Got1 (glutamic-oxaloacetic transaminase 1) - Rat Genome Database

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Gene: Got1 (glutamic-oxaloacetic transaminase 1) Rattus norvegicus
Analyze
Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1
RGD ID: 2721
Description: Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine transaminase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and negative regulation of collagen biosynthetic process. Located in axon terminus. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1); PARTICIPATES IN gluconeogenesis pathway; AGAT deficiency pathway; alkaptonuria pathway; INTERACTS WITH (E)-thiamethoxam; (R,R)-tramadol; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AAT1; ASAT; aspartate aminotransferase 1; aspartate aminotransferase, cytoplasmic; Aspat; cAspAT; cCAT; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; Gaspat; glutamate oxaloacetate transaminase 1; glutamate oxaloacetate transaminase 1, soluble; Glutamic-oxaloacetic transaminase 1 soluble (aspartate aminotransferase cytosolic) see also D1Mgh12; glutamic-oxaloacetic transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12; transaminase A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Rf1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,306,541 - 252,337,622 (-)NCBIGRCr8
mRatBN7.21242,357,293 - 242,381,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,357,306 - 242,380,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,507,277 - 250,530,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,204,438 - 257,227,634 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01249,857,429 - 249,880,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,246,248 - 263,269,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,691,424 - 270,714,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,324,285 - 247,347,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1238,178,819 - 238,202,121 (-)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q54NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(E)-thiamethoxam  (EXP)
(R,R)-tramadol  (EXP)
(S)-colchicine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-methylcholine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
Alisol B  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apremilast  (EXP)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
aucubin  (ISO)
Augmentin  (EXP)
baicalin  (EXP)
barium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Bergenin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
buprofezin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (EXP)
capsaicin  (EXP)
captopril  (EXP)
carbamazepine  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofloxacin  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
digoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
eumelanin  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
Fexaramine  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (EXP)
glucose  (ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
hexachlorobenzene  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
imetit  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
iodide salt  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
iron(3+) sulfate  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP)
isotretinoin  (EXP)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
levetiracetam  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
loperamide  (EXP)
malaoxon  (ISO)
mancozeb  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
Microcystin la  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nicotinic acid  (ISO)
nitrofen  (EXP)
oltipraz  (ISO)
oxaloacetic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
ranitidine  (EXP)
resveratrol  (EXP)
rifampicin  (ISO)
risperidone  (EXP)
rotenone  (EXP)
S-allylcysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
sodium arsenite  (EXP)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sodium silicate  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfur dioxide  (EXP)
sunitinib  (ISO)
syringic acid  (EXP)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thiamethoxam  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tramadol  (EXP)
trans-caffeic acid  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tuberostemonine  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon terminus  (IDA)
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Exploration of the therapeutic potential effect of Sepia officinalis in animal model of sepsis induced by cecal ligation and puncture. Abd El-Latif AA, etal., Injury. 2016 Dec;47(12):2709-2717. doi: 10.1016/j.injury.2016.10.003. Epub 2016 Oct 6.
2. Purification and characterization of cysteine aminotransferase from rat liver cytosol. Akagi R Acta Med Okayama. 1982 Jun;36(3):187-97.
3. Immunolocalization of cytosolic aspartate aminotransferase (cAAT) in axon terminals that form synapses in the rat cerebellar cortex. A study at the electron microscopic level. Arenas Diaz G and Martinez-Rodriguez R, Brain Res. 1990 May 14;516(1):77-83.
4. Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver. Athmouni K, etal., Int J Biol Macromol. 2018 Mar;108:853-862. doi: 10.1016/j.ijbiomac.2017.10.175. Epub 2017 Oct 31.
5. Additive effect of lipid lowering drug (simvastatin) in combination with antidiabetic drug (glibenclamide) on alloxan induced diabetic rats with long term dyslipidemia. Begum MM, etal., Indian J Clin Biochem. 2014 Oct;29(4):452-61. doi: 10.1007/s12291-013-0393-1. Epub 2013 Oct 24.
6. Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms. Berry MN, etal., FEBS Lett. 1988 Apr 11;231(1):19-24.
7. Protective effects of probiotic Lactobacillus plantarum BJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats. Bouhafs L, etal., Ren Fail. 2015;37(8):1370-8. doi: 10.3109/0886022X.2015.1073543. Epub 2015 Aug 14.
8. Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats. Chen S, etal., Lab Invest. 2015 Feb;95(2):142-56. doi: 10.1038/labinvest.2014.147. Epub 2015 Jan 12.
9. Induction of chronic cholestasis without liver cirrhosis - Creation of an animal model. Dondorf F, etal., World J Gastroenterol. 2017 Jun 21;23(23):4191-4199. doi: 10.3748/wjg.v23.i23.4191.
10. Differences in prefrontal cortex GABA/glutamate ratio after acute restraint stress in rats are associated with specific behavioral and neurobiological patterns. Drouet JB, etal., Neuroscience. 2015 Jan 29;285:155-65. doi: 10.1016/j.neuroscience.2014.10.058. Epub 2014 Nov 6.
11. Peripheral and central effects of intracerebroventricular microinjection of Hottentotta gentili (Pallary, 1924) (Scorpiones, Buthidae) venom. El Hidan MA, etal., Toxicon. 2016 Mar 1;111:22-30. doi: 10.1016/j.toxicon.2015.12.010. Epub 2015 Dec 22.
12. Carcinogenic Activities and Sperm Abnormalities of Methicillin Resistance Staphylococcus aureus and Inhibition of Their Virulence Potentials by Ayamycin. El-Gendy MMAA, etal., Appl Biochem Biotechnol. 2017 Nov;183(3):833-852. doi: 10.1007/s12010-017-2467-7. Epub 2017 Apr 7.
13. Possible mechanism for the decrease of mitochondrial aspartate aminotransferase activity in ischemic and hypoxic rat retinas. Endo S, etal., Biochim Biophys Acta. 1999 Jul 8;1450(3):385-96.
14. Anti-fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats. Fahmy SR, BMC Complement Altern Med. 2015 Feb 5;15:14. doi: 10.1186/s12906-015-0533-7.
15. Antihepatotoxic efficacy of Mangifera indica L. polysaccharides against cyclophosphamide in rats. Fahmy SR, etal., Chem Biol Interact. 2016 Jan 25;244:113-20. doi: 10.1016/j.cbi.2015.11.009. Epub 2015 Nov 22.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats. Han Y, etal., Neurosci Lett. 2014 Mar 20;563:149-54. doi: 10.1016/j.neulet.2013.12.042. Epub 2013 Dec 25.
19. Time-dependent alterations of cerebral proteins following short-term normobaric hyperoxia. Hinkelbein J, etal., Mol Cell Biochem. 2010 Jun;339(1-2):9-21. doi: 10.1007/s11010-009-0365-1. Epub 2010 Jan 5.
20. Induction of cytosolic aspartate aminotransferase by glucagon in primary cultured rat hepatocytes. Horio Y, etal., Biochem Biophys Res Commun. 1988 May 31;153(1):410-6.
21. Rat cytosolic aspartate aminotransferase: molecular cloning of cDNA and expression in Escherichia coli. Horio Y, etal., J Biochem (Tokyo) 1988 May;103(5):797-804.
22. Glutamate-synthesizing enzymes in GABAergic neurons of the neocortex: a double immunofluorescence study in the rat. Kaneko T and Mizuno N, Neuroscience. 1994 Aug;61(4):839-49.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Effect of 3-keto-1,5-bisphosphonates on obese-liver's rats. Lahbib K and Touil S, Biomed Pharmacother. 2016 Oct;83:186-193. doi: 10.1016/j.biopha.2016.06.022. Epub 2016 Jun 28.
26. Can TiC nanoparticles produce toxicity in oral administration to rats? Laloy J, etal., Toxicol Rep. 2014 May 12;1:172-187. doi: 10.1016/j.toxrep.2014.03.004. eCollection 2014.
27. Regulation of hepatic stellate cell proliferation and activation by glutamine metabolism. Li J, etal., PLoS One. 2017 Aug 10;12(8):e0182679. doi: 10.1371/journal.pone.0182679. eCollection 2017.
28. Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. Liang Y, etal., Lab Invest. 2011 Jan;91(1):12-23. doi: 10.1038/labinvest.2010.156. Epub 2010 Aug 23.
29. Mechanical stretching stimulates collagen synthesis via down-regulating SO2/AAT1 pathway. Liu J, etal., Sci Rep. 2016 Feb 16;6:21112. doi: 10.1038/srep21112.
30. Lipidomic analysis of molecular cardiolipin species in livers exposed to ischemia/reperfusion. Martens JC, etal., Mol Cell Biochem. 2015 Feb;400(1-2):253-63. doi: 10.1007/s11010-014-2282-1. Epub 2014 Nov 23.
31. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Stimulation by aminooxyacetate of fluorescein uptake in rat renal tubules in vitro: role of intracellular alpha-ketoglutarate. Nikiforov AA J Pharmacol Exp Ther. 1995 Sep;274(3):1204-8.
34. Nucleotide sequence and glucocorticoid regulation of the mRNAs for the isoenzymes of rat aspartate aminotransferase. Pave-Preux M, etal., J Biol Chem 1988 Nov 25;263(33):17459-66.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia. Pérez-Mato M, etal., Cell Death Dis. 2014 Jan 9;5:e992. doi: 10.1038/cddis.2013.507.
38. Regulation of 2-oxoglutarate metabolism in rat liver by NADP-isocitrate dehydrogenase and aspartate aminotransferase. Rakhmanova TI and Popova TN, Biochemistry (Mosc). 2006 Feb;71(2):211-7.
39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. Rink C, etal., Antioxid Redox Signal. 2011 May 15;14(10):1777-85. doi: 10.1089/ars.2011.3930. Epub 2011 Mar 28.
42. Oxygen-sensitive outcomes and gene expression in acute ischemic stroke. Rink C, etal., J Cereb Blood Flow Metab. 2010 Jul;30(7):1275-87. doi: 10.1038/jcbfm.2010.7. Epub 2010 Feb 10.
43. Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment. Ruban A, etal., Neurodegener Dis. 2015;15(4):233-42. doi: 10.1159/000382034. Epub 2015 Jun 23.
44. Therapeutic effect of apple pectin in obese rats. Samout N, etal., Biomed Pharmacother. 2016 Oct;83:1233-1238. doi: 10.1016/j.biopha.2016.08.038. Epub 2016 Aug 23.
45. Effect of pyridoxine-deficiency on degradation of cytosolic aspartate aminotransferase in rat liver lysosomes. Sato A, etal., J Nutr Sci Vitaminol (Tokyo). 1991 Aug;37(4):419-24.
46. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Son J, etal., Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27.
47. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
48. Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling. Sun Y, etal., Lab Invest. 2010 Jan;90(1):68-82. Epub 2009 Oct 12.
49. Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. Tordjman J, etal., J Biol Chem. 2007 Aug 10;282(32):23591-602. Epub 2007 Jun 1.
50. Pirimidine derivatives as hepatoprotective agents. Vyshtakalyuk AB, etal., Int J Risk Saf Med. 2015;27 Suppl 1:S78-9. doi: 10.3233/JRS-150698.
51. Cytosolic aspartate aminotransferase mediates the mitochondrial membrane potential and cell survival by maintaining the calcium homeostasis of BV2 microglia. Wang C, etal., Neuroreport. 2018 Jan 17;29(2):99-105. doi: 10.1097/WNR.0000000000000914.
52. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
53. Targeting glutamatergic and cellular prion protein mechanisms of amyloid ß-mediated persistent synaptic plasticity disruption: Longitudinal studies. Zhang D, etal., Neuropharmacology. 2017 Jul 15;121:231-246. doi: 10.1016/j.neuropharm.2017.03.036. Epub 2017 Apr 5.
54. Brain neuroprotection by scavenging blood glutamate. Zlotnik A, etal., Exp Neurol. 2007 Jan;203(1):213-20. doi: 10.1016/j.expneurol.2006.08.021. Epub 2006 Oct 2.
Additional References at PubMed
PMID:1914521   PMID:2182221   PMID:2241899   PMID:2307672   PMID:2731362   PMID:3242498   PMID:4193185   PMID:6391741   PMID:7060339   PMID:7444718   PMID:8396422   PMID:15489334  
PMID:19056867   PMID:19199708   PMID:20458337   PMID:21630459   PMID:22871113   PMID:23376485   PMID:23533145   PMID:24611772   PMID:25446530   PMID:35038133  


Genomics

Comparative Map Data
Got1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,306,541 - 252,337,622 (-)NCBIGRCr8
mRatBN7.21242,357,293 - 242,381,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,357,306 - 242,380,633 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1250,507,277 - 250,530,462 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,204,438 - 257,227,634 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01249,857,429 - 249,880,622 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,246,248 - 263,269,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01270,691,424 - 270,714,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41247,324,285 - 247,347,553 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1238,178,819 - 238,202,121 (-)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q54NCBI
GOT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,396,870 - 99,430,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,396,870 - 99,430,624 (-)EnsemblGRCh38hg38GRCh38
GRCh3710101,156,627 - 101,190,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,146,618 - 101,180,336 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410101,146,617 - 101,180,336NCBI
Celera1094,893,454 - 94,927,360 (-)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1094,783,264 - 94,817,025 (-)NCBIHuRef
CHM1_110101,438,925 - 101,472,830 (-)NCBICHM1_1
T2T-CHM13v2.010100,278,791 - 100,312,550 (-)NCBIT2T-CHM13v2.0
Got1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,488,191 - 43,514,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,488,191 - 43,513,044 (-)EnsemblGRCm39 Ensembl
GRCm381943,499,752 - 43,524,605 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,499,752 - 43,524,605 (-)EnsemblGRCm38mm10GRCm38
MGSCv371943,574,242 - 43,599,095 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361943,553,066 - 43,577,820 (-)NCBIMGSCv36mm8
Celera1944,291,421 - 44,309,811 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
Got1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,346,838 - 5,370,072 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555075,346,937 - 5,370,072 (-)NCBIChiLan1.0ChiLan1.0
GOT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28111,304,324 - 111,338,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110111,309,640 - 111,343,509 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,012,345 - 96,046,266 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11099,506,205 - 99,540,178 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,506,205 - 99,540,178 (-)Ensemblpanpan1.1panPan2
GOT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,352,658 - 12,377,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,352,659 - 12,414,579 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2812,536,462 - 12,561,764 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02812,820,566 - 12,845,869 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2812,820,567 - 12,882,397 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,367,262 - 12,392,563 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,398,502 - 12,423,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,539,850 - 12,565,179 (-)NCBIUU_Cfam_GSD_1.0
Got1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,578,280 - 34,601,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636617,356 - 640,932 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936636617,376 - 640,424 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GOT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,608,430 - 110,635,874 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114110,608,422 - 110,635,825 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,054,006 - 120,080,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GOT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,463,017 - 92,489,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,462,782 - 92,488,310 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604853,459,704 - 53,486,298 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Got1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,115,066 - 11,153,211 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473711,114,818 - 11,153,209 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Got1
200 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:214
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000022309
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
631690Scl5Serum cholesterol level QTL 52.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1236125214260522016Rat
631836Stl31Serum triglyceride level QTL 314.640.00000487blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1237147813260522016Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1238699859259647894Rat

Markers in Region
D1Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01270,716,905 - 270,717,037NCBIRnor5.0
RGSC_v3.41247,322,146 - 247,322,277RGDRGSC3.4
RGSC_v3.11247,436,621 - 247,436,752RGD
Celera1238,204,080 - 238,204,181UniSTS
RH 3.4 Map11616.91UniSTS
RH 3.4 Map11616.91RGD
RH 2.0 Map11221.1RGD
SHRSP x BN Map1133.51RGD
Cytogenetic Map1q54UniSTS
GOT1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,361,857 - 242,362,003 (+)MAPPERmRatBN7.2
Rnor_6.01263,250,813 - 263,250,958NCBIRnor6.0
Rnor_5.01270,695,989 - 270,696,134UniSTSRnor5.0
RGSC_v3.41247,342,845 - 247,342,990UniSTSRGSC3.4
Celera1238,183,384 - 238,183,529UniSTS
Cytogenetic Map1q54UniSTS
RH128564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,357,367 - 242,357,560 (+)MAPPERmRatBN7.2
Rnor_6.01263,246,323 - 263,246,515NCBIRnor6.0
Rnor_5.01270,691,499 - 270,691,691UniSTSRnor5.0
RGSC_v3.41247,347,288 - 247,347,480UniSTSRGSC3.4
Celera1238,178,894 - 238,179,086UniSTS
RH 3.4 Map11619.38UniSTS
Cytogenetic Map1q54UniSTS
RH132794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,357,883 - 242,358,074 (+)MAPPERmRatBN7.2
Rnor_6.01263,246,839 - 263,247,029NCBIRnor6.0
Rnor_5.01270,692,015 - 270,692,205UniSTSRnor5.0
RGSC_v3.41247,346,774 - 247,346,964UniSTSRGSC3.4
Celera1238,179,410 - 238,179,600UniSTS
Cytogenetic Map1q54UniSTS
RH94745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,357,493 - 242,357,651 (+)MAPPERmRatBN7.2
Rnor_6.01263,246,449 - 263,246,606NCBIRnor6.0
Rnor_5.01270,691,625 - 270,691,782UniSTSRnor5.0
RGSC_v3.41247,347,197 - 247,347,354UniSTSRGSC3.4
Celera1238,179,020 - 238,179,177UniSTS
RH 3.4 Map11619.22UniSTS
Cytogenetic Map1q54UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 55 41 17 41 8 11 74 35 41 11 8
Low 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB578328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK600227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM055803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN802619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB922163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB922489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC979572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC979898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000022309   ⟹   ENSRNOP00000022309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,359,355 - 242,380,633 (-)Ensembl
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000119131   ⟹   ENSRNOP00000080441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,357,306 - 242,379,572 (-)Ensembl
RefSeq Acc Id: NM_012571   ⟹   NP_036703
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,306,541 - 252,329,871 (-)NCBI
mRatBN7.21242,357,293 - 242,380,623 (-)NCBI
Rnor_6.01263,246,248 - 263,269,762 (-)NCBI
Rnor_5.01270,691,424 - 270,714,958 (-)NCBI
RGSC_v3.41247,324,285 - 247,347,553 (+)RGD
Celera1238,178,819 - 238,202,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280638   ⟹   XP_063136708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,310,933 - 252,337,622 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036703   ⟸   NM_012571
- UniProtKB: Q64570 (UniProtKB/Swiss-Prot),   Q6P721 (UniProtKB/Swiss-Prot),   P13221 (UniProtKB/Swiss-Prot),   A6JHC9 (UniProtKB/TrEMBL),   A0A8I6G6L5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022309   ⟸   ENSRNOT00000022309
RefSeq Acc Id: ENSRNOP00000080441   ⟸   ENSRNOT00000119131
RefSeq Acc Id: XP_063136708   ⟸   XM_063280638
- Peptide Label: isoform X1
Protein Domains
Aminotransferase class I/classII

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13221-F1-model_v2 AlphaFold P13221 1-413 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690925
Promoter ID:EPDNEW_R1449
Type:initiation region
Name:Got1_1
Description:glutamic-oxaloacetic transaminase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,269,747 - 263,269,807EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2721 AgrOrtholog
BioCyc Gene G2FUF-55626 BioCyc
BioCyc Pathway ASPARAGINE-DEG1-PWY-1 [L-asparagine degradation III (mammalian)] BioCyc
  ASPARTATE-DEG1-PWY [L-aspartate degradation I] BioCyc
  ASPARTATESYN-PWY [L-aspartate biosynthesis] BioCyc
  MALATE-ASPARTATE-SHUTTLE-PWY [malate/L-aspartate shuttle pathway] BioCyc
  PWY-5886 [3-(4-hydroxyphenyl)pyruvate biosynthesis] BioCyc
  PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
  TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image ASPARAGINE-DEG1-PWY-1 BioCyc
  ASPARTATE-DEG1-PWY BioCyc
  ASPARTATESYN-PWY BioCyc
  MALATE-ASPARTATE-SHUTTLE-PWY BioCyc
  PWY-5886 BioCyc
  PWY-6318 BioCyc
  TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000016356 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055004126 UniProtKB/Swiss-Prot
  ENSRNOG00060023531 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022309 ENTREZGENE
  ENSRNOT00000022309.8 UniProtKB/TrEMBL
  ENSRNOT00000119131.1 UniProtKB/TrEMBL
  ENSRNOT00055006596 UniProtKB/Swiss-Prot
  ENSRNOT00060040812 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.1150.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599273 IMAGE-MGC_LOAD
InterPro Aminotransferase_I/II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Asp_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NHTrfase_class1_PyrdxlP-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PyrdxlP-dep_Trfase_small UniProtKB/TrEMBL
KEGG Report rno:24401 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72537 IMAGE-MGC_LOAD
NCBI Gene 24401 ENTREZGENE
PANTHER ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Got1 PhenoGen
PRINTS TRANSAMINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AA_TRANSFER_CLASS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016356 RatGTEx
  ENSRNOG00055004126 RatGTEx
  ENSRNOG00060023531 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6G6L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UJT3_RAT UniProtKB/TrEMBL
  A6JHC9 ENTREZGENE, UniProtKB/TrEMBL
  A6JHD0_RAT UniProtKB/TrEMBL
  AATC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64570 ENTREZGENE
  Q6P721 ENTREZGENE
UniProt Secondary Q64570 UniProtKB/Swiss-Prot
  Q6P721 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Got1  glutamic-oxaloacetic transaminase 1  Got1  glutamic-oxaloacetic transaminase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Got1  glutamic-oxaloacetic transaminase 1, soluble  Got1  glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Got1  glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)  Got1  glutamate oxaloacetate transaminase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Got1  glutamate oxaloacetate transaminase 1, soluble  Got1  glutamate oxaloacetate transaminase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Got1  glutamate oxaloacetate transaminase 1    Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12  Name updated 625702 APPROVED
2002-06-10 Got1  Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation enzyme activity in liver and kidney increase in response to glucocorticoids 632937