Lck Rat Gene (lymphocyte-specific protein tyrosine kinase)

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Keyword

Gene:
Lck ( Rattus norvegicus )
lymphocyte-specific protein tyrosine kinase
Description: member of the Src family of protein tyrosine kinases; may be involved in activation-induced T cell apoptosis
Synonyms: lymphocyte protein tyrosine kinase (predicted); Lck_mapped; Lcktkr; lck_mapped; lymphocyte protein tyrosine kinase (mapped); lymphocyte protein tyrosine kinase; Lck1; Lck_predicted;  (details...)
ArrayIDs: 5779047; 6730966; 5676211; rc_AA800684_at; 5645319; GE16791; 6079611; 6727269; 6448665; 6330793; A_42_P808559; 6238728; 1383320_at; 6005233; A_44_P548790; 5628745; 6674680; A_44_P511304; 6150551; 5902540; 6367024;  (details...)
Gene Type: protein-coding

Additional Data

Markers: D5Wox15

Homologs
Homo sapiens: LCK     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Lck     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Lck Rat Celera Assembly 5 140363583 - 140391817
RGSC genome assembly v3.4 5 148707496 - 148735990
Cytogenetic 5 q36
Mus musculus Lck Mouse genome assembly build 36.1 4 129225602 - 129235616
Cytogenetic 4 4 D2.2
Homo sapiens LCK human genome assembly 1 32386024 - 32420854
Human genome assembly build 36.2 1 32489520 - 32524348
Cytogenetic 1 p34.3

View comparative maps:      NCBI MapViewer

Genome
View:

Other Map Data:
Associated SSLP Map Locations
No mapping information currently available in RGD for D5Wox15

Annotation
Molecular Function

Gene Ontology

SH2 domain binding,  protein kinase binding,  nucleotide binding ... (details...)
Biological Process

Gene Ontology

B cell receptor signaling pathway,  cellular zinc ion homeostasis,  peptidyl-tyrosine phosphorylation ... (details...)
Cellular Component

Gene Ontology

membrane raft,  cytoplasm,  plasma membrane ... (details...)
Disease

Ontology

HIV Infections,  Conjunctivitis, Allergic (details...)

External Links
Databases
DATABASE ID SOURCE
SMART: SH3 IPI
SMART: TyrKc IPI
SMART: SH2 IPI
PROSITE: SH3 IPI
PROSITE: SH2 IPI
PROSITE: PROTEIN_KINASE_TYR IPI
PROSITE: PROTEIN_KINASE_DOM IPI
PROSITE: PROTEIN_KINASE_ATP IPI
UNIPARC: UPI00001CF81E IPI
KEGG Report: rno:313050 ENTREZGENE
HomoloGene Group ID: 3911 ENTREZGENE
Pfam: SH2 IPI
Pfam: Pkinase_Tyr IPI
Pfam: SH3_1 IPI
KEGG Pathway: 04650 ENTREZGENE
KEGG Pathway: 04660 ENTREZGENE
KEGG Pathway: 05340 ENTREZGENE
InterPro: Kinase-like_dom. IPI
InterPro: Tyr_prot_kinase_AS. IPI
InterPro: Tyr_prot_kinase_cat_dom. IPI
InterPro: Tyr_prot_kinase_subgr_cat_dom. IPI
InterPro: Tyr_kinase_non-rcpt_Lck. IPI
InterPro: SH3_region. IPI
InterPro: SH3_domain. IPI
InterPro: SH2. IPI
InterPro: Protein_kinase_ATP_BS. IPI
InterPro: Prot_kinase_cat_dom. IPI
InterPro: Tyr_prot_kinase. IPI
Ensembl Protein: ENSRNOP00000012936 IPI
IPI: IPI00205116 IPI
Gene3D-CATH: SH2 IPI
Entrez Gene: Lck ENTREZGENE
IMAGE_CLONE: IMAGE:7381544 IMAGE-MGC_LOAD
IMAGE_CLONE: IMAGE:7384919 IMAGE-MGC_LOAD
MGC_CLONE: MGC:116394 IMAGE-MGC_LOAD
MGC_CLONE: MGC:188286 IMAGE-MGC_LOAD
Ensembl Genes: ENSRNOG00000009705 IPI
UniProt: LCK_RAT IPI
UniProt: Q4FZR6_RAT IPI
RatMap: 34142 ENTREZGENE
Superfamily-SCOP: Kinase_like IPI
Superfamily-SCOP: SH3 IPI
PANTHER: Tyr_prot_kinase IPI
PANTHER: Tyr_kinase_non-rcpt_Lck IPI
PRINTS: SH3DOMAIN. IPI
PRINTS: SH2DOMAIN. IPI
Sequences
Nucleotide: NM_001100709 Get FASTA Search GEO Profiles
Nucleotide: BC099218 Get FASTA Search GEO Profiles
Nucleotide: Z15029 Get FASTA Search GEO Profiles
Nucleotide: CH473968 Get FASTA Search GEO Profiles
Nucleotide: BC160881 Get FASTA Search GEO Profiles
Nucleotide: XM_001061773 Get FASTA Search GEO Profiles
Nucleotide: XM_001061667 Get FASTA Search GEO Profiles
Nucleotide: XM_232763 Get FASTA Search GEO Profiles
Nucleotide: XM_001062229 Get FASTA Search GEO Profiles
(View all 9 Nucleotide Accessions)
Protein: Q01621 Get FASTA
Protein: Q4FZR6 Get FASTA
Protein: AAI60881 Get FASTA
Protein: AAH99218 Get FASTA
Protein: CAA78748 Get FASTA
Protein: EDL80546 Get FASTA
Protein: NP_001094179 Get FASTA
Protein: XP_232763 Get FASTA
Protein: XP_001062229 Get FASTA
Protein: XP_001061773 Get FASTA
Protein: XP_001061667 Get FASTA
(View all 11 Protein Accessions)
Clusters
UniGene: 22791

References
Curated References
13 references in RGD related to Lck

Other References
13 other references at PubMed related to Lck

Database Information
RGD ID 2994
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

17-NOV-08: Lck lymphocyte-specific protein tyrosine kinase Lck lymphocyte protein tyrosine kinase APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863

14-MAR-07: Lck lymphocyte protein tyrosine kinase Lck_predicted lymphocyte protein tyrosine kinase (predicted) APPROVED Symbol and Name updated 1299863

05-MAR-07: Lck_mapped lymphocyte protein tyrosine kinase (mapped) Lck_retired APPROVED Data Merged 737654

19-NOV-06: Lck lymphocyte protein tyrosine kinase (mapped) PROVISIONAL Symbol and Name status set to provisional 70820

17-NOV-05: Lck_mapped lymphocyte protein tyrosine kinase (mapped) APPROVED Symbol and Name updated 1556543

10-JUN-02: Lck Lymphocyte-specific protein tyrosine kinase APPROVED Symbol and Name status set to approved 70586