Irf1 (interferon regulatory factor 1) - Rat Genome Database

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Gene: Irf1 (interferon regulatory factor 1) Rattus norvegicus
Analyze
Symbol: Irf1
Name: interferon regulatory factor 1
RGD ID: 2920
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including canonical NF-kappaB signal transduction; cellular response to cytokine stimulus; and cellular response to exogenous dsRNA. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. Used to study endometrial adenocarcinoma. Biomarker of allergic conjunctivitis; lung disease; respiratory syncytial virus infectious disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 117; lung cancer (multiple); smallpox; and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1); PARTICIPATES IN Jak-Stat signaling pathway; nuclear factor kappa B signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: IRF-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bmd4 Eau7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,417,935 - 38,424,946 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,417,148 - 38,424,947 (+)EnsemblGRCr8
mRatBN7.21037,917,155 - 37,924,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,916,670 - 37,924,166 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,609,084 - 42,616,097 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,099,164 - 42,106,177 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,602,877 - 37,609,890 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,109,530 - 39,116,532 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,109,522 - 39,116,531 (+)Ensemblrn6Rnor6.0
Rnor_5.01038,891,468 - 38,898,470 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,220,600 - 39,227,602 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,260,559 - 37,267,561 (+)NCBICelera
RGSC_v3.11039,229,846 - 39,236,848 (+)NCBI
RH 3.4 Map10405.3RGD
Cytogenetic Map10q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(-)-demecolcine  (ISO)
(R)-lipoic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-bromohexadecanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium selenide  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dacarbazine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dimethyl fumarate  (ISO)
dimethylarsinic acid  (EXP)
divanadium pentaoxide  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
glucose  (ISO)
glyphosate  (ISO)
GW 1929  (ISO)
hexachlorobenzene  (EXP)
indole-3-methanol  (EXP)
isotretinoin  (ISO)
leflunomide  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
mangiferin  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nevirapine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP)
paclitaxel  (EXP)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
puromycin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Ro 41-5253  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
SR 144528  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
Tributyltin oxide  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO,ISS)
canonical NF-kappaB signal transduction  (IMP)
CD8-positive, alpha-beta T cell differentiation  (ISO)
cellular response to exogenous dsRNA  (IEP)
cellular response to interferon-beta  (IEA,IEP,ISO)
cellular response to interleukin-1  (IDA)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to peptide hormone stimulus  (IDA)
cellular response to retinoic acid  (IEP)
cellular response to tumor necrosis factor  (IDA)
cellular response to type II interferon  (IEP)
defense response to virus  (IEA,ISO,ISS)
female pregnancy  (IEP)
immune system process  (IBA,IEA)
innate immune response  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO,ISS)
negative regulation of protein modification process  (IMP)
negative regulation of regulatory T cell differentiation  (ISO,ISS)
positive regulation of apoptotic process  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO,ISS)
positive regulation of interferon-beta production  (IEA,ISO,ISS)
positive regulation of interleukin-12 production  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,IMP,ISO,ISS)
positive regulation of type I interferon production  (ISO,ISS)
regulation of CD8-positive, alpha-beta T cell proliferation  (ISO,ISS)
regulation of cell cycle  (IEA,ISO,ISS)
regulation of cell population proliferation  (NAS)
regulation of DNA-templated transcription  (IEA,TAS)
regulation of gene expression  (ISO)
regulation of MyD88-dependent toll-like receptor signaling pathway  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
response to growth hormone  (IDA)
toll-like receptor 3 signaling pathway  (ISO)
type II interferon-mediated signaling pathway  (ISO,ISS)

Cellular Component
chromatin  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Prolactin activation of IRF-1 transcription involves changes in histone acetylation. Book McAlexander M and Yu-Lee L, FEBS Lett. 2001 Jan 12;488(1-2):91-4.
2. Anti-inflammatory roles of retinoic acid in rat brain astrocytes: Suppression of interferon-gamma-induced JAK/STAT phosphorylation. Choi WH, etal., Biochem Biophys Res Commun. 2005 Apr 1;329(1):125-31.
3. Expression of the nitric oxide synthase 2 gene is not essential for early control of Mycobacterium tuberculosis in the murine lung. Cooper AM, etal., Infect Immun. 2000 Dec;68(12):6879-82.
4. Taxol activates inducible nitric oxide synthase in rat astrocytes: the role of MAP kinases and NF-kappaB. Cvetkovic I, etal., Cell Mol Life Sci. 2004 May;61(10):1167-75.
5. Prolactin activates interferon regulatory factor-1 expression in normal lympho-hemopoietic cells. Dogusan Z, etal., Eur Cytokine Netw. 2000 Sep;11(3):435-42.
6. Type I interferons and IRF-1 play a critical role in the control of a gammaherpesvirus infection. Dutia BM, etal., Virology. 1999 Sep 1;261(2):173-9.
7. Interferon regulatory factor 1 tryptophan 11 to arginine point mutation abolishes DNA binding. Eason DD, etal., Biochim Biophys Acta. 1999 Jul 7;1446(1-2):140-4.
8. Differential expression and signaling of IFN-gamma in the conjunctiva between Lewis and Brown Norway rats. Fukushima A, etal., Microbiol Immunol. 2003;47(10):785-96.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. Guidotti LG, etal., J Virol. 2002 Mar;76(6):2617-21. doi: 10.1128/jvi.76.6.2617-2621.2002.
12. Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-gamma-mediated cytotoxic effects on oligodendroglial progenitor cells. Horiuchi M, etal., J Neuroinflammation. 2011 Jan 24;8(1):8.
13. In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium. Kelley TJ and Elmer HL, J Clin Invest. 2000 Aug;106(3):403-10.
14. Identification of differentially expressed genes after heat shock in isolated rat aorta. Kim JI, etal., Clin Exp Pharmacol Physiol. 2007 Jul;34(7):636-40.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Growth hormone stimulates interferon regulatory factor-1 gene expression in the liver. Le Stunff C and Rotwein P, Endocrinology. 1998 Mar;139(3):859-66.
17. Histone deacetylase-1 is enriched at the platelet-derived growth factor-D promoter in response to interleukin-1beta and forms a cytokine-inducible gene-silencing complex with NF-kappab p65 and interferon regulatory factor-1. Liu MY and Khachigian LM, J Biol Chem. 2009 Dec 11;284(50):35101-12. Epub 2009 Oct 20.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. Moore F, etal., J Biol Chem. 2011 Jan 14;286(2):929-41. Epub 2010 Oct 27.
20. Double-stranded RNA-induced interferon regulatory factor-1 gene expression in FRTL-5 rat thyroid cells. Mori K, etal., Mol Cell Endocrinol. 2001 Nov 26;184(1-2):77-86.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Mutation screening of interferon regulatory factor 1 gene (IRF-1) as a candidate gene for atopy/asthma. Noguchi E, etal., Clin Exp Allergy. 2000 Nov;30(11):1562-7.
23. Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. Nozawa H, etal., Int J Cancer. 1998 Aug 12;77(4):522-7.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
27. Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia. Raghavendra Rao VL, etal., J Neurochem 2002 Dec;83(5):1072-86.
28. Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis. Raghavendra Rao VL, etal., J Neurosci Res. 2003 Jan 15;71(2):208-19.
29. Genetic basis for adverse events after smallpox vaccination. Reif DM, etal., J Infect Dis. 2008 Jul 1;198(1):16-22. doi: 10.1086/588670.
30. GOA pipeline RGD automated data pipeline
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. Comprehensive gene review and curation RGD comprehensive gene curation
34. Peptide YY reverses TNF-alpha induced transcription factor binding of interferon regulatory factor-1 and p53 in pancreatic acinar cells. Rizvi IA, etal., J Surg Res. 2006 Nov;136(1):25-30. Epub 2006 Sep 15.
35. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. Sampath D, etal., J Clin Invest. 1999 May;103(9):1353-61.
36. Molecular classification of spontaneous endometrial adenocarcinomas in BDII rats. Samuelson E, etal., Endocr Relat Cancer. 2009 Mar;16(1):99-111. Epub 2008 Dec 15.
37. Altered expression of immune modulator and structural genes in neonatal unilateral ureteral obstruction. Silverstein DM, etal., Kidney Int. 2003 Jul;64(1):25-35.
38. GeneChip analysis after acute spinal cord injury in rat. Song G, etal., J Neurochem. 2001 Nov;79(4):804-15.
39. IFN-gamma promotes apoptosis of the uterus and placenta in pregnant rat and human cytotrophoblast cells. Sun QH, etal., J Interferon Cytokine Res. 2007 Jul;27(7):567-78.
40. Activation of type II alveolar epithelial cells during acute endotoxemia. Sunil VR, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L872-80.
41. [Transcription factors in spinal dorsal root ganglion in rats recurrently infected with respiratory syncytial virus]. Tan H, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Dec;34(12):1189-95.
42. Molecular mechanisms of iNOS induction by IL-1 beta and IFN-gamma in rat aortic smooth muscle cells. Teng X, etal., Am J Physiol Cell Physiol 2002 Jan;282(1):C144-52.
43. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
44. Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. Wang TN, etal., Clin Exp Allergy. 2006 Sep;36(9):1147-52.
45. Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1. Wieland CW, etal., Infect Immun. 2002 Mar;70(3):1352-8.
46. Interferon-regulatory factor 1 is an immediate-early gene under transcriptional regulation by prolactin in Nb2 T cells. Yu-Lee LY, etal., Mol Cell Biol 1990 Jun;10(6):3087-94.
Additional References at PubMed
PMID:11359801   PMID:12477932   PMID:14568984   PMID:15509808   PMID:17018642   PMID:17159910   PMID:17516545   PMID:17723228   PMID:18035482   PMID:18084608   PMID:18641303   PMID:19593445  
PMID:19606498   PMID:19851330   PMID:20308629   PMID:20451243   PMID:21389130   PMID:21478870   PMID:21909274   PMID:21937806   PMID:22200613   PMID:22292067   PMID:22367195   PMID:22427665  
PMID:22434733   PMID:23042740   PMID:24119616   PMID:24743731   PMID:26342280   PMID:37098476  


Genomics

Comparative Map Data
Irf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,417,935 - 38,424,946 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,417,148 - 38,424,947 (+)EnsemblGRCr8
mRatBN7.21037,917,155 - 37,924,166 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,916,670 - 37,924,166 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,609,084 - 42,616,097 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,099,164 - 42,106,177 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,602,877 - 37,609,890 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,109,530 - 39,116,532 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,109,522 - 39,116,531 (+)Ensemblrn6Rnor6.0
Rnor_5.01038,891,468 - 38,898,470 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,220,600 - 39,227,602 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,260,559 - 37,267,561 (+)NCBICelera
RGSC_v3.11039,229,846 - 39,236,848 (+)NCBI
RH 3.4 Map10405.3RGD
Cytogenetic Map10q22NCBI
IRF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,481,609 - 132,490,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,440,440 - 132,508,719 (-)Ensemblhg38GRCh38
GRCh375131,817,301 - 131,826,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,846,679 - 131,854,326 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345131,846,683 - 131,854,326NCBI
Celera5127,947,368 - 127,956,530 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,009,541 - 127,018,697 (-)NCBIHuRef
CHM1_15131,250,016 - 131,259,179 (-)NCBICHM1_1
T2T-CHM13v2.05133,001,395 - 133,010,551 (-)NCBIT2T-CHM13v2.0
Irf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,660,841 - 53,669,200 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,660,841 - 53,669,200 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,770,014 - 53,778,374 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,770,014 - 53,778,374 (+)Ensemblmm10GRCm38
MGSCv371153,583,516 - 53,591,876 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,613,501 - 53,620,746 (+)NCBIMGSCv36mm8
Celera1158,349,840 - 58,358,199 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.0NCBI
Irf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,880,155 - 3,887,973 (-)Ensembl
ChiLan1.0NW_0049554083,882,282 - 3,887,965 (-)NCBIChiLan1.0ChiLan1.0
IRF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,800,658 - 127,808,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,938,753 - 125,947,988 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,903,887 - 127,913,843 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,066,250 - 134,075,035 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,067,441 - 134,075,035 (-)EnsemblpanPan2panpan1.1
IRF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,773,801 - 20,781,106 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,760,120 - 20,781,608 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1119,575,525 - 19,582,746 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01121,559,527 - 21,566,744 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,559,526 - 21,566,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,278,269 - 20,285,484 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,126,105 - 20,133,315 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,768,242 - 20,775,474 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Irf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,683,543 - 115,690,876 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,686,414 - 2,693,636 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,686,247 - 2,693,633 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,776,129 - 134,783,801 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12134,776,122 - 134,783,646 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,229,799 - 140,252,658 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2q24-q29NCBI
IRF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,309,058 - 35,317,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,307,772 - 35,316,763 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603442,627,248 - 42,635,033 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,596,501 - 39,603,526 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473339,596,565 - 39,603,428 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Irf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1936,243,693 - 36,250,223 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Irf1
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:713
Count of miRNA genes:281
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000010968
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH94542  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81038,424,389 - 38,424,550 (+)Marker Load Pipeline
mRatBN7.21037,923,609 - 37,923,770 (+)MAPPERmRatBN7.2
Rnor_6.01039,115,976 - 39,116,136NCBIRnor6.0
Rnor_5.01038,897,914 - 38,898,074UniSTSRnor5.0
RGSC_v3.41039,227,046 - 39,227,206UniSTSRGSC3.4
Celera1037,267,005 - 37,267,165UniSTS
RH 3.4 Map10405.3UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000010968   ⟹   ENSRNOP00000010968
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1038,417,148 - 38,424,947 (+)Ensembl
mRatBN7.2 Ensembl1037,916,670 - 37,924,166 (+)Ensembl
Rnor_6.0 Ensembl1039,109,522 - 39,116,531 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122023   ⟹   ENSRNOP00000109068
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1038,418,292 - 38,424,944 (+)Ensembl
RefSeq Acc Id: NM_012591   ⟹   NP_036723
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81038,417,935 - 38,424,946 (+)NCBI
mRatBN7.21037,917,155 - 37,924,166 (+)NCBI
Rnor_6.01039,109,530 - 39,116,532 (+)NCBI
Rnor_5.01038,891,468 - 38,898,470 (+)NCBI
RGSC_v3.41039,220,600 - 39,227,602 (+)RGD
Celera1037,260,559 - 37,267,561 (+)RGD
Sequence:
RefSeq Acc Id: NP_036723   ⟸   NM_012591
- UniProtKB: P23570 (UniProtKB/Swiss-Prot),   Q6DGG4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010968   ⟸   ENSRNOT00000010968
Ensembl Acc Id: ENSRNOP00000109068   ⟸   ENSRNOT00000122023
Protein Domains
IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23570-F1-model_v2 AlphaFold P23570 1-328 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697183
Promoter ID:EPDNEW_R7707
Type:multiple initiation site
Name:Irf1_1
Description:interferon regulatory factor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01039,109,506 - 39,109,566EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2920 AgrOrtholog
BioCyc Gene G2FUF-25132 BioCyc
Ensembl Genes ENSRNOG00000008144 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000122023 ENTREZGENE
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099391 IMAGE-MGC_LOAD
InterPro Interferon_reg_fac_CS UniProtKB/Swiss-Prot
  Interferon_reg_fact_DNA-bd_dom UniProtKB/Swiss-Prot
  IRF1/IRF2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:24508 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93592 IMAGE-MGC_LOAD
NCBI Gene 24508 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/Swiss-Prot
  PTHR11949:SF3 UniProtKB/Swiss-Prot
Pfam IRF UniProtKB/Swiss-Prot
PhenoGen Irf1 PhenoGen
PIRSF IFN_RF1/2 UniProtKB/Swiss-Prot
PRINTS INTFRNREGFCT UniProtKB/Swiss-Prot
PROSITE IRF_1 UniProtKB/Swiss-Prot
  IRF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008144 RatGTEx
SMART IRF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
TIGR TC206594
UniProt A0ABK0M328_RAT UniProtKB/TrEMBL
  A6HEE2_RAT UniProtKB/TrEMBL
  A6HEE6_RAT UniProtKB/TrEMBL
  F7EXR9_RAT UniProtKB/TrEMBL
  IRF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6DGG4 ENTREZGENE, UniProtKB/TrEMBL
  Q812C6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Irf1  Interferon regulatory factor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression isolated from Prl-stimulated T cells 633034
gene_homology protein is 97% and 92% identical to the mouse IRF-1 and human IRF-1 respectively 633034
gene_process regulates growth-inhibitory interferon genes during cell proliferation 633034