Grik1 (glutamate ionotropic receptor kainate type subunit 1) - Rat Genome Database

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Gene: Grik1 (glutamate ionotropic receptor kainate type subunit 1) Rattus norvegicus
Analyze
Symbol: Grik1
Name: glutamate ionotropic receptor kainate type subunit 1
RGD ID: 2732
Description: Enables several functions, including glutamate binding activity; ligand-gated monoatomic ion channel activity; and scaffold protein binding activity. Contributes to heterocyclic compound binding activity. Involved in ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; and nervous system development. Located in dendrite; neuronal cell body; and terminal bouton. Part of kainate selective glutamate receptor complex. Is active in glutamatergic synapse and presynaptic membrane. Used to study status epilepticus. Human ortholog(s) of this gene implicated in childhood absence epilepsy. Orthologous to human GRIK1 (glutamate ionotropic receptor kainate type subunit 1); PARTICIPATES IN long term potentiation; glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: GluK1; GluR-5; GluR5; glutamate receptor 5; glutamate receptor ionotropic kainate 1; glutamate receptor ionotropic, kainate 1; glutamate receptor, ionotropic kainate 1; glutamate receptor, ionotropic, kainate 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81140,655,974 - 41,056,966 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1140,655,975 - 41,056,517 (-)EnsemblGRCr8
mRatBN7.21127,169,739 - 27,571,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,169,740 - 27,570,645 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1135,873,718 - 36,274,020 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01128,573,961 - 28,974,261 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,741,791 - 28,141,806 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1142,560,497 - 42,961,005 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1140,852,025 - 41,258,620 (-)NCBILyon_Normotensive
Lyon_Hypertensive1141,794,712 - 42,195,210 (-)NCBILyon_Hypertensive
F344_StmMcwi1140,502,168 - 40,908,759 (-)NCBIF344_StmMcwi
Rnor_6.01127,811,954 - 28,213,940 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensemblrn6Rnor6.0
Rnor_5.01131,426,627 - 31,828,737 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41127,703,874 - 28,106,450 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,906,345 - 27,304,585 (-)NCBICelera
RGSC_v3.11127,703,874 - 28,106,450 (-)NCBI
Cytogenetic Map11q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development. Bettler B, etal., Neuron 1990 Nov;5(5):583-95.
2. Kainate receptors are involved in synaptic plasticity. Bortolotto ZA, etal., Nature. 1999 Nov 18;402(6759):297-301.
3. Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala. Braga MF, etal., J Neurosci. 2003 Jan 15;23(2):442-52.
4. Contributions of different kainate receptor subunits to the properties of recombinant homomeric and heteromeric receptors. Fisher MT and Fisher JL, Neuroscience. 2014 Oct 10;278:70-80. doi: 10.1016/j.neuroscience.2014.08.009. Epub 2014 Aug 17.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons. Gryder DS and Rogawski MA, J Neurosci 2003 Aug 6;23(18):7069-74.
8. Activation of spinal kainate receptors after inflammation: behavioral hyperalgesia and subunit gene expression. Guo W, etal., Eur J Pharmacol 2002 Oct 11;452(3):309-18.
9. Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP. Hirbec H, etal., Neuron. 2003 Feb 20;37(4):625-38. doi: 10.1016/s0896-6273(02)01191-1.
10. A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. Lauri SE, etal., Neuron. 2003 Jul 17;39(2):327-41. doi: 10.1016/s0896-6273(03)00369-6.
11. Kainate receptors expressed by a subpopulation of developing nociceptors rapidly switch from high to low Ca2+ permeability. Lee CJ, etal., J Neurosci. 2001 Jul 1;21(13):4572-81. doi: 10.1523/JNEUROSCI.21-13-04572.2001.
12. High-affinity kainate and domoate receptors in rat brain. Lomeli H, etal., FEBS Lett 1992 Jul 28;307(2):139-43.
13. Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn. Lu CR, etal., J Comp Neurol. 2005 May 30;486(2):169-78.
14. Presynaptic low- and high-affinity kainate receptors in nociceptive spinal afferents. Lucifora S, etal., Pain. 2006 Jan;120(1-2):97-105. Epub 2005 Dec 15.
15. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. Mayer ML, etal., J Neurosci. 2006 Mar 15;26(11):2852-61.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Differential distribution of ionotropic glutamate receptor subunits in the rat olfactory bulb. Montague AA and Greer CA, J Comp Neurol. 1999 Mar 8;405(2):233-46. doi: 10.1002/(sici)1096-9861(19990308)405:2<233::aid-cne7>3.0.co;2-a.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
20. GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors. Paternain AV, etal., J Neurosci. 2000 Jan 1;20(1):196-205.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. GluR5 kainate receptors, seizures, and the amygdala. Rogawski MA, etal., Ann N Y Acad Sci. 2003 Apr;985:150-62.
25. Glutamate receptor subunits GluR5 and KA-2 are coexpressed in rat trigeminal ganglion neurons. Sahara Y, etal., J Neurosci. 1997 Sep 1;17(17):6611-20. doi: 10.1523/JNEUROSCI.17-17-06611.1997.
26. Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway. Salinas GD, etal., J Biol Chem. 2006 Dec 29;281(52):40164-73. Epub 2006 Oct 24.
27. Effects of the kainate receptor agonist ATPA on glutamatergic synaptic transmission and plasticity during early postnatal development. Sallert M, etal., Neuropharmacology. 2007 May;52(6):1354-65. Epub 2007 Feb 4.
28. Allelic association of juvenile absence epilepsy with a GluR5 kainate receptor gene (GRIK1) polymorphism. Sander T, etal., Am J Med Genet 1997 Jul 25;74(4):416-21.
29. Structural and compositional diversity in the kainate receptor family. Selvakumar P, etal., Cell Rep. 2021 Oct 26;37(4):109891. doi: 10.1016/j.celrep.2021.109891.
30. Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. Shibata H, etal., Psychiatr Genet. 2001 Sep;11(3):139-44.
31. A glutamate receptor channel with high affinity for domoate and kainate. Sommer B, etal., EMBO J. 1992 Apr;11(4):1651-6. doi: 10.1002/j.1460-2075.1992.tb05211.x.
32. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
33. Conformational restriction blocks glutamate receptor desensitization. Weston MC, etal., Nat Struct Mol Biol. 2006 Dec;13(12):1120-7. Epub 2006 Nov 19.
Additional References at PubMed
PMID:8889548   PMID:9069287   PMID:9335499   PMID:10516295   PMID:11069933   PMID:11144357   PMID:11985817   PMID:12223554   PMID:14715943   PMID:14724198   PMID:15014126   PMID:15458844  
PMID:15483117   PMID:15509753   PMID:15513934   PMID:15537878   PMID:15673679   PMID:15928066   PMID:17174564   PMID:17245443   PMID:17569736   PMID:18046310   PMID:18678878   PMID:19043593  
PMID:19123252   PMID:20848775   PMID:21734292   PMID:22279215   PMID:24069373   PMID:28100490   PMID:30421168   PMID:30451858  


Genomics

Comparative Map Data
Grik1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81140,655,974 - 41,056,966 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1140,655,975 - 41,056,517 (-)EnsemblGRCr8
mRatBN7.21127,169,739 - 27,571,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1127,169,740 - 27,570,645 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1135,873,718 - 36,274,020 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01128,573,961 - 28,974,261 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01127,741,791 - 28,141,806 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1142,560,497 - 42,961,005 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1140,852,025 - 41,258,620 (-)NCBILyon_Normotensive
Lyon_Hypertensive1141,794,712 - 42,195,210 (-)NCBILyon_Hypertensive
F344_StmMcwi1140,502,168 - 40,908,759 (-)NCBIF344_StmMcwi
Rnor_6.01127,811,954 - 28,213,940 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensemblrn6Rnor6.0
Rnor_5.01131,426,627 - 31,828,737 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41127,703,874 - 28,106,450 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,906,345 - 27,304,585 (-)NCBICelera
RGSC_v3.11127,703,874 - 28,106,450 (-)NCBI
Cytogenetic Map11q11NCBI
GRIK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382129,536,933 - 29,939,996 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2129,536,933 - 29,940,033 (-)Ensemblhg38GRCh38
GRCh372130,909,254 - 31,312,314 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362129,831,125 - 30,234,153 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342129,831,126 - 30,234,153NCBI
Celera2116,092,373 - 16,495,412 (-)NCBICelera
Cytogenetic Map21q21.3NCBI
HuRef2116,317,387 - 16,721,110 (-)NCBIHuRef
CHM1_12130,470,770 - 30,873,809 (-)NCBICHM1_1
T2T-CHM13v2.02127,902,775 - 28,305,893 (-)NCBIT2T-CHM13v2.0
Grik1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391687,692,789 - 88,087,751 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1687,692,788 - 88,087,153 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381687,895,901 - 88,290,863 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1687,895,900 - 88,290,265 (-)Ensemblmm10GRCm38
MGSCv371687,896,142 - 88,290,503 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361687,784,754 - 88,179,102 (-)NCBIMGSCv36mm8
Celera1688,093,673 - 88,486,750 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1650.23NCBI
Grik1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540728,899,899 - 29,308,470 (-)Ensembl
ChiLan1.0NW_00495540728,899,643 - 29,308,936 (-)NCBIChiLan1.0ChiLan1.0
GRIK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22225,727,337 - 26,107,844 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12120,585,887 - 20,966,442 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02115,976,931 - 16,357,578 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12129,363,972 - 29,743,940 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2129,364,269 - 29,743,379 (-)EnsemblpanPan2panpan1.1
GRIK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13124,477,319 - 24,839,502 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3124,478,696 - 24,839,434 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3124,471,425 - 24,648,177 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03124,592,133 - 24,768,924 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3124,592,138 - 24,953,198 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13124,542,198 - 24,719,018 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03124,544,158 - 24,720,948 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03125,015,707 - 25,192,582 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grik1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497124,931,282 - 25,310,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650012,157,765 - 12,536,224 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650012,157,215 - 12,536,555 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13192,877,606 - 193,294,952 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113192,877,707 - 193,296,954 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213203,411,219 - 203,897,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1262,286,828 - 62,692,061 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660714,856,919 - 5,276,564 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grik1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474517,592,874 - 17,986,759 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474517,592,587 - 17,986,863 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grik1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1455,563,597 - 55,946,907 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grik1
3053 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:67
Interacting mature miRNAs:70
Transcripts:ENSRNOT00000042581, ENSRNOT00000050073, ENSRNOT00000051060
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11381815448818154Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)111080612555806125Rat
634341Bw121Body weight QTL 1213.56abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)113532319955805892Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)112995899657754989Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
2290451Scl58Serum cholesterol level QTL 583.48blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)112631803155806125Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat

Markers in Region
RH132302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,169,788 - 27,169,979 (+)MAPPERmRatBN7.2
Rnor_6.01127,812,004 - 27,812,194NCBIRnor6.0
Rnor_5.01131,426,677 - 31,426,867UniSTSRnor5.0
RGSC_v3.41127,703,924 - 27,704,114UniSTSRGSC3.4
Celera1126,906,395 - 26,906,585UniSTS
RH 3.4 Map11137.5UniSTS
Cytogenetic Map11q11UniSTS
D10S224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,188,185 - 27,189,584 (+)MAPPERmRatBN7.2
Rnor_6.01127,830,716 - 27,832,114NCBIRnor6.0
Rnor_5.01131,445,389 - 31,446,787UniSTSRnor5.0
RGSC_v3.41127,722,321 - 27,723,719UniSTSRGSC3.4
Celera1126,924,740 - 26,926,138UniSTS
Cytogenetic Map11q11UniSTS
UniSTS:478959  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21127,413,001 - 27,413,216 (+)MAPPERmRatBN7.2
Rnor_6.01128,056,384 - 28,056,598NCBIRnor6.0
Rnor_5.01131,671,205 - 31,671,419UniSTSRnor5.0
RGSC_v3.41127,948,442 - 27,948,656UniSTSRGSC3.4
Celera1127,149,365 - 27,149,579UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 3 30 134 39 35 20 51 20 6 171 97 3 119 44 81 15 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001111114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001111117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006248054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039088253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI145540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z11714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000042581   ⟹   ENSRNOP00000050263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,672,604 - 40,828,792 (-)Ensembl
mRatBN7.2 Ensembl1127,169,742 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000050073   ⟹   ENSRNOP00000045594
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,655,977 - 41,056,517 (-)Ensembl
mRatBN7.2 Ensembl1127,169,742 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,812,235 - 27,971,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051060   ⟹   ENSRNOP00000046164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,655,975 - 41,056,517 (-)Ensembl
mRatBN7.2 Ensembl1127,169,740 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081066   ⟹   ENSRNOP00000074448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,656,771 - 41,056,517 (-)Ensembl
mRatBN7.2 Ensembl1127,170,536 - 27,570,645 (-)Ensembl
Rnor_6.0 Ensembl1127,812,751 - 27,971,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085629   ⟹   ENSRNOP00000069424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,655,977 - 40,814,595 (-)Ensembl
mRatBN7.2 Ensembl1127,169,742 - 27,328,359 (-)Ensembl
Rnor_6.0 Ensembl1127,811,957 - 27,971,359 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100916   ⟹   ENSRNOP00000078137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,673,970 - 41,056,517 (-)Ensembl
mRatBN7.2 Ensembl1127,187,235 - 27,570,645 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147508   ⟹   ENSRNOP00000105903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1140,672,604 - 41,056,517 (-)Ensembl
RefSeq Acc Id: NM_001111114   ⟹   NP_001104584
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,655,974 - 41,056,503 (-)NCBI
mRatBN7.21127,169,739 - 27,570,273 (-)NCBI
Dahl_SR_JrHsd1142,560,497 - 42,961,005 (-)NCBI
Lyon_Normotensive1140,852,025 - 41,258,620 (-)NCBI
Lyon_Hypertensive1141,794,712 - 42,195,210 (-)NCBI
F344_StmMcwi1140,502,168 - 40,908,759 (-)NCBI
Rnor_6.01127,811,954 - 28,213,539 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
RGSC_v3.41127,703,874 - 28,106,450 (-)RGD
Celera1126,906,345 - 27,304,585 (-)RGD
Sequence:
RefSeq Acc Id: NM_001111117   ⟹   NP_001104587
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,655,974 - 41,056,503 (-)NCBI
mRatBN7.21127,169,739 - 27,570,273 (-)NCBI
Dahl_SR_JrHsd1142,560,497 - 42,961,005 (-)NCBI
Lyon_Normotensive1140,852,025 - 41,258,620 (-)NCBI
Lyon_Hypertensive1141,794,712 - 42,195,210 (-)NCBI
F344_StmMcwi1140,502,168 - 40,908,759 (-)NCBI
Rnor_6.01127,811,954 - 28,213,539 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
RGSC_v3.41127,703,874 - 28,106,450 (-)RGD
Celera1126,906,345 - 27,304,585 (-)RGD
Sequence:
RefSeq Acc Id: NM_017241   ⟹   NP_058937
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,655,974 - 41,056,503 (-)NCBI
mRatBN7.21127,169,739 - 27,570,273 (-)NCBI
Dahl_SR_JrHsd1142,560,497 - 42,961,005 (-)NCBI
Lyon_Normotensive1140,852,025 - 41,258,620 (-)NCBI
Lyon_Hypertensive1141,794,712 - 42,195,210 (-)NCBI
F344_StmMcwi1140,502,168 - 40,908,759 (-)NCBI
Rnor_6.01127,811,954 - 28,213,539 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
RGSC_v3.41127,703,874 - 28,106,450 (-)RGD
Celera1126,906,345 - 27,304,585 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248053   ⟹   XP_006248115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,655,974 - 41,056,966 (-)NCBI
mRatBN7.21127,170,020 - 27,570,088 (-)NCBI
Rnor_6.01127,811,954 - 28,213,940 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006248054   ⟹   XP_006248116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,666,740 - 41,056,966 (-)NCBI
mRatBN7.21127,187,281 - 27,570,119 (-)NCBI
Rnor_6.01127,828,400 - 28,213,940 (-)NCBI
Rnor_5.01131,426,627 - 31,828,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597947   ⟹   XP_017453436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,655,974 - 40,827,889 (-)NCBI
mRatBN7.21127,169,739 - 27,341,648 (-)NCBI
Rnor_6.01127,811,954 - 27,984,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039088252   ⟹   XP_038944180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,666,740 - 41,056,966 (-)NCBI
mRatBN7.21127,187,370 - 27,570,088 (-)NCBI
RefSeq Acc Id: XM_039088253   ⟹   XP_038944181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,686,822 - 41,056,966 (-)NCBI
mRatBN7.21127,200,581 - 27,571,131 (-)NCBI
RefSeq Acc Id: XM_063270448   ⟹   XP_063126518
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,655,974 - 40,829,108 (-)NCBI
RefSeq Acc Id: XM_063270449   ⟹   XP_063126519
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,666,740 - 40,829,109 (-)NCBI
RefSeq Acc Id: XM_063270451   ⟹   XP_063126521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,656,328 - 41,056,966 (-)NCBI
RefSeq Acc Id: XR_005491017
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81140,656,280 - 41,056,966 (-)NCBI
mRatBN7.21127,170,034 - 27,570,119 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001104584 (Get FASTA)   NCBI Sequence Viewer  
  NP_001104587 (Get FASTA)   NCBI Sequence Viewer  
  NP_058937 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248115 (Get FASTA)   NCBI Sequence Viewer  
  XP_006248116 (Get FASTA)   NCBI Sequence Viewer  
  XP_017453436 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944180 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944181 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126518 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126519 (Get FASTA)   NCBI Sequence Viewer  
  XP_063126521 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA02873 (Get FASTA)   NCBI Sequence Viewer  
  AAA02874 (Get FASTA)   NCBI Sequence Viewer  
  CAA77775 (Get FASTA)   NCBI Sequence Viewer  
  CAA77776 (Get FASTA)   NCBI Sequence Viewer  
  CAA77777 (Get FASTA)   NCBI Sequence Viewer  
  EDM10647 (Get FASTA)   NCBI Sequence Viewer  
  EDM10648 (Get FASTA)   NCBI Sequence Viewer  
  EDM10649 (Get FASTA)   NCBI Sequence Viewer  
  EDM10650 (Get FASTA)   NCBI Sequence Viewer  
  EDM10651 (Get FASTA)   NCBI Sequence Viewer  
  EDM10652 (Get FASTA)   NCBI Sequence Viewer  
  EDM10653 (Get FASTA)   NCBI Sequence Viewer  
  EDM10654 (Get FASTA)   NCBI Sequence Viewer  
  EDM10655 (Get FASTA)   NCBI Sequence Viewer  
  EDM10656 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045594
  ENSRNOP00000046164
  ENSRNOP00000050263
  ENSRNOP00000069424
  ENSRNOP00000078137
  ENSRNOP00000105903
GenBank Protein P22756 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058937   ⟸   NM_017241
- Peptide Label: isoform 2
- UniProtKB: P22756 (UniProtKB/Swiss-Prot),   A0A140TAF9 (UniProtKB/TrEMBL),   A6JL85 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104584   ⟸   NM_001111114
- Peptide Label: isoform 3
- UniProtKB: P22756 (UniProtKB/Swiss-Prot),   A6JL83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104587   ⟸   NM_001111117
- Peptide Label: isoform 1 precursor
- UniProtKB: P22756 (UniProtKB/Swiss-Prot),   F1M7M9 (UniProtKB/TrEMBL),   A6JL86 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248115   ⟸   XM_006248053
- Peptide Label: isoform X1
- UniProtKB: P22756 (UniProtKB/Swiss-Prot),   A0A140TAG6 (UniProtKB/TrEMBL),   A6JL84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248116   ⟸   XM_006248054
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K830 (UniProtKB/TrEMBL),   A6JL87 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453436   ⟸   XM_017597947
- Peptide Label: isoform X4
- UniProtKB: A0A0G2JVC0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069424   ⟸   ENSRNOT00000085629
Ensembl Acc Id: ENSRNOP00000046164   ⟸   ENSRNOT00000051060
Ensembl Acc Id: ENSRNOP00000050263   ⟸   ENSRNOT00000042581
Ensembl Acc Id: ENSRNOP00000074448   ⟸   ENSRNOT00000081066
Ensembl Acc Id: ENSRNOP00000045594   ⟸   ENSRNOT00000050073
RefSeq Acc Id: XP_038944180   ⟸   XM_039088252
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y1Z7 (UniProtKB/TrEMBL),   A6JL88 (UniProtKB/TrEMBL),   A0A0G2K830 (UniProtKB/TrEMBL),   A6JL87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944181   ⟸   XM_039088253
- Peptide Label: isoform X7
- UniProtKB: A6JL92 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078137   ⟸   ENSRNOT00000100916
RefSeq Acc Id: XP_063126518   ⟸   XM_063270448
- Peptide Label: isoform X5
- UniProtKB: A0A0G2JVC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126521   ⟸   XM_063270451
- Peptide Label: isoform X8
- UniProtKB: A0A0G2K830 (UniProtKB/TrEMBL),   A6JL87 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126519   ⟸   XM_063270449
- Peptide Label: isoform X6
- UniProtKB: A0A0G2K830 (UniProtKB/TrEMBL),   A6JL87 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105903   ⟸   ENSRNOT00000147508
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22756-F1-model_v2 AlphaFold P22756 1-949 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2732 AgrOrtholog
BioCyc Gene G2FUF-22035 BioCyc
Ensembl Genes ENSRNOG00000001575 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042581 ENTREZGENE
  ENSRNOT00000050073 ENTREZGENE
  ENSRNOT00000051060 ENTREZGENE
  ENSRNOT00000085629 ENTREZGENE
  ENSRNOT00000100916 ENTREZGENE
  ENSRNOT00000147508 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:29559 UniProtKB/Swiss-Prot
NCBI Gene 29559 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
PhenoGen Grik1 PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001575 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
TIGR TC221180
UniProt A0A0G2JVC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K830 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAF9 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y1Z7 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LJK6_RAT UniProtKB/TrEMBL
  A6JL82_RAT UniProtKB/TrEMBL
  A6JL83 ENTREZGENE, UniProtKB/TrEMBL
  A6JL84 ENTREZGENE, UniProtKB/TrEMBL
  A6JL85 ENTREZGENE, UniProtKB/TrEMBL
  A6JL86 ENTREZGENE, UniProtKB/TrEMBL
  A6JL87 ENTREZGENE, UniProtKB/TrEMBL
  A6JL88 ENTREZGENE, UniProtKB/TrEMBL
  A6JL89_RAT UniProtKB/TrEMBL
  A6JL91_RAT UniProtKB/TrEMBL
  A6JL92 ENTREZGENE, UniProtKB/TrEMBL
  F1M7M9 ENTREZGENE, UniProtKB/TrEMBL
  GRIK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grik1  glutamate ionotropic receptor kainate type subunit 1  Grik1  glutamate receptor, ionotropic, kainate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grik1  Glutamate receptor, ionotropic, kainate 1      Symbol and Name status set to approved 70586 APPROVED