   ⟸   ENSRNOT00000128180
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88368-F1-model_v2 AlphaFold O88368 1-526 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693271
Promoter ID:EPDNEW_R3796
Type:single initiation site
Name:Mitf_1
Description:melanogenesis associated transcription factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04130,172,727 - 130,172,787EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3092 AgrOrtholog
BioCyc Gene G2FUF-43595 BioCyc
Ensembl Genes ENSRNOG00000008658 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000051121 ENTREZGENE
  ENSRNOT00000083127 ENTREZGENE
  ENSRNOT00000094478 ENTREZGENE
  ENSRNOT00000128180 ENTREZGENE
  ENSRNOT00000171312 ENTREZGENE
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot
InterPro bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot
  MiT/TFE_C UniProtKB/Swiss-Prot
  MiT/TFE_N UniProtKB/Swiss-Prot
KEGG Report rno:25094 UniProtKB/Swiss-Prot
NCBI Gene 25094 ENTREZGENE
PANTHER MIP04163P UniProtKB/Swiss-Prot
  PTHR45776:SF4 UniProtKB/Swiss-Prot
Pfam DUF3371 UniProtKB/Swiss-Prot
  HLH UniProtKB/Swiss-Prot
  MITF_TFEB_C_3_N UniProtKB/Swiss-Prot
PhenoGen Mitf PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008658 RatGTEx
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot
UniProt A0A0G2K5U8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYC4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2ULS4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L6S3_RAT UniProtKB/TrEMBL
  A0ABK0LB89_RAT UniProtKB/TrEMBL
  A6IBG2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQV3 ENTREZGENE
  MITF_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LQV3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-10-16 Mitf  melanocyte inducing transcription factor  Mitf  melanogenesis associated transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-02 Mitf  melanogenesis associated transcription factor  Mitf  microphthalmia-associated transcription factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Mitf  Microphthalmia-associated transcription factor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease deletion in gene may be associated with osteopetrosis 729082
gene_process may be involved in pigmentation, mast cells, and bone development 729082